Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia

Jeleazcov C, Lavielle M, Schüttler J, Ihmsen H (2015)

Publication Type: Journal article

Publication year: 2015

Journal

British Journal of Anaesthesia Oxford University Press (OUP): Policy B - Oxford Open Option B

Book Volume: 115

Pages Range: 213-26

Journal Issue: 2

DOI: 10.1093/bja/aeu553

Abstract

Concentration effect relationships are commonly described with a direct response model as for example the sigmoid E(max) model with one effect compartment as site of action. In this study we investigated whether models with more than one effect site, or indirect response, or counter-regulatory response models may be more appropriate for modelling the propofol effect on arterial blood pressure.Nine young healthy volunteers received propofol as target controlled infusion with predefined increasing and decreasing plasma target concentrations. Propofol concentrations were determined from arterial blood samples. Arterial blood pressure was measured invasively at radial artery site. Pharmacokinetic/-pharmacodynamic modelling was performed by population analysis with MONOLIX, testing different direct, indirect and counter-regulatory response models.Propofol plasma concentrations were well described by a three-compartment model. The propofol effect on arterial blood pressure was best described by a direct sigmoid E(max) model with two effect site compartments.Two effect sites were needed to describe the propofol effect on arterial blood pressure. This may reflect different pathways of arterial blood pressure response to propofol.

Authors with CRIS profile

Christian Jeleazcov Medizinische Fakultät Jürgen Schüttler Lehrstuhl für Anästhesiologie

Involved external institutions

University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud FR France (FR)

How to cite

APA:

Jeleazcov, C., Lavielle, M., Schüttler, J., & Ihmsen, H. (2015). Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia. British Journal of Anaesthesia, 115(2), 213-26. https://dx.doi.org/10.1093/bja/aeu553

MLA:

Jeleazcov, Christian, et al. "Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia." British Journal of Anaesthesia 115.2 (2015): 213-26.

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