Preliminary results on the influence of engineered artificial mucus layer on phonation
Döllinger M, Gröhn F, Berry DA, Eysholdt U, Luegmair G (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: American Speech-Language-Hearing Association
Book Volume: 57
Pages Range: S637-47
Journal Issue: 2
DOI: 10.1044/2014_JSLHR-S-12-0277
Abstract
PURPOSE Previous studies have confirmed the influence of dehydration and an altered mucus (e.g., due to pathologies) on phonation. However, the underlying reasons for these influences are not fully understood. This study was a preliminary inquiry into the influences of mucus architecture and concentration on vocal fold oscillation. METHOD Two excised human larynges were investigated in an in vitro setup. The oscillations of the vocal folds at various airflow volume rates were recorded through the use of high-speed imaging. Engineered mucus containing polymers (interconnected polymers and linear polymers) was applied to the vocal folds. From the high-speed footage, glottal parameters were extracted through the use of objective methods and were compared to a gold standard (physiological saline solution). RESULTS Variations were found for all applications of mucus. Fundamental frequency dropped and the oscillatory behavior (speed quotient [SQ], closing quotient [CQ]) changed for both larynges. The 2 applied mucus architectures displayed different effects on the larynges. The interconnected polymer displayed clear low-pass filter characteristics not found for the linear polymer. Increase of polymer concentration affected parameters to a certain point. CONCLUSION The data confirm results found in previous studies. Furthermore, the different effects-comparing architecture and concentration-suggest that, in the future, synthetic mucus can be designed to improve phonation.
Authors with CRIS profile
Michael Döllinger
Professur für Computational Medicine (DFG-Forschungsprofessur)
Franziska Gröhn
Professur für Molekulare Nanostrukturen
Georg Luegmair
Professur für Computational Medicine (DFG-Forschungsprofessur)
Involved external institutions
United States (USA) (US)How to cite
APA:
Döllinger, M., Gröhn, F., Berry, D.A., Eysholdt, U., & Luegmair, G. (2014). Preliminary results on the influence of engineered artificial mucus layer on phonation. Journal of Speech Language and Hearing Research, 57(2), S637-47. https://doi.org/10.1044/2014_JSLHR-S-12-0277
MLA:
Döllinger, Michael, et al. "Preliminary results on the influence of engineered artificial mucus layer on phonation." Journal of Speech Language and Hearing Research 57.2 (2014): S637-47.
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