Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure
Madonna R, Van Laake L, Davidson SM, Engel F, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JPG (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 37
Pages Range: 1789-98
Journal Issue: 23
Abstract
Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.
Authors with CRIS profile
Involved external institutions
National University of Singapore (NUS)
Singapore (SG)
Charité - Universitätsmedizin Berlin
Germany (DE)
Leiden University
Netherlands (NL)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Texas Heart Institute
United States (USA) (US)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
University College London (UCL)
United Kingdom (GB)
University of Cape Town (UCT)
South Africa (ZA)
Tel Aviv University
Israel (IL)
Università degli Studi di Napoli Federico II
Italy (IT)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitetet i Tromsø / The Arctic University of Norway (UiT)
Norway (NO)
Singapore (SG)
Charité - Universitätsmedizin Berlin
Germany (DE)
Leiden University
Netherlands (NL)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Belgium (BE)
Texas Heart Institute
United States (USA) (US)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
University College London (UCL)
United Kingdom (GB)
University of Cape Town (UCT)
South Africa (ZA)
Tel Aviv University
Israel (IL)
Università degli Studi di Napoli Federico II
Italy (IT)
Justus-Liebig-Universität Gießen
Germany (DE)
Universitetet i Tromsø / The Arctic University of Norway (UiT)
Norway (NO)
How to cite
APA:
Madonna, R., Van Laake, L., Davidson, S.M., Engel, F., Hausenloy, D.J., Lecour, S.,... Sluijter, J.P.G. (2016). Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. European Heart Journal, 37(23), 1789-98. https://doi.org/10.1093/eurheartj/ehw113
MLA:
Madonna, Rosalinda, et al. "Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure." European Heart Journal 37.23 (2016): 1789-98.
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