Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study

Crema MD, Felson DT, Guermazi A, Nevitt MC, Niu J, Lynch JA, Marra MD, Torner J, Lewis CE, Roemer F (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Osteoarthritis and Cartilage Elsevier

Book Volume: 25

Pages Range: 1647-1653

Journal Issue: 10

DOI: 10.1016/j.joca.2017.05.019

Abstract

To assess the associations of atrophic tibiofemoral osteoarthritis (OA) with progression of radiographic joint space narrowing (JSN) and magnetic resonance imaging (MRI)-defined progression of cartilage damage.Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included. The atrophic OA phenotype was defined as Osteoarthritis Research Society International (OARSI) grades 1 or 2 for JSN and grade 0 for osteophytes. Based on MRI, atrophic OA was defined as tibiofemoral (TF) cartilage damage grades >=3 in at least 2 of 10 subregions with absent or tiny osteophytes in all TF subregions. Progression of JSN and cartilage loss on MRI, was defined as (1) no, (2) slow, and (3) fast progression. Co-variance and logistic regression with generalized estimated equations were performed to assess the association of atrophic knee OA with any progression, compared to non-atrophic OA knees.A total of 476 knees from 432 participants were included. There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition. Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage. Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss.In this sample, the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss compared to the non-atrophic knee OA phenotype.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

University of Alabama at Birmingham (UAB) US United States (USA) (US) University of Iowa US United States (USA) (US) Boston University US United States (USA) (US) University of California San Francisco (UCSF) US United States (USA) (US)

How to cite

APA:

Crema, M.D., Felson, D.T., Guermazi, A., Nevitt, M.C., Niu, J., Lynch, J.A.,... Roemer, F. (2017). Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study. Osteoarthritis and Cartilage, 25(10), 1647-1653. https://doi.org/10.1016/j.joca.2017.05.019

MLA:

Crema, M. D., et al. "Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study." Osteoarthritis and Cartilage 25.10 (2017): 1647-1653.

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