Chronic stress has long been identified as a determinant of adverse health outcomes. Chronic stress can have many different causes, such as work overload or unemployment, or caring for a family member with chronic illness, to name a few. While many potential mechanisms linking chronic stress with disease have been investigated, many pieces of stress-disease puzzle remain unknown. Here we focus on chronic low-grade inflammation as a pathway linking stress with disease, and we study specifically the psychological and biological determinants of inflammatory disinhibition.