Professur für Hämatologie/Onkologie mit dem Schwerpunkt Tumorimmunologie

Address:
Ulmenweg 18
91054 Erlangen


Publications (Download BibTeX)

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Haug, T., Aigner, M., Peuser, M.M., Strobl, C., Hildner, K., Mougiakakos, D.,... Völkl, S. (2019). Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity. Frontiers in Immunology, 10. https://dx.doi.org/10.3389/fimmu.2019.00883
Jitschin, R., Böttcher, M., Saul, D., Lukassen, S., Bruns, H., Loschinski, R.,... Mougiakakos, D. (2019). Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation. Leukemia. https://dx.doi.org/10.1038/s41375-018-0376-6
Bruns, H., Jitschin, S., Gamali, S., Saul, D., Böttcher, M., Mackensen, A.,... Mougiakakos, D. (2019). A novel immunoregulatory function of beta-2-microglobulin as a promoter of myeloid derived suppressor cell induction. Leukemia. https://dx.doi.org/10.1038/s41375-018-0345-0
Ganzleben, I., He, G.W., Günther, C., Prigge, E.S., Richter, K., Rieker, R.,... Becker, C. (2019). PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis. Cellular and Molecular Life Sciences. https://dx.doi.org/10.1007/s00018-019-03133-1
Böttcher, M., Panagiotidis, K., Mackensen, A., & Mougiakakos, D. (2018). Stroma Cells Promote a S100A8/A9(high)-Subset of AML Blasts with Distinct Metabolic Features in a Jak/STAT3-Dependent Manner. In BLOOD. San Diego, CA, US: WASHINGTON: AMER SOC HEMATOLOGY.
Chaturvedi, A., Cruz, M.M.A., Goparaju, R., Gabdoulline, R., Schottmann, R., Goerlich, K.,... Heuser, M. (2018). Prolyl Hydroxylase 3 (Phd3) Is a Therapeutic Target in Isocitrate Dehydrogenase 1 (IDH1) Mutated Acute Myeloid Leukemia. In BLOOD. San Diego, CA, US: WASHINGTON: AMER SOC HEMATOLOGY.
Bach, C., Leffler, M., Flamann, C., Kronke, J., Mougiakakos, D., Mackensen, A., & Bruns, H. (2018). Role of N6-Methyladenosine (m6A) RNA Modification in Multiple Myeloma. In BLOOD. San Diego, CA, US: WASHINGTON: AMER SOC HEMATOLOGY.
Iacobaeus, E., Douagi, I., Jitschin, R., Marcusson-Stahl, M., Andren, A.T., Gavin, C.,... Le Blanc, K. (2018). Phenotypic and functional alterations of myeloid-derived suppressor cells during the disease course of multiple sclerosis. Immunology and Cell Biology, 96(8), 820-830. https://dx.doi.org/10.1111/imcb.12042
Böttcher, M., Renner, K., Berger, R., Mentz, K., Thomas, S., Cardenas-Conejo, Z.E.,... Mougiakakos, D. (2018). D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization. OncoImmunology, 7(7). https://dx.doi.org/10.1080/2162402X.2018.1445454
Busch, L., Mougiakakos, D., Büttner-Herold, M., Müller, M.J., Volmer, D.A., Bach, C.,... Bruns, H. (2018). Lenalidomide enhances MOR202-dependent macrophage-mediated effector functions via the vitamin D pathway. Leukemia. https://dx.doi.org/10.1038/s41375-018-0114-0
Loschinski, R., Böttcher, M., Stoll, A., Bruns, H., Mackensen, A., & Mougiakakos, D. (2018). IL-21 modulates memory and exhaustion phenotype of T-cells in a fatty acid oxidation-dependent manner. Oncotarget, 9(17), 13125-13138. https://dx.doi.org/10.18632/oncotarget.24442
Schwab, A., Siddiqui, A., Vazakidou, M.E., Napoli, F., Böttcher, M., Menchicchi, B.,... Ceppi, P. (2018). Polyol pathway links glucose metabolism to the aggressiveness of cancer cells. Cancer Research. https://dx.doi.org/10.1158/0008-5472.CAN-17-2834
Lucas, S., Omata, Y., Hofmann, J., Böttcher, M., Iljazovic, A., Sarter, K.,... Zaiss, M. (2018). Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 9(1), 55. https://dx.doi.org/10.1038/s41467-017-02490-4
Jitschin, R., Saul, D., Braun, M., Tohumeken, S., Völkl, S., Kischel, R.,... Mougiakakos, D. (2018). CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells. Journal for ImmunoTherapy of Cancer, 6(1). https://dx.doi.org/10.1186/s40425-018-0432-9
Urbanczyk, S., Stein, M., Schuh, W., Jäck, H.-M., Mougiakakos, D., & Mielenz, D. (2018). Regulation of Energy Metabolism during Early B Lymphocyte Development. International Journal of Molecular Sciences, 19(8). https://dx.doi.org/10.3390/ijms19082192
Lucas, S., Omata, Y., Böttcher, M., Hofmann, J., Krishnacoumar, B., Krönke, G.,... Zaiss, M. (2017). Short chain fatty acids are potent regulators of systemic bone mass and protect for pathological bone loss by inhibiting osteoclasts. European Journal of Immunology, 47, 217-217.
Bruns, H., Böttcher, M., Qorraj, M., Fabri, M., Jitschin, S., Dindorf, J.,... Mougiakakos, D. (2017). CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D. Leukemia. https://dx.doi.org/10.1038/leu.2016.378
Steven, A., Leisz, S., Wickenhauser, C., Schulz, K., Mougiakakos, D., Kiessling, R.,... Seliger, B. (2017). Linking CREB function with altered metabolism in murine fibroblast-based model cell lines. Oncotarget, 8(57), 97439-97463. https://dx.doi.org/10.18632/oncotarget.22135
Krebs, A.M., Mitschke, J., Losada, M.L., Schmalhofer, O., Boerries, M., Busch, H.,... Pilarsky, C. (2017). The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Nature Cell Biology, 19(5), 518-529. https://dx.doi.org/10.1038/ncb3513
Kravic, B., Harbauer, A.B., Romanello, V., Simeone, L., Vögtle, F.N., Kaiser, T.,... Hashemolhosseini, S. (2017). In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy, 1-65. https://dx.doi.org/10.1080/15548627.2017.1403716

Last updated on 2019-24-04 at 10:22