Simon D, Simon C, Kleyer A, Schett G (2017)
Publication Type: Journal article, Letter
Publication year: 2017
DOI: 10.1002/jbmr.3208
We thank Rossini and colleagues for their letter (1) commenting on our article (2) "Age- and Sex-Dependent Changes of intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis". In fact, we could not more agree with the view of the authors and congratulate them for this concise summary of the key mechanism involved in bone loss of rheumatoid arthritis. In addition, we think that this letter raises two important points related to inflammatory bone loss: First, Rossini and colleagues point out that bone loss in rheumatoid arthritis arises from a combination of (i) factors specific to rheumatoid arthritis, in particular inflammation and autoimmunity and (ii) more common factors related to age, sex and menopausal status. Hence, age, postmenopausal state and inflammation/autoimmunity join efforts to trigger bone disease in patients with rheumatoid arthritis. Our data support this concept by showing age-, sex- and disease- associated changes of intra-articular bone mass and microstructures, which is likely the most sensitive indicator of bone loss in the context of arthritis. This article is protected by copyright. All rights reserved.
APA:
Simon, D., Simon, C., Kleyer, A., & Schett, G. (2017). Reply to: Osteoporosis: An Independent Determinant of Bone Erosions in Rheumatoid Arthritis? Journal of Bone and Mineral Research. https://dx.doi.org/10.1002/jbmr.3208
MLA:
Simon, David, et al. "Reply to: Osteoporosis: An Independent Determinant of Bone Erosions in Rheumatoid Arthritis?" Journal of Bone and Mineral Research (2017).
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