Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

Journal article


Publication Details

Author(s): Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, Nagtegaal ID, Palmqvist R, Masucci GV, Botti G, Tatangelo F, Delrio P, Maio M, Laghi L, Grizzi F, Asslaber M, D'Arrigo C, Vidal-Vanaclocha F, Zavadova E, Chouchane L, Ohashi PS, Hafezi-Bakhtiari S, Wouters BG, Roehrl M, Nguyen L, Kawakami Y, Hazama S, Okuno K, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Wang Y, Kopetz S, Sinicrope FA, Scripcariu V, Ascierto PA, Marincola FM, Fox BA, Pages F
Journal: Journal of Pathology
Publisher: Wiley-Blackwell
Publication year: 2014
Volume: 232
Journal issue: 2
Pages range: 199-209
ISSN: 0022-3417


Abstract

The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named 'Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.


FAU Authors / FAU Editors

Hartmann, Arndt Prof. Dr. med.
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie


External institutions with authors

Avicenne Hospital / Hôpital Avicienne
CEU San Pablo University / Universidad CEU San Pablo
Cornell University
Dorset County Hospital
Fondazione IRCCS: Istituto Nazionale dei Tumori
Georges Pompidou European Hospital / Hôpital Européen Georges-Pompidou (HEGP)
Grigore T. Popa University of Medicine and Pharmacy / Universitatea de Medicină și Farmacie "Grigore T. Popa" (UMF Iași)
Gujarat Cancer & Research Institute
Harvard University
Istituto Clinico Humanitas
Karolinska Institute
Keio University / 慶應義塾大学
Kinki University / 近畿大学
Kurume University / 久留米大学
Mayo Clinic
Medizinische Universität Graz
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
Princess Margaret Cancer Centre / Princess Margaret Hospital
Providence Portland Medical Center
Radboud University Nijmegen
Royal Melbourne Hospital (RMH)
Sapporo Medical University / 札幌医科大学
Sidra Medical and Research Center
The University of Melbourne
Umeå University
Università degli Studi di Siena (UNISI) / University of Siena
Universität Bern
University Health Network (UHN)
University of Texas MD Anderson Cancer Center
Univerzita Karlova v Praze / Charles University in Prague
Xi’an Jiaotong-Liverpool University (XJTLU)
Yamaguchi University


How to cite

APA:
Galon, J., Mlecnik, B., Bindea, G., Angell, H.K., Berger, A., Lagorce, C.,... Pages, F. (2014). Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. Journal of Pathology, 232(2), 199-209. https://dx.doi.org/10.1002/path.4287

MLA:
Galon, Jerome, et al. "Towards the introduction of the 'Immunoscore' in the classification of malignant tumours." Journal of Pathology 232.2 (2014): 199-209.

BibTeX: 

Last updated on 2018-05-10 at 02:21