Lehrstuhl für Pharmazeutische Chemie

Nikolaus-Fiebiger-Str. 10
91058 Erlangen

Subordinate Organisational Units

Professur für Pharmazeutische Chemie
Professur für Pharmazeutische Chemie

Publications (Download BibTeX)

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Xu, J., Hu, Y., Kaindl, J., Risel, P., Hübner, H., Maeda, S.,... Kobilka, B.K. (2019). Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. Molecular Cell, 75(1), 53-65.e7. https://dx.doi.org/10.1016/j.molcel.2019.04.028
Kling, R., Burchardt, C., Einsiedel, J., Hübner, H., & Gmeiner, P. (2019). Structure-based exploration of an allosteric binding pocket in the NTS1 receptor using bitopic NT(8-13) derivatives and molecular dynamics simulations. Journal of Molecular Modeling, 25(7). https://dx.doi.org/10.1007/s00894-019-4064-x
Schwalbe, T., Hübner, H., & Gmeiner, P. (2019). Development of covalent antagonists for beta 1-and beta 2-adrenergic receptors. Bioorganic & Medicinal Chemistry, 27(13), 2959-2971. https://dx.doi.org/10.1016/j.bmc.2019.05.034
Pegoli, A., Wifling, D., Gruber, C.G., She, X., Hübner, H., Bernhardt, G.,... Keller, M. (2019). Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity. Journal of Medicinal Chemistry, 62(11), 5358-5369. https://dx.doi.org/10.1021/acs.jmedchem.8b01967
Stanek, M., Picard, L.P., Schmidt, M., Kaindl, J., Hübner, H., Bouvier, M.,... Gmeiner, P. (2019). Hybridization of β-Adrenergic Agonists and Antagonists Confers G Protein Bias. Journal of Medicinal Chemistry, 62(10), 5111-5131. https://dx.doi.org/10.1021/acs.jmedchem.9b00349
Sommer, T., Dlugash, G., Hübner, H., Gmeiner, P., & Pischetsrieder, M. (2019). Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples. Food Chemistry, 276, 745-753. https://dx.doi.org/10.1016/j.foodchem.2018.10.067
Halbig, C.E., Lasch, R., Krüll, J., Pirzer, A., Wang, Z., Kirchhof, J.N.,... Eigler, S. (2019). Selective Functionalization of Graphene at Defect-Activated Sites by Arylazocarboxylic tert-Butyl Esters. Angewandte Chemie International Edition, 58(11), 3599-3603. https://dx.doi.org/10.1002/anie.201811192
Pirzer, A., Alvarez, E.-M., Friedrich, H., & Heinrich, M. (2019). Radical Carbofluorination of Alkenes with Arylhydrazines and Selectfluor: Additives, Mechanistic Pathways, and Polar Effects. Chemistry - A European Journal, 25(11), 2786-2792. https://dx.doi.org/10.1002/chem.201805256
Trushkov, I.V., Uchuskin, M.G., Abaev, V.T., & Serdyuk, O. (2019). Indolylvinyl Ketones: Building Blocks for the Synthesis of Natural Products and Bioactive Compounds. Synthesis-Stuttgart, 51(4), 787-815. https://dx.doi.org/10.1055/s-0037-1611702
Sawengngen, N., Chalikidi, P.N., Araby, S., Hampel, F., Gmeiner, P., & Serdyuk, O. (2019). Synthesis of pyrazolylvinyl ketones from furan derivatives. Organic & Biomolecular Chemistry, 17(19), 4850-4855. https://dx.doi.org/10.1039/c9ob00701f
Di Pizio, A., Waterloo, L., Brox, R., Löber, S., Weikert, D., Behrens, M.,... Niv, M.Y. (2019). Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back. Cellular and Molecular Life Sciences. https://dx.doi.org/10.1007/s00018-019-03194-2
Fish, I., Stößel, A., Eitel, K., Valant, C., Albold, S., Hübner, H.,... Gmeiner, P. (2017). Structure-Based Design and Discovery of New M-2 Receptor Agonists. Journal of Medicinal Chemistry, 60(22), 9239-9250. https://dx.doi.org/10.1021/acs.jmedchem.7b01113
Männel, B., Hübner, H., Möller, D., & Gmeiner, P. (2017). beta-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation. Bioorganic & Medicinal Chemistry, 25(20), 5613-5628. https://dx.doi.org/10.1016/j.bmc.2017.08.037
Schwalbe, T., Kaindl, J., Hübner, H., & Gmeiner, P. (2017). Potent haloperidol derivatives covalently binding to the dopamine D2 receptor. Bioorganic & Medicinal Chemistry, 25(19), 5084-5094. https://dx.doi.org/10.1016/j.bmc.2017.06.034
Männel, B., Jaiteh, M., Zeifinan, A., Randakova, A., Möller, D., Hübner, H.,... Carlsson, J. (2017). Structure-Guided Screening for Functionally Selective D-2 Dopamine Receptor Ligands from a Virtual Chemical Library. Acs Chemical Biology, 12(10), 2652-2661. https://dx.doi.org/10.1021/acschembio.7b00493
Lachmann, D., Studte, C., Männel, B., Hübner, H., Gmeiner, P., & Koenig, B. (2017). Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides. Chemistry - A European Journal, 23(54), 13423-13434. https://dx.doi.org/10.1002/chem.201702147
Hofmann, J., Gans, E., Clark, T., & Heinrich, M. (2017). Radical Arylation of Anilines and Pyrroles via Aryldiazotates. Chemistry - A European Journal, 23(40), 9647-9656. https://dx.doi.org/10.1002/chem.201701429
Männel, B., Dengler, D., Shonberg, J., Hübner, H., Möller, D., & Gmeiner, P. (2017). Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for beta-Arrestin-Biased D2R Agonists. Journal of Medicinal Chemistry, 60(11), 4693-4713. https://dx.doi.org/10.1021/acs.jmedchem.7b00363
Pegoli, A., She, X., Wifling, D., Hübner, H., Bernhardt, G., Gmeiner, P., & Keller, M. (2017). Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M-2 Muscarinic Acetylcholine Receptor. Journal of Medicinal Chemistry, 60(8), 3314-3334. https://dx.doi.org/10.1021/acs.jmedchem.6b01892
Möller, D., Banerjee, A., Uzuneser, T., Skultety, M., Huth, T., Plouffe, B.,... Gmeiner, P. (2017). Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. Journal of Medicinal Chemistry, 60(7), 2908-2929. https://dx.doi.org/10.1021/acs.jmedchem.6b01857

Last updated on 2019-24-04 at 10:21