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@article{faucris.204640170,
abstract = {BACKGROUND: A major complication after allogeneic hematopoietic stem cell transplantation (aSCT) is the reactivation of herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Both viruses cause significant mortality and compromise quality of life after aSCT. Preventive transfer of virus-specific T cells can suppress reactivation by re-establishing functional antiviral immune responses in immunocompromised hosts.
METHODS: We have developed a good manufacturing practice protocol to generate CMV/EBV-peptide-stimulated T cells from leukapheresis products of G-CSF mobilized and non-mobilized donors. Our procedure selectively expands virus-specific CD8+ und CD4+ T cells over 9 days using a generic pool of 34 CMV and EBV peptides that represent well-defined dominant T-cell epitopes with various HLA restrictions. For HLA class I, this set of peptides covers at least 80% of the European population.
RESULTS: CMV/EBV-specific T cells were successfully expanded from leukapheresis material of both G-CSF mobilized and non-mobilized donors. The protocol allows administration shortly after stem cell transplantation (d30+), storage over liquid nitrogen for iterated applications, and protection of the stem cell donor by avoiding a second leukapheresis.
CONCLUSION: Our protocol allows for rapid and cost-efficient production of T cells for early transfusion after aSCT as a preventive approach. It is currently evaluated in a phase I/IIa clinical trial.},
author = {Gary, Regina and Aigner, Michael and Moi, Stephanie and Schaffer, Susann and Gottmann, Anja and Maas, Stefanie and Zimmermann, Robert and Zingsem, Jürgen and Strobel, Joachim and Mackensen, Andreas and Mautner, Josef and Moosmann, Andreas and Gerbitz, Armin},
doi = {10.1186/s12967-018-1498-3},
faupublication = {yes},
journal = {Journal of Translational Medicine},
note = {EVALuna2:34166},
peerreviewed = {Yes},
title = {{Clinical}-grade generation of peptide-stimulated {CMV}/{EBV}-specific {T} cells from {G}-{CSF} mobilized stem cell grafts},
volume = {16},
year = {2018}
}
@inproceedings{faucris.117258064,
abstract = {Mutations in the extra-sarcomeric protein desmin give rise to protein aggregate
myopathies that interfere with cellular function. The R350P mutation is
the most common human desminopathy. A murine DesR349P model of human
DesR350P desminopathy was previously engineered. In this study, we
followed the hypothesis of whether muscle cytoarchitecture and
biomechanical properties are already altered in preclinical stages of
R349P desminopathy. We applied non-linear second harmonic generation
(SHG) and 2-photon fluorescence morphometry analysis to single fibres of
fast- and slow-twitch muscle to analyze sarcomeric architecture and
nuclear morphology. We found a vast disruption of the lateral sarcomere
lattice (indicated by large ‘vernier’ densities) and myofibrillar
angular deviations (indicated by cosine angle sums) in single DesR349P
fibres. Homozygous fibres were more severely affected than heterozygous.
The former showed a marked nuclear pathology with spheric nuclei,
increased nuclear number and density. For biomechanics, we assessed
active and passive properties. Axial stiffness of DesR349P muscle was
much increased, both in fibre and myofibrillar homozygous bundles.
Lateral stiffness of the membrane complex in myoblasts was increased in
cells heterozygous for DesR349P while homozygous were similar to wt.
Caffeine-induced force was compromised in heterozygous fibre bundles but
increased in homozygous bundles. This was explained by a marked shift
of myofibrillar Ca2+ sensitivity: heterozygous bundles being less sensitive but homozygous more sensitive to Ca2+.
This points towards a specific compensatory mechanism in homozygous
mutation to cope with otherwise compromised force production already at
preclinical stages of desminopathy. Our findings provide a very first
complete picture to explain compromised force in heterozygous DesR350P
patients: increased muscle stiffness, higher susceptibility towards
stretch-induced injury, disrupted myofibrillar alignment and compromised
active force productio},
author = {Diermeier, Stefanie and Haug, Michael and Reischl, Barbara and Buttgereit, Andreas and Schürmann, Sebastian and Spörrer, Marina and Goldmann, Wolfgang and Fabry, Ben and Elhimine, F. and Stehle, Robert and Pfitzer, Gabriele and Winter, L. and Clemen, C. and Schröder, Rolf and Friedrich, Oliver},
doi = {10.1016/j.bpj.2015.11.1629},
faupublication = {yes},
pages = {303A-303A},
peerreviewed = {Yes},
publisher = {Elsevier (Cell Press) / Biophysical Society},
title = {{DesR349P} {Mutation} {Results} in {Ultrastructural} {Disruptions} and {Compromise} of {Skeletal} {Muscle} {Biomechanics} {Already} at {Preclinical} {Stages} in {Young} {Mice} before the {Onset} of {Protein} {Aggregation}},
volume = {110},
year = {2016}
}
@article{faucris.240763274,
abstract = {BACKGROUND: Organizational health care research focuses on describing structures and processes in organizations and investigating their impact on the quality of health care. In the setting of residential long-term care, this effort includes the examination and description of structural differences among the organizations (e.g., nursing homes). The objective of the analysis is to develop an empirical typology of living units in nursing homes that differ in their structural characteristics. METHODS: Data from the DemenzMonitor Study were used. The DemenzMonitor is an observational study carried out in a convenience sample of 103 living units in 51 nursing homes spread over 11 German federal states. Characteristics of living units were measured by 19 variables related to staffing, work organization, building characteristics and meal preparation. Multiple correspondence analysis (MCA) and agglomerative hierarchical cluster analysis (AHC) are suitable to create a typology of living units. Both methods are multivariate and explorative. We present a comparison with a previous typology (created by a nonexplorative and nonmultivariate process) of the living units derived from the same data set. RESULTS: The MCA revealed differences among the living units, which are defined in particular by the size of the living unit (number of beds), the additional qualifications of the head nurse, the living concept and the presence of additional financing through a separate benefit agreement. We identified three types of living units; these clusters occur significantly with a certain combination of characteristics. In terms of content, the three clusters can be defined as: "house community", "dementia special care units" and "usual care". CONCLUSION: A typology is useful to gain a deeper understanding of the differences in the care structures of residential long-term care organizations. In addition, the study provides a practical recommendation on how to apply the results, enabling living units to be assigned to a certain type. The typology can be used as a reference for definitions.},
author = {Bergmann, Johannes Michael and Ströbel, Armin Michael and Holle, Bernhard and Palm, Rebecca},
doi = {10.1186/s12913-020-05401-4},
faupublication = {yes},
journal = {BMC Health Services Research},
keywords = {Care structures; Explorative; Hierarchical clustering; Multiple correspondence analysis; Nursing; Residential long-term care; Typology},
note = {CRIS-Team Scopus Importer:2020-07-24},
pages = {646-},
peerreviewed = {Yes},
title = {{Empirical} development of a typology on residential long-term care units in {Germany} - results of an exploratory multivariate data analysis},
volume = {20},
year = {2020}
}
@article{faucris.316364475,
abstract = {Objectives: Skull morphology and growth patterns are essential for orthodontic treatment, impacting clinical decision making. We aimed to determine the association of different cephalometric skeletal configurations on midface parameters as measured in 3D CT datasets. Materials and methods: After sample size calculation, a total of 240 fully dentulous patients between 20 and 79 years of age (mean age: 42 ± 15), who had received a CT of the skull within the scope of trauma diagnosis or intracranial bleeding, were retrospectively selected. On the basis of cephalometric analysis, using MPR reconstructions, patients were subdivided into three different vertical skull configurations (brachyfacial, mesofacial, dolichofacial) and the respective skeletal Class I, II, and III relationships. Anatomic parameters were measured using a three-dimensional post-processing console: the thickness of the maxillary and palatine bones as well as the alveolar crest, maxillary body and sutural length, width and height of the hard palate, maxillary facial wall thickness, and masseter muscle thickness and length. Results: Individuals with brachyfacial configurations had a significantly increased palatal and alveolar ridge thicknesses compared to those with dolichofacial- or mesofacial configurations. Brachyfacial configurations presented a significantly increased length and thickness of the masseter muscle (4.599 cm; 1.526 cm) than mesofacial (4.431 cm; 1.466 cm) and dolichofacial configurations (4.405 cm; 1.397 cm) (p < 0.001). Individuals with a skeletal Class III had a significantly shorter palatal length (5.313 cm) than those with Class I (5.406 cm) and Class II (5.404 cm) (p < 0.01). Sutural length was also significantly shorter in Class III (p < 0.05). Conclusions: Skeletal configurations have an impact on parameters of the bony skull. Also, measurable adaptations of the muscular phenotype could result. Clinical relevance: The association between viscerocranial morphology and midface anatomy might be beneficial for tailoring orthodontic appliances to individual anatomy and planning cortically anchored orthodontic appliances.},
author = {Willershausen, Ines and Ehrenfried, Amelie and Krautkremer, Franziska and Ströbel, Armin and Seidel, Corinna Lesley and Paulsen, Friedrich and Kopp, Markus and Uder, Michael and Gölz, Lina and May, Matthias},
doi = {10.1007/s00784-023-05472-7},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Anatomy; Cephalometry; Computed tomography; Midface; Orthodontics; Ultra-high-resolution datasets},
month = {Jan},
note = {CRIS-Team Scopus Importer:2024-01-12},
peerreviewed = {Yes},
title = {{Impact} of different cephalometric skeletal configurations on anatomic midface parameters in adults},
volume = {28},
year = {2024}
}
@article{faucris.276687224,
abstract = {Background: Deep inferior epigastric perforator and muscle sparing transverse rectus abdominis muscle flaps are commonly used flaps for autologous breast reconstruction. CT-angiography allows to analyse the perforator course preoperatively. Our aim was to compare the different aspects of perforator anatomy in the most detailed study. Methods: CT-angiographies of 300 female patients with autologous breast reconstruction of 10 years were analysed regarding the anatomy of the deep inferior epigastric artery and every perforator. Results: Overall, 2260 perforators were included. We identified correlations regarding the DIEA branching point and number of perforators and their intramuscular course. The largest perforator emerged more often from the medial branch of the DIEA than the smaller perforators (70% (416/595) vs. 54% (878/1634), p < 0.001) and more often had a direct connection to the SIEV (large 67% (401/595) vs. small 39% (634/1634), p < 0.01). Medial row perforators were larger than the laterals (lateral 1.44 mm ± 0.43 (n = 941) vs. medial 1.58 mm ± 0.52 (n = 1304) (p < 0.001)). The larger and more medial the perforator, the more likely it was connected to the SIEV: perforators with direct connection to the SIEV had a diameter of 1.65 mm ± 0.53 (n = 1050), perforators with indirect connection had a diameter of 1.43 ± 0.43 (n = 1028), perforators without connection had a diameter of 1.31 mm ± 0.37 (n = 169) (p < 0.001). Medial perforators were more often directly connected to the SIEV than lateral perforators (medial 56% (723/1302) vs. lateral 35% (327/941), p < 0.001). A lateral perforator more often had a short intramuscular course than medial perforators (69% (554/800) vs. 45% (474/1055), p < 0.001), which was also more often observed in the case of a small perforator and a caudal exit of the rectus sheath. Conclusion: The largest perforator emerges more often from the medial branch of the DIEA and frequently has a direct connection to the SIEV, making medial row perforators ideal for DIEP flap transplantation.},
author = {Frank, Katharina and Stroebel, Armin and Ludolph, Ingo and Hauck, Theresa and May, Matthias and Beier, Justus and Horch, Raymund E. and Arkudas, Andreas},
doi = {10.3390/jpm12050701},
faupublication = {yes},
journal = {Journal of Personalized Medicine},
keywords = {autologous breast reconstruction; CTA; DIEP flap; MS-TRAM flap; perforator},
note = {CRIS-Team Scopus Importer:2022-06-10},
peerreviewed = {Yes},
title = {{Improving} the {Safety} of {DIEP} {Flap} {Transplantation}: {Detailed} {Perforator} {Anatomy} {Study} {Using} {Preoperative} {CTA}†},
volume = {12},
year = {2022}
}
@article{faucris.314304878,
abstract = {Introduction: Allogeneic stem cell transplantation is used to cure hematologic malignancies or deficiencies of the hematopoietic system. It is associated with severe immunodeficiency of the host early after transplant and therefore early reactivation of latent herpesviruses such as CMV and EBV within the first 100 days are frequent. Small studies and case series indicated that application of herpes virus specific T cells can control and prevent disease in this patient population. Methods: We report the results of a randomized controlled multi centre phase I/IIa study (MULTIVIR-01) using a newly developed T cell product with specificity for CMV and EBV derived from the allogeneic stem cell grafts used for transplantation. The study aimed at prevention and preemptive treatment of both viruses in patients after allogeneic stem cell transplantation targeting first infusion on day +30. Primary endpoints were acute transfusion reaction and acute-graft versus-host-disease after infusion of activated T cells. Results: Thirty-three patients were screened and 9 patients were treated with a total of 25 doses of the T cell product. We show that central manufacturing can be achieved successfully under study conditions and the product can be applied without major side effects. Overall survival, transplant related mortality, cumulative incidence of graft versus host disease and number of severe adverse events were not different between treatment and control groups. Expansion of CMV/EBV specific T cells was observed in a fraction of patients, but overall there was no difference in virus reactivation. Discussion: Our study results indicate peptide stimulated epitope specific T cells derived from stem cell grafts can be administered safely for prevention and preemptive treatment of reactivation without evidence for induction of acute graft versus host disease. Clinical trial registration: https://clinicaltrials.gov, identifier NCT02227641.},
author = {Gerbitz, Armin and Gary, Regina and Aigner, Michael and Moosmann, Andreas and Kremer, Anita and Schmid, Christoph and Hirschbuehl, Klaus and Wagner, Eva and Hauptrock, Beate and Teschner, Daniel and Rösler, Wolf and Spriewald, Bernd and Tischer, Johanna and Moi, Stephanie and Balzer, Heidi and Schaffer, Stefanie and Bausenwein, Judith and Wagner, Anja and Schmidt, Franziska and Brestrich, Jens and Ullrich, Barbara and Maas, Stefanie and Herold, Susanne and Strobel, Julian and Zimmermann, Robert and Weisbach, Volker Günter and Hansmann, Leo and Lammoglia-Cobo, Fernanda and Remberger, Mats and Stelljes, Matthias and Ayuk, Francis and Zeiser, Robert and Mackensen, Andreas},
doi = {10.3389/fimmu.2023.1251593},
faupublication = {yes},
journal = {Frontiers in Immunology},
keywords = {allogeneic; cytomegalovirus CMV; epitope specificity; Epstein-Barr virus EBV; prevention; reactivation; stem cell transplantation (SCT)},
note = {CRIS-Team Scopus Importer:2023-11-24},
peerreviewed = {Yes},
title = {{Prevention} of {CMV}/{EBV} reactivation by double-specific {T} cells in patients after allogeneic stem cell transplantation: results from the randomized phase {I}/{IIa} {MULTIVIR}-01 study},
volume = {14},
year = {2023}
}
@article{faucris.200173911,
abstract = {
},
author = {Paslakis, Georgios and Maas, Stefanie and Gebhardt, Bernd and Mayr, Andreas and Rauh, Manfred and Erim, Yesim},
doi = {10.1186/s12888-018-1683-1},
faupublication = {yes},
journal = {BMC Psychiatry},
pages = {93},
peerreviewed = {Yes},
title = {{Prospective}, randomized, double-blind, placebo-controlled phase {IIa} clinical trial on the effects of an estrogen-progestin combination as add-on to inpatient psychotherapy in adult female patients suffering from anorexia nervosa},
volume = {18},
year = {2018}
}
@article{faucris.270681345,
abstract = {Background: Cinematic Rendering (CR) is a recently introduced post-processing three-dimensional (3D) visualization imaging tool. The aim of this study was to assess its clinical value in the preoperative planning of deep inferior epigastric artery perforator (DIEP) or muscle-sparing transverse rectus abdominis myocutaneous (MS-TRAM) flaps, and to compare it with maximum intensity projection (MIP) images. The study presents the first application of CR for perforator mapping prior to autologous breast reconstruction. Methods: Two senior surgeons independently analyzed CR and MIP images based on computed tomography angiography (CTA) datasets of 20 patients in terms of vascular pedicle characteristics, the possibility to harvest a DIEP or MS-TRAM flap, and the side of the flap harvest. We calculated inter- and intra-observer agreement in order to examine the accordance of both image techniques. Results: We observed a good inter- and intra-observer agreement concerning the type of flap and the side of the flap harvest. However, the agreement on the pedicle characteristics varies depending on the considered variable. Both investigators identified a significantly higher number of perforators with MIP compared with CR (observer 1, p<0.0001 and observer 2, p<0.0385). Conclusion: The current study serves as an explorative study, showing first experiences with CR in abdominal-based autologous breast reconstruction. In addition to MIP images, CR might improve the surgeon's understanding of the individual's anatomy. Future studies are required to compare CR with other 3D visualization tools and its possible effects on operative parameters.},
author = {Hauck, Theresa and Arkudas, Andreas and Horch, Raymund E. and Ströbel, Armin and May, Matthias and Binder, Johannes and Krautz, Christian and Ludolph, Ingo},
doi = {10.1016/j.bjps.2021.09.011},
faupublication = {yes},
journal = {Journal of Plastic Reconstructive and Aesthetic Surgery},
keywords = {3D visualization; Computed tomography angiography; DIEP; MS-TRAM},
note = {CRIS-Team Scopus Importer:2022-03-11},
pages = {536-543},
peerreviewed = {Yes},
title = {{The} third dimension in perforator mapping—{Comparison} of {Cinematic} {Rendering} and maximum intensity projection in abdominal-based autologous breast reconstruction},
volume = {75},
year = {2022}
}
@inproceedings{faucris.244326454,
address = {NEW YORK},
author = {Schmuedderich, Kathrin and Holle, Daniela and Stroebel, Armin and Trutschel, Diana and Palm, Rebecca and Stroebel, Armin},
booktitle = {INTERNATIONAL PSYCHOGERIATRICS},
doi = {10.1017/s1041610220002823},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2020-10-23},
pages = {145-145},
peerreviewed = {unknown},
publisher = {CAMBRIDGE UNIV PRESS},
title = {{Relationship} between agitation and social isolation as a dimension of quality of life in residents with dementia living in {German} nursing homes - a secondary data analysis},
year = {2020}
}
@article{faucris.256881517,
abstract = {Background: Severe agitation and its relation to single dimensions of quality of life are not well understood. The aim of this study was to gain more knowledge about severe agitation and to examine the relationships between the severity of agitation and single dimensions of quality of life among residents with dementia living in German nursing homes. Methods: This exploratory secondary analysis included data from 1947 residents of 66 German nursing homes from the DemenzMonitor study. The construct of agitation was defined as a composite score of the items agitation/aggression, irritability/lability and disinhibition from the Neuropsychiatric Inventory Questionnaire (NPI-Q); the resident was classified as severely agitated if at least one of these symptoms was rated as ‘severe’. The single dimensions of quality of life were measured with the short version of the QUALIDEM instrument. To avoid selection bias, two controls with mild or no agitation were selected for each resident with severe agitation using propensity score matching. Mixed linear regression models were then generated to determine the differences in the dimensions of quality of life for the severity of agitation and the defining items. Results: For four out of five dimensions of quality of life of the short version of QUALIDEM, residents with severe agitation had significantly lower values than residents without severe agitation. Converted to scale size, the greatest difference between both groups was found in the dimension social isolation with 23.0% (-2.07 (95% CI: -2.57, -1.57)). Further differences were found in the dimensions restless tense behaviour with 16.9% (-1.52 (95% CI: -2.04, -1.00)), positive affect with 14.0% (-1.68 (95% CI: -2.28, -1.09)) and social relations with 12.4% (-1.12 (95% CI: -1.54, -0.71)). Conclusions: Severe agitation is a relevant phenomenon among nursing home residents with dementia and is associated with lower values of quality of life in the dimensions social isolation, restless tense behaviour, positive affect and social relations from the QUALIDEM instrument. Therefore, more attention should be paid to severe agitation in nursing practice and research. Moreover, care strategies used to reduce severe agitation should be considered in terms of their impact on the dimensions of quality of life.},
author = {Schmüdderich, Kathrin and Holle, Daniela and Stroebel, Armin and Holle, Bernhard and Palm, Rebecca},
doi = {10.1186/s12888-021-03167-5},
faupublication = {yes},
journal = {BMC Psychiatry},
keywords = {Aggression; Agitation; Dementia; Nursing home; Quality of life},
note = {CRIS-Team Scopus Importer:2021-04-30},
peerreviewed = {Yes},
title = {{Relationship} between the severity of agitation and quality of life in residents with dementia living in {German} nursing homes - a secondary data analysis},
volume = {21},
year = {2021}
}