D036: Endogenous retroviruses drive tumor inflammation via RNA intermediates in bladder and ovarian cancer
FAU own research funding: EFI / IZKF / EAM ...
Start date : 01.03.2020
End date : 15.11.2022
Extension date: 28.02.2023
Project details
Scientific Abstract
This proposal will focus on the molecular basis of tumor inflammation of two different advanced cancers; Bladder cancer (MIBC) and Ovarian cancer (OVCA) with poor survival outcomes and high recurrence rates. Endogenous retrovirus (ERV) activations are linked with innate immunity and tumor inflammation. We will correlate patient immune signatures with ERVs and determine the functional role of ERVs, including dsRNA and RNA/DNA intermediates using tumors, cell lines and tumoroids of MIBC and OVCA.
