Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Jeleazcov C, Lavielle M, Schüttler J, Ihmsen H
Zeitschrift: British Journal of Anaesthesia
Jahr der Veröffentlichung: 2015
Band: 115
Heftnummer: 2
Seitenbereich: 213-26
ISSN: 0007-0912


Abstract


Concentration effect relationships are commonly described with a direct response model as for example the sigmoid E(max) model with one effect compartment as site of action. In this study we investigated whether models with more than one effect site, or indirect response, or counter-regulatory response models may be more appropriate for modelling the propofol effect on arterial blood pressure.Nine young healthy volunteers received propofol as target controlled infusion with predefined increasing and decreasing plasma target concentrations. Propofol concentrations were determined from arterial blood samples. Arterial blood pressure was measured invasively at radial artery site. Pharmacokinetic/-pharmacodynamic modelling was performed by population analysis with MONOLIX, testing different direct, indirect and counter-regulatory response models.Propofol plasma concentrations were well described by a three-compartment model. The propofol effect on arterial blood pressure was best described by a direct sigmoid E(max) model with two effect site compartments.Two effect sites were needed to describe the propofol effect on arterial blood pressure. This may reflect different pathways of arterial blood pressure response to propofol.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Jeleazcov, Christian Prof. Dr.
Medizinische Fakultät
Schüttler, Jürgen Prof. Dr.
Lehrstuhl für Anästhesiologie


Einrichtungen weiterer Autorinnen und Autoren

University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud


Zitierweisen

APA:
Jeleazcov, C., Lavielle, M., Schüttler, J., & Ihmsen, H. (2015). Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia. British Journal of Anaesthesia, 115(2), 213-26. https://dx.doi.org/10.1093/bja/aeu553

MLA:
Jeleazcov, Christian, et al. "Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia." British Journal of Anaesthesia 115.2 (2015): 213-26.

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Zuletzt aktualisiert 2018-05-10 um 02:20