Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer

Kriegmair MC, Balk M, Wirtz R, Steidler A, Weis CA, Breyer J, Hartmann A, Bolenz C, Erben P (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Anticancer Research International Institute of Anticancer Research (IIAR)

Book Volume: 36

Pages Range: 5205-5213

Journal Issue: 10

DOI: 10.21873/anticanres.11091

Abstract

To evaluate the prognostic role of the p53-upstream inhibitors MDM2, MDM4 and its splice variant MDM4-S in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC).mRNA Expression levels of MDM2, MDM4 and MDM4-S were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) in 75 RC samples. Logistic regression analyses identified predictors of recurrence-free (RFS) and cancer-specific survival (CSS).High expression was found in 42% (MDM2), 27% (MDMD4) and 91% (MDM4-S) of tumor specimens. Increased MDM2 expression was significantly associated with higher tumor stage (p=0.05) and lymphovascular invasion (LVI) (p=0.041). In the univariate analysis, low MDM4 expression (hazard ratio (HR)=5.93; p=0.002; HR=3.00; p=0.047), but not MDM2 (HR=1.63; p=0.222; HR=1.59; p=0.27), were associated with RFS and CSS. In the multivariate analysis, the combination of low MDM4 and high MDM2 was significant for RFS and CSS (HR=14.9; p=0.001; HR=5.63; p=0.019).The combination of MDM2 and MDM4 expression is an independent predictor in patients undergoing RC for MIBC.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universitätsklinikum Mannheim DE Germany (DE) Universität Ulm DE Germany (DE) Universität Regensburg DE Germany (DE) STRATIFYER Molecular Pathology GmbH DE Germany (DE)

How to cite

APA:

Kriegmair, M.C., Balk, M., Wirtz, R., Steidler, A., Weis, C.-A., Breyer, J.,... Erben, P. (2016). Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. Anticancer Research, 36(10), 5205-5213. https://doi.org/10.21873/anticanres.11091

MLA:

Kriegmair, Maximilian Christian, et al. "Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer." Anticancer Research 36.10 (2016): 5205-5213.

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