IZKF-J66 (AN): ß subunits in human stem cell-derived nociceptors - adding pieces to the puzzle of pain
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.01.2018
End date : 31.08.2020
Project details
Scientific Abstract
The objective of this study is to identify the role of regulatory proteins of voltage-gated sodium channels (ß subunits) as potential contributors and new therapeutic targets of pain. Main focus of this work will be on mutations of ß1 and ß3 that have recently been found in patients suffering from the pain syndrome erythromelalgia. Using human stem cell-derived nociceptors these mutations will be functionally characterised with electrophysiological and molecular biology methods.
Involved:
Contributing FAU Organisations:
Interdisziplinäres Zentrum für Klinische Forschung (IZKF)
Department of Anaesthesiology
Medizinische Fakultät
