D034: Role of fibroblast polarization in the pathogenesis of colorectal carcinoma
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.05.2020
End date : 31.01.2023
Extension date: 31.07.2023
Project details
Scientific Abstract
We have identified PU.1 as a key regulator of fibroblast polarization. Its role in colorectal carcinoma (CRC) is unknown. We will address the following aims: (1) characterization of cancer-associated fibroblast (CAF) heterogeneity in CRC, (2) analysis of CAF polarization-dependent fibrocrine effects in vitro and (3) in experimental animal models, and (4) validation of the results in CRC tissues. Deciphering the role of fibroblast polarization in CRC may provide a new target for therapy.
