% Encoding: UTF-8
@COMMENT{BibTeX export based on data in FAU CRIS: https://cris.fau.de/}
@COMMENT{For any questions please write to cris-support@fau.de}
@article{faucris.285007023,
author = {Capellino, Silvia and Engler, Harald and Rohleder, Nicolas},
doi = {10.1159/000524082},
faupublication = {yes},
journal = {Neuroimmunomodulation},
note = {CRIS-Team WoS Importer:2022-11-11},
pages = {1-50},
peerreviewed = {Yes},
title = {14th {Conference} of the {German} {Endocrine}-{Brain}-{Immune}-{Network} ({GEBIN})},
volume = {29},
year = {2022}
}
@article{faucris.237465505,
abstract = {Speech fluency can be impaired in stressful situations. In this study, it was investigated
whether a verbal fluency task by itself, i.e. without the presence of any further stressors,
induces responses of the hypothalamic-pituitary adrenal (HPA) axis and of the sympathetic
nervous system (SNS). The sample consisted of n = 85 participants (68.2% female; 33.3 ±
15.2 years) who performed two consecutive verbal fluency tasks for two minutes each. The
categories were either ‘stress’ or ‘disease’ and ‘animals’ or ‘foods’ which were presented in
a randomized order. Three saliva samples were collected, prior to the task (t0), immediately
after (t1), and ten minutes after it (t2). Salivary α-amylase and cortisol were assessed. Furthermore,
blood pressure, heart rate, and ratings of actual stress perception, level of effort,
and tiredness were measured. The verbal fluency task induced a HPA axis response with a
maximum cortisol level at t2 which was independent of task performance. Furthermore, perceived
stress and effort, as well as tiredness increased after the task. Moreover, tiredness
immediately after the task was negatively correlated with task performance. No α-amylase,
blood pressure, or heart rate, and therefore SNS, responses were found. Implications for
the integrated specificity model are discussed. We conclude that a verbal fluency task acts
like an acute stressor that induces a cortisol and a perceived stress response without the
need for further (e.g., social-evaluative) stress components. Therefore, it is a less time-consuming
alternative to other stress tasks that can be used in field studies with little effort.
Methods: We developed an interactive 3D PDF report document format and implemented a software tool to create these reports automatically. After more than 1000 liver CASP cases that have been reported in clinical routine using our 3D PDF report, an international user survey was carried out online to evaluate the user experience.
Results: Our solution enables the user to interactively explore the anatomical configuration and to have different analyses and various resection proposals displayed within a 3D PDF document covering only a single page that acts more like a software application than like a typical PDF file (‘‘PDF App’’). The new 3D PDF report offers many advantages over the previous solutions. According to the results of the online survey, the users have assessed the pragmatic quality (functionality, usability, perspicuity, efficiency) as well as the hedonic quality (attractiveness, novelty) very positively.
Conclusion: The usage of 3D PDF for reporting and sharing CASP results is feasible and well accepted by the target audience. Using interactive PDF with embedded 3D models is an enabler for presenting and exchanging complex medical information in an easy and platform-independent way. Medical staff as well as patients can benefit from the possibilities provided by 3D PDF. Our results open the door for a wider use of this new technology, since the basic idea can and should be applied for many medical disciplines and use cases.},
author = {Newe, Axel and Becker, Linda and Schenk, Andrea},
doi = {10.1371/journal.pone.0115697},
faupublication = {yes},
journal = {PLoS ONE},
pages = {e115697},
peerreviewed = {Yes},
title = {{Application} and {Evaluation} of {Interactive} {3D} {PDF} for {Presenting} and {Sharing} {Planning} {Results} for {Liver} {Surgery} in {Clinical} {Routine}},
volume = {9},
year = {2014}
}
@article{faucris.239333775,
abstract = {Background: Clinical trials are one of the most challenging and meaningful designs in medical research. One essential step before starting a clinical trial is screening, that is, to identify patients who fulfill the inclusion criteria and do not fulfill the exclusion criteria. The screening step for clinical trials might be supported by modern information technology (IT).
Objective: This explorative study aimed (1) to obtain insights into which tools for feasibility estimations and patient screening are actually used in clinical routine and (2) to determine which method and type of IT support could benefit clinical staff.
Methods: Semistandardized interviews were conducted in 5 wards (cardiology, gynecology, gastroenterology, nephrology, and palliative care) in a German university hospital. Of the 5 interviewees, 4 were directly involved in patient screening. Three of them were clinicians, 1 was a study nurse, and 1 was a research assistant.
Results: The existing state of study feasibility estimation and the screening procedure were dominated by human communication and estimations from memory, although there were many possibilities for IT support. Success mostly depended on the experience and personal motivation of the clinical staff. Electronic support has been used but with little importance so far. Searches in ward-specific patient registers (databases) and searches in clinical information systems were reported. Furthermore, free-text searches in medical reports were mentioned. For potential future applications, a preference for either proactive or passive systems
was not expressed. Most of the interviewees saw the potential for the improvement of the actual systems, but they were also largely satisfied with the outcomes of the current approach. Most of the interviewees were interested in learning more about the various ways in which IT could support and relieve them in their clinical routine.
Conclusions: Overall, IT support currently plays a minor role in the screening step for clinical trials. The lack of IT usage and the estimations made from memory reported by all the participants might constrain cognitive resources, which might distract from clinical routine. We conclude that electronic support for the screening step for clinical trials is still a challenge and that education of the staff about the possibilities for electronic support in clinical trials is necessary.
a healthcare setting. However, the improvement in cognitive performance cannot be associated with HapHop-Physio in this case study. Consequently, it needs to be evaluated in a controlled experiment (including a control group) to ensure that it leads to cognitive rehabilitation in reality.
Our inner clock is responsible for creating a circadian rhythm that controls our sleep-wake cycle, and, hence, is also involved in the process of awakening from sleep. Awakening is accompanied by the cortisol awakening response (CAR). The purpose of the CAR is, presumably, to prepare our body for the upcoming challenges of the day. It is assumed that our inner clock is anticipating awakening, and thus, initiates the awakening process while we are still asleep, leading to the common phenomenon of waking up immediately before a known alarm. However, the role of the inner clock on the awakening process was only assessed in sleep laboratories and using invasive, blood-based biomarkers. For that reason, we investigated n = 117 participants by collecting cortisol data from saliva samples and IMU data from a wrist-worn inertial measurement unit (IMU) sensor node in a home environment over two nights. We compared cortisol data, characterizing the CAR, and IMU features, characterizing pre-awakening movement, between spontaneous awakening, awakening by a known alarm, and by an unknown alarm. We observed significant differences between the three study conditions in both cortisol and IMU data indicating higher cortisol reactivity and less movement if participants woke up by an unknown alarm. Our findings all support the assumption that our inner clock is anticipating our wake-up time. Utilizing our results, this work lays the foundation for the development of automatic classification models aimed at determining the ideal awakening time of individuals based on the analysis of pre-awakening movement.
Insufficient sleep quality is directly linked to a series of physical and physiological diseases [1]. Therefore, reliable sleep monitoring is essential for the prevention, diagnosis, and treatment of such. As sleep laboratories are very cost- and resource-prohibitive, wearable sensors are a promising alternative for unobtrusive sleep monitoring at home. During sleep, body movements decrease compared to a wakeful state [2]. In addition, cardiac and respiratory activity changes during sleep [3]. Current systems are mostly based on wrist movement, typically assessed using actigraphy (ACT), for unobtrusive sleep/wake detection [4]. However, movement-based systems tend to overestimate sleep due to a lack of movement shortly before falling asleep or in short periods of wakefulness. Previous research showed promising improvements in sleep/wake detection by combining ACT with cardiac and respiratory information such as heart rate variability (HRV) and respiration rate variability (RRV) [5]. However, this was only evaluated on small cohorts and not in large-scale studies. For that reason, this work aims to systematically compare ACT-based sleep detection with multimodal approaches combining ACT and HRV by benchmarking different state-of-the-art machine- and deep learning algorithms on a large-scale dataset. In particular, we investigate whether the classification performance can be further improved by including respiratory information into machine learning models.
II. METHODS
The data used in this work were collected in a sleep study of 2,237 participants, which contains ACT and polysomnography (PSG). PSG was used as ground truth for sleep/wake phases as well as to extract HRV and RRV from electrocardiography and respiratory induction plethysmography respectively [7]. In total, 370 ACT features and 30 HRV features were extracted according to Zhai et al. [6]. In addition, 62 RRV features were extracted using the Neurokit2 library [8]. To find the best set of hyperparameters, a grid search with embedded 5-fold cross-validation was performed over a defined search space.
III. RESULTS & DISCUSSION
Our results show that including RRV features in the classification algorithms significantly improved the key metrics of assessing sleep/wake detection performance (Fig 1). The best-performing algorithm to discriminate between sleep and wake phases was a Multi-Layer Perceptron with an accuracy of 85.1±8.5%. In particular, specificity, which is a good marker for assessing the overprediction of sleep, showed a strong increase in performance after adding RRV (63.5±22.3% vs. 72.4±17.2%). Our findings underscore the potential of including respiratory information, which can also be extracted from wearable sensors, to improve sleep/wake detection algorithms and, thus, help to transfer sleep laboratories into a home monitoring environmen},
author = {Krauß, Daniel and Richer, Robert and Küderle, Arne and Beilner, Janina and Rohleder, Nicolas and Eskofier, Björn},
booktitle = {IEEE-EMBS International Conference on Biomedical and Health Informatics},
date = {2022-09-26/2022-09-30},
faupublication = {yes},
keywords = {Machine learning; Deep learning; Wearable sensors; Multimodal sensing; Neural networks},
peerreviewed = {unknown},
series = {IEEE-EMBS International Conference on Biomedical and Health Informatics},
title = {{Benchmarking} of {Sleep}/{Wake} {Detection} {Algorithms} on a {Large} {Cohort} using {Actigraphy}, {HRV}, and {Respiration} {Information}},
venue = {Ioaninna},
year = {2022}
}
@article{faucris.106667264,
abstract = {We have studied the effects of film and substrate thicknesses on the bending and strain of thick GaN films
grown by HVPE. Both experimental and simulation data, being in a very good agreement, show the highest
bending at a critical film thickness slightly smaller than the substrate thickness, while the strain remains
decreasing with only a small increase at much higher film thicknesses. Temperature dependent
measurements allows a separation of the thermally induced component and an extrapolation of the bending
to the growth temperature. The latter was found to be dependent on both the film and substrate
thickness and to have a strong effect on the remaining bending of freestanding films.},
author = {Paskova, Tania and Becker, Linda and Böttcher, Tim and Hommel, Detlef and Paskov, Plamen and Monemar, Bo},
doi = {10.1002/pssc.200674819},
faupublication = {no},
journal = {Physica Status Solidi (C) Current Topics in Solid State Physics},
pages = {2256– 2259},
peerreviewed = {unknown},
title = {{Bending} in {HVPE} grown {GaN} films: {Origin} and reduction possibilities},
year = {2007}
}
@article{faucris.310441852,
abstract = {In the course of digitalization, new stressors are emerging. In modern working and living environments, two ubiquitous, technology-mediated stressors are multitasking demands and work interruptions. However, biological stress response patterns to multitasking and work interruptions have been sparsely investigated so far. We thus aimed to comprehensively assess biological stress response patterns to both stressors and, additionally, test whether responses differ between digital and partially non-digital settings. A controlled experimental set-up was established and humans’ biological markers of the Sympathetic Nervous System (SNS), the hypothalamic-pituitary adrenal (HPA) axis, and the immune system were assessed. N = 186 healthy participants (mean age: 23.2 ± 4.3 years, 74.7% female, body mass-index: 22.3 ± 3.1 kg/m2) took part in this pre-registered study. Each participant was randomly assigned to one of 6 experimental conditions (1 digital single-task, 3 dual-tasks [2 parallel tasks and 1 interruption], 1 multitasking, and 1 passive, control condition). Each one of the dual-tasking as well as the multitasking conditions included a non-digital sub-task, i.e., performing a task in presence of an examiner. All other conditions involved digital tasks only. Salivary alpha-amylase (sAA) levels as a marker for SNS reactivity significantly changed in work interruptions, parallel dual-tasking, and multitasking conditions. No changes were found for control conditions. Furthermore, no significant changes over time and no differences between the conditions were identified for three biological markers: cortisol as marker for HPA axis activity as well as for two immune system markers (secretory Immunoglobulin-A, C-reactive protein). A time course similar to sAA was found for perceived stress: with increases during task execution and decreases afterwards in multitasking and parallel dual-tasking. Yet, it did not change for the work interruption, passive control, and single-tasking condition. Overall, our findings show that dual- and multitasking are perceived as stressful and are associated with an activation of the SNS, but not with responses of HPA axis or immune system. This was consistent for digital as well as partially digital task demands. Our findings will also inform future research into the differential stress effects of digital and non-digital tasks to advance our understanding of biological stress response-patterns to multitasking and work interruptions. Therefore, our findings are highly relevant for understanding the long-term biological health effects of stress in modern (digitalized) environments.},
author = {Becker, Linda and Kaltenegger, Helena C. and Nowak, Dennis and Weigl, Matthias and Rohleder, Nicolas},
doi = {10.1016/j.psyneuen.2023.106358},
faupublication = {yes},
journal = {Psychoneuroendocrinology},
keywords = {Alpha-amylase; Cortisol; Digital stress; Multitasking; Technostress; Work interruptions},
note = {CRIS-Team Scopus Importer:2023-09-15},
peerreviewed = {Yes},
title = {{Biological} stress responses to multitasking and work interruptions: {A} randomized controlled trial},
volume = {156},
year = {2023}
}
@article{faucris.123132504,
author = {Rohleder, Nicolas and Marin, Theresa and Ma, Roy and Miller, Gregory E.},
doi = {10.1200/JCO.2008.18.7435},
faupublication = {no},
journal = {Journal of Clinical Oncology},
pages = {2909-2915},
peerreviewed = {Yes},
title = {{Biologic} cost of caring for a cancer patient: {Dysregulation} of pro- and anti-inflammatory signaling pathways},
volume = {27},
year = {2009}
}
@article{faucris.265133012,
abstract = {Biopsychology is a field of psychology that analyzes how biological processes interact with
behaviour, emotion, cognition, and other mental processes. Biopsychology covers, among
others, the topics of sensation and perception, emotion regulation, movement (and control of
such), sleep and biological rhythms, as well as acute and chronic stress.
To assess the interaction between biological and mental processes a variety of different modali-
ties are used in the field of biopsychology, such as electrophysiology, assessed, for instance, via
electrocardiography (ECG), electrodermal activity (EDA), or electroencephalography (EEG),
sleep, activity and movement, assessed via inertial measurement units (IMUs), neuroendocrine
and inflammatory biomarkers, assessed by saliva and blood samples, as well as self-reports,
assessed via psychological questionnaires.
These different modalities are collected either “in the lab,” during standardized laboratory
protocols, or “in the wild,” during unsupervised protocols in home environments. The collected
data are typically analyzed using statistical methods, or, more recently, using machine learning
methods.
While some software packages exist that allow for the analysis of single data modalities, such
as electrophysiological data, or sleep, activity and movement data, no packages are available
for the analysis of other modalities, such as neuroendocrine and inflammatory biomarker,
and self-reports. In order to fill this gap, and, simultaneously, to combine all required tools
analyzing biopsychological data from beginning to end into one single Python package, we
developed BioPsyKit.},
author = {Richer, Robert and Küderle, Arne and Ullrich, Martin and Rohleder, Nicolas and Eskofier, Björn},
doi = {10.21105/joss.03702},
faupublication = {yes},
journal = {Journal of Open Source Software},
pages = {3702},
peerreviewed = {Yes},
title = {{BioPsyKit}: {A} {Python} package for the analysis of biopsychological data},
url = {https://www.theoj.org/joss-papers/joss.03702/10.21105.joss.03702.pdf},
volume = {6},
year = {2021}
}
@article{faucris.108946244,
author = {Kuras, Yulia and Assaf, Naomi and Thoma, Myriam and Gianferante, Danielle and Hanlin, Luke and Xuejie, Chen and Fiksdal, Alexander and Rohleder, Nicolas},
doi = {10.3389/fnhum.2017.00574},
faupublication = {yes},
journal = {Frontiers in Human Neuroscience},
peerreviewed = {Yes},
title = {{Blunted} {Diurnal} {Cortisol} {Activity} in {Healthy} {Adults} with {Childhood} {Adversity}},
year = {2017}
}
@article{faucris.112989184,
author = {Rohleder, Nicolas},
doi = {10.1016/j.psyneuen.2017.10.008},
faupublication = {yes},
journal = {Psychoneuroendocrinology},
peerreviewed = {Yes},
title = {{Burnout}, hair cortisol, and timing: {Hyper}- or hypocortisolism?},
year = {2017}
}
@article{faucris.289746709,
abstract = {Background
Many studies investigating the cortisol awakening response (CAR) suffer from low adherence to the study protocol as well as from the lack of precise and objective methods for assessing the awakening and saliva sampling times which leads to measurement bias on CAR quantification.
Methods
To address this issue, we have developed “CARWatch”, a smartphone application that aims to enable low-cost and objective assessment of saliva sampling times as well as to concurrently increase protocol adherence. As proof-of-concept study, we assessed the CAR of N=117 healthy participants (24.2 ± 8.7 years, 79.5% female) on two consecutive days. During the study, we recorded awakening times (AW) using self-reports, the CARWatch application, and a wrist-worn sensor, and saliva sampling times (ST) using self-reports and the CARWatch application. Using combinations of different AW and ST modalities, we derived different reporting strategies and compared the reported time information to a Naive sampling strategy assuming an ideal sampling schedule. Additionally, we compared the AUCI, computed using information from different reporting strategies, against each other to demonstrate the effect of inaccurate sampling on the CAR.
Results
The use of CARWatch led to a more consistent sampling behavior and reduced sampling delay compared to self-reported saliva sampling times. Additionally, we observed that inaccurate saliva sampling times, as resulting from self-reports, were associated with an underestimation of CAR measures. Our findings also revealed potential error sources for inaccuracies in self-reported sampling times and showed that CARWatch can help in better identifying, and possibly excluding, sampling outliers that would remain undiscovered by self-reported sampling.
Conclusion
The results from our proof-of-concept study demonstrated that CARWatch can be used to objectively record saliva sampling times. Further, it suggests its potential of increasing protocol adherence and sampling accuracy in CAR studies and might help to reduce inconsistencies in CAR literature resulting from inaccurate saliva sampling. For that reason, we published CARWatch and all necessary tools under an open-source license, making it freely accessible to every researche},
author = {Richer, Robert and Abel, Luca and Küderle, Arne and Eskofier, Björn and Rohleder, Nicolas},
doi = {10.1016/j.psyneuen.2023.106073},
faupublication = {yes},
journal = {Psychoneuroendocrinology},
keywords = {CAR; Saliva; Adherence; Sampling accuracy; Smartphone; App},
pages = {106073},
peerreviewed = {Yes},
title = {{CARWatch} – {A} smartphone application for improving the accuracy of cortisol awakening response sampling},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0306453023000513},
volume = {151},
year = {2023}
}
@article{faucris.239096980,
author = {Schreier, Hannah M. C. and Kuras, Yuliya I. and McInnis, Christine M. and Thoma, Myriam V. and St Pierre, Danielle G. and Hanlin, Luke and Chen, Xuejie and Wang, Diana and Goldblatt, Dena and Rohleder, Nicolas},
doi = {10.3389/fpsyt.2020.00504},
faupublication = {yes},
journal = {Frontiers in Psychiatry},
peerreviewed = {Yes},
title = {{Childhood} physical neglect is associated with exaggerated systemic and intracellular inflammatory responses to repeated psychosocial stress in adulthood},
volume = {11},
year = {2020}
}
@article{faucris.123102584,
author = {Miller, Gregory E. and Rohleder, Nicolas and Cole, Steve},
doi = {10.1097/PSY.0b013e318190d7de},
faupublication = {no},
journal = {Psychosomatic Medicine},
pages = {57-62},
peerreviewed = {Yes},
title = {{Chronic} interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later},
volume = {71},
year = {2009}
}
@incollection{faucris.107635264,
abstract = {Chronic stress is cross-sectionally and prospectively associated with disease development and reduced life expectancy. Chronic stress can take many different forms, from extreme or traumatic single life events such as rape, accidents, natural disasters to long-term exposure to stressful conditions, such as caregiving, and finally, to accumulation of daily hassles, in someone's private life as well as in the work environment. As summarized in this chapter, there is now strong evidence linking many different forms of chronic stress with different diseases, with shorter life expectancy. In our quest to understand, and potentially intervene against, the health effects of chronic stress, research has targeted the communication systems linking the CNS, in which stress experience is located, with the periphery of the organism, in which damage accumulates that ultimately leads to disease and death.},
author = {Rohleder, Nicolas},
booktitle = {Insights to Neuroimmune Biology},
doi = {10.1016/B978-0-12-801770-8.00009-4},
editor = {Istvan Berczi},
faupublication = {yes},
isbn = {9780128017708},
keywords = {Caregiving; Chronic stress; Dependent systems; HPA axis},
pages = {201-214},
peerreviewed = {unknown},
publisher = {Elsevier Inc.},
title = {{Chronic} {Stress} and {Disease}},
year = {2016}
}
@inproceedings{faucris.217911707,
abstract = {Modern machine learning techniques enable new possibilities for the analysis of psychological data. In the field of health psychology, it is of interest to explore the biological processes triggered by acute stress. This work introduces a method to automatically classify individuals into distinct stress responder groups based on these biological processes. Two important stress-sensitive markers were used: Salivary cortisol and Interleukin-6 (IL-6) in blood plasma. Controlled stress was induced using the Trier Social Stress Test on two consecutive days. Results show that Support Vector Machines performed best on the given dataset. We distinguished four different cortisol and three different IL-6 responder types with high mean accuracies (92.2%±9.7% and 91.2%±6.3%, respectively). Classification results were mainly limited by class imbalances and high intra-class standard deviations. Whereas promising as a first application of machine learning on such datasets, generalizability and real-world applicability of our results need to be proven by further research.
= 75). ResultsIn the total sample, DBS CRP and sCRP were significantly associated (r = 0.59, p < 0.001). Splitting the sample into BMI-dependent subgroups revealed similarly strong associations of DBS CRP with sCRP for all three groups (A: r = 0.51; B: r = 0.61; C: r = 0.53). However, comparing the mean CRP values per BMI subgroup, one-way ANOVA reported significant differences for DBS CRP, but not for sCRP mean values. ConclusionsThe significant correlation of DBS CRP with sCRP was independent of the investigated BMI range groups, yet BMI-dependent distinction was only provided by DBS CRP mean values. Overall, our results suggest that DBS CRP is likely to reflect systemic inflammation more precisely. Salivary CRP can be alternatively determined in studies with adolescents when conditions require it, given the oral health status is assessed. Considering that DBS CRP and sCRP share only 35% of common variance, further studies should examine their specific validity.},
author = {Plank, Anne-Christine and Maschke, Janina and Rohleder, Nicolas and Fasching, Peter and Beckmann, Matthias and Kornhuber, Johannes and Eichler, Anna and Moll, Gunther and Kratz, Oliver},
doi = {10.3389/fimmu.2021.795580},
faupublication = {yes},
journal = {Frontiers in Immunology},
note = {CRIS-Team WoS Importer:2022-01-14},
peerreviewed = {Yes},
title = {{Comparison} of {C}-{Reactive} {Protein} in {Dried} {Blood} {Spots} and {Saliva} of {Healthy} {Adolescents}},
volume = {12},
year = {2021}
}
@article{faucris.248456510,
abstract = {Contactless measurement of heart rate variability (HRV), which reflects changes of the autonomic
nervous system (ANS) and provides crucial information on the health status of a person, would
provide great benefits for both patients and doctors during prevention and aftercare. However, gold
standard devices to record the HRV, such as the electrocardiograph, have the common disadvantage
that they need permanent skin contact with the patient. Being connected to a monitoring device
by cable reduces the mobility, comfort, and compliance by patients. Here, we present a contactless
approach using a 24 GHz Six-Port-based radar system and an LSTM network for radar heart sound
segmentation. The best scores are obtained using a two-layer bidirectional LSTM architecture. To
verify the performance of the proposed system not only in a static measurement scenario but also
during a dynamic change of HRV parameters, a stimulation of the ANS through a cold pressor test is
integrated in the study design. A total of 638 minutes of data is gathered from 25 test subjects and
is analysed extensively. High F-scores of over 95% are achieved for heartbeat detection. HRV indices
such as HF norm are extracted with relative errors around 5%. Our proposed approach is capable to
perform contactless and convenient HRV monitoring and is therefore suitable for long-term recordings
in clinical environments and home-care scenario},
author = {Shi, Kilin and Steigleder, Tobias and Schellenberger, Sven and Michler, Fabian and Malessa, Anke and Lurz, Fabian and Rohleder, Nicolas and Ostgathe, Christoph and Weigel, Robert and Kölpin, Alexander},
doi = {10.1038/s41598-021-81101-1},
faupublication = {yes},
journal = {Scientific Reports},
keywords = {hrv, radar, vitalparameter, herztöne, berührungslos, herzratenvariabilität},
peerreviewed = {Yes},
title = {{Contactless} analysis of heart rate variability during cold pressor test using radar interferometry and bidirectional {LSTM} networks},
url = {https://www.nature.com/articles/s41598-021-81101-1},
volume = {11},
year = {2021}
}
@inproceedings{faucris.241525731,
address = {PHILADELPHIA},
author = {Hauck, Felicitas and Romero Gibu, Lucia and Valdes-Santiago, Damian and Jansen, Silke and Rohleder, Nicolas},
booktitle = {PSYCHOSOMATIC MEDICINE},
date = {2020-03-11/2020-03-14},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2020-08-14},
pages = {A122-A122},
peerreviewed = {unknown},
publisher = {LIPPINCOTT WILLIAMS & WILKINS},
title = {{CORTISOL} {AND} {ALPHA}-{AMYLASE} {RESPONSES} {TO} {A} {PSYCHOSOCIAL} {STRESS} {TEST} {IN} {GERMAN} {COMPARED} {TO} {NATIVE} {LANGUAGE}},
venue = {, CA},
year = {2020}
}
@article{faucris.306931258,
abstract = {Ex vivo culturing of isolated PBMCs from individuals vaccinated with the coronavirus disease 2019 (COVID-19) vaccine BNT162b1 revealed a pronounced T cell response in the presence of the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The latter was 10-fold more pronounced than the ex vivo response of PBMCs from the same individuals to other common pathogen T cell epitope pools, suggesting COVID-19 vaccination to induce RBD-specific T cell responses and not to facilitate T cell (re)activity in general. In the current study we investigated whether COVID-19 vaccination long-lastingly affects plasma interleukin (IL)-6 concentrations, complete blood counts, ex vivo IL-6 and IL-10 secretion of PBMCs cultured under basal conditions or in the presence of concanavalin (Con) A and lipopolysaccharide (LPS), salivary cortisol and α-amylase, mean arterial pressure (MAP), heart rate (HR) as well as mental and physical health status. The study was initially designed to investigate whether the presence vs. absence of own pets during urban upbringing has protective effects against psychosocial stress-induced immune activation during adulthood. However, as COVID-19 vaccines were approved while the study was ongoing and as, therefore, both vaccinated and non-vaccinated individuals have been recruited, we were able to stratify our data set with respect to the COVID-19 vaccination status and to assess the long-lasting effects of COVID-19 vaccination on physiological immunological, cardiovascular and psychosomatic health parameters. This data is presented in the current study. We show that isolated PBMCs from individuals vaccinated against COVID-19 show a ~ 600-fold increase in basal and a ~ 6000-fold increase in ConA-induced proinflammatory IL-6 secretion, and a ~ 2-fold increase in basal and ConA-induced antiinflammatory IL-10 secretion, both in comparison with non-vaccinated individuals. In contrast, LPS-induced ex vivo IL-6 and IL-10 secretions were not affected by vaccination status, as were plasma IL-6 concentrations, complete blood counts, salivary cortisol and α-amylase, cardiovascular measures and psychosomatic health. In summary, our findings are of relevance for many clinical studies ran before/during the pandemic, clearly indicating that consideration of participants’ vaccination status is critical, at least when assessing ex vivo PBMC functionality.},
author = {Langgartner, Dominik and Winkler, Raphael and Brunner-Weisser, Jonas and Rohleder, Nicolas and Jarczok, Marc N. and Gündel, Harald and Weimer, Katja and Reber, Stefan O.},
doi = {10.1038/s41598-023-35731-2},
faupublication = {yes},
journal = {Scientific Reports},
note = {CRIS-Team Scopus Importer:2023-06-30},
peerreviewed = {Yes},
title = {{COVID}-19 vaccination exacerbates ex vivo {IL}-6 release from isolated {PBMCs}},
volume = {13},
year = {2023}
}
@article{faucris.207360282,
abstract = {Das „Angstbewältigungsinventar für medizinische Situationen“ (ABI-MS) ist ein Situations-Reaktions-Inventar, das habituelle Präferenzen für den Einsatz kognitiv vermeidender und vigilanter Bewältigungsstrategien in potenziell bedrohlichen medizinischen Kontexten messen soll. Im ABI-MS, das sich konzeptuell und methodisch an das Angstbewältigungs-Inventar (ABI; Krohne & Egloff, 1999) anlehnt, werden vier Szenarien vorgegeben („Blutabnahme“, „Schnittwunde“, „Darmspiegelung“ und „Narkose“), in die sich die Personen hineinversetzen sollen. Zu jedem Szenario werden jeweils vier kognitiv vermeidende und vier vigilante Reaktionsoptionen gegeben, deren Zutreffen die Personen beurteilen. In der vorliegenden Untersuchung wurden Struktur und psychometrische Qualität des ABI-MS geprüft. Konfirmatorische Faktorenanalysen (N= 2131) auf der Basis des Zwei-Parameter logistischen Item-Response-Modells bestätigen die Annahme zweier situationsübergreifender Faktoren der Angstbewältigung in medizinischen Kontexten. Das Inventar erreicht zufriedenstellende Reliabilitäten. Eine Retest-Untersuchung belegt, dass primär habituelle Präferenzen erfasst werden. Korrelationen mit Verfahren zur Messung von Angstbewältigung und Persönlichkeitseigenschaften geben Hinweise auf die konvergente und diskriminante Validität des ABI-MS.
n = 26 studies were reported, with N = 1142
participants. Our main findings are that SNS activity is significantly
higher and PNS activity is significantly lower during MT/DT than during
single tasking. Only two studies were found, in which HPA axis
(re-)activity was surveyed. No eligible study was identified in which
immune system (re-)activity was investigated. This is the first
systematic synthesis of the literature base showing that stress system
activity is increased during MT/DT in comparison to single-tasking.},
author = {Becker, Linda and Kaltenegger, Helena C. and Nowak, Dennis and Rohleder, Nicolas and Weigl, Matthias},
doi = {10.1080/17437199.2022.2071323},
faupublication = {yes},
journal = {Health Psychology Review},
keywords = {Multitasking; dual-tasking; stress; sympathetic nervous system; HPA axis; digitalization},
pages = {1-26},
peerreviewed = {Yes},
title = {{Differences} in stress system (re-)activity between single and dual- or multitasking in healthy adults: a systematic review and meta-analysis},
url = {https://www.tandfonline.com/doi/full/10.1080/17437199.2022.2071323},
year = {2022}
}
@inproceedings{faucris.218994049,
address = {PHILADELPHIA},
author = {Janson, Johanna and Sturmbauer, Sarah and Rohleder, Nicolas},
booktitle = {PSYCHOSOMATIC MEDICINE},
date = {2019-03-06/2019-03-09},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2019-05-28},
pages = {A109-A109},
peerreviewed = {unknown},
publisher = {LIPPINCOTT WILLIAMS & WILKINS},
title = {{DIFFERENTIAL} {ASSOCIATIONS} {OF} {ADAPTIVE} {AND} {MALADAPTIVE} {COPING} {STRATEGIES} {WITH} {STRESS} {RESPONSE} {PATTERNS} {OF} {PLASMA} {IL}-6 {AND} {IL}-6 {GENE} {EXPRESSION}},
venue = {Vancouver},
year = {2019}
}
@article{faucris.110680724,
abstract = {The aim of this study was to explore whether different manifestations of state coping predict cortisol response and recovery in an acute stress situation. Fifty-nine healthy adults (59.3% female) were exposed to the Trier Social Stress Test (TSST), and salivary cortisol was measured repeatedly before and after stress. Hierarchical linear modeling was used to test for relationships between factor-analytically derived measures of state coping and cortisol response and recovery. Independent of sex, age, BMI, chronic stress and depression, denial coping was related with higher peak levels of cortisol (β = 0.0798, SE = 0.0381, p = 0.041) while distraction coping predicted steeper recovery after TSST (linear effect: β = −0.0430, SE = 0.0184, p = 0.023) and less pronounced curvature (quadratic effect: β = 0.0043, SE = 0.0017, p = 0.016). Our results demonstrate the stress-buffering effect of distraction coping on hypothalamic-pituitary-adrenal (HPA) axis activity in situations without sufficient control.},
author = {Janson, Johanna and Rohleder, Nicolas},
doi = {10.1016/j.biopsycho.2017.07.014},
faupublication = {yes},
journal = {Biological Psychology},
peerreviewed = {Yes},
title = {{Distraction} coping predicts better cortisol recovery after acute psychosocial stress},
year = {2017}
}
@article{faucris.109697764,
author = {Jackson, Benita and Nault, Kelly and Smart Richman, Laura and LaBelle, Onawa and Rohleder, Nicolas},
doi = {10.1080/23743603.2017.1341178},
faupublication = {yes},
journal = {Comprehensive Results in Social Psychology},
peerreviewed = {Yes},
title = {{Does} that pose become you? {Testing} the effect of body postures on self-concept},
year = {2017}
}
@article{faucris.107634164,
abstract = {Chronic stress and its subsequent effects on biological stress systems have long been recognized as predisposing and perpetuating factors in chronic fatigue, although the exact mechanisms are far from being completely understood. In this review, we propose that sensitivity of immune cells to glucocorticoids (GCs) and catecholamines (CATs) may be the missing link in elucidating how stress turns into chronic fatigue. We searched for in vitro studies investigating the impact of GCs or CATs on mitogen-stimulated immune cells in chronically stressed or fatigued populations, with 34 original studies fulfilling our inclusion criteria. Besides mixed cross-sectional findings for stress- and fatigue-related changes of GC sensitivity under basal conditions or acute stress, longitudinal studies indicate a decrease with ongoing stress. Research on CATs is still scarce, but initial findings point towards a reduction of CAT sensitivity under chronic stress. In the long run, resistance of immune cells to stress signals under conditions of chronic stress might translate into self-maintaining inflammation and inflammatory disinhibition under acute stress, which in turn lead to fatigue.},
author = {Strahler, Jana and Skoluda, Nadine and Rohleder, Nicolas and Nater, Urs},
doi = {10.1016/j.neubiorev.2016.05.008},
faupublication = {yes},
journal = {Neuroscience and Biobehavioral Reviews},
pages = {298-318},
peerreviewed = {unknown},
title = {{Dysregulated} stress signal sensitivity and inflammatory disinhibition as a pathophysiological mechanism of stress-related chronic fatigue.},
volume = {68},
year = {2016}
}
@inproceedings{faucris.267740189,
author = {Rohleder, Nicolas and Richer, Robert and Koch, Veronika and Küderle, Arne and Müller, Victoria and Wirth, Vanessa and Stamminger, Marc and Eskofier, Björn},
booktitle = {Psychosomatic Medicine},
date = {2022-03-23/2022-03-26},
editor = {Lippincott Williams & Wilkins},
faupublication = {yes},
pages = {A84-A84},
peerreviewed = {Yes},
title = {{Effect} of {Acute} {Psychosocial} {Stress} on {Body} {Movements}},
venue = {Long Beach, CA},
year = {2022}
}
@article{faucris.106666384,
abstract = {The effect of sapphire-substrate thickness on the curvature and stress in thick hydride vapor phase
epitaxial GaN films was studied by high-resolution x-ray diffraction at variable temperatures. The
curvature was found to have the maximum value for comparable thicknesses of the film and the
substrate, while the stress at the film surface decreases with increasing film thickness and increases
with increasing substrate thickness, which is in very good agreement with the simulation results.
The curvature at the growth temperature was found to be strongly influenced by the value of the
intrinsic tensile strain, which is determined by the film/substrate thickness ratio.},
author = {Paskova, Tania and Becker, Linda and Böttcher, Tim and Hommel, Detlef and Paskov, Plamen and Monemar, Bo},
doi = {10.1063/1.2817955},
faupublication = {no},
journal = {Journal of Applied Physics},
pages = {1-4},
peerreviewed = {Yes},
title = {{Effect} of sapphire-substrate thickness on the curvature of thick {GaN} films grown by hydride vapor phase epitaxy},
year = {2007}
}
@article{faucris.117371144,
author = {Rohleder, Nicolas and Wolf, Jutta and Kirschbaum, Clemens and Wolf, Oliver},
doi = {10.1016/j.ijpsycho.2008.03.010},
faupublication = {no},
journal = {International Journal of Psychophysiology},
pages = {74-80},
peerreviewed = {Yes},
title = {{Effects} of cortisol on emotional but not on neutral memory are correlated with peripheral glucocorticoid sensitivity of inflammatory cytokine production},
volume = {72},
year = {2009}
}
@article{faucris.117371364,
author = {Kirschbaum, Clemens and Gonzales Bono, Esperanza and Rohleder, Nicolas and Gessner, Claudius and Pirke, Karl Martin and Salvador, Alicia and Hellhammer, Dirk},
doi = {10.1210/jc.82.4.1101},
faupublication = {no},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1101-1105},
peerreviewed = {Yes},
title = {{Effects} of fasting and glucose load on free cortisol responses to stress and nicotine},
volume = {82},
year = {1997}
}
@article{faucris.117371584,
author = {Rohleder, Nicolas and Kirschbaum, Clemens},
doi = {10.1097/mco.0b013e3281e38808},
faupublication = {no},
journal = {Current Opinion in Clinical Nutrition and Metabolic Care},
pages = {504--510},
peerreviewed = {Yes},
title = {{Effects} of nutrition on neuro-endocrine stress responses},
volume = {10},
year = {2007}
}
@article{faucris.277348559,
abstract = {To date, only a few studies have examined whether and when stressed individuals are still prosocially motivated and willing to help others, which is in contrast to the relevance and importance that helping others has for our society. The present study investigates the impact of affective and biopsychological acute stress responses on prosociality (prosocial motivation, helping behavior) under controlled laboratory conditions. In addition, it was examined whether this relationship is affected by individuals' current life stress and the cognitive ability to keep stress-related thoughts at bay. To induce acute stress responses (heart rate, negative affect, salivary alpha-amylase, cortisol), 55 individuals (28 women, M = 24 years old, SD = 4.53) were exposed to the Trier Social Stress Test (TSST). Current life stress (cortisol) was assessed over two days of participants' everyday lives. Thought control ability was assessed with the think/no-think paradigm and was additionally manipulated after the acute stress intervention (TSST) via instructions. The results showed that acute stress was positively associated with prosociality. Specifically, negative affect was positively related to prosocial motivation and salivary alpha-amylase was positively associated with helping behavior. Current life stress moderated the relationship between salivary cortisol and helping behavior: the association was positive at low levels of current life stress. The instruction to control one's thoughts but not participants' general ability to do so reduced stress responses (negative affect). In sum, the findings suggest that prosociality increases following acute stress and that this effect depends on the level of current life stress. Additionally, adopting the strategy of controlling stress-related thoughts was found to be promising for attenuating individuals' stress responses.},
author = {Hensel, Lisa and Rohleder, Nicolas and Niessen, Cornelia},
doi = {10.1080/10253890.2022.2054697},
faupublication = {yes},
journal = {Stress. The International Journal on the Biology of Stress},
month = {Jan},
note = {CRIS-Team WoS Importer:2022-07-01},
pages = {235-245},
peerreviewed = {Yes},
title = {{Effects} of psychosocial stress on prosociality: the moderating role of current life stress and thought control},
volume = {25},
year = {2022}
}
@article{faucris.286479710,
abstract = {To determine whether video-based informational or relaxational preparation reduces the number of unexpected patient-related events and scan duration more efficiently, and to assess how patients evaluate the interventions.\nWe randomized 142 adult patients (mean age: 48 ± 16 years) to three groups. The control group (n = 48, 33.8 %) received standard care. The intervention groups watched an informational (n = 50, 35.2 %) or relaxational (n = 44, 31.0 %) video while awaiting their MRI examination. We recorded scan duration, number of motion artifacts/sequence repetitions, and patient-related incidents (e.g., interruptions, premature termination). Subjective evaluation of the interventions was provided by the patients after MRI completion.\nMean scan duration for the control, relaxation, and information group was 39.38 ± 16.62 min, 32.59 ± 11.67 min, and 34.54 ± 11.91 min. Compared to the control group, scan duration was significantly shorter in the relaxation, but not in the information group (relaxation vs control: p =.019; information vs control: p =.082). The information and relaxation group did not differ significantly (p =.704). In 35 (24.6 %) patients, one or more sequences were repeated; incidents occurred in six (4.2 %) patients. Neither the frequency of repeated sequences nor incidents differed between the groups (all p >.239). Patients evaluated both videos very positively; the information video received even better evaluations (all p <.027).\nAdditional preparation, especially information, is perceived very positively by patients and at least relaxational preparation may have a positive impact on clinical operations.\nPURPOSE\nMETHODS\nRESULTS\nCONCLUSION},
author = {Madl, Janika and Janka, Rolf Matthias and Bay, Susanne and Sturmbauer, Sarah and Rohleder, Nicolas},
doi = {10.1016/j.ejrad.2022.110621},
faupublication = {yes},
journal = {European Journal of Radiology},
pages = {110621},
peerreviewed = {Yes},
title = {{Effects} of video-based patient preparation for {MRI} on clinical processes and patient experience.},
volume = {158},
year = {2022}
}
@article{faucris.120972764,
author = {Bellingrath, Silja Bellingrath and Rohleder, Nicolas and Kudielka, Brigitte},
doi = {10.1016/j.biopsycho.2012.12.003},
faupublication = {no},
journal = {Biological Psychology},
pages = {403-409},
peerreviewed = {Yes},
title = {{Effort}-reward-imbalance in healthy teachers is associated with higher {LPS}-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro},
volume = {92},
year = {2013}
}
@misc{faucris.108516804,
author = {Göbel, Kyra and Janson, Johanna},
faupublication = {yes},
peerreviewed = {automatic},
title = {{Einfluss} der {Machtposition} auf {Selbst}- und {Fremdwahrnehmungen} bei {Frauen} und {Männern}},
year = {2013}
}
@article{faucris.121545204,
author = {Wessa, Michele and Rohleder, Nicolas},
doi = {10.1586/17446651.2.1.91},
faupublication = {no},
journal = {Expert Review of Endocrinology and Metabolism},
pages = {91-122},
peerreviewed = {unknown},
title = {{Endocrine} and inflammatory alterations in post-traumatic stress disorder},
volume = {2},
year = {2007}
}
@incollection{faucris.119807204,
address = {Göttingen},
author = {Kirschbaum, Clemens and Kudielka, Brigitte and Rohleder, Nicolas and Wolf, Jutta},
booktitle = {Enzyklopädie der Psychologie, C7V/6 Entwicklungspsychologie des mittleren und höheren Erwachsenenalters.},
editor = {Filipp, S.-H. & Staudinger, U.M.},
faupublication = {no},
peerreviewed = {unknown},
publisher = {Hogrefe},
title = {{Endokrinologie} und {Immunologie} des höheren {Lebensalters}.},
year = {2004}
}
@article{faucris.117371804,
author = {Gaab, Jens and Rohleder, Nicolas and Heitz, Vera and Schad, Tanja and Engert, Veronika and Schürmeyer, Thomas and Ehlert, Ulrike},
doi = {10.1034/j.1601-5215.2003.00033.x},
faupublication = {no},
journal = {Acta Paedopsychiatrica},
pages = {184-191},
peerreviewed = {unknown},
title = {{Enhanced} glucocorticoid sensitivity in patients with chronic fatigue syndrome},
volume = {15},
year = {2003}
}
@article{faucris.224442103,
abstract = {
In stress research, economic instruments for introducing acute stress responses are needed. In this study, we investigated whether the socially evaluated cold-pressor group test (SECPT-G) induces salivary alpha-amylase (sAA) and/or cortisol responses in the general population and whether this is associated with anthropometric, experimental, and lifestyle factors.
MethodsA sample of 91 participants from the general population was recruited. Salivary cortisol and sAA levels were assessed prior to (t0), immediately after (t1), and 10 min after the SECPT-G (t2).
ResultsA robust cortisol increase was found immediately after the SECPT-G, which further increased between t1 and t2. This was independent of most of the control variables. However, men showed a trend toward higher cortisol increases than women (p = 0.005). No sAA responses were found at all. However, sAA levels were dependent on measurement time point with highest levels between 9 pm and 9:30 pm. Participants who immersed their hands into the ice water for the maximally allowed time of 3 min showed higher sAA levels at all time points than participants who removed their hands from the water earlier.
ConclusionsWe conclude that the SECPT-G is a good means of an acute stress test when cortisol—but not necessarily sAA—responses are intended.
Modern science understands stress as a complex process, and various aspects thereof have been associated with poor health. However, defining the term still is difficult and available stress assessment tools rely on different conceptualizations and target various aspects of stress. The aim of this dissertation is to clarify stress assessment components; thereby, the focus lies on three gaps in stress assessment. The empirical studies summarized in this thesis aim at closing these gaps by 1) Offering a new life stress assessment tool, 2) Discussing a new multi-modal approach to assess a laboratory stressful task, and 3) Presenting a new developed stimulus-response inventory to assess coping. Study one presents the German version of the ‘Stress and Adversity Inventory’ for adults to assess life stress exposure (Sturmbauer, Shields, et al., 2019). Study two presents an adapted real-life situation as an example for a new stress assessment protocol to experimentally induce arousal by investigating simulated medical consultations (Sturmbauer et al., 2022). Study three presents the ‘Coping Inventory for Medical Situations’ as a new tool to assess cognitive avoidant and vigilant coping addressed for researchers and clinicians working with patients in medical care (Sturmbauer, Hock, et al., 2019). Consequently, the three empirical studies are integrated into current research and matched with a published stress typology for precise stress assessment. Finally, future directions will emphasize the future applicability of the presented tools and conclude this thesis.
Methods. Literature searches were conducted using standard databases for English language with key words including Trier Social Stress Test, TSST, Cortisol, and Laboratory Stressor among others. 186 studies met our inclusion criteria of healthy human participants without systemic immunological or endocrine dysfunction and provided sufficient information to compute a total of 237 sub-sample effect sizes.
Results and Discussion. With regard to study protocol variations that may risk confounding baseline cortisol values and thus influence subsequent reactivity measures, meta-analytical examination revealed that acclimation periods pre-TSST below 30 or perhaps even 15 minutes may suffice, at least as long as no interfering activities, i.e., questionnaires, are taking place during that timeframe. Assessing the effects of TSST protocol variations on cortisol response strength, several observations are noteworthy. First, shortening speech preparation time did not change cortisol responses in any way, nor did including questionnaires during that period show an effect. As such, our findings suggest that speech preparation time is one TSST element that can be used to reduce the burden for participants as well as laboratory logistics. Secondly, having an all female panel and instructing
panel members to show negative instead of neutral behavior towards the participants both were associated with considerably reduced cortisol stress response strengths. Thirdly, several variables of interest, such as content of the speech task or gender match between active panel member and participant, were problematic to evaluate due to the large number of studies not reporting those details. This calls for future studies to report more details regarding potentially relevant protocol specifications.},
author = {Goodman, William and Janson, Johanna and Wolf, Jutta M.},
doi = {10.1016/j.psyneuen.2017.02.030},
faupublication = {yes},
journal = {Psychoneuroendocrinology},
keywords = {cortisol; stress; TSST; confounds; protocol variations; research methodology},
pages = {26 - 35},
peerreviewed = {Yes},
title = {{Meta}-analytical assessment of the effects of protocol variations on cortisol responses to the {Trier} {Social} {Stress} {Test}},
volume = {80},
year = {2017}
}
@inproceedings{faucris.265180748,
address = {OXFORD},
author = {Karan, Kalpita R. and Trumpff, Caroline and Sturm, Gabriel and Thomas, Jacob E. and Mcgill, Marlon A. and Rohleder, Nicolas and Sloan, Richard P. and Picard, Martin},
booktitle = {PSYCHONEUROENDOCRINOLOGY},
doi = {10.1016/j.psyneuen.2018.12.170},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2021-10-18},
pages = {S49-S50},
peerreviewed = {unknown},
publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
title = {{Mitochondrial} modulation of {LPS}-induced inflammation and glucocorticoid sensitivity in human blood},
venue = {Irvine, CA},
year = {2019}
}
@article{faucris.239075603,
author = {Karan, Kalpita Rashmi and Trumpff, Caroline and McGill, Marlon A. and Thomas, Jacob E. and Sturm, Gabriel and Lauriola, Vincenzo and Sloan, Richard P. and Rohleder, Nicolas and Kaufman, Brett A. and Marsland, Anna L. and Picard, Martin},
doi = {10.1016/j.bbih.2020.100080},
faupublication = {yes},
journal = {Brain, Behavior, & Immunity-Health},
peerreviewed = {Yes},
title = {{Mitochondrial} respiratory capacity modulates {LPS}-induced inflammatory signatures in human blood},
volume = {5},
year = {2020}
}
@inproceedings{faucris.226685825,
address = {OXFORD},
author = {Karan, Kalpita Rashmi and Trumpff, Caroline and Mcgill, Marlon A. and Thomas, Jacob E. and Sturm, Gabriel and Lauriola, Vincenzo and Rohleder, Nicolas and Sloan, Richard P. and Picard, Martin},
booktitle = {PSYCHONEUROENDOCRINOLOGY},
date = {2019-08-29/2019-08-31},
doi = {10.1016/j.psyneuen.2019.07.029},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2019-09-17},
pages = {11-11},
peerreviewed = {unknown},
publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
title = {{Mitochondrial} respiratory capacity regulates acute {LPS}-stimulated inflammatory signatures in human blood},
venue = {Milan},
year = {2019}
}
@article{faucris.117377084,
author = {Wirtz, Petra and von Känel, Roland and Rohleder, Nicolas and Fischer, Joachim},
doi = {10.1136/hrt.2002.003426},
faupublication = {no},
journal = {Heart},
pages = {853-858},
peerreviewed = {Yes},
title = {{Monocyte} proinflammatory cytokine release is higher and glucocorticoid sensitivity is lower in middle aged men than in women independent of cardiovascular risk factors},
volume = {90},
year = {2004}
}
@article{faucris.269962983,
abstract = {Objective: Despite being noninvasive and painless, MRI is recurrently associated with stress and anxiety in patients. This adversely affects patient experience and may be associated with negative outcomes for the health care provider. This study examined the psychological and physiological response of patients to MRI and how these response levels relate, the role of different potentially influencing factors, and the relation to procedural outcomes. Methods: Data of 96 patients (mean 48.77 ± 15.11 years; 61.5% female) were included. The patients’ psychological or physiological response was assessed before and after MRI via questionnaires on anxiety, strain, agitation, and mood and salivary α-amylase, and cortisol. Data on potentially influencing factors and outcomes of the clinical workflow were collected via questionnaires. Results: We observed significant improvements of all psychological measures from pre- to post-MRI (all P < .001) but not of the physiological stress markers (all P > .258). The psychological response correlated with levels of cortisol but not α-amylase. The valence of previous MRI experiences was particularly predictive of the patients’ reaction. Stress and anxiety in patients significantly predicted the probability of scan repetitions (Nagelkerke's R2 = .31, P = .011) and scan duration (adjusted R2 = .22, P < .001). Conclusion: These findings imply that various factors contribute to the patients’ response to MRI. Stress and anxiety in patients, in turn, may impact the clinical workflow. Therefore, these factors should be considered in the medical treatment to provide both a positive patient experience and smooth clinical workflows.},
author = {Madl, Janika and Janka, Rolf Matthias and Bay, Susanne and Rohleder, Nicolas},
doi = {10.1016/j.jacr.2021.11.020},
faupublication = {yes},
journal = {JACR Journal of the American College of Radiology},
keywords = {Anxiety; MRI; patient experience; physiological stress response; unexpected patient-related events},
note = {CRIS-Team Scopus Importer:2022-02-25},
peerreviewed = {unknown},
title = {{MRI} as a {Stressor}: {The} {Psychological} and {Physiological} {Response} of {Patients} to {MRI}, {Influencing} {Factors}, and {Consequences}},
year = {2022}
}
@article{faucris.123107644,
author = {Het, Serkan and Rohleder, Nicolas and Schoofs, Daniela and Kirschbaum, Clemens and Wolf, Oliver T.},
doi = {10.1016/j.psyneuen.2009.02.008},
faupublication = {no},
journal = {Psychoneuroendocrinology},
pages = {1075-1086},
peerreviewed = {Yes},
title = {{Neuroendocrine} and psychometric evaluation of a placebo version of the '{Trier} {Social} {Stress} {Test}'},
volume = {34},
year = {2009}
}
@article{faucris.237814105,
abstract = {Externalizing and internalizing behavior problems can have deleterious psychosocial consequences for youth. Both sympathetic nervous system (SNS) and hypothalamic-pituitary adrenal (HPA) axis activity and reactivity may contribute to behavior problems but have largely been studied separately, with inconsistent findings. Because the SNS and HPA axis interact to carry out physiological processes (e.g., responding to stressors), considering SNS and HPA axis activity jointly may elucidate disparate findings. This review discusses studies that simultaneously assessed SNS and HPA axis (re)activity and youth behavior problems using measures of salivary alpha amylase (sAA) and salivary cortisol. Multiple patterns of SNS and HPA axis coordination were associated with problem behaviors, especially when considering individual differences and youth's psychosocial context. Importantly, many study findings may be artifacts of widespread methodological differences. The reviewed studies lay the foundation for future research on neuroendocrine coordination as a contributing factor to youth problem behaviors and some recommendations for future research are discussed.},
author = {Jones, Emily J. and Rohleder, Nicolas and Schreier, Hannah M.C.},
doi = {10.1016/j.yhbeh.2020.104750},
faupublication = {yes},
journal = {Hormones and Behavior},
keywords = {Cortisol; Externalizing behavior; Hypothalamic-pituitary adrenal axis; Internalizing behavior; Salivary alpha amylase; Sympathetic nervous system},
note = {CRIS-Team Scopus Importer:2020-04-28},
peerreviewed = {Yes},
title = {{Neuroendocrine} coordination and youth behavior problems: {A} review of studies assessing sympathetic nervous system and hypothalamic-pituitary adrenal axis activity using salivary alpha amylase and salivary cortisol},
volume = {122},
year = {2020}
}
@inproceedings{faucris.241527720,
address = {PHILADELPHIA},
author = {Jones, Emily J. and Rohleder, Nicolas and Schreier, Hannah M. C.},
booktitle = {PSYCHOSOMATIC MEDICINE},
date = {2020-03-11/2020-03-14},
doi = {10.1016/j.yhbeh.2020.104750},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2020-08-14},
pages = {A73-A73},
peerreviewed = {unknown},
publisher = {LIPPINCOTT WILLIAMS & WILKINS},
title = {{NEUROENDOCRINE} {COORDINATION} {AND} {YOUTH} {BEHAVIOR} {PROBLEMS}: {A} {REVIEW} {OF} {STUDIES} {ASSESSING} {SYMPATHETIC} {NERVOUS} {SYSTEM} {AND} {HYPOTHALAMIC}-{PITUITARY} {ADRENAL} {AXIS} {ACTIVITY} {USING} {SALIVARY} {ALPHA} {AMYLASE} {AND} {SALIVARY} {CORTISOL}},
year = {2020}
}
@incollection{faucris.200684464,
address = {London},
author = {Rohleder, Nicolas},
booktitle = {Routledge International Handbook of Social Neuroendocrinology},
doi = {10.4324/9781315200439-39},
editor = {Oliver Schultheiss, Pranjal Mehta},
faupublication = {yes},
month = {Jan},
note = {CRIS-Team WoS Importer:2020-01-17},
pages = {717-729},
peerreviewed = {Yes},
publisher = {Routledge},
title = {{Neuroendocrine}-{Immune} {Interactions} in {Health} and {Disease}},
year = {2019}
}
@article{faucris.123108084,
author = {Rohleder, Nicolas and Wolf, Jutta and Herpfer, Inga and Fiebich, Bernd and Kirschbaum, Clemens and Lieb, Klaus},
doi = {10.1016/j.lfs.2005.12.016},
faupublication = {no},
journal = {Life Sciences},
pages = {3082-3089},
peerreviewed = {Yes},
title = {{No} response of plasma substance {P}, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress},
volume = {78},
year = {2006}
}
@inproceedings{faucris.314807751,
abstract = {We present openTSST, an open web platform to assess stress-related motion changes from video data with the goal to enable a more holistic stress assessment. Our proof-of-concept study shows that stress-induced changes in body posture and movements can reliably be measured using openTSST. With this work, we lay the groundwork for an ecological and large-scale analysis of human behavior during stress which can contribute to new findings in stress research.
d = −0.24, p = 0.377). For studies with longitudinal designs, significantly lower SA symptoms were found after PA treatments (d = −0.22, p = 0.001). The effect of PA on SA was stronger for adults than for children and adolescents (p = 0.003). For cross-sectional studies, a small negative association between SA symptoms and the amount of PA was found, i.e., lower SA was found for people who were more physically active (r = −0.12, p = 0.003). We conclude that PA is a promising means for the (additional) treatment of SAD or to reduce SA in general in non-clinical samples, but more research in which high-quality studies with randomized controlled trial designs are used is needed. Furthermore, open questions with respect to moderating variables (e.g., age, sex, BMI, type of intervention, stress, amount of regular PA before the intervention, and comorbidities) remain still open.
Background
The biopsychological response patterns to digital stress have been sparsely investigated so far. Important potential stressors in modern working environments due to increased digitalization are multitasking and work interruptions. In this study protocol, we present a protocol for a laboratory experiment, in which we will investigate the biopsychological stress response patterns to multitasking and work interruptions.
In total, N = 192 healthy, adult participants will be assigned to six experimental conditions in a randomized order (one single-task, three dual-task (two in parallel and one as interruption), one multitasking, and one passive control condition). Salivary alpha-amylase as well as heart rate as markers for Sympathetic Nervous System Activity, heart rate variability as measure for Parasympathetic Nervous System (PNS) activity, and cortisol as measure for activity of the hypothalamic-pituitary adrenal (HPA) axis will be assessed at six time points throughout the experimental session. Furthermore, inflammatory markers (i.e., IL-6, C-reactive protein (CRP), and secretory immunoglobulin-A) will be assessed before and after the task as well as 24 hours after it (IL-6 and CRP only). Main outcomes will be the time course of these physiological stress markers. Reactivity of these measures will be compared between the experimental conditions (dual-tasking, work interruptions, and multitasking) with the control conditions (single-tasking and passive control).
With this study protocol, we present a comprehensive experiment, which will enable an extensive investigation of physiological stress-responses to multitasking and work interruptions. Our planned study will contribute to a better understanding of physiological response patterns to modern (digital) stressors. Potential risks and limitations are discussed. The findings will have important implications, especially in the context of digital health in modern working and living environments.
SiFAr-Stress investigates the impact of cycling on stress levels in older adults. Uncertainty due to change to motorized bicycle or fear of falling can be perceived as stressors for cyclists. Stress activates different physiological signal cascades and stimulates the hypothalamic-pituitary-adrenal (HPA) axis, which leads to the release of the stress hormone cortisol and further effects such as the development of low-grade inflammation. Both can—in the long term—be associated with negative health outcomes. The aim of the study SiFAr-Stress is to analyze inflammatory processes as well as the activity of stress systems before and after a cycling intervention for older adults.
In this study, community-dwelling older adults aged 65 years and older will be randomly assigned to either a cycling or a control intervention in a parallel-group design. Objective HPA axis–related measures (saliva cortisol and hair cortisol) will be assessed before, after, and 6–9 months after the cycling and control intervention (T0, T1, and T2). Furthermore, changes in cortisol reactivity in response to the cycling intervention will be investigated at the second and seventh training lessons. Furthermore, secondary outcomes (fear of falling, perceived stress, salivary alpha amylase, and C-reactive protein) will be assessed at T0, T1, and T2.
The study will be the first, in which stress- and health-related bio-physiological outcomes will be assessed in the context of a multicomponent exercise intervention, addressing cycling in older adults. It will enable us to better understand the underlying patho-physiological and psychological mechanisms and will help to improve interventions for this target group.
ClinicalTrials.govNCT04362514. Prospectively registered on 27 April 2020
Chronic low-grade inflammation has been suggested as a key factor in the association between stress exposure and long-term health. Care work is recognized as a profession with a high degree of job stress and health risks. However, for care professionals, the study base on inflammatory activity due to adverse working conditions is limited.
The aim of this study was to explore associations between self-reported psychosocial working conditions and care professionals’ biomarkers of systemic low-grade inflammation.
N = 140 geriatric care professionals (79.3% females, mean age = 44.1 years) of six care facilities were enrolled in a cross-sectional study consisting of standardized medical examinations and employee surveys. Standardized questionnaires were used for evaluation of psychosocial work characteristics (work overload, job autonomy, social support) based on Karasek’s job strain model. Blood samples were drawn for two biomarkers of inflammatory activity: C-reactive protein (CRP) and leukocyte count. Analyses comprised uni- and multivariate logistic and linear regression analyses.
We determined a proportion of 5.4% of care professionals with increased low-grade inflammation. We further observed a relationship between job autonomy and CRP, such that reports of high job autonomy were associated with increased levels of CRP (adjusted OR = 4.10, 95% CI [1.10, 15.26], p = .035), which was robust in additional analyses on further potential confounders. No significant associations with participants’ leukocyte numbers were found.
This exploratory study contributes to the research base on links between workplace stress and ensuing illness in care professionals. Our findings may help to identify risk and protective factors of the work environment for chronic low-grade inflammation. The results require further scrutiny, and future prospective studies on associations of psychosocial working conditions, low-grade inflammation and long-term health outcomes in care professionals are needed.
Materials and Methods: One hundred sarcopenic obese men aged 70 years and older were randomly balanced (1-1-1) and allocated to one of the three study arms. During 16 weeks of intervention, these groups either performed WB-EMS and took a protein supplement (WB-EMS&P), solely received the protein supplement (Protein) or served as control group (CG). WB-EMS consisted of 1.5× 20 min (85 Hz, 350 μs, 4 s of strain to 4 s of rest) applied with moderate-to-high intensity while moving. We further generated a daily protein intake of 1.7– 1.8 g/kg/body mass per day. At baseline and 8– 10 days after completion of the intervention, blood was drawn and biomarkers of muscle, cardiac and renal health were assessed.
Results: Hereby, we found slight but significant elevations of creatine kinase (CK) levels in the WB-EMS group pointing to minor damages of the skeletal muscle (140 U/l [81– 210], p < 0.001). This was accompanied by a significant, low-grade increase of creatine kinase–muscle brain (CK-MB, 0.43 ng/mL [− 0.29– 0.96], p < 0.01) and high-sensitivity troponin T (hsTnT, 0.001 ng/mL. [0.000– 0.003], p < 0.001) but without a higher risk of developing heart failure according to N-terminal prohormone of brain natriuretic peptide (NT-proBNP, − 5.7 pg/mL [− 38.8– 24.6], p = 0.17). Estimated glomerular filtration rate (eGFR) was impaired neither by the high-protein supplementation alone nor in combination with WB-EMS (CG 76.0 mL/min/1.73 m2 [71.9– 82.2] vs Protein 73.2 mL/min/1.73 m2 [63.0– 78.9] vs WB-EMS&P 74.6 mL/min/1.73 m2 [62.8– 84.1], p = 0.478).
Conclusion: In conclusion, even in the vulnerable group of sarcopenic obese seniors, the combination of WB-EMS with a high-protein intake revealed no short-term, negative impact on the eGFR, but potential consequences for the cardiovascular system need to be addressed in future studies.
Objective: The objective of this review was to provide an overview of existing publications that apply 3D PDF technology and the protocols and tools for the creation of model files and 3D PDFs for scholarly purposes to demonstrate the possibilities and the ways to use this technology.
Methods: A systematic literature review was performed using PubMed and Google Scholar. Articles searched for were in English, peer-reviewed with biomedical reference, published since 2005 in a journal or presented at a conference or scientific meeting. Ineligible articles were removed after screening. The found literature was categorized into articles that (1) applied 3D PDF for visualization, (2) showed ways to use 3D PDF, and (3) provided tools or protocols for the creation of 3D PDFs or necessary models. Finally, the latter category was analyzed in detail to provide an overview of the state of the art.
Results: The search retrieved a total of 902 items. Screening identified 200 in-scope publications, 13 covering the use of 3D PDF for medical purposes. Only one article described a clinical routine use case; all others were pure research articles. The disciplines that were covered beside medicine were many. In most cases, either animal or human anatomies were visualized. A method, protocol, software, library, or other tool for the creation of 3D PDFs or model files was described in 19 articles. Most of these tools required advanced programming skills and/or the installation of further software packages. Only one software application presented an all-in-one solution with a graphical user interface.
Conclusions: The use of 3D PDF for visualization
purposes in clinical communication and in biomedical publications is
still not in common use, although both the necessary technique and
suitable tools are available, and there are many arguments in favor of
this technique. The potential of 3D PDF usage should be disseminated in
the clinical and biomedical community. Furthermore, easy-to-use,
standalone, and free-of-charge software tools for the creation of 3D
PDFs should be develope},
author = {Newe, Axel and Becker, Linda},
doi = {10.2196/10295},
faupublication = {yes},
journal = {JMIR Medical Informatics},
keywords = {3D PDF; 3D visualization; apps; biomedical science; clinical communication; electronic publishing; interactive; online data sharing; protocols; scholarly publishing; tools},
pages = {1-22},
peerreviewed = {Yes},
title = {{Three}-{Dimensional} {Portable} {Document} {Format} ({3D} {PDF}) in {Clinical} {Communication} and {Biomedical} {Sciences}: {Systematic} {Review} of {Applications}, {Tools}, and {Protocols}},
url = {http://medinform.jmir.org/2018/3/e10295/},
volume = {6},
year = {2018}
}
@article{faucris.217899922,
abstract = {Whether stress affects memory depends on which stress pathway becomes
activated and which specific memory system is involved. The activation
of the sympathetic nervous system (SNS), leads to a release of
catecholamines. The activation of the hypothalamic-pituitary-adrenal
(HPA) axis, leads to a release of glucocorticoids. In thus study, it was
investigated whether SNS and/or HPA axis activation are associated with
long-term memory (LTM) and/or working memory (WM) performance in
humans. Thirty-three participants underwent the socially evaluated
cold-pressor test. Salivary alpha-amylase (sAA) was used as a marker for
the activation of the SNS and cortisol as marker for HPA axis
activation. Memory was assessed by means of word lists with 15 words
each. The primacy effect (i.e., the correctly recalled words from the
beginning of the lists) of the serial position curve was considered as
indicator for LTM. The recency effect (i.e., the correctly recalled
words from the end of the lists) were used as estimator for WM
performance. In sAA responders, the recency effect and, therefore, WM
performance increased immediately after the stressor. This was not found
in sAA non-responders. In cortisol responders, the primacy effect and,
thus, LTM performance decreased 20 minutes after the stressor. No change
in LTM performance was found in cortisol non-responders. Our study
supports the assumptions that 1) SNS activation is associated with WM
processes via stimulation of the prefrontal cortex, and 2) HPA axis
activation is associated with LTM processes through interactions with
the hippocampu},
author = {Becker, Linda and Rohleder, Nicolas},
doi = {10.1371/journal.pone.0213883},
faupublication = {yes},
journal = {PLoS ONE},
keywords = {acute stress; salivary alpha-amylase; cortisol; working memory; long-term memory; primacy effect; recency effect},
pages = {1-15},
peerreviewed = {Yes},
title = {{Time} course of the physiological stress response to an acute stressor and its associations with the primacy and recency effect of the serial position curve},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213883},
volume = {14},
year = {2019}
}
@article{faucris.117382584,
author = {Kern, Simone and Rohleder, Nicolas and Eisenhofer, Grame and Lange, Jan and Ziemssen, Tjalf},
doi = {10.1016/j.bbi.2014.04.006},
faupublication = {no},
journal = {Brain Behavior and Immunity},
pages = {82--89},
peerreviewed = {Yes},
title = {{Time} matters – {Acute} stress response and glucocorticoid sensitivity in early multiple sclerosis},
volume = {41},
year = {2014}
}
@article{faucris.117383024,
author = {Ebrecht, M. and Buske-Kirschbaum, Angelika and Hellhammer, Dirk and Kern, S. and Rohleder, Nicolas and Walker, B. and Kirschbaum, Clemens},
faupublication = {no},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {3733-3739},
peerreviewed = {Yes},
title = {{Tissue} specificity of glucocorticoid sensitivity in healthy adults},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-0033761854&partnerID=MN8TOARS},
volume = {85},
year = {2000}
}
@article{faucris.110731984,
abstract = {Background
The analysis of electronic health records for an automated detection of adverse drug reactions is an approach to solve the problems that arise from traditional methods like spontaneous reporting or manual chart review. Algorithms addressing this task should be modeled on the criteria for a standardized case causality assessment defined by the World Health Organization. One of these criteria is the temporal relationship between drug intake and the occurrence of a reaction or a laboratory test abnormality. Appropriate data that would allow for developing or validating related algorithms is not publicly available, though.
Methods
In order to provide such data, retrospective routine data of drug administrations and temporally corresponding laboratory observations from a university clinic were extracted, transformed and evaluated by experts in terms of a reasonable time relationship between drug administration and lab value alteration.
Result
The result is a data corpus of 400 episodes of normalized laboratory parameter values in temporal context with drug administrations. Each episode has been manually classified whether it contains data that might indicate a temporal correlation between the drug administration and the change of the lab value course, whether such a change is not observable or whether a decision between those two options is not possible due to the data. In addition, each episode has been assigned a concordance value which indicates how difficult it is to assess. This is the first open data corpus of a computable ground truth of temporal correlations between drug administration and lab value alterations.
Discussion
The main purpose of this data corpus is the provision of data for further research and the provision of a ground truth which allows for comparing the outcome of other assessments of this data with the outcome of assessments made by human experts. It can serve as a contribution towards systematic, computerized ADR detection in retrospective data. With this lab value curve data as a basis, algorithms for detecting temporal relationships can be developed, and with the classification made by human experts, these algorithms can immediately be validated. Due to the normalization of the lab value data, it allows for a generic approach rather than for specific or solitary drug/lab value combination},
author = {Newe, Axel and Wimmer, Stefan and Neubert, Antje and Becker, Linda and Prokosch, Hans-Ulrich and Beckmann, Matthias and Fietkau, Rainer and Forster, Christian and Neurath, Markus and Schett, Georg and Ganslandt, Thomas},
doi = {10.1371/journal.pone.0136131},
faupublication = {yes},
journal = {PLoS ONE},
pages = {e0136131},
peerreviewed = {Yes},
title = {{Towards} a {Computable} {Data} {Corpus} of {Temporal} {Correlations} between {Drug} {Administration} and {Lab} {Value} {Changes}},
volume = {10},
year = {2015}
}
@article{faucris.244955015,
abstract = {When children suffer from cognitive disorders, school performance and social environment are affected. Measuring changes in cognitive progress is essential for assessing the clinical follow-up of the patient's cognitive abilities. This process is considered as a challenge in ambulatory settings, where follow-ups should be non-invasive and continuous. Psychophysiological measures are an objective and unobtrusive evaluation alternative for recognizing cognitive changes. This paper aims to validate the relationship between cognition and the changes in physiological signals of children suffering from Specic Learning Disorders (SLD). This validation was carried out in an eHealth rehabilitation context (with the HapHop-Physio game). Electrodermal activity (EDA) signals were collected, processed, and analyzed through a machine learning approach. Obtained results were: a dataset built from wearable physiological data and a supervised classication model. The classication model can identify the children's cognitive performance (class) from the features of the tonic component of the EDA signal (attributes) with an accuracy of 79.95%. The presented results evidence that psychophysiological measures could allow for a highly objective follow-up for patients. They can also lead to creating a basis for further improvement of rehabilitation environments and developing neurofeedback applications.