Extracorporeal perfusion - reduced to a one-way infusion.

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Taeger CD, Friedrich O, Horch RE, Drechsler C, Weigand A, Hopf F, Geppert C, Münch F, Birkholz T, Wenzel C, Geis S, Prantl L, Buchholz R, Präbst K
Zeitschrift: Clinical hemorheology and microcirculation
Jahr der Veröffentlichung: 2017
ISSN: 1875-8622
Sprache: Englisch


Extracorporeal perfusion (EP) is moving into focus of research in reconstructive and transplantation medicine for the preservation of amputates and free tissue transplants. The idea behind EP is the reduction of ischemia-related cell damage between separation from blood circulation and reanastomosis of the transplant. Most experimental approaches are based on a complex system that moves the perfusate in a circular course.
In this study, we aimed to evaluate if a simple perfusion by an infusion bag filled with an electrolyte solution can provide acceptable results in terms of flow stability, oxygen supply and viability conservation for EP of a muscle transplant. The results are compared to muscles perfused with a pump system as well as muscles stored under ischemic conditions with a one-time intravasal flushing with Jonosteril.
With this simple method a sufficient oxygen supply could be achieved and functionality could be maintained between 3.35 times and 4.60 times longer compared to the control group. Annexin V positive nuclei, indicating apoptosis, increased by 9.7% in the perfused group compared to 24.4% in the control group.
Overall, by decreasing the complexity of the system, EP by one-way infusion can become more feasible in clinical situations.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Birkholz, Torsten Dr.
Anästhesiologische Klinik
Buchholz, Rainer Prof. Dr.
Technische Fakultät
Drechsler, Caroline
Professur für Plastische Chirurgie und Handchirurgie
Friedrich, Oliver Prof. Dr. Dr.
Lehrstuhl für Medizinische Biotechnologie
Geppert, Carol
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Hopf, Fabio
Lehrstuhl für Elektrokatalyse (HIERN)
Horch, Raymund E. Prof. Dr.
Professur für Plastische Chirurgie und Handchirurgie
Münch, Frank
Medizinische Fakultät
Präbst, Konstantin
Lehrstuhl für Bioverfahrenstechnik
Kengelbach-Weigand, Annika Dr.
Plastisch- und Handchirurgische Klinik

Einrichtungen weiterer Autorinnen und Autoren

Universitätsklinikum Regensburg


Taeger, C.D., Friedrich, O., Horch, R.E., Drechsler, C., Weigand, A., Hopf, F.,... Präbst, K. (2017). Extracorporeal perfusion - reduced to a one-way infusion. Clinical hemorheology and microcirculation. https://dx.doi.org/10.3233/CH-170298

Taeger, Christian Dirk, et al. "Extracorporeal perfusion - reduced to a one-way infusion." Clinical hemorheology and microcirculation (2017).


Zuletzt aktualisiert 2018-29-11 um 15:23