Radical arylation of tyrosine residues in peptides

Journal article
(Original article)

Publication Details

Author(s): Fehler S, Pratsch G, Östreicher C, Fürst M, Pischetsrieder M, Heinrich M
Journal: Tetrahedron
Publisher: Elsevier Ltd
Publication year: 2016
Volume: 72
Journal issue: 48
Pages range: 7888-7893
ISSN: 1464-5416


The radical arylation of the phenolic side chain of tyrosine in peptides was investigated. Aryl radicals were generated from aryldiazonium salts using titanium(III) chloride as stoichiometric reductant. Due to the high selectivity with which 3-aryltyrosine derivatives were formed, this reaction type represents a new strategy for the direct functionalization of peptides.

FAU Authors / FAU Editors

Fehler, Stefanie
Professur für Pharmazeutische Chemie
Fürst, Michael
Professur für Pharmazeutische Chemie
Heinrich, Markus Prof. Dr.
Professur für Pharmazeutische Chemie
Östreicher, Christiane
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Pratsch, Gerald
Professur für Pharmazeutische Chemie

How to cite

Fehler, S., Pratsch, G., Östreicher, C., Fürst, M., Pischetsrieder, M., & Heinrich, M. (2016). Radical arylation of tyrosine residues in peptides. Tetrahedron, 72(48), 7888-7893. https://dx.doi.org/10.1016/j.tet.2016.04.084

Fehler, Stefanie, et al. "Radical arylation of tyrosine residues in peptides." Tetrahedron 72.48 (2016): 7888-7893.


Last updated on 2018-19-04 at 03:41