Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function.

Journal article
(Review article)


Publication Details

Author(s): Gahbauer S, Böckmann R
Journal: Frontiers in Physiology
Publisher: Frontiers Research Foundation / Frontiers Media
Publication year: 2016
Volume: 7
Pages range: 494
ISSN: 1664-042X
Language: English


Abstract


The dimerization or even oligomerization of G protein coupled receptors (GPCRs) causes ongoing, controversial debates about its functional role and the coupled biophysical, biochemical or biomedical implications. A continously growing number of studies hints to a relation between oligomerization and function of GPCRs and strengthens the assumption that receptor assembly plays a key role in the regulation of protein function. Additionally, progress in the structural analysis of GPCR-G protein and GPCR-ligand interactions allows to distinguish between actively functional and non-signaling complexes. Recent findings further suggest that the surrounding membrane, i.e., its lipid composition may modulate the preferred dimerization interface and as a result the abundance of distinct dimeric conformations. In this review, the association of GPCRs and the role of the membrane in oligomerization will be discussed. An overview of the different reported oligomeric interfaces is provided and their capability for signaling discussed. The currently available data is summarized with regard to the formation of GPCR oligomers, their structures and dependency on the membrane microenvironment as well as the coupling of oligomerization to receptor function.



FAU Authors / FAU Editors

Böckmann, Rainer Prof. Dr.
Professur für Computational Biology
Gahbauer, Stefan
Professur für Computational Biology


How to cite

APA:
Gahbauer, S., & Böckmann, R. (2016). Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function. Frontiers in Physiology, 7, 494. https://dx.doi.org/10.3389/fphys.2016.00494

MLA:
Gahbauer, Stefan, and Rainer Böckmann. "Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function." Frontiers in Physiology 7 (2016): 494.

BibTeX: 

Last updated on 2019-08-08 at 14:18