Cholesterol activates the G-protein coupled receptor smoothened to promote hedgehog signaling - Luchetti, Giovanni; Sircar, Ria; Kong, Jennifer H.; Nachtergaele, Sigrid; Sagner, Andreas; Byrne, Eamon F. X.; Covey, Douglas F.; Siebold, Christian; Rohatgi, Rajat (eLife, 2016)