Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Peytrignet S, Denton CP, Lunt M, Hesselstrand R, Mouthon L, Silman A, Pan X, Brown E, Czirjak L, Distler J, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk M, Ancuta C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt O, Jordan AC, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov N, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, Macgregor AJ, Mchugh N, Muller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, Inanc M, Mclaren JS, Van Laar JM, Pathare S, Proudman S, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Herrick AL
Zeitschrift: Rheumatology
Jahr der Veröffentlichung: 2017
ISSN: 1462-0324


Abstract

Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features.Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement. Correlations between 12-month changes were also examined.The 326 patients recruited (median disease duration 11.9 months) displayed high levels of disability [mean ( s . d .) HAQ-DI 1.1 (0.83)], with 'grip' and 'activity' being most affected. Of the 18 activities assessed in the CHFS, those involving fine finger movements were most affected. High HAQ-DI and CHFS scores were both associated with high mRSS (? = 0.34, P < 0.0001 and ? = 0.35, P < 0.0001, respectively). HAQ-DI was higher in patients with digital ulcers ( P = 0.004), pulmonary fibrosis ( P = 0.005), cardiac ( P = 0.005) and muscle involvement ( P = 0.002). As anticipated, HAQ-DI, CHFS, the Functional Assessment of Chronic Illness Therapy and SF36 scores were all highly correlated, in particular the HAQ-DI with the CHFS (? = 0.84, P < 0.0001). Worsening HAQ-DI over 12 months was strongly associated with increasing mRSS (? = 0.40, P < 0.0001), decreasing hand function (? = 0.57, P < 0.0001) and increasing fatigue (? = -0.53, P < 0.0001).The European Scleroderma Observational Study highlights the burden of disability in early dcSSc, with high levels of disability and fatigue, associating with the degree of skin thickening (mRSS). Impaired hand function is a major contributor to overall disability.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Distler, Jörg PD Dr.
Heisenberg-Professur für Molekulare Mechanismen der Organfibrose


Einrichtungen weiterer Autorinnen und Autoren

Assistance Publique-Hôpitaux de Paris (AP-HP)
Cambridge University Hospital
Cannock Chase Hospital
Centre Hospitalier Régional Universitaire de TOURS
Charité - Universitätsmedizin Berlin
Gateshead Health NHS Foundation Trust
Glasgow Royal Infirmary (GRI)
Grigore T. Popa University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Grigore T. Popa" (UMF Iași)
Hôpital Edouard Herriot
Hôpital général juif - Jewish General Hospital
Hôpital Saint Joseph
Hospices Civils de Lyon (CHU)
Hospital Center University De Limoges Dupuytren
Hospital Universitario 12 de Octubre
Istanbul University / İstanbul Üniversitesi
James Cook University Hospital
Justus-Liebig-Universität Gießen
LILLE 1 University - Science and Technology
Llandudno General Hospital
Lund University / Lunds universitet
Monash University
North Bristol NHS Trust
Nottingham University Hospitals
Oslo University Hospital / Oslo Universitetssykehus
Radboud University Nijmegen
Royal Adelaide Hospital
Royal National Hospital for Rheumatic Diseases
Royal Perth Hospital
Salford Royal NHS Foundation Trust
Sheffield Teaching Hospitals NHS Foundation Trust
Stanford University
St Vincent's Hospital
St Vincent's University Hospital
Technion - Israel Institute of Technology
The University of Liverpool
Università degli Studi di Firenze / University of Florence
Universität Köln
Universität zu Lübeck
Universität Zürich (UZH)
Université de Nantes
University College London (UCL)
University Hospitals Birmingham NHS Foundation Trust
University Medical Centre Utrecht (UMC Utrecht)
University of Belgrade / Универзитет у Београду
University of Copenhagen
University of East Anglia
University of Gothenburg / Göteborgs universitet
University of Leeds
University of Manchester
University of Oxford
University of Paris 4 - Paris-Sorbonne / Université paris IV Paris-Sorbonne
University of Pécs
Whytemans Brae Hospital


Zitierweisen

APA:
Peytrignet, S., Denton, C.P., Lunt, M., Hesselstrand, R., Mouthon, L., Silman, A.,... Herrick, A.L. (2017). Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. Rheumatology. https://dx.doi.org/10.1093/rheumatology/kex410

MLA:
Peytrignet, Sebastien, et al. "Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study." Rheumatology (2017).

BibTeX: 

Zuletzt aktualisiert 2018-05-10 um 02:25