Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex

Journal article


Publication Details

Author(s): Öchsner E, Etzold B, Junge K, Beller M, Wasserscheid P
Journal: Advanced Synthesis & Catalysis
Publisher: Wiley-VCH Verlag
Publication year: 2009
Volume: 351
Journal issue: 1-2
Pages range: 235--245
ISSN: 1615-4150


Abstract


The asymmetric hydrogenation of methyl acetoacetate (MAA) in methanol using dibromobis(S)-4-phenyl-4,5-dihydro-3H-dinaphtho[2,1-c: 1$\prime$,2$\prime$-e]phosphepine-ruthenium was studied in detail. For the determination of the reaction network, data from kinetic experiments were compared to different possible reaction networks using the kinetic software Presto Kinetics. The simulation was optimised to describe the reaction accurately with a minimal set of process parameters and reaction equations. For the best model the reaction orders, collision factors and activation energy of all reaction steps were determined. Additionally, the influence of reaction temperature and hydrogen pressure on the enantiomeric excess (ee) of the reaction was studied. It was found that high reaction temperatures and high hydrogen pressures result in increasing enantioselectivities.



FAU Authors / FAU Editors

Etzold, Bastian Prof. Dr.
Professur für Katalytische Materialien
Wasserscheid, Peter Prof. Dr.
Lehrstuhl für Chemische Reaktionstechnik


Additional Organisation
Exzellenz-Cluster Engineering of Advanced Materials


External institutions
Leibniz-Institut für Katalyse (LIKAT) / Leibniz Institute for Catalysis


How to cite

APA:
Öchsner, E., Etzold, B., Junge, K., Beller, M., & Wasserscheid, P. (2009). Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex. Advanced Synthesis & Catalysis, 351(1-2), 235--245. https://dx.doi.org/10.1002/adsc.200800531

MLA:
Öchsner, Eva, et al. "Kinetic Study of the Asymmetric Hydrogenation of Methyl Acetoacetate in the Presence of a Ruthenium Binaphthophosphepine Complex." Advanced Synthesis & Catalysis 351.1-2 (2009): 235--245.

BibTeX: 

Last updated on 2018-08-09 at 07:08