Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells
Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP, Hartner A (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Landes Bioscience
Book Volume: 8
Pages Range: 389-95
Journal Issue: 4
DOI: 10.4161/cam.28988
Abstract
Fibrillin-1 is a microfibrillar extracellular matrix protein that was described to be a ligand for ?8 integrin. ?8 integrin is a matrix receptor specifically expressed in mesangial and smooth muscle cells of the kidney. In previous studies we detected glomerular expression of fibrillin-1. Moreover, fibrillin-1 promoted adhesion, migration, and proliferation of mesangial cells. We hypothesized that fibrillin-1 and ?8 integrin might interact in the glomerulus, and thus, regulate mesangial cell properties. Our studies showed that fibrillin-1 and ?8 integrin colocalize in the glomerular mesangium. Induction of experimental glomerulonephritis led to an increase of both fibrillin-1 and ?8 integrin expression. In vitro studies revealed that mesangial cells deficient for ?8 integrin adhere weaker to fibrillin-1 and migrate more easily on fibrillin-1 than wild-type mesangial cells. Baseline proliferation on fibrillin-1 is higher in ?8 integrin-deficient mesangial cells, but the induction of proliferation is not different in ?8 integrin-deficient and wild-type mesangial cells. We conclude that fibrillin-1 and ?8 integrin interact, and thus, regulate mesangial cell adhesion and migration. The concomitant induction of both fibrillin-1 and ?8 integrin in a self-limited model of glomerular injury points to a protective role of the interaction of fibrillin-1 with ?8 integrin in the glomerulus resulting in reduced damage of the glomerular tuft as a consequence of firm adhesion of mesangial cells.
Authors with CRIS profile
Karl Friedrich Hilgers
Professur für Innere Medizin (Hochdruckforschung)
Wolfgang Rascher
Lehrstuhl für Kinder- und Jugendmedizin
Andrea Hartner
Department of Paediatrics and Adolescent Medicine
Involved external institutions
Canada (CA)How to cite
APA:
Marek, I., Volkert, G., Hilgers, K.F., Bieritz, B., Rascher, W., Reinhardt, D.P., & Hartner, A. (2014). Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Cell Adhesion and Migration, 8(4), 389-95. https://doi.org/10.4161/cam.28988
MLA:
Marek, Ines, et al. "Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells." Cell Adhesion and Migration 8.4 (2014): 389-95.
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