New insights into the interaction of Mycobacterium tuberculosis and human macrophages

Bruns H, Stenger S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Future Microbiology Future Medicine

Book Volume: 9

Pages Range: 327-41

DOI: 10.2217/fmb.13.164

Abstract

Mycobacterium tuberculosis is a facultative intracellular pathogen. It infects macrophages where it avoids elimination by interfering with host defense mechanisms. Until recently, it was assumed that the acidification of phagosomes is the major strategy of macrophages to eliminate M. tuberculosis. However, there is emerging evidence demonstrating that human macrophages are equipped with additional antimicrobial effector functions. Specifically, autophagy, efferocytosis and antimicrobial peptides have been identified as mechanisms to restrict mycobacterial proliferation. Here we review recent findings on effector functions of human macrophages and mechanisms of the pathogen to interfere with them.

Authors with CRIS profile

Heiko Bruns Department of Medicine 5 – Haematology and Oncology

Involved external institutions

Universitätsklinikum Ulm DE Germany (DE)

How to cite

APA:

Bruns, H., & Stenger, S. (2014). New insights into the interaction of Mycobacterium tuberculosis and human macrophages. Future Microbiology, 9, 327-41. https://dx.doi.org/10.2217/fmb.13.164

MLA:

Bruns, Heiko, and Steffen Stenger. "New insights into the interaction of Mycobacterium tuberculosis and human macrophages." Future Microbiology 9 (2014): 327-41.

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