A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice

Kruse M, Fiallo A, Tao J, Susztak K, Amann KU, Katz EB, Charron MJ (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Kidney & Blood Pressure Research Karger

Book Volume: 42

Pages Range: 468-482

Journal Issue: 3

DOI: 10.1159/000479383

Abstract

Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring.Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L. After weaning male offspring were placed on a standard rodent chow until 24 weeks of age.All offspring exposed to a maternal HFD showed increased heart and kidney weight and reduced cardiac insulin responsiveness. G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT1- receptors compared to G4+/- on a C diet. This group showed decreased cardiac expression of key genes involved in fatty acid oxidation compared to WT on a C diet.These results indicate an interaction between a HFD diet and genotype during early life development that can enhance susceptibility to cardio-renal diseases later in life.

Authors with CRIS profile

Kerstin Ute Amann Department of Nephropathology

Involved external institutions

Albert Einstein College of Medicine US United States (USA) (US) University of Pennsylvania US United States (USA) (US)

How to cite

APA:

Kruse, M., Fiallo, A., Tao, J., Susztak, K., Amann, K.U., Katz, E.B., & Charron, M.J. (2017). A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice. Kidney & Blood Pressure Research, 42(3), 468-482. https://doi.org/10.1159/000479383

MLA:

Kruse, Michael, et al. "A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice." Kidney & Blood Pressure Research 42.3 (2017): 468-482.

BibTeX: Download