Dietary fatty acids and susceptibility to multiple sclerosis

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Haase S, Haghikia A, Gold R, Linker R
Zeitschrift: Multiple sclerosis journal
Jahr der Veröffentlichung: 2018
Band: 24
Heftnummer: 1
Seitenbereich: 12-16
ISSN: 1352-4585
eISSN: 1477-0970


Abstract


The gut microbiome as well as dietary habits have recently been established as environmental contributors to the pathogenesis of multiple sclerosis (MS), a T-cell-mediated autoimmune disease of the central nervous system (CNS).To summarize recent findings on the Janus-faced effects of dietary short-chain fatty acids (SCFAs) and long-chain fatty acids (LCFAs) on T-cell immunity with a special focus on the gut and the microbiome as an interface linking diet and T-cell responses during MS.Review article.The autoimmune basis of MS most likely stems from an imbalance between pro-inflammatory T helper cell (Th)1 and Th17 cells and anti-inflammatory or regulatory mechanisms including regulatory T cells (Treg). Hence, the rationale of currently available therapeutic interventions is to either suppress pathogenic Th1/Th17 and/or to foster Treg responses. Dietary fatty acids are often discussed for their detrimental role in MS. However, recent studies investigating saturated fatty acids in animal models of MS revealed harmful as well as beneficial effects depending on their aliphatic chain length.Dietary SCFAs constitute interesting candidates as safe and potent add-on therapy in the immunomodulatory treatment armamentarium for relapsing-remitting MS.



FAU-Autoren / FAU-Herausgeber

Linker, Ralf PD Dr.
Stiftungsprofessur für Neuroimmunologie


Autor(en) der externen Einrichtung(en)
Ruhr-Universität Bochum (RUB)


Zitierweisen

APA:
Haase, S., Haghikia, A., Gold, R., & Linker, R. (2018). Dietary fatty acids and susceptibility to multiple sclerosis. Multiple sclerosis journal, 24(1), 12-16. https://dx.doi.org/10.1177/1352458517737372

MLA:
Haase, Stefanie, et al. "Dietary fatty acids and susceptibility to multiple sclerosis." Multiple sclerosis journal 24.1 (2018): 12-16.

BibTeX: 

Zuletzt aktualisiert 2019-01-01 um 12:10