Advanced Optical Laser Technologies for Life Sciences and personalized Medicine (ADVENDO-LIFE)

FAU-eigene Forschungsfinanzierung: EFI / ETI / ...


Details zum Projekt

Projektleiter/in:
Prof. Dr. Dr. Oliver Friedrich

Projektbeteiligte:
Prof. Dr.-Ing. Alfred Leipertz
Prof. Dr. Gerhard Leuchs
Prof. Dr. Markus Neurath
Prof. Dr. Vahid Sandoghdar
Prof. Dr.-Ing. Michael Schmidt
Dr. rer. nat. Sebastian Schürmann
Prof. Dr. Stefan Schwab

Beteiligte FAU-Organisationseinheiten:
Lehrstuhl für Experimentalphysik (Alexander-von-Humboldt-Professur)
Lehrstuhl für Experimentalphysik (Optik)
Lehrstuhl für Innere Medizin I
Lehrstuhl für Medizinische Biotechnologie
Lehrstuhl für Neurologie
Lehrstuhl für Photonische Technologien
Lehrstuhl für Technische Thermodynamik

Akronym: ADVENDO-LIFE
Projektstart: 01.01.2014
Projektende: 31.12.2015


Abstract (fachliche Beschreibung):

The identification of specific tissue and organ diseases, in particular tumours and inflammation, at an earliest possible stage, is one of the most challenging tasks in modern medicine to provide an adequate personalized and minimally invasive therapy. The specific and highly resolved visualization of diseased cells and tissue components requires the development of novel optical technologies at the edge of optical resolution to reveal structures that would be otherwise invisible to the naked eye. Laser applications already are capable today to endoscopically visualize tumours, e.g. of the gastro-intestinal tract. However, those techniques are still limited by their specificity and additionally require the use of external labels to mark pathological processes. Multiphoton excitation of specific marker molecules within the tissue can circumvent the need for such dyes. The central goal of the ADVENDO-LIFE project is the miniaturization of state-of-the-art multiphoton imaging into a novel generation of optical endoscopes that will be suitable to visualize diseased individual cells in tissues and tissue architecture in vivo. This will be first attempted in animal models and later translated into clinical practice. To achieve this goal, our multidisciplinary project team, consisting of laser physicists, optical engineers, biotechnologists and physicians will develop and validate a suitable prototype of a multiphoton-laser-endoscope. The image information resulting from this technology will be the grounds to build a morphometrical database of ‚Ultrastructure in Diseases‘ as a novel diagnostic tool for clinicians in early diagnosis and monitoring of, e.g., tumours and chronic inflammatory diseases.


Publikationen

Dilipkumar, A., Al-Shemmary, A., Kreiß, L., Cvecek, K., Carlé, B.-E., Knieling, F.,... Schürmann, S. (2019). Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging. Advanced Science, 6(8). https://dx.doi.org/10.1002/advs.201801735
Friedrich, O., Diermeier, S., & Larsson, L. (2018). Weak by the machines: muscle motor protein dysfunction - a side effect of intensive care unit treatment. Acta Physiologica, 222(1). https://dx.doi.org/10.1111/apha.12885
Diermeier, S., Iberl, J., Vetter, K., Haug, M., Pollmann, C., Reischl, B.,... Friedrich, O. (2017). Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice. Scientific Reports, 7(1), 1391. https://dx.doi.org/10.1038/s41598-017-01485-x
Waldner, M., Rath, T., Schürmann, S., Bojarski, C., & Atreya, R. (2017). Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives. Frontiers in Immunology, 8. https://dx.doi.org/10.3389/fimmu.2017.01256
Diermeier, S., Buttgereit, A., Schürmann, S., Winter, L., Xu, H., Murphy, R.M.,... Friedrich, O. (2017). Preaged remodeling of myofibrillar cytoarchitecture in skeletal muscle expressing R349P mutant desmin. Neurobiology of Aging, 58, 77-87. https://dx.doi.org/10.1016/j.neurobiolaging.2017.06.001
Diermeier, S., Buttgereit, A., Clemen, C., Schröder, R., & Friedrich, O. (2016). Aging-related progressive skeletal muscle weakness in mutant DesR349P muscles: a matter of compromised cytoarchitecture. Acta Physiologica, 216.
Diermeier, S., Haug, M., Reischl, B., Buttgereit, A., Schürmann, S., Spörrer, M.,... Friedrich, O. (2016, February). DesR349P Mutation Results in Ultrastructural Disruptions and Compromise of Skeletal Muscle Biomechanics Already at Preclinical Stages in Young Mice before the Onset of Protein Aggregation. Poster presentation.
Diermeier, S., Buttgereit, A., Winter, L., Clemen, C.S., Schröder, R., & Friedrich, O. (2015, March). Structure-related force deficit predicted by quantitative multiphoton microscopy of single skeletal muscle fibers from an animal model of human desminopathy. Poster presentation.

Zuletzt aktualisiert 2019-10-07 um 13:54