Ralf Kling


Lehrstuhl für Pharmazeutische Chemie

Publikationen (Download BibTeX)

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Kling, R., Burchardt, C., Einsiedel, J., Hübner, H., & Gmeiner, P. (2019). Structure-based exploration of an allosteric binding pocket in the NTS1 receptor using bitopic NT(8-13) derivatives and molecular dynamics simulations. Journal of Molecular Modeling, 25(7). https://dx.doi.org/10.1007/s00894-019-4064-x
Simeth, N.A., Bause, M., Dobmeier, M., Kling, R., Lachmann, D., Hübner, H.,... Koenig, B. (2017). NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids. Bioorganic & Medicinal Chemistry, 25(1), 350-359. https://dx.doi.org/10.1016/j.bmc.2016.10.039
Kling, R., Clark, T., & Gmeiner, P. (2016). Comparative MD Simulations Indicate a Dual Role for Arg132(3.50) in Dopamine-Dependent D2R Activation. PLoS ONE, 11(1). https://dx.doi.org/10.1371/journal.pone.0146612
Kling, R., Plomer, M., Lang, C., Banerjee, A., Hübner, H., & Gmeiner, P. (2016). Development of Covalent Ligand-Receptor Pairs to Study the Binding Properties of Nonpeptidic Neurotensin Receptor 1 Antagonists. ACS chemical biology, 11(4), 869-875. https://dx.doi.org/10.1021/acschembio.5b00965
Milanos, L., Saleh, N., Kling, R., Kaindl, J., Tschammer, N., & Clark, T. (2016). Identification of Two Distinct Sites for Antagonist and Biased Agonist Binding to the Human Chemokine Receptor CXCR3. Angewandte Chemie-International Edition, 55(49), 15277-15281. https://dx.doi.org/10.1002/anie.201607831
Manglik, A., Lin, H., Aryal, D.K., Mccorvy, J.D., Dengler, D., Corder, G.,... Shoichet, B.K. (2016). Structure-based discovery of opioid analgesics with reduced side effects. Nature, 537(7619), 185-190. https://dx.doi.org/10.1038/nature19112
Möller, D., Mohamed, I.A.S., Kling, R., Hübner, H., & Gmeiner, P. (2015). 1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: quantitative structure selectivity investigations, docking, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry, 23, 6195-6209. https://dx.doi.org/10.1016/j.bmc.2015.07.050
Shonberg, J., Kling, R., Gmeiner, P., & Löber, S. (2015). GPCR crystal structures: Medicinal chemistry in the pocket. Bioorganic & Medicinal Chemistry, 23, 3880-3906. https://dx.doi.org/10.1016/j.bmc.2014.12.034
Weichert, D., Banerjee, A., Hiller, C., Kling, R., Hübner, H., & Gmeiner, P. (2015). Molecular Determinants of Biased Agonism at the Dopamine D2 Receptor. Journal of Medicinal Chemistry, 58, 2703-2717. https://dx.doi.org/10.1021/jm501889t
Huang, W., Manglik, A., Venkatakrishnan, A., Laeremans, T., Feinberg, E.N., Sanborn, A.L.,... Kobilka, B.K. (2015). Structural insights into µ-opioid receptor activation. Nature, 524, 315-321. https://dx.doi.org/10.1038/nature14886

Zuletzt aktualisiert 2019-16-03 um 22:59