Lehrstuhl für Pharmazeutische Biologie

Staudtstraße 5
91058 Erlangen


21- Hydroxpregnan-21-O-Malonyltransferasen: Heterologe Expression in Escherichia coli und Saccharomyces cerevisiae, Charakterisierung und Bedeutung für die Cardenolid-Biosynthese
Prof. Dr. Wolfgang Kreis
(01.06.2019 - 31.05.2021)

(The genus Digitalis: Molecular taxonomy, preservation, active constituents and therapeutic applications):
DIGITALIS: The genus Digitalis: Molecular taxonomy, preservation, active constituents and therapeutic applications
Prof. Dr. Wolfgang Kreis
(01.05.2012 - 30.04.2016)

Verbesserung des Meerrettichanbaus
Prof. Dr. Wolfgang Kreis
(01.01.2009 - 31.12.2017)

Publikationen (Download BibTeX)

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Rieck, C., Geiger, D., Munkert, J., Messerschmidt, K., Petersen, J., Strasser, J.,... Kreis, W. (2019). Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae. MicrobiologyOpen. https://dx.doi.org/10.1002/mbo3.925
Kreis, W., & Munkert, J. (2019). Exploiting enzyme promiscuity to shape plant specialized metabolism. Journal of Experimental Botany, 70(5), 1435-1445. https://dx.doi.org/10.1093/jxb/erz025
Boff, L., Munkert, J., Ottoni, F.M., Schneider, N.F.Z., Ramos, G.S., Kreis, W.,... Simões, C.M.O. (2019). Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives. European Journal of Medicinal Chemistry, 167, 546-561. https://dx.doi.org/10.1016/j.ejmech.2019.01.076
Meitinger, N., & Kreis, W. (2018). Development and validation of a quick assay for the total glucosinolate content in horseradish (Armoracia rusticana) using glucose strips and a blood glucose meter. Journal of Applied Botany and Food Quality-Angewandte Botanik, 91, 232-236. https://dx.doi.org/10.5073/JABFQ.2018.091.031
Gomes, E.R., Novais, M.V.M., Silva, I.T., Barros, A.L.B., Leite, E.A., Munkert, J.,... Oliveira, M.C. (2018). Long-circulating and fusogenic liposomes loaded with a glucoevatromomoside derivative induce potent antitumor response. Biomedicine & Pharmacotherapy, 108, 1152 - 1161. https://dx.doi.org/10.1016/j.biopha.2018.09.109
Schmidt, K., Petersen, J., Munkert, J., Egerer-Sieber, C., Hornig, M., Muller, Y., & Kreis, W. (2018). PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism. Phytochemistry, 156, 9-19. https://dx.doi.org/10.1016/j.phytochem.2018.08.012
Silva, I.T., Munkert, J., Nolte, E., Schneider, N.F.Z., Rocha, S.C., Ramos, A.C.P.,... Simões, C.M.O. (2018). Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+ -ATPase inhibition. Biomedicine & Pharmacotherapy, 107, 464-474. https://dx.doi.org/10.1016/j.biopha.2018.08.028
Yücesan, B., Eker, İ., Lazzarini, L.E.S., Aslam, N., Mohammed, A., Pinto, J.E.B.P.,... Gürel, E. (2018). Shoot-tip Cultivation and Cardenolide Content Analysis of Natural Populations of Digitalis lanata Ehrh. subsp. lanata (wooly foxglove) in Thrace Region. International Journal of Agriculture and Wildlife Science, 4(1), 55-62. https://dx.doi.org/10.24180/ijaws.390582
Schneider, N.F.Z., Cerella, C., Lee, J.-Y., Mazumder, A., Kim, K.R., de Carvalho, A.,... Diederich, M. (2018). Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-specific Cell Death. Frontiers in Pharmacology, 9. https://dx.doi.org/10.3389/fphar.2018.00070
Schneider, N.F.Z., Persich, L., Rocha, S.C., Ramos, A.C.P., Cortes, V.F., Silva, I.T.,... Simões, C.M.O. (2017). Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase. Biomedicine & Pharmacotherapy, 97, 684-696. https://dx.doi.org/10.1016/j.biopha.2017.10.128
Munkert, J., Santiago Franco, M., Nolte, E., Silva, I.T., Oliveira Castilho, R., Ottoni, F.M.,... De Padua, R.M. (2017). Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture. Planta medica. https://dx.doi.org/10.1055/s-0043-109557
Kreis, W. (2017). The Foxgloves (Digitalis) Revisited. Planta Medica. https://dx.doi.org/10.1055/s-0043-111240
Schneider, N.F.Z., Silva, I.T., Persich, L., de Carvalho, A., Rocha, S.C., Marostica, L.L.,... Simões, C.M.O. (2017). Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation. Molecular and Cellular Biochemistry, 428(1), 23-39. https://dx.doi.org/10.1007/s11010-016-2914-8
Nolte, E., Wach, S., Silva, I.T., Lukat, S., Ekici, A.B., Munkert, J.,... Lai, X. (2017). A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. Oncotarget. https://dx.doi.org/10.18632/oncotarget.14644
Kreis, W., Munkert, J., & De Padua, R.M. (2017). Biossíntese de metabólitos primários e secundários. In Letícia Bispo de Lima (Eds.), Farmacognosia do Produto Natural ao Medicamento. (pp. 147 - 166). Porto Alegre, Brazil: Artmed Editora Ltda..
Munkert, J., & Kreis, W. (2017). Herzglykoside und ihr Potenzial für die Tumortherapie. Deutsche Zeitschrift für Onkologie, 49(3), 129-135. https://dx.doi.org/10.1055/s-0043-115681
Sahin, S., Eulenburg, V., Kreis, W., Villmann, C., & Pischetsrieder, M. (2016). Three-step test system for the identification of novel GABAa receptor modulating food plants. Plant Foods For Human Nutrition, 71, 355-360. https://dx.doi.org/10.1007/s11130-016-0566-1
Maia de Pádua, R., Meitinger, N., Hennemann, M., Schebitz, P., Waibel, R., Löber, S.,... Kreis, W. (2016). Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides. Tetrahedron, 72, 4556-4563. https://dx.doi.org/10.1016/j.tet.2016.06.024
Yücesan, B., Mohammed, A., Eker, İ., Sameeullah, M., Demir-Ordu, Ö., Cihangir, C.,... Gürel, E. (2016). In vitro propagation and cardenolide profiling of Digitalis ferruginea subsp schischkinii, a medicinally important foxglove species with limited distribution in Northern Turkey. In Vitro Cellular & Developmental Biology-Plant, 52(3), 322-329. https://dx.doi.org/10.1007/s11627-016-9759-4
Meitinger, N., Munkert, J., Maia de Pádua, R., De Souza Filho, J.D., Maid, H., Bauer, W.,... Kreis, W. (2016). The catalytic mechanism of the 3-ketosteroid isomerase of Digitalis lanata involves an intramolecular proton transfer and the activity is not associated with the 3 beta-hydroxysteroid dehydrogenase activity. Tetrahedron Letters, 57(14), 1567-1571. https://dx.doi.org/10.1016/j.tetlet.2016.02.099

Zuletzt aktualisiert 2019-24-04 um 10:30