Biological Membranes in Action: A Unified Approach to Complexation, Scaffolding and Active Transport

Drittmittelfinanzierte Einzelförderung


Details zum Projekt

Projektleiter/in:
Prof. Dr. Ana-Suncana Smith


Beteiligte FAU-Organisationseinheiten:
Professur für Theoretische Physik

Mittelgeber: EU - 7. RP / Ideas / ERC Starting Independent Researcher Grant (StG)
Akronym: MEMBRANESACT
Projektstart: 01.10.2013
Projektende: 30.09.2019


Abstract (fachliche Beschreibung):


In recent breakthrough publications, the effect of fluctuations on the affinity of membrane-confined molecules has been evaluated, and a quantitative model for the time evolution of small adhesion domains has been developed under my leadership. Now I propose to bring my research to a new level by tackling the problem of active and passive organisation of proteins into macromolecular structures on fluctuating fluid membranes, using a physicist's approach across established disciplinary boundaries.The formation and transport of supramolecular complexes in membranes is ubiquitous to nearly all functions of biological cells. Today, there is a variety of experiments suggesting that macromolecular complexes act as scaffolds for free proteins, overall yielding obstructed diffusion, counterbalanced by active transport by molecular motors. However, an integrative view connecting complexation and transport is largely missing. Furthermore, the effects of membrane mediated interactions and (non)-thermal fluctuations were so far overlooked. Gaining a quantitative insight into these processes is key to understanding the fundamental functioning of cells.Together with my carefully selected team, I will address these intrinsically biological problems, by means of theoretical physics. Phenomena such as active and anomalous transport, as well as complexation are also currently subject to intense research in the statistical and soft matter physics communities. In this context, the aim of this proposal is to bridge the divide between the two worlds and significantly contribute to both physics and the life sciences by developing general principles that can be applied to processes in cells. Resolving these issues is of fundamental importance since it would identify how interactions on the cell surface arise, and may translate directly into pharmaceutical applications.



Externe Partner

Institute Ruđer Bošković


Publikationen
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Cvitkovic, M., Smith, A.-S., & Pande, J. (2017). Asymptotic expansions of the hypergeometric function with two large parameters-application to the partition function of a lattice gas in a field of traps. Journal of Physics A: Mathematical and Theoretical, 50(26), 1-24. https://dx.doi.org/10.1088/1751-8121/aa7213
Pande, J., Merchant, L., Krueger, T., Harting, J., & Smith, A.-S. (2017). Effect of body deformability on microswimming. Soft Matter, 13(21), 3984-3993. https://dx.doi.org/10.1039/c7sm00181a
Fenz, S.F., Bihr, T., Schmidt, D., Merkel, R., Seifert, U., Sengupta, K., & Smith, A.-S. (2017). Membrane fluctuations mediate lateral interaction between cadherin bonds. Nature Physics, 13(9), 906-913. https://dx.doi.org/10.1038/NPHYS4138
Bihr, T., Sadafi, F.-Z., Smith, A.-S., Klupp Taylor, R., & Seifert, U. (2017). Radial Growth in 2D Revisited: The Effect of Finite Density, Binding Affinity, Reaction Rates, and Diffusion. Advanced Materials Interfaces, 4(1). https://dx.doi.org/10.1002/admi.201600310
Pande, J., Merchant, L., Kruger, T., Harting, J., & Smith, A.-S. (2017). Setting the pace of microswimmers: when increasing viscosity speeds up self-propulsion. New Journal of Physics, 19. https://dx.doi.org/10.1088/1367-2630/aa6e3a
Smith, A.-S. (2016). BIOPHYSICS Alive and twitching. NATURE PUBLISHING GROUP.
Kaliman, S., Jayachandran, C., Rehfeldt, F., & Smith, A.-S. (2016). Limits of Applicability of the Voronoi Tessellation Determined by Centers of Cell Nuclei to Epithelium Morphology. Frontiers in Physiology, 7. https://dx.doi.org/10.3389/fphys.2016.00551
Monzel, C., Schmidt, D., Seifert, U., Smith, A.-S., Merkel, R., & Sengupta, K. (2016). Nanometric thermal fluctuations of weakly confined biomembranes measured with microsecond time-resolution. Soft Matter, 12(21), 4755-4768. https://dx.doi.org/10.1039/c6sm00412a
Schmidt, D., Bihr, T., Fenz, S., Merkel, R., Seifert, U., Sengupta, K., & Smith, A.-S. (2015). Crowding of receptors induces ring-like adhesions in model membranes. Biochimica Et Biophysica Acta-Molecular Cell Research, 1853(11), 2984-2991. https://dx.doi.org/10.1016/j.bbamcr.2015.05.025
Monzel, C., Schmidt, D., Kleusch, C., Kirchenbuechler, D., Seifert, U., Smith, A.-S.,... Merkel, R. (2015). Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy. Nature Communications, 6. https://dx.doi.org/10.1038/ncomms9162

Zuletzt aktualisiert 2018-22-11 um 19:00