Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

Journal article


Publication Details

Author(s): Hausenloy DJ, Garcia-Dorado D, Botker HE, Davidson SM, Downey J, Engel F, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P
Journal: Cardiovascular Research
Publication year: 2017
Volume: 113
Journal issue: 6
Pages range: 564-585
ISSN: 0008-6363


Abstract


Ischaemic heart disease and the heart failure that often results, remain the leading causes of death and disability in Europe and worldwide. As such, in order to prevent heart failure and improve clinical outcomes in patients presenting with an acute ST-segment elevation myocardial infarction and patients undergoing coronary artery bypass graft surgery, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). During the last three decades, a wide variety of ischaemic conditioning strategies and pharmacological treatments have been tested in the clinic-however, their translation from experimental to clinical studies for improving patient outcomes has been both challenging and disappointing. Therefore, in this Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart, we critically analyse the current state of ischaemic conditioning in both the experimental and clinical settings, provide recommendations for improving its translation into the clinical setting, and highlight novel therapeutic targets and new treatment strategies for reducing acute myocardial IRI.



FAU Authors / FAU Editors

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


External institutions with authors

Aarhus University Hospital / Aarhus Universitetshospital
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Chaim Sheba Medical Center at Tel HaShomer / המרכז הרפואי ע"ש חיים שיבא – תל השומר‎‎
Duke University
Emory University
Hopital Louis Pradel
Justus-Liebig-Universität Gießen
Semmelweis University
Università degli Studi di Napoli Federico II
Università degli Studi Gabriele D'Annunzio
Universitätsklinikum Essen
Université d'Angers
University College London (UCL)
University Medical Centre Utrecht (UMC Utrecht)
University of Cape Town (UCT)
University of South Alabama
University of Tromsø


How to cite

APA:
Hausenloy, D.J., Garcia-Dorado, D., Botker, H.E., Davidson, S.M., Downey, J., Engel, F.,... Ferdinandy, P. (2017). Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovascular Research, 113(6), 564-585. https://dx.doi.org/10.1093/cvr/cvx049

MLA:
Hausenloy, Derek J., et al. "Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart." Cardiovascular Research 113.6 (2017): 564-585.

BibTeX: 

Last updated on 2019-24-07 at 07:28