Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

Journal article


Publication Details

Author(s): Philippart A, Boccardi E, Pontiroli L, Beltrán AM, Inayat A, Vitale-Brovarone C, Schwieger W, Spiecker E, Boccaccini AR
Journal: Advances in Science and Technology
Publication year: 2014
Volume: 96
Pages range: 54-60
ISSN: 1662-8969
Language: English


Abstract


Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Boccardi, Elena
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Inayat, Alexandra Dr.-Ing.
Lehrstuhl für Chemische Reaktionstechnik
Philippart, Anahi
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Schwieger, Wilhelm Prof. Dr.
Professur für Technische Chemie (Reaktionstechnik)
Spiecker, Erdmann Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)


Additional Organisation
Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)


External institutions with authors

Politecnico di Torino


How to cite

APA:
Philippart, A., Boccardi, E., Pontiroli, L., Beltrán, A.M., Inayat, A., Vitale-Brovarone, C.,... Boccaccini, A.R. (2014). Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities. Advances in Science and Technology, 96, 54-60. https://dx.doi.org/10.4028/www.scientific.net/AST.96.54

MLA:
Philippart, Anahi, et al. "Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities." Advances in Science and Technology 96 (2014): 54-60.

BibTeX: 

Last updated on 2019-29-05 at 15:53