IZKF-J73 (CH): Intracellular signal transduction pathways relaying SPARCL1 activity in colorectal carcinoma
FAU own research funding: EFI / IZKF / EAM ...
Start date : 16.09.2018
End date : 30.06.2020
Project details
Scientific Abstract
The tumor microenvironment (TME) plays a pivotal role in tumorigenesis, prognosis and therapy. SPARCL1 is a vascular derived anti-tumorigenic factor that counteracts CRC tumorigenesis in a TME-dependent manner. Preliminary results indicate that SPARCL1 regulates ERK phosphorylation and subcellular localization in endothelial and CRC cells. This project aims to elucidate the signaling pathways by which SPARCL1 transmits its anti-proliferative and anti-angiogenic functions, mainly focusing on ERK.
Involved:
Contributing FAU Organisations:
Professur für Molekulare und Experimentelle Chirurgie
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Interdisziplinäres Zentrum für Klinische Forschung IZKF Nachwuchsgruppe 1 Prof. Dr. Ceppi
Medizinische Fakultät
