Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications

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Details zur Publikation

Autorinnen und Autoren: Li W, Zaloga J, Ding Y, Liu Y, Janko C, Pischetsrieder M, Alexiou C, Boccaccini AR
Zeitschrift: Scientific Reports
Verlag: Nature Publishing Group: Open Access Journals - Option B
Jahr der Veröffentlichung: 2016
Band: 6
ISSN: 2045-2322


Abstract


The promising potential of magnetic polymer microspheres in various biomedical applications has been frequently reported. However, the surface hydrophilicity of superparamagnetic iron oxide nanoparticles (SPIONs) usually leads to poor or even failed encapsulation of SPIONs in hydrophobic polymer microspheres using the emulsion method. In this study, the stability of SPIONs in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) solution was significantly increased after surface modification with lauric acid. As a result, magnetic PHBV microspheres with high encapsulation efficiencies (71.0-87.4%) were prepared using emulsion-solvent extraction/evaporation method. Magnetic resonance imaging (MRI) showed significant contrast for the magnetic PHBV microspheres. The toxicity of these magnetic PHBV microspheres towards human T-lymphoma suspension cells and adherent colon carcinoma HT-29 cells was investigated using flow cytometry, and they were shown to be non-toxic in a broad concentration range. A model drug, tetracycline hydrochloride, was used to demonstrate the drug delivery capability and to investigate the drug release behavior of the magnetic PHBV microspheres. The drug was successfully loaded into the microspheres using lauric acid-coated SPIONs as drug carrier, and was released from the microspheres in a diffusion controlled manner. The developed magnetic PHBV microspheres are promising candidates for biomedical applications such as targeted drug delivery and MRI.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ding, Yaping
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Janko, Christina Dr. rer. nat.
Lehrstuhl für Genetik
Li, Wei
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Liu, Yufang
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Zaloga, Jan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


Zitierweisen

APA:
Li, W., Zaloga, J., Ding, Y., Liu, Y., Janko, C., Pischetsrieder, M.,... Boccaccini, A.R. (2016). Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications. Scientific Reports, 6. https://dx.doi.org/10.1038/srep23140

MLA:
Li, Wei, et al. "Facile preparation of multifunctional superparamagnetic PHBV microspheres containing SPIONs for biomedical applications." Scientific Reports 6 (2016).

BibTeX: 

Zuletzt aktualisiert 2019-28-02 um 06:04