Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Journal article


Publication Details

Author(s): Madonna R, Van Laake L, Davidson SM, Engel F, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JPG
Journal: European Heart Journal
Publication year: 2016
Volume: 37
Journal issue: 23
Pages range: 1789-98
ISSN: 0195-668X
eISSN: 1522-9645


Abstract


Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.



FAU Authors / FAU Editors

Engel, Felix Prof. Dr. rer. nat.
Professur für Experimentelle Nieren- und Kreislaufforschung


External institutions with authors

Charité - Universitätsmedizin Berlin
Justus-Liebig-Universität Gießen
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Leiden University
National University of Singapore (NUS)
Semmelweis University
Tel Aviv University
Texas Heart Institute
Università degli Studi di Napoli Federico II
Università degli Studi Gabriele D'Annunzio
Universitätsklinikum Hamburg-Eppendorf (UKE)
University College London (UCL)
University Medical Centre Utrecht (UMC Utrecht)
University of Cape Town (UCT)
University of Tromsø


How to cite

APA:
Madonna, R., Van Laake, L., Davidson, S.M., Engel, F., Hausenloy, D.J., Lecour, S.,... Sluijter, J.P.G. (2016). Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. European Heart Journal, 37(23), 1789-98. https://dx.doi.org/10.1093/eurheartj/ehw113

MLA:
Madonna, Rosalinda, et al. "Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure." European Heart Journal 37.23 (2016): 1789-98.

BibTeX: 

Last updated on 2019-26-07 at 09:03