Interleukin-10-regulated tumour tolerance in non-small cell lung cancer

Vahl JM, Friedrich J, Mittler S, Trump S, Heim L, Kachler K, Balabko L, Fuhrich N, Geppert CI, Trufa D, Sopel N, Rieker R, Sirbu H, Finotto S (2017)

Publication Type: Journal article

Publication year: 2017

Journal

British Journal of Cancer Cancer Research UK

DOI: 10.1038/bjc.2017.336

Abstract

Lung cancer is the most life-threatening cancer type worldwide. Treatment options include surgery, radio- and chemotherapy, as well as the use of immunomodulatory antibodies. Interleukin (IL)-10 is an immunosuppressive cytokine involved in tumour immune escape.Immunohistochemistry (IHC) on human lung surgery tissue as well as human tumour cell line cultures, FACS analysis, real-time PCR and experimental lung cancer.Here we discovered a positive correlation between IL-10 and IL-10 receptor (IL-10R) expression in the lung with tumour diameter in patients with lung cancer (non-small cell lung cancer), the most life-threatening cancer type worldwide. IL-10 and IL-10R were found induced in cells surrounding the lung tumour cells, and IL-10R was mainly expressed on the surface of Foxp-3(+) T-regulatory lymphocytes infiltrating the tumour of these patients where its expression inversely correlated with programmed cell death 1. These findings were confirmed in translational studies. In a human lung adenocarcinoma cell line, IL-10R was found induced under metabolic restrictions present during tumour growth, whereby IL-10 inhibited PDL1 and tumour cell apoptosis.These new findings suggest that IL-10 counteracts IFN-? effects on PD1/PDL1 pathway, resulting in possible resistance of the tumour to anti-PD1/PDL1 immunotherapy.British Journal of Cancer advance online publication 10 October 2017 doi:10.1038/bjc.2017.336 www.bjcancer.com.

Authors with CRIS profile

Julius Malte Vahl Professur für Molekulare Pneumologie Juliane Friedrich Department of Molecular Pneumology Liubov Balabko Professur für Molekulare Pneumologie Carol-Immanuel Geppert Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Denis Trufa Department of Thoracic Surgery Nina Sopel Department of Molecular Pneumology Ralf Rieker Institute of Pathology Horia Sirbu Department of Thoracic Surgery Susetta Neurath-Finotto Department of Molecular Pneumology

How to cite

APA:

Vahl, J.M., Friedrich, J., Mittler, S., Trump, S., Heim, L., Kachler, K.,... Finotto, S. (2017). Interleukin-10-regulated tumour tolerance in non-small cell lung cancer. British Journal of Cancer. https://doi.org/10.1038/bjc.2017.336

MLA:

Vahl, Julius Malte, et al. "Interleukin-10-regulated tumour tolerance in non-small cell lung cancer." British Journal of Cancer (2017).

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