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@article{faucris.308913571,
abstract = {We aimed to validate the metric accuracy of a 3-dimensional (3D) facial scanner (FS) and an intraoral scanner (IOS) in capturing the nasolabial region in ex vivo unilateral cleft lip and palate (UCLP) models. The nasolabial region of 10 UCLP models was scanned using a 3D FS as well as an IOS and a previously validated stationary 3D scanner as a reference. Intraoral scan was performed directly on the UCLP models. In order to apply the FS on the models, they were embedded in a 3D printed sample face. Both test groups were aligned to the reference by applying a section-based best-fit algorithm. Subsequent analysis of the metric deviation from the reference was performed with a 3D analysis tool. Mean distance and integrated distance served as main parameters for surface and volume comparison. Point comparison served as an additional parameter. Statistical analysis was carried out using t-test for unconnected samples. Considering mean distance and integrated distance as main parameters for 3D evaluation of the scanner’s accuracy, FS and IOS differ significantly in their metric precision in scanning the cleft model compared to the reference. The IOS proved to be significantly more accurate than the FS compared to the previously described stationary 3D scanner as reference and validated baseline. Further validation of the tested IOS and FS for 3D assessment of the nasolabial region is presented by adding the previously validated ATOS III Triple Scan blue light scanner as a reference. The IOS shows, compared to a validated baseline scan, significantly higher metric precision in experimental cleft model scanning. The collected data provides a basis for clinical application of the IOS for 3D assessment of the nasolabial region.},
author = {Olmos, Manuel and Matta, Ragai and Buchbender, Mayte and Jaeckel, Fabian and Nobis, Christopher-Philipp and Weber, Manuel and Kesting, Marco Rainer and Lutz, Rainer},
doi = {10.1038/s41598-023-39352-7},
faupublication = {yes},
journal = {Scientific Reports},
note = {CRIS-Team Scopus Importer:2023-08-11},
peerreviewed = {Yes},
title = {{3D} assessment of the nasolabial region in cleft models comparing an intraoral and a facial scanner to a validated baseline},
volume = {13},
year = {2023}
}
@article{faucris.261342184,
abstract = {This study aimed to investigate accuracy in different sectional planes of the TMA Grand Master (3DHISTECH) Workstation in various soft tissue samples collected from Wistar rats. A total of 108 animals were sacrificed and 963 tissue specimens collected from 12 soft-tissue types. A total of 3307 tissue cores were punched and transferred into 40 recipient TMA blocks. Digital image analysis was performed. Core loss showed a significant correlation with tissue type and was highest in skin tissue (p < 0.001), renal medulla and femoral artery, nerve, and vein bundle (p < 0.01). Overall, 231 of 3307 tissue cores (7.0%) were lost. Hit rate analysis was performed in 1852 punches. The target was hit completely, partially and missed totally by 89.4%, 7.2% and 2.2%. A total of 54.5% of punches had good accuracy with less than 200 mu m deviation from the centre of the targeted region and 92.6% less than 500 mu m. Accuracy decreases with greater sectional depth. In the deepest sectional plane of roughly 0.5 mm median depth, almost 90% of cores had a deviation below 500 mu m. Recommendations for automated TMA creation are given in this article. The ngTMA(R)-method has proven accurate and reliable in different soft tissues, even in deeper sectional layers.},
author = {Werry, Jan-Erik and Müller, Stefan and Wehrhan, Falk and Geppert, Carol-Immanuel and Frohwitter, Gesche and Kaemmerer, Peer W. and Möst, Tobias and Lutz, Rainer and Homm, Andi and Kesting, Marco Rainer and Weber, Manuel and Ries, Jutta},
doi = {10.3390/app11125589},
faupublication = {yes},
journal = {Applied Sciences},
note = {CRIS-Team WoS Importer:2021-07-09},
peerreviewed = {Yes},
title = {{Accuracy} {Analysis} of a {Next}-{Generation} {Tissue} {Microarray} on {Various} {Soft} {Tissue} {Samples} of {Wistar} {Rats}},
volume = {11},
year = {2021}
}
@article{faucris.250573013,
abstract = {Objective: Temporomandibular dysfunction (TMD) reduces patients’ quality of life (QoL). The aim was to assess the effects of initial Aqualizer™ therapy. Methods: Group 1 (initial Aqualizer™ therapy) before definitive splint therapy or Group 2 (no initial therapy). Patients with arthrosis, partial/total prosthesis, or were undergoing splint therapy were excluded. Subjective parameters were evaluated: duration and intensity of pain, influence on wellbeing, changes in the head/neck area, handling and improvement of the Aqualizer™, improvement in QoL. The statistical significance level was 5% (p < 0.05). Results: In 53 patients (Group 1 n = 25; Group 2 n = 28), the improvement in patients’ well-being and intensity of pain in both groups was significant (p < 0.001). An improvement in QoL was found in 84% of patients in Group 1 and 75% in Group 2. Conclusion: Initial Aqualizer™ therapy can decrease the intensity of pain and increase patients’.},
author = {Buchbender, Mayte and Keplinger, Lukas and Kesting, Marco Rainer and Adler, Werner and Schmitt, Christian},
doi = {10.1080/08869634.2021.1885887},
faupublication = {yes},
journal = {Cranio-The Journal of Craniomandibular Practice},
keywords = {Aqualizer splint; headache; myofascial; pain; TMD/TMJ},
note = {CRIS-Team Scopus Importer:2021-02-26},
peerreviewed = {Yes},
title = {{A} clinical trial: {Aqualizer} ™ therapy and its effects on myopathies or temporomandibular dysfunctions. {Part} {II}: {Subjective} parameters},
year = {2021}
}
@article{faucris.316121196,
abstract = {OBJECTIVE: Symptoms of temporomandibular dysfunction (TMD) may include pain in the muscles or restrictions opening the mouth. The aim of this study was to assess the effects of initial Aqualizer™ therapy.
METHODS: Group 1 received initial Aqualizer™ therapy before definitive hard splint; Group 2 received no initial therapy. Patients with arthrosis, partial/total prosthesis or undergoing splint therapy were excluded. Objective (temporomandibular joint palpation, temporomandibular joint auscultation, palpation of the chewing muscles, and mobility of the lower jaw) parameters were evaluated. The level of statistical significance was 5% (p < 0.05).
RESULTS: In 53 patients (Group 1 n = 25; Group 2 n = 28), a significant improvement (p < 0.001) was found in Group 1 in pain on palpation (masseter muscle, temporal muscle, post-mandibular region, lateral pterygoid muscle, and suboccipital region), but no significant differences in jaw mobility were found.
CONCLUSION: Aqualizer™ therapy produces significant improvement of primary symptoms.},
author = {Buchbender, Mayte and Keplinger, Lukas and Kesting, Marco Rainer and Adler, Werner and Schmitt, Christian},
doi = {10.1080/08869634.2021.1885886},
faupublication = {yes},
journal = {Cranio-The Journal of Craniomandibular Practice},
note = {EVALuna2:465271},
pages = {1-9},
peerreviewed = {Yes},
title = {{A} clinical trial: {Aqualizer} ™ therapy and its effects on myopathies or temporomandibular dysfunctions. {Part} {I}: {Objective} parameters.},
volume = {42},
year = {2024}
}
@inproceedings{faucris.223037306,
abstract = {The Er:YAG laser has gained significant interest in the field of oral
surgery due to its high water absorptivity, precision and patient
acceptance. However, its application is limited by the lack of a
contact-free feedback system which would enable safe laser guidance. In
this work, a potential new, robust feedback modality based on
speckle-analysis is presented which detects the acoustic signals
produced during laser surgery. Oral soft- and hard tissue samples are
investigated ex-vivo for its differentiation capability using the
speckle modality. This technique might help to broaden the clinical
application of Er:YAG laser},
author = {Lengenfelder, Benjamin and Schwarzkopf, Karen and Oetter, Nicolai and Mehari, Fanuel and Eschner, Eric and Klämpfl, Florian and Stelzle, Florian and Kesting, Marco Rainer and Zalevsky, Zeev and Schmidt, Michael},
booktitle = {Opto-Acoustic Methods and Applications in Biophotonics IV; 110771L (2019)},
date = {2019-06-23/2019-06-27},
doi = {10.1117/12.2526578},
editor = {SPIE},
faupublication = {yes},
keywords = {Laser surgery; Er:YAG laser; tissue differentiation},
peerreviewed = {Yes},
title = {{Acoustic} differentiation of dental soft and hard tissues using remote speckle-analysis during {Er}:{YAG} ablation},
venue = {Munich},
year = {2019}
}
@article{faucris.306956790,
abstract = {Purpose: Medication-related osteonecrosis occurs exclusively in the jaw bones. However, the exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) and the unique predisposition of the jaw bones have not been elucidated, making its treatment a challenge. Recent evidence indicates that macrophages might play a pivotal role in MRONJ pathogenesis. The aim of the present study was to compare the macrophage populations between the craniofacial and extracranial skeleton and to investigate the changes induced by zoledronate (Zol) application and surgical interventions. Materials and methods: An in vivo experiment was performed. 120 wistar rats were randomized to 4 groups (G1, G2, G3, G4). G1 served as an untreated control group. G2 and G4 received Zol injections for 8 weeks. Afterwards, the right lower molar of the animals from G3 and G4 was extracted and the right tibia osteotomized followed by osteosynthesis. Tissue samples were taken from the extraction socket and the tibia fracture at fixed time points. Immunohistochemistry was conducted to determine the labeling indexes of CD68+ and CD163+ macrophages. Results: Comparing the mandible and the tibia, we observed a significantly higher number of macrophages and a heightened pro-inflammatory environment in the mandible compared to the tibia. Tooth extraction caused an increase of the overall number of macrophages and a shift toward a more pro-inflammatory microenvironment in the mandible. Zol application amplified this effect. Conclusion: Our results indicate fundamental immunological differences between the jaw bone and the tibia, which might be a reason for the unique predisposition for MRONJ in the jaw bones. The more pro-inflammatory environment after Zol application and tooth extraction might contribute to the pathogenesis of MRONJ. Targeting macrophages might represent an attractive strategy to prevent MRONJ and improve therapy. In addition, our results support the hypothesis of an anti-tumoral and anti-metastatic effect induced by BPs. However, further studies are needed to delineate the mechanisms and specify the contributions of the various macrophage phenotypes.},
author = {Struckmeier, Ann-Kristin and Wehrhan, Falk and Preidl, Raimund and Mike, Melanie and Mönch, Tina and Eilers, Lea and Ries, Jutta and Trumet, Leah and Lutz, Rainer and Geppert, Carol-Immanuel and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.3389/fimmu.2023.1204188},
faupublication = {yes},
journal = {Frontiers in Immunology},
keywords = {bisphosphonate; macrophage; MRONJ; osteonecrosis; tooth extraction},
note = {CRIS-Team Scopus Importer:2023-06-30},
peerreviewed = {Yes},
title = {{Alterations} in macrophage polarization in the craniofacial and extracranial skeleton after zoledronate application and surgical interventions – an in vivo experiment},
volume = {14},
year = {2023}
}
@article{faucris.123247124,
abstract = {Aberrant microRNA (miRNA) expression in blood of cancer patients is a common finding. The present study aimed at evaluating the differences in miRNA expression in whole blood samples of oral squamous cell carcinoma (OSCC) patients compared to healthy controls.Microarray based miRNA profiling was performed on whole blood samples of 20 OSCC patients and 20 healthy volunteers and the differences in expression patterns between the two groups were evaluated. The results were validated by Reverse Transcription quantitative-Polymerase Chain Reaction (RT-qPCR) in 50 OSCC patients and 35 volunteers.21 miRNAs were identified to be significantly differentially expressed in whole blood of OSCC patients compared to healthy controls. The impact of miR-186 (p=0.002), miR-494 (p=0.001) and miR-3651 (p=0.0001) could be validated by RT-qPCR.The aberrant expressions of miR-186, miR-494 and miR-3651 in whole blood of OSCC patients may serve as the basis for establishing minimally-invasive screening methods for OSCC based on miRNAs as biomarkers.},
author = {Ries, Jutta and Vairaktaris, Eleftherios and Kintopp, Rita and Baran, Christoph and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
faupublication = {yes},
journal = {In Vivo},
note = {EVALuna2:24185},
pages = {851-61},
peerreviewed = {Yes},
title = {{Alterations} in {miRNA} expression patterns in whole blood of {OSCC} patients},
volume = {28},
year = {2014}
}
@article{faucris.205087941,
abstract = {OBJECTIVES: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins.
MATERIALS AND METHODS: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]).
RESULTS: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02).
CONCLUSIONS: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin.
CLINICAL RELEVANCE: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.},
author = {Kerker, Florian and Adler, Werner and Brunner, Kathrin and Moest, Tobias and Wurm, Matthias and Nkenke, Emeka and Neukam, Friedrich Wilhelm and von Wilmowsky, Cornelius},
doi = {10.1007/s00784-018-2424-z},
faupublication = {yes},
journal = {Clinical Oral Investigations},
note = {EVALuna2:34226},
pages = {1625-1630},
peerreviewed = {Yes},
title = {{Anatomical} locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study},
volume = {22},
year = {2018}
}
@article{faucris.122975644,
abstract = {Three-dimensional radiological imaging data play an increasingly role in planning, simulation, and navigation in oral and maxillofacial surgery. The aim of this study was to establish a new, highly precise, in vitro measurement technology for the evaluation of the geometric accuracy down to the micrometric range of digital imaging data.A macerated human mandible was scanned optically with an industrial, non-contact, white light scanner, and a three-dimensional (3D) model was obtained, which served as a master model. The mandible was then scanned 10 times by cone beam computed tomography (CBCT), and the generated 3D surface bone model was virtually compared with the master model. To evaluate the accuracy of the CBCT scans, the standard deviation and the intraclass coefficient were determined.A total of 19 measurement points in 10 CBCT scans were investigated, and showed an average value of 0.2676 mm with a standard deviation of 0.0593 mm. The standard error of the mean was 0.0043 mm. The intraclass correlation coefficient (ICC) within the 10 CBCT scans was 0.9416.This highly precise measuring technology was demonstrated to be appropriate for the evaluation of the accuracy of digital imaging data, down to the micrometric scale. This method is able to exclude human measurement errors, as the software calculates the superimposition and deviation. Thus inaccuracies caused by measurement errors can be avoided. This method provides a highly precise determination of deviations of different CBCT parameters and 3D models for surgical, navigational, and diagnostic purposes. Thus, surgical procedures and the post-operative outcomes can be precisely simulated to benefit the patient.},
author = {von Wilmowsky, Cornelius and Bergauer, Bastian and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Neuhuber, Winfried and Lell, Michael and Keller, Andrea and Eitner, Stephan and Matta, Ragai-Edward},
doi = {10.1016/j.jcms.2015.06.021},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:4148},
pages = {1335-9},
peerreviewed = {Yes},
title = {{A} new, highly precise measurement technology for the in vitro evaluation of the accuracy of digital imaging data},
volume = {43},
year = {2015}
}
@article{faucris.225333217,
abstract = {Objectives: The preclinical study aimed to establish a standardized preclinical model to investigate osseous graft consolidation in defect configurations of limited regenerative capacity. Material and methods: Critical size defects (CSD) were prepared and titanium tubes inserted for defect separation from local bone in the forehead area of 18 pigs. Defects were filled with demineralized bovine bone mineral (DBBM) or served as empty controls and were covered with a resorbable collagen membrane (CM) or left untreated. Six randomly selected pigs were sacrificed after 4, 8 and 12 weeks. Specimens were histologically and histomorphometrically analysed focusing on newly formed bone (NFB), demineralized bovine bone mineral (DBBM) and soft tissue (ST) proportions. Results: Four weeks after defect preparation, no statistically significant difference concerning NFB quantity could be detected within the groups. Defects covered with the CM showed lower amounts of DBBM. After 6 and 12 weeks, defects augmented with DBBM in combination with a CM (8 weeks: 43.12 ± 4.31; 12 weeks: 43.05 ± 3.01) showed a statistically significant higher NFB rate compared to empty control defects covered with 8 weeks: 7.66 ± 0.59; 12 weeks or without a CM; 8 weeks: 8.62 ± 2.66; 12 weeks: 18.40 ± 2.40. CM application showed no significant impact on osseous defect regeneration or soft tissue formation. Superior NFB could be detected for basal aspect for several evaluation time points. Conclusions: The modification of CSD with titanium tubes represents a suitable model to imitate a one-wall defect regeneration situation. Clinical relevance: The established model represents a promising method to evaluate graft consolidation in one-wall defect configuration.},
author = {Möst, Tobias and Schlegel, Karl Andreas and Kesting, Marco Rainer and Fenner, Matthias and Lutz, Rainer and Beck, Daniele Machado and Nkenke, Emeka and von Wilmowsky, Cornelius},
doi = {10.1007/s00784-019-03020-w},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Animal model; Bone substitutes; Critical size defect; Demineralized bovine bone mineral},
note = {CRIS-Team Scopus Importer:2019-08-30},
peerreviewed = {Yes},
title = {{A} new standardized critical size bone defect model in the pig forehead for comparative testing of bone regeneration materials},
year = {2019}
}
@article{faucris.309899246,
abstract = {Background: Bilateral cleft lip surgery is very challenging and requires a high level of skill, knowledge and experience. Existing high-fidelity simulation models that can be used by novice cleft surgeons to gain experience and expand their knowledge are rare and expensive. In this study, we developed a bilateral cleft lip model using porcine snout discs, which are available anywhere and inexpensive. Methods: Anatomic reference points of a patient with a bilateral cleft lip were superimposed with landmarks of the porcine snout disc on a foil template. The template was used to construct an ex vivo bilateral cleft lip model. Surgery was performed on the model according to Millard and the surgical steps were photodocumented analogous to two clinical cases of bilateral cleft lip surgery. The suitability of the model was further tested by twelve participants and evaluated using self-assessment questionnaires. Results: The bilateral cleft lip ex vivo model made of a porcine snout disc proved to be a suitable model with very low cost and ease of fabrication, as the template is reusable on any snout disc. The Millard procedure was successfully performed and the surgical steps of the lip plasty were simulated close to the clinical situation. Regarding the nasal reconstruction, the model lacks three-dimensionality. As a training model, it enhanced the participants comprehension of cleft surgery as well as their surgical skills. All participants rated the model as valuable for teaching and training. Conclusions: The porcine snout discs can be used as a useful ex vivo model for bilateral cleft lip surgery with limitations in the construction of the nose, which cannot be realistically performed with the model due to anatomical differences with humans. Benefits include a realistic tissue feel, the simulation of a multi-layered lip construction, a wide and rapid availability and low cost. This allows the model to be used by novice surgeons also in low-income countries. It is therefore useful as a training model for gaining experience, but also as a model for refining, testing and evaluating surgical techniques for bilateral lip plasty.},
author = {Lutz, Rainer and Kesting, Marco Rainer and Weber, Manuel and Olmos, Manuel and Tasyürek, Deniz and Möst, Tobias and Bürstner, Jan and Schulz, Katja},
doi = {10.1186/s12909-023-04575-9},
faupublication = {yes},
journal = {BMC Medical Education},
keywords = {Bilateral cleft lip; Cadaver model; Cheiloplasty; Ex vivo model; Lip plasty; Porcine snout disc; Residency training; Skills lab; Surgical simulation; Teaching},
note = {CRIS-Team Scopus Importer:2023-09-01},
peerreviewed = {Yes},
title = {{An} ex vivo model for education and training of bilateral cleft lip surgery},
volume = {23},
year = {2023}
}
@article{faucris.264579535,
abstract = {Purpose This study aimed to determine whether peer-assisted learning (PAL) is a more effective learning and test method in terms of oral- and maxillofacial surgery. Material and methods In July 2020, a total of 267 students took a PAL-based exam on fictional patients with surgical issues, in which they had to evaluate two fellow students and were themselves evaluated by two fellow students. The students evaluated their experience with the PAL-based exam through a questionnaire which consisted of five given statements (answer possibilities: agree, disagree, neutral) and two questions (answer possibilities: better, equal, worse) to rate. Results In the survey, 77.9% of the students rated PAL as a better learning method and 21% rated it as at least equally effective to the known multiple-choice (MC) test. A total of 74.9% of the students indicated that they learned more content with PAL and 20.2% said they learned the same amount; 83.7% said that their "clinical thinking has improved" through PAL. In the comments, 73% of the students noted that they think PAL is a good learning method, and at least 22% rated it as useful but in need of improvements. Only 5% did not see PAL as an acceptable learning method. In contrast to this, 1.3% saw PAL as a "bad alternative to MC tests." Conclusion PAL, especially peer assessment, might represent a better learning method as it might encourage students to deal more intensively with the learning content and to improve clinical thinking.},
author = {Holfert, Jonathan and Kesting, Marco Rainer and Buchbender, Mayte},
doi = {10.1002/jdd.12790},
faupublication = {yes},
journal = {Journal of Dental Education},
note = {CRIS-Team WoS Importer:2021-10-01},
peerreviewed = {Yes},
title = {{An} observational study of learning effects of peer-assisted learning tests in {COVID}-19 pandemic times},
year = {2021}
}
@article{faucris.122250304,
abstract = {This investigation focused on histological characteristics and 5-year implant survival after sinus floor augmentation with anorganic bovine bone (ABB, Bio-Oss(®) ) and ABB plus autologous bone (AB) with a ratio of 1/1.Nineteen consecutive patients with bony atrophy of the posterior edentulous maxilla and a vertical bone height <=4 mm were prospectively included in this study. In the first surgical stage, the maxillary sinus was non-randomized either augmented with ABB alone (n = 12) or a 1/1 mixture of ABB and AB (n = 7). After a mean healing period of 167 days, biopsies were harvested in the region of the grafted sinus with a trephine burr and implants were placed simultaneously, ABB n = 18 and ABB + AB n = 12. The samples were microradiographically and histomorphometrically analyzed judging the newly formed bone (bone volume, BV), residual bone substitute material volume (BSMV), and intertrabecular volume (soft tissue volume, ITV) in the region of the augmented maxillary sinus. Implant survival was retrospectively evaluated from patient's records.No significant difference in residual bone substitute material (BSMV) in the ABB group (31.21 ± 7.74%) and the group with the mixture of ABB and AB (28.41 ± 8.43%) was histomorphologically determined. Concerning the de novo bone formation, also both groups showed statistically insignificant outcomes; ABB 26.02 ± 5.23% and ABB + AB 27.50 ± 6.31%. In all cases, implants were installed in the augmented sites with sufficient primary stability. After a mean time in function of 5 years and 2 months, implant survival was 93.75% in the ABB and 92.86% in the ABB + AB group with no statistically significant differences.The usage of ABB plus AB to a 1/1 ratio leads to an amount of newly formed bone comparable with the solitary use of ABB after grafting of the maxillary sinus. Considering that ABB is a non-resorbable bone substitute, it can be hypothesized that this leads to stable bone over time and long-term implant success. Importantly, in the sole use of ABB, bone grafting and therefore donor site morbidities can be avoided.},
author = {Schmitt, Christian and Moest, Tobias and Lutz, Rainer and Neukam, Friedrich Wilhelm and Schlegel, Karl Andreas},
doi = {10.1111/clr.12396},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24380},
pages = {1043-50},
peerreviewed = {Yes},
title = {{Anorganic} bovine bone ({ABB}) vs. autologous bone ({AB}) plus {ABB} in maxillary sinus grafting. {A} prospective non-randomized clinical and histomorphometrical trial},
volume = {26},
year = {2015}
}
@article{faucris.314823825,
abstract = {The anatomically complex and often spatially restricted conditions of anastomosis in the head and neck region cannot be adequately reproduced by training exercises on current ex vivo or small animal models. With the development of a Realistic Anatomical Condition Experience (RACE) model, complex spatial-anatomical surgical areas and the associated intraoperative complexities could be transferred into a realistic training situation in head and neck surgery. The RACE model is based on a stereolithography file generated by intraoperative use of a three-dimensional surface scanner after neck dissection and before microvascular anastomosis. Modelling of the acquired STL file using three-dimensional processing software led to the model’s final design. As a result, we have successfully created an economical, sustainable and realistic model for microsurgical education and provide a step-by-step workflow that can be used in surgical and general medical education to replicate and establish comparable models. We provide an open source stereolithography file of the head-and-neck RACE model for printing for educational purposes. Once implemented in other fields of surgery and general medicine, RACE models could mark a shift in medical education as a whole, away from traditional teaching principles and towards the use of realistic and individualised simulators.},
author = {Weber, Manuel and Backhaus, Joy and Lutz, Rainer and Nobis, Christopher-Philipp and Zeichner, Samuel and Koenig, Sarah and Kesting, Marco Rainer and Olmos, Manuel},
doi = {10.1038/s41598-023-47225-2},
faupublication = {yes},
journal = {Scientific Reports},
note = {CRIS-Team Scopus Importer:2023-12-08},
peerreviewed = {Yes},
title = {{A} novel approach to microsurgical teaching in head and neck surgery leveraging modern {3D} technologies},
volume = {13},
year = {2023}
}
@article{faucris.121176484,
abstract = {We present a mild one-pot freeze gelation process for fabricating near-net, complex-shaped hydroxyapatite scaffolds and to directly incorporate active proteins during scaffold processing. In particular, the direct protein incorporation enables a simultaneous adjustment and control of scaffold microstructure, porosity, resorbability and enhancement of initial mechanical and handling stability. Two proteins, serum albumin and lysozyme, are selected and their effect on scaffold stability and microstructure investigated by biaxial strength tests, electron microscopy, and mercury intrusion porosimetry. The resulting hydroxyapatite/protein composites feature adjustable porosities from 50% to 70% and a mechanical strength ranging from 2 to 6 MPa comparable to that of human spongiosa without any sintering step. Scaffold degradation behaviour and protein release are assessed by in vitro studies. A preliminary in vivo assessment of scaffold biocompatibility and resorption behaviour in adult domestic pigs is discussed. After implantation, composites were resorbed up to 50% after only 4 weeks and up to 65% after 8 weeks. In addition, 14% new bone formation after 4 weeks and 37% after 8 weeks were detected. All these investigations demonstrate the outstanding suitability of the one-pot-process to create, in a customisable and reliable way, biocompatible scaffolds with sufficient mechanical strength for handling and surgical insertion, and for potential use as biodegradable bone substitutes and versatile platform for local drug delivery.},
author = {Mueller, Bent and Koch, Dietmar and Lutz, Rainer and Schlegel, Karl A. and Treccani, Laura and Rezwan, Kurosch},
doi = {10.1016/j.msec.2014.05.017},
faupublication = {yes},
journal = {Materials Science and Engineering C},
note = {EVALuna2:24389},
pages = {137-45},
peerreviewed = {Yes},
title = {{A} novel one-pot process for near-net-shape fabrication of open-porous resorbable hydroxyapatite/protein composites and in vivo assessment},
volume = {42},
year = {2014}
}
@article{faucris.212499124,
abstract = {Introduction: Impaired wound healing, chronic wounds and extended soft tissue defects present a crucial problem in reconstructive surgery of the head and neck region, even more after radiation therapy. In such cases the standard is a prolonged open wound treatment. The negative pressure instillation therapy might present an alternative therapy option.},
author = {Eckstein, Fabian and Pinsel, Valesca and Wurm, Matthias and Wilkerling, André and Dietrich, Eva-Maria and Kreißel, Sebastian and von Wilmowsky, Cornelius and Schlittenbauer, Tilo},
doi = {10.1016/j.jcms.2018.12.006},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {CRIS-Team WoS Importer:2019-03-06},
pages = {389-393},
peerreviewed = {Yes},
title = {{Antiseptic} negative pressure instillation therapy for the treatment of septic wound healing deficits in oral and maxillofacial surgery},
volume = {47},
year = {2019}
}
@article{faucris.280965253,
abstract = {Structured examination and treatment are essential in medicine. For dental students, a structured approach to the assessment of oral mucosal lesions is missing thus far. To validate an approach, a structured questionnaire was compared with the habitually used free description of oral lesions (white lesions, ulcers, hyperplasia). Thirty-three dental students were divided into two groups (Group 1 (n = 17) used the free description; Group 2 (n = 16) used a guided questionnaire) to characterize mucosal lesions in patients and make a tentative diagnosis. Although no difference was found between the groups regarding the suspected diagnosis or the histopathological findings, there was a significant advantage of the structured questionnaire in all aspects of the description compared to the free description (p = 0.000018). Thus, a structured description is an important aspect in the evaluation of oral mucosal changes, and a guided questionnaire should be implemented in the study of dentistry.},
author = {Röschmann, Nico and Rau, Andrea and Kesting, Marco Rainer and Maier, Eva and Buchbender, Mayte},
doi = {10.3390/ijerph19159663},
faupublication = {yes},
journal = {International Journal of Environmental Research and Public Health},
note = {CRIS-Team WoS Importer:2022-08-26},
peerreviewed = {Yes},
title = {{A} {Prospective} {Comparative} {Analysis} {Regarding} the {Assessment} of {Oral} {Mucosal} {Disease} {Using} a {Validated} {Questionnaire} to {Improve} the {Teaching} of {Dental} {Students}},
volume = {19},
year = {2022}
}
@article{faucris.265335626,
abstract = {Background: The aim of this prospective study was to investigate the occurrence and severity of postoperative bleeding following dentoalveolar surgery in patients with uninterrupted anticoagulation therapy (AT). Methods: Patients receiving AT (vitamin k antagonist (VK), direct oral anticoagulants (DOAC) or antiplatelet therapy (APT) and in need of surgical intervention classified as A, B or C (single or serial tooth extraction, osteotomy, or implant placement) were studied between 2019 and 2021. A healthy, non-anticoagulated cohort (CG) served as a control group. The main outcomes measured were the frequency of postoperative bleeding, the classification of the severity of postoperative bleeding (1a, 1b, 1c, 2, 3), and the correlation with the AT surgical intervention classification. Results: In total, 195 patients were included in the study, with 95 patients in the AT group and 100 in the CG. Postoperative bleeding was significant in the AT group vs. the CG (p = 0.000), with a significant correlation with surgical intervention class C (p = 0.013) and the severity class of bleeding 1a (p = 0.044). There was no significant correlation with procedures of type A, B or C for the other postoperative bleeding gradations (1b, 1c, 2 and 3). There was a statistically significant difference in the occurrence of postoperative bleeding events between the DOAC/APT group and the VK group (p = 0.036), but there were no significant differences regarding the other AT agents. Conclusion: The continuation of anticoagulation therapy for surgical interventions also seems reasonable for high-risk interventions. Although significantly more postoperative bleeding occurs, the severity of bleeding is low. The perioperative management of anticoagulated patients requires well-coordinated interdisciplinary teamwork and detailed instruction of patients. Clinical trial registration The study is registered (29.03.2021) at the German clinical trial registry (DRKS00024889).},
author = {Buchbender, Mayte and Schlee, Nicola and Kesting, Marco Rainer and Grimm, Jannik and Fehlhofer, Jakob Paul and Rau, Andrea},
doi = {10.1186/s12903-021-01868-7},
faupublication = {yes},
journal = {BMC Oral Health},
keywords = {Anticoagulant agents; Direct-acting oral anticoagulants; Hematological agents; Oral hemorrhages; Oral surgical procedures; Postoperative hemorrhages},
note = {CRIS-Team Scopus Importer:2021-10-22},
peerreviewed = {Yes},
title = {{A} prospective comparative study to assess the risk of postoperative bleeding after dental surgery while on medication with direct oral anticoagulants, antiplatelet agents, or vitamin {K} antagonists},
volume = {21},
year = {2021}
}
@article{faucris.315874776,
abstract = {AIM: As a common procedure in oral surgery, the removal of wisdom teeth (3M) is associated with a variety of postoperative complications. This study reports of deep tissue abscesses after the removal of 3M in correlation to several factors.
MATERIALS AND METHODS: Patients between 2012 and 2017 with removed 3M were retrospectively evaluated in terms of clinical condition and localization and thus assigned tog A (removal of asymptomatic 3M) or group B (removal of symptomatic 3M). Moreover, they were analyzed in terms of abscesses after the removal and correlation with various parameters: localization of the abscess, general diseases, perioperative antibiotic treatment, number of days from removal of the tooth to abscess formation, and postoperative complications after primary abscess incision.
RESULTS: About 82 patients (male n = 44, female n = 38) were included, with 88 wisdom teeth removed and postoperative abscesses. Postoperative abscesses occurred more frequently in group B (n = 53) with n = 29 in IIB localization, without a significant correlation. Patients in this group were older, and there were more surgical abscess incisions needed, despite a longer treatment with oral and intravenous antibiosis that correlated with neurologic diseases and age. Younger patients reported significantly more pain.
CONCLUSIONS: Detection of potential 3M pathologies at an early and asymptomatic stage is essential to avoid postoperative complications following 3M removal. Additional prospective studies are necessary to develop corresponding guidelines.
CLINICAL SIGNIFICANCE: Wisdom tooth extraction is the most common operation in oral surgery, and therefore, adequate risk evaluation is still required.},
author = {Fehlhofer, Jakob Paul and Fernandez-Ulrich, Carlos and Wohlers, Aron and Kesting, Marco Rainer and Rau, Andrea and Buchbender, Mayte},
doi = {10.5005/jp-journals-10024-3427},
faupublication = {yes},
journal = {Journal of Contemporary Dental Practice},
note = {EVALuna2:544990},
pages = {1079-1084},
peerreviewed = {Yes},
title = {{A} {Retrospective} {Analysis} of {Postoperative} {Abscess} {Formation} {Following} {Wisdom} {Tooth} {Removal} and {Their} {Clinical} {Condition} and {Localization}.},
volume = {23},
year = {2022}
}
@article{faucris.273203564,
abstract = {This study aimed to analyse the development of medication-related osteonecrosis of the jaw (MRONJ) in patients who underwent surgical intervention to identify potential risk factors between three different groups sorted by the type of oral surgery (single tooth extraction, multiple extraction, osteotomy). Data from patients with this medical history between 2010 and 2017 were retrospectively analysed. The following parameters were collected: sex, age, medical status, surgical intervention location of dentoalveolar intervention and form of medication. A total of 115 patients fulfilled the criteria and underwent 115 dental surgical interventions (female n = 90, male n = 25). In total, 73 (63.47%) of them had metastatic underlying diseases, and 42 (36.52%) had osteoporotic ones. MRONJ occurred in 10 patients (8.70%) (female n = 5, male n = 5). The occurrence of MRONJ was significantly correlated (p ≤ 0.05) with the mandible site and male sex. Tooth removal at the mandible site remains the main risk factor for the development of MRONJ. The risk profile of developing MRONJ after dentoalveolar interventions could be expected as follows: tooth osteotomy > multiple extractions > single tooth extraction.},
author = {Buchbender, Mayte and Bauerschmitz, Charlotte and Pirkl, Sebastian and Kesting, Marco Rainer and Schmitt, Christian},
doi = {10.3390/ijerph19074339},
faupublication = {yes},
journal = {International Journal of Environmental Research and Public Health},
keywords = {antiresorptive therapy; MRONJ; oral surgery; risk profile},
note = {CRIS-Team Scopus Importer:2022-04-15},
peerreviewed = {Yes},
title = {{A} {Retrospective} {Data} {Analysis} for the {Risk} {Evaluation} of the {Development} of {Drug}-{Associated} {Jaw} {Necrosis} through {Dentoalveolar} {Interventions}},
volume = {19},
year = {2022}
}
@article{faucris.112068264,
abstract = {Among numerous techniques that have been described for lip repair, the Tennison-Randall method has gained popularity over time and is preferred by many surgeons due to the predictability of the outcome. This study aims to evaluate the esthetic outcome reached in the nasolabial region following primary lip repair with the use of this method.Forty-four patients with unilateral cleft lip (with or without alveolar cleft) were assessed retrospectively through a photographic evaluation by two clinicians with regard to the aesthetics of the lip and nose separately as anatomical subunits as well as of the nasolabial region as an anatomical complex. The collected data were statistically analyzed with regard to the cleft subtype and the performance of corrective surgeries for the lip and/or the nose.The method was associated with good results, especially when it comes to the appearance of the nose as an anatomical subunit, as well as of the nasolabial region as a complex, regarding cleft lip patients without an alveolar cleft.The Tennison-Randall technique proved to be a very satisfying method in terms of the esthetic long-term outcome in our patient collective.},
author = {Iliopoulos, Christos and Mitsimponas, Konstantinos and Lazaridou, Dimitra and Neukam, Friedrich Wilhelm and Stelzle, Florian},
doi = {10.1016/j.jcms.2014.05.013},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24385},
pages = {1679-83},
peerreviewed = {Yes},
title = {{A} retrospective evaluation of the aesthetics of the nasolabial complex after unilateral cleft lip repair using the {Tennison}-{Randall} technique: {A} study of 44 cases treated in a single cleft center},
volume = {42},
year = {2014}
}
@article{faucris.285705977,
author = {Glajzer, Jacek and Castillo-Tong, Dan Cacsire and Richter, Rolf and Vergote, Ignace and Kulbe, Hagen and Vanderstichele, Adriaan and Ruscito, Ilary and Trillsch, Fabian and Mustea, Alexander and Kreuzinger, Caroline and Gourley, Charlie and Gabra, Hani and Taube, Eliane T. and Dorigo, Oliver and Horst, David and Keunecke, Carlotta and Baum, Joanna and Angelotti, Timothy and Sehouli, Jalid and Braicu, Elena Ioana},
doi = {10.1245/s10434-022-12681-z},
faupublication = {yes},
journal = {Annals of Surgical Oncology},
note = {CRIS-Team WoS Importer:2022-11-25},
peerreviewed = {unknown},
title = {{ASO} {Visual} {Abstract}: {Impact} of {BRCA} {Mutation} {Status} on {Tumor} {Dissemination} {Pattern}, {Surgical} {Outcome}, and {Patient} {Survival} in {Primary} and {Recurrent} {High}-{Grade} {Serous} {Ovarian} {Cancer} ({HGSOC}). {A} {Multicenter}, {Retrospective} {Study} of the {Ovarian} {Cancer} {Therapy}-{Innovative} {Models} {Prolong} {Survival} ({OCTIPS}) {Consortium}},
year = {2022}
}
@article{faucris.205590390,
abstract = {OBJECTIVES: The purpose of this study was to compare two-dimensional (2D) lateral photographs versus three-dimensional (3D) face scans in analyzing facial profiles using Schwarz's concept of the jaw profile field (JPF) in its original 2D and in a modified 3D version. In addition, the distribution of the facial profile types described by Schwarz were examined.
MATERIALS AND METHODS: Of 75 adult volunteers recruited specifically for this study, we obtained both photographs (Nikon D 300S; Nikon, Düsseldorf, Germany) and scans (FaceSCAN3DScientific Photolab 60 Hz; 3D-Shape, Erlangen, Germany) in a standardized setting. Four raters analyzed the pertinent measurements using image analysis software (Onyx Ceph 3; Image Instruments, Chemnitz, Germany). Statistical analysis was conducted using the R suite environment (v. 3.2.1; R Foundation for Statistical Computing, Vienna, Austria).
RESULTS: Intraobserver reliability was substantial for two raters (κ = 0.61-0.8), moderate for one (κ = 0.41-0.60), and almost perfect for one (κ = 0.81-1.00). As for interobserver reliability, we observed moderate agreement between the two basic technologies tested, but internal agreement was only moderate even within the 2D view modes (average κ = 0.51) versus almost perfect within the 3D view modes (κ = 0.84-0.94). Forward-slanting anteface was clearly the most common (43.27%) and straight retroface the least common (0.3%) diagnosis. Only a minority of patients (18.38% of women and 16.15% of men) had straight as opposed to slanting profiles.
CONCLUSIONS: Given our findings of acceptable agreement between 3D scanning and 2D lateral photography, in combination with almost perfect internal agreement between different 3D view modes, it appears useful to adapt Schwarz's method of facial profile assessment for clinical use in 3D virtual environments.},
author = {Fink, Martin and Hirschfelder, Ursula and Hirschinger, Veronika and Schmid, Matthias and Spitzl, Caroline and Detterbeck, Andreas and Hofmann, Elisabeth},
doi = {10.1007/s00056-016-0055-z},
faupublication = {yes},
journal = {Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie},
note = {EVALuna2:33786},
pages = {70-76},
peerreviewed = {Yes},
title = {{Assessment} of facial soft-tissue profiles based on lateral photographs versus three-dimensional face scans},
volume = {78},
year = {2017}
}
@article{faucris.123334904,
abstract = {Microsurgical tissue transfer represents a standard technique for reconstruction in craniomaxillofacial surgery. The transferred tissue is anastomosed to vessels of varying diameters and different physiological conditions. The aim of this study was to evaluate the blood flow in free flaps at their origin and compare this with the flow after reperfusion. In 24 patients undergoing microsurgical procedures (13 radial forearm free flaps (RFFF) and 11 parascapular/scapular free flaps (PSFF)), blood flow was evaluated by intraoperative fluorescence angiography after flap raising and again after reperfusion in the neck area (Flow800, Carl Zeiss AG, Oberkochen, Germany). Flow is expressed by the blood flow index (BFI), maximum intensity (MaxInt) and half-time to MaxInt (t1/2) and was measured in the flap pedicle itself, as well as in the supplying vessels. Following anastomosis of the free flaps in the head and neck area, both the arterial and the venous BFI and MaxInt significantly increased, whereas t1/2 decreased significantly. There was no significant difference in the perfusion parameters between RFFF and PSFF. Intraoperative fluorescence angiography is a reliable method for assessing the perfusion of free microvascular flaps. In the head and neck area, free flaps undergo a significant increase in perfusion but show no differences between varying flap types.},
author = {Preidl, Raimund and Schlittenbauer, Tilo and Weber, Manuel and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
doi = {10.1016/j.jcms.2015.03.013},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24400},
pages = {643-8},
peerreviewed = {Yes},
title = {{Assessment} of free microvascular flap perfusion by intraoperative fluorescence angiography in craniomaxillofacial surgery},
volume = {43},
year = {2015}
}
@article{faucris.302873097,
abstract = {Background: This retrospective case series study aims to demonstrate a salvage technique for the treatment of carotid blow-out syndrome (CBS) in irradiated head and neck cancer patients with a vessel-depleted neck. Methods: Between October 2017 and October 2021, two patients (N = 2) with CBS were treated at our institution in a multidisciplinary approach together with the Department of Vascular Surgery. Patients were characterized based on diagnoses, treatment procedures, and the subsequent postoperative course. Results: Surgical emergency intervention was performed in both cases. The transition zone from the common carotid artery (CCA) to the internal carotid artery (ICA) was resected and reconstructed with a xenogic (case 1) or autogenic (case 2) interposition (end-to-end anastomosis). To allow reconstruction of the vascular defect, an additional autologous vein graft was anastomosed to the interposition graft in an end-to-side technique, allowing arterial anastomosis for a free microvascular flap without re-clamping of the ICA. Because of the intraoperative ICA reconstruction, none of the patients suffered a neurological deficit. Conclusions: The techniques presented in the form of two case reports allow for acute bleeding control, cerebral perfusion, and the creation of a vascular anastomosis option in the vessel-depleted neck.},
author = {Möst, Tobias and Kesting, Marco Rainer and Rohde, Maximilian and Lang, Werner and Meyer, Alexander and Weber, Manuel and Lutz, Rainer},
doi = {10.3390/jcm12093221},
faupublication = {yes},
journal = {Journal of Clinical Medicine},
keywords = {carotid blow out syndrome; irradiation; vessel graft; vessel-depleted neck},
note = {CRIS-Team Scopus Importer:2023-05-26},
peerreviewed = {Yes},
title = {{A} {Treatment} {Approach} for {Carotid} {Blowout} {Syndrome} and {Soft} {Tissue} {Reconstruction} after {Radiotherapy} in {Patients} with {Oral} {Cancer}: {A} {Report} of 2 {Cases}},
volume = {12},
year = {2023}
}
@article{faucris.123787004,
abstract = {To analyse the morbidity arising from autogenous bone graft harvesting, graft resorption and implant survival in grafted sites.Only comparative clinical trials on the harvest of autogenous bone grafts were selected. Studies were excluded if they compared autogenous bone grafts to bone substitutes or vascularised free bone grafts.A total of 24 studies were included in the review. Six intraoral or distant donor sites were identified. The highest level of evidence was reached by a randomised controlled trial. The mandibular ramus was the source of bone that was preferred by the patients. From this intraoral donor site bone was harvested under local anaesthesia on an outpatient basis. Patients' acceptance of chin bone harvesting was low. It led to a considerable morbidity that included pain, superficial skin sensitivity disorders and wound healing problems at the donor site. Patients even preferred iliac crest bone harvesting over bone harvesting from the chin, although this distant donor site required general anaesthesia and a hospital stay. The harvest of posterior iliac crest block led to less morbidity than the harvest of anterior iliac crest block grafts. When only cancellous bone was needed, percutaneous bone harvesting from the iliac crest led to less morbidity than an open approach to the iliac crest.Dependent on the required graft structure and amount of bone needed, ramus grafts, block bone grafts from the posterior iliac crest and cancellous bone grafts harvested with a trephine from the anterior iliac crest should be chosen.},
author = {Nkenke, Emeka and Neukam, Friedrich Wilhelm},
faupublication = {yes},
journal = {European Journal of Oral Implantology},
note = {EVALuna2:24186},
pages = {S203-17},
peerreviewed = {Yes},
title = {{Autogenous} bone harvesting and grafting in advanced jaw resorption: morbidity, resorption and implant survival},
volume = {7 Suppl 2},
year = {2014}
}
@article{faucris.120334104,
author = {Schuster, Maria and Maier, Andreas and Bocklet, Tobias and Nkenke, Emeka and Holst, Alexandra and Eysholdt, Ulrich and Stelzle, Florian},
doi = {10.1016/j.ijporl.2011.12.010},
faupublication = {yes},
journal = {International Journal of Pediatric Otorhinolaryngology},
pages = {362-369},
peerreviewed = {Yes},
title = {{Automatically} evaluated degree of intelligibility of children with different cleft type from preschool and elementary school measured by automatic speech recognition},
volume = {76.0},
year = {2012}
}
@inproceedings{faucris.108182404,
address = {Ljubljana, Slovenia},
author = {Maier, Andreas and Nöth, Elmar and Nkenke, Emeka and Schuster, Maria},
booktitle = {Language Technologies, IS-LTC 2006},
date = {2006-10-09/2006-10-10},
editor = {Erjavec Tomaz, Zganec Gros Jerneja},
faupublication = {yes},
pages = {31-35},
peerreviewed = {Yes},
publisher = {Infornacijska Druzba (Information Society)},
title = {{Automatic} {Assessment} of {Children}'s {Speech} with {Cleft} {Lip} and {Palate}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2006/Maier06-AAO.pdf},
venue = {Ljubljana},
year = {2006}
}
@inproceedings{faucris.121846824,
address = {Singapore},
author = {Nkenke, Emeka and Neukam, Friedrich Wilhelm and Häusler, Gerd and et al.},
author_hint = {Maier Tobias, Benz Michaela, Schön Nikolaus, Nkenke Emeka, Neukam Friedrich Wilhelm, Vogt F., Häusler Gerd},
booktitle = {Perspective in Image-Guided Surgery, Proceedings of the Scientific Workshop on Medical Robotics, Navigation and Visualizatiom},
faupublication = {yes},
note = {UnivIS-Import:2015-04-16:Pub.2004.nat.dphy.optik.1optik.autima},
pages = {51-58},
peerreviewed = {No},
publisher = {Verlag World Scientific},
support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'},
title = {{Automatic} {Coarse} {Registration} of {3D} {Surface} {Data} in {Oral} and {Maxillofacial} {Surgery}},
year = {2004}
}
@article{faucris.119082304,
abstract = {Dental rehabilitation of edentulous patients with complete dentures includes not only aesthetics and mastication of food, but also speech quality. It was the aim of this study to introduce and validate a computer-based speech recognition system (ASR) for automatic speech assessment in edentulous patients after dental rehabilitation with complete dentures. To examine the impact of dentures on speech production, the speech outcome of edentulous patients with and without complete dentures was compared. Twenty-eight patients reading a standardized text were recorded twice - with and without their complete dentures in situ. A control group of 40 healthy subjects with natural dentition was recorded under the same conditions. Speech quality was evaluated by means of a polyphone-based ASR according to the percentage of the word accuracy (WA). Speech acceptability assessment by expert listeners and the automatic rating of the WA by the ASR showed a high correlation (corr = 0.71). Word accuracy was significantly reduced in edentulous speakers (55.42 +/- 13.1) compared to the control group's WA (69.79 +/- 10.6). On the other hand, wearing complete dentures significantly increased the WA of the edentulous patients (60.00 +/- 15.6). Speech production quality is significantly reduced after complete loss of teeth. Reconstitution of speech production quality is an important part of dental rehabilitation and can be improved for edentulous patients by means of complete dentures. The ASR has proven to be a useful and easily applicable tool for automatic speech assessment in a standardized way.},
author = {Stelzle, Florian and Ugrinovic, Biljana and Knipfer, Christian and Bocklet, Tobias and Nöth, Elmar and Schuster, Maria and Eitner, Stefan and Seiss, Martin and Nkenke, Emeka},
doi = {10.1111/j.1365-2842.2009.02047.x},
faupublication = {yes},
journal = {Journal of Oral Rehabilitation},
keywords = {speech quality;automatic speech recognition;objective speech assessment;edentulism;complete dentures;oral rehabilitation},
pages = {209-216},
peerreviewed = {Yes},
title = {{Automatic}, computer-based speech assessment on edentulous patients with and without complete dentures - preliminary results},
volume = {37},
year = {2010}
}
@article{faucris.107898604,
author = {Maier, Andreas and Hönig, Florian Thomas and Bocklet, Tobias and Nöth, Elmar and Stelzle, Florian and Nkenke, Emeka and Schuster, Maria},
doi = {10.1121/1.3216913},
faupublication = {yes},
journal = {Journal of the Acoustical Society of America},
pages = {2589-2602},
peerreviewed = {Yes},
title = {{Automatic} detection of articulation disorders in children with cleft lip and palate},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2009/Maier09-ADO.pdf},
volume = {126.0},
year = {2009}
}
@inproceedings{faucris.108207264,
author = {Stelzle, Florian and Schuster, Maria and Maier, Andreas and Bocklet, Tobias and Nöth, Elmar and Seiß, Martin and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
booktitle = {3rd International IZKF-Symposium},
date = {2009-05-14/2009-05-16},
editor = {Reis André},
faupublication = {yes},
pages = {-- (Poster)},
peerreviewed = {Yes},
title = {{Automatic} {Objective} {Analysis} of {Speech} {Disorders} on {Patients} with {Oral} {Squamous} {Cell} {Carcinoma}},
venue = {Bad Staffelstein},
year = {2009}
}
@article{faucris.108117724,
author = {Stelzle, Florian and Maier, Andreas and Nöth, Elmar and Bocklet, Tobias and Knipfer, Christian and Schuster, Maria and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
doi = {10.1016/j.joms.2010.05.077},
faupublication = {yes},
journal = {Journal of Maxillofacial and Oral Surgery},
pages = {1493-1500},
peerreviewed = {unknown},
title = {{Automatic} {Quantification} of {Speech} {Intelligibility} in {Patients} after {Treatment} for {Oral} {Squamous} {Cell} {Carcinoma}},
volume = {69.0},
year = {2011}
}
@article{faucris.111851124,
author = {Windrich, Martin and Maier, Andreas and Kohler, Regina and Nöth, Elmar and Nkenke, Emeka and Eysholdt, Ulrich and Schuster, Maria},
doi = {10.1159/000121004},
faupublication = {yes},
journal = {Folia Phoniatrica Et Logopaedica},
pages = {151-156},
peerreviewed = {Yes},
title = {{Automatic} {Quantification} of {Speech} {Intelligibility} of {Adults} with {Oral} {Squamous} {Cell} {Carcinoma}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2008/Windrich08-AQO.pdf},
volume = {60/2008},
year = {2008}
}
@inproceedings{faucris.113151984,
address = {Bonn},
author = {Maier, Andreas and Schuster, Maria and Batliner, Anton and Nöth, Elmar and Nkenke, Emeka},
booktitle = {Interspeech 2007},
date = {2007-08-27/2007-08-31},
editor = {Interspeech},
faupublication = {yes},
pages = {1206-1209},
peerreviewed = {Yes},
publisher = {Uni Bonn},
title = {{Automatic} {Scoring} of the {Intelligibility} in {Patients} with {Cancer} of the {Oral} {Cavity}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2007/Maier07-ASO.pdf},
venue = {Antwerpen},
year = {2007}
}
@article{faucris.121356664,
author = {Maier, Andreas and Haderlein, Tino and Stelzle, Florian and Nöth, Elmar and Nkenke, Emeka and Rosanowski, Frank and Schützenberger, Anne and Schuster, Maria},
doi = {10.1155/2010/926951},
faupublication = {yes},
journal = {EURASIP Journal on Audio, Speech, and Music Processing},
pages = {-},
peerreviewed = {Yes},
title = {{Automatic} {Speech} {Recognition} {Systems} for the {Evaluation} of {Voice} and {Speech} {Disorders} in {Head} and {Neck} {Cancer}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2010/Maier10-ASR.pdf},
year = {2010}
}
@article{faucris.121038544,
author = {Häusler, Gerd and Wittenberg, Thomas and Nkenke, Emeka and Ettl, Svenja and et al.},
author_hint = {Göb S., Maier Tobias, Benz Michaela, Ettl Svenja, Wittenberg Thomas, Kullmann W., Nkenke Emeka, Neukam F.W., Häusler Gerd},
faupublication = {yes},
journal = {Informatik aktuell},
note = {UnivIS-Import:2015-03-09:Pub.2006.nat.dphy.optik.1optik.automa},
pages = {-},
peerreviewed = {Yes},
support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'},
title = {{Automatische} {Segmentierung} der {Gewebegrenzen} in {2D}-{Ultraschalldaten} aus der {Mund}-{Kiefer}- und {Gesichtschirurgie}},
year = {2006}
}
@article{faucris.273204573,
abstract = {Background: The involvement of immune cell infiltration and immune regulation in the progression of oral squamous cell carcinoma (OSCC) is shown. Anti‐PD‐1 therapy is approved for the treatment of advanced OSCC cases, but not all patients respond to immune checkpoint inhibi-tors. Hence, further targets for therapeutic approaches are needed. The number of identified cellular receptors with immune checkpoint function is constantly increasing. This study aimed to perform a comparative analysis of a large number of immune checkpoints in OSCC in order to identify possible targets for therapeutic application. Materials and Methods: A NanoString mRNA analysis was performed to assess the expression levels of 21 immune regulatory checkpoint molecules in OSCC tissue (n = 98) and healthy oral mucosa (NOM; n = 41). The expression rates were compared between the two groups, and their association with prognostic parameters was determined. Additionally, relevant correlations between the expression levels of different checkpoints were examined. Results: In OSCC tissue, significantly increased expression of CD115, CD163, CD68, CD86, CD96, GITRL, CD28 and PD‐L1 was detected. Additionally, a marginally significant increase in CD8 expression was observed. BTLA and PD‐1 levels were substantially increased, but the differential expression was not statistically significant. The expression of CD137L was significantly downregulated in OSCC compared to NOM. Correlations between immune checkpoint expression levels were demonstrated, and some occurred specifically in OSCC tissue. Conclusions: The upregulation of inhibitory receptors and ligands and the downregulation of activators could contribute to reduced effector T‐cell function and could induce local immunosuppression in OSCC. Increased expression of activating actors of the immune system could be explained by the increased infiltration of mye-loid cells and T‐cells in OSCC tissue. The analysis contributes to the understanding of immune es-cape in OSCC and reveals potential targets for oral cancer immunotherapy.},
author = {Weber, Manuel and Lutz, Rainer and Olmos, Manuel and Glajzer, Jacek and Baran, Christoph and Nobis, Christopher-Philipp and Möst, Tobias and Eckstein, Markus and Kesting, Marco Rainer and Ries, Jutta},
doi = {10.3390/cancers14071812},
faupublication = {yes},
journal = {Cancers},
keywords = {head and neck cancer; HNSCC; immune checkpoints; immunotherapy; macro-phage; MDSC; OSCC; T‐cell},
note = {CRIS-Team Scopus Importer:2022-04-15},
peerreviewed = {Yes},
title = {{Beyond} {PD}‐{L1}—{Identification} of {Further} {Potential} {Therapeutic} {Targets} in {Oral} {Cancer}},
volume = {14},
year = {2022}
}
@article{faucris.122078044,
abstract = {Site-specific suppression of bone remodelling has been implicated in bisphosphonate-(BP)-related osteonecrosis of the jaws (BRONJ). Due to the origin of jaw bone from cranial neural crest, osseous differentiation is regulated specifically by the antagonizing BMP-2-downstream-transcription factors Msx-1 and Dlx-5. Osteopontin has been implicated in bone remodelling and angiogenesis. The osteoblast and osteoclast progenitor proliferation mediating Msx-1 has been demonstrated to be suppressed in BRONJ. In vitro BPs were shown to increase Dlx-5 and to suppress osteopontin expression. This study targeted Dlx-5 and osteopontin in BRONJ-related and BP-exposed jaw bone compared with healthy jaw bone samples at protein- and messenger RNA (mRNA) level, since increased Dlx-5 and suppressed osteopontin might account for impaired bone turnover in BRONJ.Fifteen BRONJ-exposed, 15 BP-exposed and 20 healthy jaw bone samples were processed for real-time reverse transcription polymerase chain reaction (RT-PCR) and for immunohistochemistry. Targeting Dlx-5, osteopontin and glyceraldehyde 3-phosphate dehydrogenase mRNA was extracted, quantified by the LabChip-method, followed by quantitative RT-PCR. For immunohistochemistry, an autostaining-based alkaline phosphatase antialkaline phosphatase (APAPP) staining kit was used. Semiquantitative assessment was performed measuring the ratio of stained cells/total number of cells (labelling index, Bonferroni adjustment).The labelling index was significant decreased for osteopontin (p < 0.017) and significantly increased for Dlx-5 (p < 0.021) in BRONJ samples. In BRONJ specimens, a significant fivefold decrease in gene expression for osteopontin (p < 0.015) and a significant eightfold increase in Dlx-5 expression (p < 0.012) were found.BRONJ-related suppression of bone turnover is consistent with increased Dlx-5 expression and with suppression of osteopontin. The BP-related impaired BMP-2-Msx-1-Dlx-5 axis might explain the jaw bone specific alteration by BP.The findings of this study help to explain the restriction of RONJ to craniofacial bones. BRONJ might serve as a model of disease elucidating the specific signal transduction of neural crest cell-derived bone structures in health and disease.},
author = {Wehrhan, Falk and Amann, Kerstin Ute and Moebius, Patrick and Weber, Manuel and Preidl, Raimund and Ries, Jutta and Stockmann, Philipp},
doi = {10.1007/s00784-014-1354-7},
faupublication = {yes},
journal = {Clinical Oral Investigations},
note = {EVALuna2:24383},
pages = {1289-98},
peerreviewed = {Yes},
title = {{BRONJ}-related jaw bone is associated with increased {Dlx}-5 and suppressed osteopontin-implication in the site-specific alteration of angiogenesis and bone turnover by bisphosphonates},
volume = {19},
year = {2015}
}
@article{faucris.285677441,
abstract = {Background: Prognosis of patients with recurrent or metastatic head and neck cancer is generally poor. Adjuvant immunotherapy (IT) featuring immune checkpoint inhibition (ICI) is standard of care in advanced stage head and neck squamous cell carcinoma (HNSCC) and cutaneous squamous cell carcinoma (CSCC). ICI response rates in CSCC are described as higher than in HNSCC. IT is constantly shifting into earlier disease stages which confronts the surgeon with immunotherapeutically pre-treated patients. It is therefore becoming increasingly difficult to assess which patients with symptomatic tumor disease and a lack of curative surgical option might benefit from salvage surgery. Case presentations: The following 6 cases describe therapeutic decision-making regarding ICI and (salvage) surgery in patients with advanced stage HNSCC or CSCC. Cases A and B focus on neoadjuvant ICI followed by salvage surgery. In Cases C and D salvage surgery was performed after short-term stabilization with partial response to ICI. The last two cases (Cases E and F) address the surgical approach after failure of ICI. All cases are discussed in the context of the current study landscape and with focus on individual decision-making. For better understanding, a timetable of the clinical course is given for each case. Conclusions: ICI is rapidly expanding its frontiers into the neoadjuvant setting, frequently confronting the surgeon with heavily pretreated patients. Salvage surgery is a viable therapeutic concept despite the rise of systemic treatment options. Decision-making on surgical intervention in case of a salvage surgery remains an individual choice. For neoadjuvant ICI monitoring regarding pathological tumor response or tumor necrosis rate, we suggest correlation between the initial biopsy and the definite tumor resectate in order to increase its significance as a surrogate marker. Scheduling of neoadjuvant ICI should be further investigated, as recent studies indicate better outcomes with shorter time frames.},
author = {Olmos, Manuel and Lutz, Rainer and Büntemeyer, Tjark-Ole and Glajzer, Jacek and Nobis, Christopher-Philipp and Ries, Jutta and Möst, Tobias and Eckstein, Markus and Hecht, Markus and Gostian, Antoniu-Oreste and Erdmann, Michael and Foerster, Yannick and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.3389/fimmu.2022.970823},
faupublication = {yes},
journal = {Frontiers in Immunology},
keywords = {anti-PD 1; checkpoint inhibition; CSCC; HNSCC; immunotherapy; neoadjuvant; OSCC; salvage surgery},
note = {CRIS-Team Scopus Importer:2022-11-25},
peerreviewed = {Yes},
title = {{Case} report: {Patient} specific combination of surgery and immunotherapy in advanced squamous cell carcinoma of the head and neck – a case series and review of literature},
volume = {13},
year = {2022}
}
@article{faucris.109300224,
abstract = {The Oral Squamous Cell Carcinoma (OSCC) frequently metastasizes lymphogenously. Haematogenous dissemination is less common. This report describes a rare case of a metastatic OSCC of the floor of the mouth to the patients' left upper arm. To our knowledge this is the first of such case described in the literature.Twelve months after R0 tumor resection surgery, including microvascular reconstruction of the lower jaw followed by adjuvant radiotherapy, the patient was admitted for osteosynthesis plates removal. During clinical examination a tumor located at his left upper arm was detected. According to the patient the tumor has demonstrated rapid growth. Macroscopic appearance and conventional imaging led to the differential diagnosis of an abscess. MR-imaging could not differentiate between a tumor of soft tissue origin and a metastasis. A biopsy was taken and the pathological examination confirmed the diagnosis of an OSCC metastasis. The postoperative interdisciplinary tumor board recommended radiation therapy.Due to the fact that patients with regional lymph node metastases have a higher probability to develop distant metastasis a more detailed screening might be considered - especially when hemangiosis carcinomatosa was histologically or macroscopically found.},
author = {Wurm, Matthias and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Moest, Tobias and Lutz, Rainer and Wehrhan, Falk and Brunner, Kathrin and Mitsimponas, Konstantinos and Schlechtweg, Philipp and von Wilmowsky, Cornelius},
doi = {10.1186/s12903-015-0007-9},
faupublication = {yes},
journal = {BMC Oral Health},
note = {EVALuna2:6693},
pages = {22},
peerreviewed = {unknown},
title = {{Case} report: upper arm metastasis of an oral squamous cell carcinoma},
volume = {15},
year = {2015}
}
@article{faucris.268931161,
abstract = {Objectives: Magnetic resonance imaging (MRI) enables a 3D-volume-imaging without ionizing radiation. Therefore, it was the aim of this study to present a post-processing-free method for cephalometric analysis of a MRI-dataset and to examine whether there is a significant difference between cephalometric analysis of conventional 2D cephalograms and MRI scans.},
author = {März, Karoline and Chepura, Taras and Plewig, Blanka and Haddad, Daniel and Weber, Daniel and Schmid, Matthias and Hirschfelder, Ursula and Gölz, Lina},
doi = {10.1093/ejo/cjaa066},
faupublication = {yes},
journal = {European Journal of Orthodontics},
note = {CRIS-Team WoS Importer:2022-02-04},
pages = {614-621},
peerreviewed = {Yes},
title = {{Cephalometry} without complex dedicated postprocessing in an oriented magnetic resonance imaging dataset: a pilot study},
volume = {43},
year = {2021}
}
@article{faucris.111081124,
abstract = {Chronic recurrent multifocal osteomyelitis (CRMO) is a rare acquired inflammatory skeletal disorder of unknown origin. CRMO was first described by Gideon in 1972 and mainly affects children and young adults of female gender. The CRMO is part of the clinical picture of non-bacterial Osteomyelitis (NBO) and typically presents a relapsing recurring course with both remission and spontaneous exacerbation. CRMO is typically encountered in the limbs and the metaphysis of long bones in particular. Usually the clinical symptoms include painful swellings of the affected regions. This case report describes the rare case of a CRMO of the mandible in association with pyoderma gangraenosum.A 14-year old female caucasian patient, residing in the south of Germany, presented in the oncological outpatient clinic of our Department of Paediatrics and Adolescent Medicine in June 2014 complaining of increasing neck pain and progressive swelling at her left cheek ongoing for about 6 weeks. These symptoms had been occurring quarterly for 4 years, but had never been as pronounced. Blood biochemistry showed a moderately elevated CRP (35 mg/l) and a significantly increased blood sedimentation rate (BSR 48/120 mm). The panoramic radiograph, however, revealed a bone alteration in the left mandibular region. Further investigations confirmed the diagnosis of CRMO.The present case underlines the fact that rare diseases might occasionally present with even more rare symptoms. These occasions can obviously be considered to present a considerable diagnostic challenge.},
author = {Wurm, Matthias and Brecht, Ines and Lell, Michael and Brunner, Kathrin and Mitsimponas, Konstantinos Theodorou and Chada, Martin and Jahn, Julia and Neukam, Friedrich Wilhelm and von Wilmowsky, Cornelius},
doi = {10.1186/s12903-016-0275-z},
faupublication = {yes},
journal = {BMC Oral Health},
note = {EVALuna2:14591},
pages = {85},
peerreviewed = {Yes},
title = {{Chronic} recurrent multifocal osteomyelitis in association with pyoderma gangraenosum},
volume = {16},
year = {2016}
}
@article{faucris.217155649,
abstract = {Purpose: Vestibuloplasty is a frequently performed surgical procedure to create or increase soft tissue mucosal sealing around dental restorations. Collagen matrices have exhibited comparable clinical results as free gingival grafts in the context of intraoral tissue augmentation. However, the process of matrix vascularization, the basic requirement for local healing, is incompletely understood. Therefore, this study investigated collagen matrix perfusion in a clinical intraoral setting. Materials and Methods: In a prospective cohort study, vestibuloplasty was performed during implant exposure using prefabricated collagen matrices. Matric perfusion was determined intraoperatively and at days 2, 5, 7, 14, 30, and 90 using a laser Doppler spectrophotometer measuring oxygen saturation, relative amount of hemoglobin, blood flow, and blood velocity as primary outcome variables. These parameters were compared with perfusion of the oral mucosa surrounding the matrices. Statistical analysis was performed by applying variance and regression models. Results: In 10 patients (average age, 60.9 yr), vestibuloplasty was performed exclusively in the anterior mandible. Blood flow and tissue oxygen saturation in the augmented zones markedly increased until postoperative day 5 and approximated perfusion values of the adjacent mucosa at the following 2 time points. Likewise, matrix oxygen saturation markedly increased until day 7 and subsequently converged to perfusion parameters of the surrounding mucosa at the following time points. Conclusion: Flow signals in incorporated collagen matrices occurred on day 2 after vestibuloplasty and further increased until days 5 to 7. Therefore, matrix perfusion mainly occurs within the first postoperative week, converging to perfusion levels of the surrounding mucosa with minimal alterations during the following course.},
author = {Preidl, Raimund and Wehrhan, Falk and Weber, Manuel and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Schmitt, Christian},
doi = {10.1016/j.joms.2019.03.010},
faupublication = {yes},
journal = {Journal of Oral and Maxillofacial Surgery},
note = {CRIS-Team Scopus Importer:2019-05-09},
peerreviewed = {Yes},
title = {{Collagen} {Matrix} {Vascularization} in a {Peri}-{Implant} {Vestibuloplasty} {Situation} {Proceeds} {Within} the {First} {Postoperative} {Week}},
year = {2019}
}
@inproceedings{faucris.286631080,
address = {BASEL},
author = {Lutz, Rainer and Büntemeyer, Tjark-Ole and Olmos, Manuel and Glajzer, Jacek and Ries, Jutta and Kesting, Marco Rainer and Weber, Manuel},
booktitle = {ONCOLOGY RESEARCH AND TREATMENT},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2022-12-16},
pages = {132-132},
peerreviewed = {unknown},
publisher = {KARGER},
title = {{Combining} surgery and immunotherapy in the treatment of head and neck cancer - from neoadjuvant immunotherapy to salvage surgery},
year = {2022}
}
@article{faucris.111984224,
abstract = {Advanced Cardiovascular Life Support (ACLS) in life-threatening situations is perceived as a basic skill for dental professionals. However, medical emergency training in dental schools is often not standardized. The dental students' knowledge transfer to an ACLS setting thus remains questionable. The aim of the study was to evaluate dental pre-doctorate students' practical competence in ACLS in a standardized manner to enable the curriculum to be adapted to meet their particular needs.Thirty dental students (age 25.47 ± 1.81; 16 male/14 female) in their last year of dental studies were randomly assigned to 15 teams. Students' ability to successfully manage ACLS was assessed by a scenario-based approach (training module: Laerdal® ALS Skillmaster). Competence was assessed by means of (a) an observation chart, (b) video analysis and (c) training module analysis (Laerdal HeartSim®4000; Version 1.4). The evaluation was conducted by a trained anesthesiologist with regard to the 2010 guidelines of the European Resuscitation Council (ERC).Only five teams (33.3%) checked for all three vital functions (response, breathing and circulation). All teams initiated cardiopulmonary resuscitation (CPR). Only 54.12% of the compressions performed during CPR were sufficient. Four teams stopped the CPR after initiation. In total, 93% of the teams used the equipment for bag-valve-mask ventilation and 53.3% used the AED (Automated external defibrillator).ACLS training on a regular basis is necessary and, consistent with a close link between dentistry and medicine, should be a standardized part of the medical emergency curriculum for dental students with a specific focus on the deficiencies revealed in this study.},
author = {Breuer, Georg and Knipfer, Christian and Huber, Tobias and Hüttl, Stephan and Shams, Nima and Knipfer, Kristin and Neukam, Friedrich Wilhelm and Schüttler, Jürgen and Stelzle, Florian},
doi = {10.3109/00016357.2015.1042782},
faupublication = {yes},
journal = {Acta Odontologica Scandinavica},
note = {EVALuna2:16677},
pages = {241-9},
peerreviewed = {Yes},
title = {{Competency} in managing cardiac arrest: {A} scenario-based evaluation of dental students},
volume = {74},
year = {2016}
}
@article{faucris.124222824,
abstract = {This report describes a complex, surgical, and prosthodontic hemimaxillary rehabilitation with a prefabricated vascularized free fibula graft. The treatment was based on 3-dimensional skull and fibula models but avoided software-based virtual planning of the reconstructive procedure or the implant positions. Cast-based surgical guides were used for implant placement during prefabrication of the fibula graft and for the positioning of the prefabricated graft in the maxilla during the reconstructive procedure. This procedure allowed the definitive prosthesis to be attached to the implants of the reconstructed maxilla during the inpatient period.},
author = {Nkenke, Emeka and Eitner, Stephan},
doi = {10.1016/j.prosdent.2013.07.028},
faupublication = {yes},
journal = {Journal of Prosthetic Dentistry},
note = {EVALuna2:24363},
pages = {521-4},
peerreviewed = {Yes},
title = {{Complex} hemimaxillary rehabilitation with a prefabricated fibula flap and cast-based vacuum-formed surgical template},
volume = {111},
year = {2014}
}
@article{faucris.211605673,
abstract = {The posterior segment of the edentulous region represents an anatomical peculiarity when planning for the restoration of missing teeth with dental implants. Alveolar atrophy and pneumatization of the maxillary sinus often preclude the insertion of implants at standard lengths (> 8 mm). In cases of advanced atrophy and a residual bone height of less than 4 mm, it may also be impossible to place short implants (4 to 6 mm). In such cases, augmentation of the maxillary sinus (sinus elevation) is a predictable procedure to generate sufficient bone height for the insertion of dental implants. Depending on the residual bone height of the alveolar ridge, the anatomical conditions, and the planned restorative protocol, sinus elevation can be performed simultaneously with implant insertion (single-stage approach) or prior to implant insertion (two-stage approach). The main techniques for increasing the vertical bone height of the posterior maxilla are the transalveolar (internal) and lateral (external) sinus augmentation procedures. Both techniques have a high success rate. However, complications can arise during or after sinus elevation, and practitioners must be aware of how to address them. This article summarizes the most common complications in external sinus floor augmentation and discusses their prevention and management.},
author = {Schlegel, Karl Andreas and Hoehmann, Benedikt and Schmitt, Christian},
faupublication = {yes},
journal = {Implantologie},
note = {EVALuna2:35695},
pages = {39-48},
peerreviewed = {Yes},
title = {{Complications} in external sinus floor augmentation: {A} literature overview},
volume = {26},
year = {2018}
}
@article{faucris.263536893,
abstract = {Introduction: Up to the second half of the twentieth century, pedicled flaps marked the gold standard in reconstructive surgery. Followed by the introduction of microsurgical techniques, these flaps were increasingly abandoned. We conducted a retrospective study to determine the value of two-stage pedicle flaps in modern maxillofacial reconstruction. Material & Methods: A chart review from October 2017 to November 2020 was performed to identify patients who were treated by a two-stage pedicle flap in our Department of Oral and Maxillofacial Surgery. Results: A total of 31 patients, 17 female and 14 males received 36 two-stage pedicle flaps. All patients were in noticeably impaired health condition with a majority of ASA-score 3. The defect location mainly contained extraoral resections (58.3%). A variety of flaps were harvested consisting of buccal flaps, Abbe flaps, forehead flaps, deltopectoral flaps, nasolabial flaps, and a tubed flap. Discussion: The study outlines two indications for the use of two-stage pedicle flaps. Firstly, as a back-up strategy in heavily pre-treated wound beds and secondly in an almost contrarily indication as a first-choice reconstructive option of the facial skin in esthetic demanding cases. Conclusion: The timesaving and straight forward surgical approach as well as their low postsurgical complications and strong long-time success rates secure the two-stage pedicle flap a justified niche role in times of microsurgical maxillofacial reconstruction.},
author = {Frohwitter, Gesche and Lutz, Rainer and Baran, Christoph and Weber, Margarete and Nobis, Christopher-Philipp and Rau, A. and Kesting, Marco Rainer},
doi = {10.1007/s12663-021-01635-9},
faupublication = {yes},
journal = {Journal of Maxillofacial and Oral Surgery},
keywords = {Back-up procedures; Pedicle flaps; Reconstructive surgery; Transplant autonomy},
note = {CRIS-Team Scopus Importer:2021-09-03},
peerreviewed = {unknown},
title = {{Consistent} {Value} of {Two}-{Stage} {Pedicle} {Flaps} in the {Age} of {Microsurgical} {Maxillofacial} {Reconstruction}},
year = {2021}
}
@article{faucris.122041084,
abstract = {Postoperative pain management is important for improved patient care. Our primary objective was to investigate the effect of analgesic treatment adaptation by the pain clinic on postoperative pain relief at an oral and maxillofacial surgery department. Additionally, we aimed to present patients' pain characteristics and the administered analgesic treatment.A total of 128 patients treated at our clinic in the period 2012-2015 who required analgesic treatment adaptation by our pain clinic were included. They were further divided into 10 groups: tumor, temporomandibular joint disorder, tooth extraction, osteomyelitis, bisphosphonate-related osteonecrosis of the jaw, submandibular abscess, orthognathic surgery, cyst, sinusitis, and fracture. Pain characteristics evaluated were intensity on a numerical rating scale (NRS) before and after intervention of the pain clinic, quality, genesis, and type.Post treatment pain intensity values at rest 1.8 (SD: 1.4) and on exercise (walking and physical therapy) 4 (SD: 2) were statistically significant better compared to pretreatment values (4.2, SD: 2.5, and 6.8 SD: 2, respectively). The highest pain intensities were reported after tooth extractions, orthognathic surgery, cystectomies, and fracture reposition. Pain was mainly continuous and related to a combination of a somatic and a neuropathic pathophysiological mechanism.Intervention by a specialized pain clinic leads to reduction of postoperative pain.},
author = {Dietrich, Eva-Maria and Grießinger, Norbert and Neukam, Friedrich Wilhelm and Schlittenbauer, Tilo},
doi = {10.1016/j.jcms.2016.12.009},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:16744},
peerreviewed = {Yes},
title = {{Consultation} with a specialized pain clinic reduces pain after oral and maxillofacial surgery},
year = {2016}
}
@article{faucris.216818241,
abstract = {The following note was inadvertently omitted from the published paper: This work was performed in (partial) fulfillment of the requirements for the first author’s obtaining the degree Dr. med. dent.},
author = {Kerker, Florian and Adler, Werner and Brunner, Kathrin and Möst, Tobias and Wurm, Matthias and Nkenke, Emeka and Neukam, Friedrich Wilhelm and von Wilmowsky, Cornelius},
doi = {10.1007/s00784-018-2781-7},
faupublication = {yes},
journal = {Clinical Oral Investigations},
month = {Jan},
note = {CRIS-Team Scopus Importer:2019-05-02},
pages = {509-},
peerreviewed = {Yes},
title = {{Correction} to: {Anatomical} locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin—a retrospective study ({Clinical} {Oral} {Investigations}, (2018), 22, 4, (1625-1630), 10.1007/s00784-018-2424-z)},
volume = {23},
year = {2019}
}
@article{faucris.232030305,
abstract = {The original version of this article unfortunately contained a mistake. The correct version of the Acknowledgements is given below: Acknowledgements This study was supported by the ELAN-Fond (University of Erlangen-Nürnberg). The authors thank Carsten Kronauer and Florian Obstmeier for conducting the immunohistochemical staining and detecting the expression of mediators.},
author = {Preidl, Raimund and Möbius, Patrick and Weber, Manuel and Amann, Kerstin Ute and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Geppert, Carol-Immanuel and Wehrhan, Falk},
doi = {10.1007/s00066-019-01564-0},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
note = {CRIS-Team Scopus Importer:2020-01-21},
peerreviewed = {Yes},
title = {{Correction} to: {Long}-term endothelial dysfunction in irradiated vessels: an immunohistochemical analysis ({Strahlentherapie} und {Onkologie}, (2019), 195, 1, (52-61), 10.1007/s00066-018-1382-3)},
year = {2020}
}
@article{faucris.212319852,
abstract = {Introduction: Magnetic resonance imaging has been established as the gold standard for assessment of the temporomandibular joint. Apart from an excellent assessment of the soft tissues it has the advantage not to expose the patient to ionizing radiation. There is a lack of literature concerning the correlation between pain intensity and radiological findings of the temporomandibular joint. Moreover there is the question of whether a progressive degeneration of the cartilaginous components is accompanied by an increasing degeneration of the osseous parts of the mandibular joint and vice versa. Therefore, this study aims at analyzing correlations between pain and radiological findings. Furthermore, the link between osseous and cartilaginous degeneration is studied.
Materials and methods: 91 patients who attend our outpatient clinic for temporomandibular disorders are included in this prospective study. Apart from a detailed anamnesis and clinical examination - adapted to the Research Diagnostic Criteria for Temporomandibular Disorders -magnetic resonance imaging of both mandibular joints is performed. Pain intensity is measured using the visual analog scale. To assess and grade the radiological findings a classification system is established. The evaluation of the osseous components is based on the classification of osteoarthritis by Kellgren and Lawrence whereas the rating of the cartilaginous components is adapted to the Research Diagnostic Criteria for Temporomandibular Disorders. Correlations are verified by Spearman-Rho.
Results: 83,5% of all patients are female. Most of the time, both sides are affected (47.25%). Women state an average pain of 5.7 (+/- 2.4), men 3.5 (+/- 2.5). 182 discs are examined and assessed with our classification system. Most discs (n = 71) show no pathological changes. The majority of patients show no dislocation (n = 104). The most common forms of dislocation are anterior dislocations (n = 51). The majority of patients show no changes in the osseous component (n = 115). Weak to moderate correlations are found between disc and bone degeneration. Moderate to strong correlations are found between left and right TMJ.
Conclusions: The classification system which is designed and applied during the study proves to be a reliable and practical Instrument. A standardized evaluation of pathologies concerning the temporomandibular joint is possible by using this system. Numerous patients attending our outpatient clinic do not show any signs of degenerative dysfunctions in the mandibular joints. Degenerations of the osseous components tend to be connected with degenerations of the cartilaginous components and vice versa. The question remains if in the future new procedures in imaging will be able to record pathologies not yet detected. (c) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.},
author = {Wurm, Matthias and Behrends, Tessa and Wüst, Wolfgang and Wiesmüller, Marco and Wilkerling, André and Neukam, Friedrich Wilhelm and Schlittenbauer, Tilo},
doi = {10.1016/j.jcms.2017.12.029},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:35087},
pages = {1167-1171},
peerreviewed = {Yes},
title = {{Correlation} between pain and {MRI} findings in {TMD} patients},
volume = {46},
year = {2018}
}
@article{faucris.119839324,
author = {Moest, Tobias and Wrede, Jan and Schmitt, Christian and Stamp, Melanie and Neukam, Friedrich Wilhelm and Schlegel, Andreas},
doi = {10.1016/j.jcms.2017.09.009},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24445},
pages = {2135},
peerreviewed = {No},
title = {{Corrigendum} to "{The} influence of different abutment materials on tissue regeneration after surgical treatment of peri-implantitis - {A} randomized controlled preclinical study" [{J} {Cranio}-{Maxillo}-{Facial} {Surg} 45 (2017) 1190-1196]},
volume = {45},
year = {2017}
}
@article{faucris.280323305,
abstract = {BACKGROUND: Due to the SARS-CoV-2 pandemic and the accompanying contact restrictions, a new challenge arose for dental education. Despite the limited overall situation, it must be ensured that, in addition to theoretical content, practical skills in particular continue to be taught. Therefore, the aim of this study was to develop and implement an online hands-on course for dental students that ensures practical training, even during the pandemic. METHODS: The newly developed course was held from April 2020 to March 2021. A total of six groups (each consisting of approximately 40-50 students) took part in the course. The participating students were in their 3rd, 4th or 5th year of study. The course taught theoretical basics (via an online platform) and promoted the learning of practical/surgical techniques on models such as bananas, pork bellies, or chicken thighs with live demonstrations (via ZOOM) and interactive post-preparation by students at home (and in a rotating small group of 3-7 students on site). Student self-evaluation (at the beginning and end of the course) and course evaluation were performed using questionnaires. The learning success was analyzed (through self-evaluations) using Wilcoxon signed-rank tests (significance level alpha = 0.05). RESULTS: Concerning students´ self-evaluations, the theoretical knowledge, general surgical skills (such as surgical instrument handling), and specific surgical skills (such as performing a kite flap) improved during the course, with significant results (p < 0.001 for each). About 60% of the students rated the course overall as excellent (grades 9 or 10 on a Likert scale of 1 to 10). The technical implementation of the course was rated with a median of 9 (= very good, on a Likert scale of 1 to 10). 38.5% described the applicability of the skills learned for their later professional life as extremely good. CONCLUSIONS: The results of this work suggest that, within the limitations of this study, the introduced concept of an online hands-on course could be an appropriate form of teaching practical dental skills, even during a pandemic. Further research is needed in the field of digital education for dental students.},
author = {Oetter, Nicolai and Möst, Tobias and Weber, Manuel and Buchbender, Mayte and Rohde, Maximilian and Foerster, Yannick and Bauerschmitz, Charlotte and Röschmann, Nico and Adler, Werner and Rau, Andrea and Meyerolbersleben, Marion and Kesting, Marco Rainer and Lutz, Rainer},
doi = {10.1186/s12909-022-03638-7},
faupublication = {yes},
journal = {BMC Medical Education},
keywords = {Asynchronous; Coronavirus; Dentistry; Digital; Education; Pandemic; Synchronous},
note = {Created from Fastlane, Scopus look-up},
pages = {591-},
peerreviewed = {Yes},
title = {{COVID}-19 pandemic and its impact on dental education: digitalization - progress or regress? {Example} of an online hands-on course},
volume = {22},
year = {2022}
}
@article{faucris.240536940,
abstract = {Background: Craniofacial osteosarcomas (COS) and extracranial osteosarcomas (EOS) show distinct clinical differences. COS show a remarkably lower incidence of metastases and a better survival. However, in contrast to EOS, they show a poor response to neoadjuvant chemotherapy. Tumor-associated macrophages and their polarization as well as developmental biological signaling pathways are possible candidates for explaining the clinical differences between COS and EOS. The aim of the study was to analyze differential expression of macrophage markers and important regulators of these pathways. Methods: Twenty osteosarcoma cases (10 COS and 10 EOS) were immunohistochemically stained to assess CD68, CD11c, CD163, MRC1, Gli1, and Gli2 expression. Statistical differences between COS and EOS were tested using the Mann–Whitney U test. Additionally, the paper describes an example of multidisciplinary treatment of a patient suffering from COS and discusses the surgical challenges in treatment and rehabilitation of COS. Results: COS showed a significantly (p < 0.05) increased infiltration of CD11c-positive M1 macrophages and a shift toward M1 polarization compared to EOS. Additionally, COS revealed a significantly (p < 0.05) lower Gli1 expression than EOS. Conclusion: The reduced Gli1 expression in COS can be interpreted as reduced activation of the Hedgehog (Hh) signaling pathway. The increased M1 polarization and reduced Hh activation in COS could explain the low incidence of metastases in these osteosarcomas.},
author = {Weber, Manuel and Söder, Stephan and Sander, Janina and Ries, Jutta and Geppert, Carol-Immanuel and Kesting, Marco Rainer and Wehrhan, Falk},
doi = {10.3389/fonc.2020.00745},
faupublication = {yes},
journal = {Frontiers in Oncology},
keywords = {craniofacial osteosarcoma; Gli1; hedgehog; M1; M2; macrophage polarization; osteosarcoma of the jaw},
note = {CRIS-Team Scopus Importer:2020-07-17},
peerreviewed = {Yes},
title = {{Craniofacial} {Osteosarcoma}—{Pilot} {Study} on the {Expression} of {Osteobiologic} {Characteristics} and {Hypothesis} on {Metastasis}},
volume = {10},
year = {2020}
}
@article{faucris.205560106,
abstract = {OBJECTIVES: The importance of excellent oral health is known to be crucial in children with congenital heart diseases (CHD). Data about dental health and disease awareness is limited. This study aims to assess preventive measures taken to improve dental health in children with CHD and to gain insight into disease awareness and knowledge about the importance of oral health in children with CHD and to propose measures that could be taken.
MATERIAL AND METHODS: Parents of 150 children with CHD were asked to complete a questionnaire containing specific questions about the preventive measures taken by the parents and dental and medical practitioners and their knowledge about underlying disease and the importance of oral health.
RESULTS: Our results show an absence of information in parents concerning preventive measures and oral hygiene. Knowledge of the indications for antibiotic prophylaxis and for actually given medications was lacking. Preventive dental measures were not performed according to current guidelines.
CONCLUSIONS: Knowledge of parents about the importance of oral health in children with CHD could be improved. However, specialized centers involving pediatric cardiologists and pediatric dentists could coordinate the education of parents at an early stage. Moreover, general dentists should be trained more frequently concerning the indications for antibiotic prophylaxis, in particular, and the dental care of children with chronic diseases, in general. Warning cards such as the heart pass should be issued to parents of children with CHD.
CLINICAL RELEVANCE: The current study reveals the need for the structured training of medical and dental practitioners to support parents of children with CHD.},
author = {Koerdt, Steffen and Hartz, Julia and Hollatz, Stefan and Frohwitter, Gesche and Kesting, Marco Rainer and Ewert, Peter and Oberhoffer, Renate and Deppe, Herbert},
doi = {10.1007/s00784-017-2256-2},
faupublication = {yes},
journal = {Clinical Oral Investigations},
note = {EVALuna2:33957},
pages = {1487-1493},
peerreviewed = {Yes},
title = {{Dental} prevention and disease awareness in children with congenital heart disease},
volume = {22},
year = {2018}
}
@article{faucris.106330224,
abstract = {Confocal laser endomicroscopy (CLE) is an optical biopsy method allowing in vivo microscopic imaging at 1000-fold magnification. It was the aim to evaluate CLE in the human oral cavity for the differentiation of physiological/carcinomatous mucosa and to establish and validate, for the first time, a scoring system to facilitate CLE assessment.The study consisted of 4 phases: (1) CLE-imaging (in vivo) was performed after the intravenous injection of fluorescein in patients with histologically confirmed carcinomatous oral mucosa; (2) CLE-experts (n = 3) verified the applicability of CLE in the oral cavity for the differentiation between physiological and cancerous tissue compared to the gold standard of histopathological assessment; (3) based on specific patterns of tissue changes, CLE-experts (n = 3) developed a classification and scoring system (DOC-Score) to simplify the diagnosis of oral squamous cell carcinomas; (4) validation of the newly developed DOC-Score by non-CLE-experts (n = 3); final statistical evaluation of their classification performance (comparison to the results of CLE-experts and the histopathological analyses).Experts acquired and edited 45 sequences (260 s) of physiological and 50 sequences (518 s) of carcinomatous mucosa (total: 95 sequences/778 s). All sequences were evaluated independently by experts and non-experts (based on the newly proposed classification system). Sensitivity (0.953) and specificity (0.889) of the diagnoses by experts as well as sensitivity (0.973) and specificity (0.881) of the non-expert ratings correlated well with the results of the present gold standard of tissue histopathology. Experts had a positive predictive value (PPV) of 0.905 and a negative predictive value (NPV) of 0.945. Non-experts reached a PPV of 0.901 and a NPV of 0.967 with the help of the DOC-Score. Inter-rater reliability (Fleiss` kappa) was 0.73 for experts and 0.814 for non-experts. The intra-rater reliability (Cronbach's alpha) of the experts was 0.989 and 0.884 for non-experts.CLE is a suitable and valid method for experts to diagnose oral cancer. Using the DOC-Score system, an accurate chair-side diagnosis of oral cancer is feasible with comparable results to the gold standard of histopathology-even in daily clinical practice for non-experienced raters.},
author = {Oetter, Nicolai and Knipfer, Christian and Rohde, Maximilian and von Wilmowsky, Cornelius and Maier, Andreas and Brunner, Kathrin and Adler, Werner and Neukam, Friedrich Wilhelm and Neumann, Helmut and Stelzle, Florian},
doi = {10.1186/s12967-016-0919-4},
faupublication = {yes},
journal = {Journal of Translational Medicine},
note = {EVALuna2:2055},
pages = {159},
peerreviewed = {Yes},
title = {{Development} and validation of a classification and scoring system for the diagnosis of oral squamous cell carcinomas through confocal laser endomicroscopy},
volume = {14},
year = {2016}
}
@article{faucris.212319619,
abstract = {Introduction: The authors developed a semi-standardised resection and cutting guide for mandibular reconstruction with free fibula flap based on data of mandible sizes and angles.
Methods: After analyzing the angles and lengths of mandibular angles and segments on computer tomography, a partly-adjustable resection guide for the mandible and cutting guide for the fibula were designed.
Results: After testing and optimizing the guides on plastic models and cadavers, the guides were successfully used for mandible resection and reconstruction with free fibula flap in 8 patients with segmental mandibulectomy. Application of the cutting and resection guides and functional results like occlusion and aesthetic appearence were satisfactory in all cases.
Conclusions: The developed semi-standardised device is a helpful instrument for facilitating reconstruction of segmental mandibular defects with free fibula flaps. No extensive preoperative preparation and 3D printing is necessary which can avoid additional costs for virtual planning. Especially for lower budget health systems this can be an alternative to virtual planning. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.},
author = {Weitz, Jochen and Wolff, Klaus-Dietrich and Kesting, Marco Rainer and Nobis, Christopher-Philipp},
doi = {10.1016/j.jcms.2018.09.007},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:35080},
pages = {1975-1978},
peerreviewed = {Yes},
title = {{Development} of a novel resection and cutting guide for mandibular reconstruction using free fibula flap},
volume = {46},
year = {2018}
}
@article{faucris.232332191,
abstract = {Objectives: Mandibular reconstruction after segmental mandibulectomy can be challenging without virtual surgical planning and osteotomy guides. The purpose of this study was to analyze anatomic parameters to facilitate the evaluation of ideal fibula wedge osteotomies to reconstruct the neomandibula in a simple and cost-effective manner without the need for preoperative virtual planning. Materials and methods: Computed tomography scans were acquired from randomly selected patients, and all images were obtained from routine clinical diagnostics, e.g., tumor staging, or preoperatively before reconstruction. Data was used to calculate stereolithographic models of the mandible for length and angle measurements. Statistical analysis was performed (p < 0.05). Results: CT scans of 100 patients were analyzed: 39 were female and 61 were male patients, mean age was 59.08a. The mandibular arch angle proved to be constant with 241.07 ± 2.39°. The outside B-segment length was 80.05 ± 5.16 mm; the anterior S-segment length was 27.69 ± 3.16 mm. The angle of the mandibular arch showed differences in means (p = 0.004) between age groups, but effect was proved low. No relevant statistical significances were detected. Conclusions: The development of a mandible reconstruction template tool would benefit the majority of head and neck patients, which is due to a constant mandibular arch angle and symphysis segment length throughout the general patient population, allowing the mimicking of a harmonic mandibular arch with up to three fibula segments. Clinical relevance: The developed mandible reconstruction template tool can facilitate the fibula wedge osteotomies necessary for reconstruction of an ideal neomandibula providing a novel approach which is simple and cost-effective.},
author = {Nobis, Christopher Philipp and Kesting, Marco Rainer and Wolff, Klaus Dietrich and Frohwitter, Gesche and Rau, Andrea and Weitz, Jochen},
doi = {10.1007/s00784-019-03177-4},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Digital morphology analysis; Fibula osteotomy; Head and neck anatomy; Mandible reconstruction; Microvascular fibula transplant; Reconstructive surgery},
note = {CRIS-Team Scopus Importer:2020-01-24},
peerreviewed = {Yes},
title = {{Development} of a template tool for facilitating fibula osteotomy in reconstruction of mandibular defects by digital analysis of the human mandible},
year = {2020}
}
@article{faucris.211603872,
abstract = {This review provides an overview of review and consensus articles of the past 5 years regarding surgical complications in implant dentistry. The focus in this article is on surgical complications occurring after implant insertion and on risk factors that compromise oral implant osseointegration.
},
author = {Lutz, Rainer and Schmitt, Christian and Buchbender, Mayte and Neukam, Friedrich Wilhelm},
faupublication = {yes},
journal = {European Journal of Oral Implantology},
note = {EVALuna2:35697},
pages = {S21-S25},
peerreviewed = {Yes},
title = {{Diagnosis}, avoidance and management of complications of implant-based treatments},
volume = {11 Suppl 1},
year = {2018}
}
@article{faucris.313475429,
abstract = {Objective: Accurate preoperative prediction of lymph node (LN) status plays a pivotal role in determining the extension of neck dissection (ND) required for patients with oral squamous cell carcinoma (OSCC). This study aims to evaluate the diagnostic accuracy of contrast-enhanced computed tomography (CT) in detecting LN metastases (LNMs) and to explore clinicopathological factors associated with its reliability. Methods: Data from 239 patients with primary OSCC who underwent preoperative CT and subsequent radical surgery involving ND were retrospectively reviewed. Suspicious LNs were categorized into three groups: accentuated (< 10 mm), enlarged (≥ 10 mm), and melted. Statistical analysis encompassing correlation and comparative analysis, and determination of sensitivity, specificity, PPV, and NPV were performed. Results: Overall, sensitivity was significantly higher in the accentuated LNs group (83.54%) compared to the melted LNs group (39.24%, p < 0.05, t test). Conversely, specificity was significantly higher in the melted LNs group (98.19%) compared to the accentuated LNs group (55.15%, p < 0.05, t test). Accentuated LNs exhibited a false negative rate of 13.00%. False positive rates were 51.80%, 30.26% and 8.82%, respectively. Diagnostic accuracy for detecting LNMs in level IIa and IIb exceeded that of level III. Patients with solely accentuated LNs were more likely to have a small, well-differentiated tumor. However, no distinctions emerged in terms of the occurrence of T4 tumors among the three groups. Conclusion: CT proves sufficient to predict LNMs in patients with OSCC. Looking ahead, the potential integration of artificial intelligence and deep learning holds promise to further enhance the reliability of CT in LNMs detection. However, this prospect necessitates further investigation.},
author = {Struckmeier, Ann-Kristin and Yekta, Ebrahim and Agaimy, Abbas and Kopp, Markus and Buchbender, Mayte and Möst, Tobias and Lutz, Rainer and Kesting, Marco Rainer},
doi = {10.1007/s00432-023-05470-y},
faupublication = {yes},
journal = {Journal of Cancer Research and Clinical Oncology},
keywords = {Computed tomography; Diagnostic accuracy; Lymph node metastasis; Oral squamous cell carcinoma},
note = {CRIS-Team Scopus Importer:2023-11-03},
peerreviewed = {Yes},
title = {{Diagnostic} accuracy of contrast-enhanced computed tomography in assessing cervical lymph node status in patients with oral squamous cell carcinoma},
year = {2023}
}
@article{faucris.262179888,
abstract = {DICER1, a member of the ribonuclease III family, is involved in the biogenesis of microRNAs and, hence, it influences gene expression regulation. DICER1 germline (associated with the inherited DICER1 syndrome) or somatic mutations have been linked to tumorigenesis in histogenetically diverse benign and malignant neoplasms in different organs including pleuropulmonary blastoma, cystic nephroma, embryonal rhabdomyosarcoma, nasal chondromesenchymal hamartoma, poorly differentiated thyroid carcinoma, thyroblastoma, intracranial sarcoma and gonadal Sertoli-Leydig cell tumors in addition to others. Moreover, rare botryoid (giant) fibroepithelial polyps may harbor this mutation. Herein, we describe the first reported case of a DICER1-mutated botryoid fibroepithelial polyp occurring within the parotid duct of a 65-year-old female who has no other features or family history of the DICER1 syndrome. Based on its distinctive morphology, we tested this lesion specifically for DICER1 mutations and confirmed the presence of a pathogenic DICER1 variant with a low allele frequency, consistent with a somatic mutation.},
author = {Erber, Ramona and Preidl, Raimund and Stöhr, Robert and Haller, Florian and Hartmann, Arndt and Kesting, Marco Rainer and Agaimy, Abbas},
doi = {10.1007/s12105-021-01364-y},
faupublication = {yes},
journal = {Head and Neck Pathology},
note = {CRIS-Team WoS Importer:2021-07-30},
peerreviewed = {Yes},
title = {{DICER1}-{Mutated} {Botryoid} {Fibroepithelial} {Polyp} of the {Parotid} {Duct}: {Report} of the {First} {Case}},
year = {2021}
}
@article{faucris.227166391,
abstract = {Introduction: Dental cysts can be of inflammatory (radicular cysts) or noninflammatory (dentigerous cysts) origin. Apical periodontitis is a necrosis of the pulp and infection of the root canal causing the development of apical granulomas or radicular cysts. The immunology of granuloma and cyst formation is important because modern root filling materials are immunologically active and can contribute to the resolution of apical granulomas. In contrast, radicular cysts often require apicectomy. A better understanding of the pathophysiology of inflammation and bone resorption in apical periodontitis could be the basis for developing new root filling materials with superior immunomodulatory properties. Methods: Forty-one apical granulomas, 23 radicular cysts, and 23 dentigerous cysts were analyzed in this study. A tissue microarray of the 87 consecutive specimens was created, and human leukocyte antigen–DR isotype (HLA-DR)-, CD83-, receptor activator of nuclear factor kappa B ligand–, macrophage colony-stimulating factor (MCSF)-, galectin-3 (Gal3)-, CD4-, and CD8-positive cells were detected by immunohistochemistry. Tissue microarrays were digitized, and the expression of markers was quantitatively assessed. Results: HLA-DR, CD83, MCSF, and Gal3 expression was significantly (P < .05) higher in radicular cysts compared with apical granulomas. HLA-DR, CD83, MCSF, receptor activator of nuclear factor kappa B ligand, and Gal3 expression in dentigerous cysts was significantly (P < .05) lower than in both periapical lesions (apical granulomas and radicular cysts). CD4 and CD8 infiltration was not statistically different between apical granulomas and radicular cysts. Dentigerous cysts showed a significantly (P < .05) lower T-cell infiltration than apical periodontitis. The CD4/CD8 ratio was not significantly different between the analyzed groups. Conclusions: The development of radicular cysts in apical periodontitis is associated with an increased expression of myeloid inflammatory markers and bone resorption parameters. Antigen-presenting cells and myeloid cells might be more relevant for the pathogenesis of apical periodontitis than T cells. Increased inflammation might promote the formation of radicular cysts and more pronounced bone resorption.},
author = {Weber, Manuel and Ries, Jutta and Büttner-Herold, Maike and Geppert, Carol-Immanuel and Kesting, Marco Rainer and Wehrhan, Falk},
doi = {10.1016/j.joen.2019.06.014},
faupublication = {yes},
journal = {Journal of Endodontics},
keywords = {Apical granuloma; apical periodontitis; bone resorption; follicular cyst; periapical lesion; radicular cysts},
note = {CRIS-Team Scopus Importer:2019-09-27},
pages = {1200-1208},
peerreviewed = {Yes},
title = {{Differences} in {Inflammation} and {Bone} {Resorption} between {Apical} {Granulomas}, {Radicular} {Cysts}, and {Dentigerous} {Cysts}},
volume = {45},
year = {2019}
}
@inproceedings{faucris.288032866,
abstract = {Objective: Laser surgery has many advantages. However, due to a lack of haptic feedback it is accompanied by the risk of iatrogenic nerve damage. The aim of this study was to evaluate the possibilities of optical nerve identification by diffuse reflectance spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Materials and Methods: Diffuse reflectance spectra of nerve tissue, skin, mucosa, fat tissue, muscle, cartilage and bone (15120 spectra) of ex vivo pig heads were acquired in the wavelength range of 350-650 nm. Tissue differentiation was performed by principal components analysis (PCA) followed by linear discriminant analysis (LDA). Specificity and sensitivity were calculated by receiver operating characteristic (ROC) analysis and the area under curve (AUC). Results: Nerve tissue could correctly be identified and differed from skin, mucosa, fat tissue, muscle, cartilage and bone in more than 90% of the cases (AUC results) with a specificity of over 78% and a sensitivity of more than 86%. Conclusion: Nerve tissue can be identified by diffuse reflectance spectroscopy with high precision and reliability. The results may set the base for a feedback system to prevent iatrogenic nerve damage performing oral and maxillofacial laser surgery. © 2010 Published by Elsevier B.V.},
author = {Stelzle, Florian and Zam, Azhar and Adler, Werner and Douplik, Alexandre and Tangermann-Gerk, Katja and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Schmidt, Michael},
booktitle = {Physics Procedia},
doi = {10.1016/j.phpro.2010.08.094},
faupublication = {yes},
keywords = {Laser surgery; Nerve preservation; Optical tissue differentiation; Oral and maxillofacial surgery; Remote surgical methods},
note = {Created from Fastlane, Scopus look-up},
pages = {647-654},
peerreviewed = {unknown},
publisher = {Elsevier B.V.},
title = {{Diffuse} reflectance spectroscopy for optical nerve identification - {Preliminary} ex vivo results for feedback controlled oral and maxillofacial laser surgery},
volume = {5},
year = {2010}
}
@article{faucris.241846712,
abstract = {Background and Objective: Laser surgery does not provide haptic feedback for operating layer-by-layer and thereby preserving vulnerable anatomical structures like nerve tissue or blood vessels. Diffuse reflectance spectra can facilitate remote optical tissue differentiation. It is the aim of the study to use this technique on soft tissue samples, to set a technological basis for a remote optical feedback system for tissue-specific laser surgery. Materials and Methods: Diffuse reflectance spectra (wavelength range: 350-650 nm) of ex vivo types of soft tissue (a total of 10,800 spectra) of the midfacial region of domestic pigs were remotely measured under reduced environmental light conditions and analyzed in order to differentiate between skin, mucosa, muscle, subcutaneous fat, and nerve tissue.Weperformed a principal components (PC) analysis (PCA) to reduce the number of variables. Linear discriminant analysis (LDA) was utilized for classification. For the tissue differentiation, we calculated the specificity and sensitivity by receiver operating characteristic (ROC) analysis and the area under curve (AUC). Results: Six PCs were found to be adequate for tissue differentiation with diffuse reflectance spectra using LDA. All of the types of soft tissue could be differentiated with high specificity and sensitivity. Only the tissue pairs nervous tissue/fatty tissue and nervous tissue/mucosa showed a decline of differentiation due to bio-structural similarity. However, both of these tissue pairs could still be differentiated with a specificity and sensitivity of more than 90%. Conclusions: Analyzing diffuse reflectance spectroscopy with PCA and LDA allows for remote differentiation of biological tissue. Considering the limitations of the ex vivo conditions, the obtained results are promising and set a basis for the further development of a feedback system for tissue-specific laser surgery. © 2010 Wiley-Liss, Inc.},
author = {Stelzle, Florian and Adler, Werner and Zam, Azhar and Schmidt, Michael and Douplik, Alexandre and Nkenke, Emeka and Tangermann-Gerk, Katja},
doi = {10.1002/lsm.20909},
faupublication = {yes},
journal = {Lasers in Surgery and Medicine},
keywords = {Diffuse reflectance; Optical tissue differentiation; Principal component analysis; Remote optical measurement; Remote surgical methods; Spectra analysis},
note = {Created from Fastlane, Scopus look-up},
pages = {319-325},
peerreviewed = {Yes},
title = {{Diffuse} reflectance spectroscopy for optical soft tissue differentiation as remote feedback control for tissue-specific laser surgery},
volume = {42},
year = {2010}
}
@article{faucris.242002865,
abstract = {Mucins as highly glycosylated proteins comprise multiple functions like protection, homeostasis, immune defense, cell signaling. Various epithelial tissues including glandular structures express different specific mucin types. We investigated labial salivary glands in infants for the occurrence of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC7 by immunohistochemistry. MUC1 and MUC4 were detected in serous and ductal glandular cells, partially intensified at the apical plasma membrane. MUC3 was found in ductal glandular cells and in myoepithelial cells. MUC5B exhibited a mosaic expression pattern in mucous glandular endpieces. MUC2 and MUC7 were abundant in serous acini. Glandular structures were negative for MUC5AC. A comprehensive study of specific mucins in labial salivary glands of infants was presented for the first time. As a representative of the minor salivary glands, labial glands are, due to their localization, directly exposed to environmental influences. The distribution of a broad spectrum of mucins in infantile labial glands indicates their importance early in human development to sustain oral health.},
author = {Stoeckelhuber, Mechthild and Kesting, Marco Rainer and Loeffelbein, Denys J. and Schmitz, Christoph and Wolff, Klaus-Dietrich},
doi = {10.14670/HH-18-213},
faupublication = {yes},
journal = {Histology and Histopathology},
note = {CRIS-Team WoS Importer:2020-08-28},
pages = {903-909},
peerreviewed = {Yes},
title = {{Diversity} of mucins in labial glands of infants},
volume = {35},
year = {2020}
}
@article{faucris.235412086,
abstract = {Aim: Evaluating radiotherapy treatment plans of the prospective DIREKHT trial (ClinicalTrials.gov, NCT02528955) investigating de-intensification of radiotherapy in patients with head and neck cancer. Patients and Methods: The first 30 patients from the DIREKHT trial of the leading study centre were included in this analysis. Standard treatment plans and study treatment plans derived from the protocol were calculated for each patient. Sizes of planning target volumes (PTVs) and mean doses to organs at risk were compared using the Student’s t-test with paired samples. Results: Mean PTV3 including primary tumor region and ipsilateral elective neck up to a dose of 50 Gy in the study treatment plans was 662 mL (+/− 165 mL standard deviation (SD)) and therefore significantly smaller than those of the standard treatment plans (1166 mL (+/− 266 mL SD). In the medial and inferior constrictor muscles, cricopharyngeal muscle, glottic and supraglottic laryngeal areas, arytenoid cartilages, contralateral major salivary glands highly significant dose reductions (p < 0.0001) of more than 10 Gy were achieved in study treatment plan compared to standard treatment plan. Conclusion: De-intensification of radiotherapy led to smaller planning target volumes and clinical relevant dose reductions in the swallowing apparatus and in the contralateral salivary glands.},
author = {Haderlein, Marlen and Speer, Stefan and Ott, Oliver and Lettmaier, Sebastian and Hecht, Markus and Semrau, Sabine and Frey, Benjamin and Scherl, Claudia and Iro, Heinrich and Kesting, Marco Rainer and Fietkau, Rainer},
doi = {10.3390/cancers12030538},
faupublication = {yes},
journal = {Cancers},
keywords = {De-intensification; Head neck cancer; Ipsilateral elective neck irradiation only; Postoperative; Radiotherapy; Salivary glands; Swallowing apparatus},
note = {CRIS-Team Scopus Importer:2020-03-06},
peerreviewed = {Yes},
title = {{Dose} reduction to the swallowing apparatus and the salivary glands by de-intensification of postoperative radiotherapy in patients with head and neck cancer: {First} (treatment planning) results of the prospective multicenter {DIREKHT} trial},
volume = {12},
year = {2020}
}
@inproceedings{faucris.286633316,
address = {BASEL},
author = {Weber, Manuel and Lutz, Rainer and Glajzer, Jacek and Werry, Jan-Erik and Baran, Christoph and Frohwitter, Gesche and Eckstein, Markus and Kesting, Marco Rainer and Ries, Jutta},
booktitle = {ONCOLOGY RESEARCH AND TREATMENT},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2022-12-16},
pages = {131-131},
peerreviewed = {unknown},
publisher = {KARGER},
title = {{Dysregulation} of immune checkpoint molecules in oral cancer},
year = {2022}
}
@article{faucris.276872182,
abstract = {Pierre Robin sequence (PRS) is characterized by mandibular micrognathia, glossoptosis, and airway obstruction. We report a case of a female infant with PRS in combination with deletion of chromosome 4q and cardiac insufficiency due to an atrioventricular septum defect. The child was transferred to our center from a peripheral hospital with respiratory insufficiency. Initially, respiration was ensured using a continuous positive airway pressure (CPAP) device because a Tuebingen plate was not tolerated. After a pediatric cardiac surgery intervention, CPAP ventilation proved to be insufficient, and the young patient had to be resuscitated and endotracheal intubation was required for recurrent severe respiratory failure. To avoid tracheostomy, an interdisciplinary decision was made to perform an early mandibular distraction. In the fifth week of life, two patient-specific internal distractors were implanted after prior virtual surgery planning. This approach allows for shorter surgical time through preoperative vector planning and fabrication of a patient-specific distractor, in combination with reduced morbidity through maximum protection of adjacent structures such as the tooth follicles and inferior alveolar nerves. An advancement of the mandible by 15mm could be achieved within 2 weeks. Thereafter, the small patient could be extubated successfully, and there was no further episode of major respiratory insufficiency. We demonstrate that mandibular early distraction with a patient-specific distractor is a successful method to treat severe respiratory insufficiency in PRS, and it can prevent the necessity for tracheostomy with the resulting disadvantages. We provide details concerning our therapeutic algorithm, metric analyses, and a discussion of relevant literature.},
author = {Lutz, Rainer and Olmos, Manuel and Schmidt, Joachim and Morhart, Patrick and Nobis, Christopher-Philipp and Möst, Tobias and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.1097/GOX.0000000000004361},
faupublication = {yes},
journal = {Plastic and Reconstructive Surgery Global Open},
note = {CRIS-Team WoS Importer:2022-06-17},
peerreviewed = {Yes},
title = {{Early} {MDO} with a {Virtually} {Planned} {Distractor} in a {Neonate} with {Pierre} {Robin} {Sequence}},
volume = {10},
year = {2022}
}
@article{faucris.291583889,
author = {Horch, Raymund E. and Kesting, Marco Rainer and Kersting, S. and Fichtner-Feigl, S. and Arkudas, Andreas},
doi = {10.3389/fonc.2023.1146719},
faupublication = {yes},
journal = {Frontiers in Oncology},
keywords = {cancer surgery; interdisciplinary surgical approaches; outcome; quality of life; surgical tumor reconstruction},
note = {CRIS-Team Scopus Importer:2023-03-10},
peerreviewed = {Yes},
title = {{Editorial}: {Interdisciplinary} surgical strategies for complex tumor defects in modern oncology},
volume = {13},
year = {2023}
}
@article{faucris.124086204,
abstract = {The augmentation of the alveolar ridge using iliac cortico-spongeous bone grafts is routinely used. However, bone grafts show a substantial degree of resorption, which may negatively affect the long-term success of dental implants in the augmented area. The aim of this study was to evaluate the effect of a deproteinized bovine bone matrix coverage on the resorption of iliac bone grafts.Two cohorts consisting of 40 patients who received a vertical augmentation of the alveolar ridge with onlay grafts from the iliac crest were prospectively investigated over a period of 2 years. In half of the patients (n = 40), the grafts were covered by a thin layer of deproteinized bovine bone matrix (DBBM cohort). The other 40 patients received the identical surgical procedure without a DBBM coverage (non-DBBM cohort). The graft height/resorption was radiographically determined immediately after surgery, 6 months, 1 year, and 2 years postoperatively.The height of the bone graft 6 months after surgery accounted 92.15% of the initial value in the DBBM cohort and 87.76% in the non-DBBM cohort. One year after augmentation, the height reduced to 83.95% in the DBBM cohort and 72.92% in the non-DBBM cohort. Two years after surgery, the resorption slowed down and the height of the grafts accounted 81.27% in the DBBM cohort and 71.43% in the non-DBBM cohort. The difference was statistically significant.Deproteinized bovine bone matrix reduces the postoperative resorption of iliac bone block grafts and may therefore enhance the long-term implant prognosis in the augmented area.},
author = {Wiltfang, Joerg and Jaetschmann, Nadine and Hedderich, Juergen and Neukam, Friedrich Wilhelm and Schlegel, Andreas and Gierloff, Matthias},
doi = {10.1111/clr.12074},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24346},
pages = {e127-32},
peerreviewed = {Yes},
title = {{Effect} of deproteinized bovine bone matrix coverage on the resorption of iliac cortico-spongeous bone grafts - a prospective study of two cohorts},
volume = {25},
year = {2014}
}
@article{faucris.212501068,
abstract = {Background Indocyanine green (ICG) videoangiography is routinely used to evaluate skin and organ perfusion and to assess patency rates of microvascular anastomoses. This study uses ICG angiography as a novel approach to qualitatively and quantitatively evaluate bone perfusion of microvascular fibula grafts intraoperatively and to assess the effect of fibula segment length and number of osteotomies on bone perfusion.},
author = {Fichter, Andreas M. and Ritschl, Lucas M. and Georg, Rali and Kolk, Andreas and Kesting, Marco Rainer and Wolff, Klaus-Dietrich and Muecke, Thomas},
doi = {10.1055/s-0038-1667364},
faupublication = {yes},
journal = {Journal of Reconstructive Microsurgery},
note = {CRIS-Team WoS Importer:2019-03-06},
pages = {108-116},
peerreviewed = {Yes},
title = {{Effect} of {Segment} {Length} and {Number} of {Osteotomy} {Sites} on {Cancellous} {Bone} {Perfusion} in {Free} {Fibula} {Flaps}},
volume = {35},
year = {2019}
}
@article{faucris.222466368,
author = {von Wilmowsky, Cornelius and Vairaktaris, Eleftherios and Pohle, Dirk and Rechtenwald, Thomas and Lutz, Rainer and Münstedt, Helmut and Koller, Garrit and Schmidt, Michael and Neukam, Friedrich Wilhelm and Schlegel, Andreas and Nkenke, Emeka},
doi = {10.1002/jbm.a.31822},
faupublication = {yes},
journal = {Journal of Biomedical Materials Research Part A},
note = {LFT Import::2019-07-16 (1422)},
peerreviewed = {Yes},
title = {{Effects} of {Bioglass} and ß-{TCP} containing three-dimensional laser sintered polyetheretherketone composites on osteoblasts in vitro},
year = {2007}
}
@article{faucris.124072344,
abstract = {The aim of the study was to assess the suitability of different Ti-6Al-4V surfaces produced by the electron beam melting (EBM) process as matrices for attachment, proliferation, and differentiation of human fetal osteoblasts (hFOB 1.19). Human osteoblasts were cultured in vitro on smooth and rough-textured Ti-6Al-4V alloy disks. By means of cell number and vitality and SEM micrographs cell attachment and proliferation were observed. The differentiation rate was examined by using quantitative real-time PCR analysis for the gene expression of alkaline phosphatase (ALP), type I collagen (Coll-I), bone sialoprotein (BSP) and osteocalcin (OC). After 3 days of incubation there was a significant higher vitality (p < 0.02) and proliferation (p < 0.02) of hFOB cells on smooth surfaces (R = 0.077 μm) and compact surfaces with adherent partly molten titanium particles on the surface (R ≤ 24.9 μm). On these samples cells spread over almost the whole surface. On porous surfaces with higher R values, cell proliferation was reduced significantly. Quantitative real-time PCR analysis showed that the expression of osteogenic differentiation markers was not influenced by surface characteristics. Gene expression did not differ more than twofold for the different samples. Compact titanium samples with adherent partly molten titanium particles on the surface (R ≤ 24.9 μm) fabricated by the EBM process turned out to be best suited for cell proliferation, while highly rough surfaces (R ≥ 56.9 μm) reduced proliferation of hFOB cells. Surface characteristics of titanium can easily be changed by EBM in order to further improve proliferation. © 2007 Wiley Periodicals, Inc.},
author = {Ponader, Sabine and Vairaktaris, Eleftherios and Heinl, Peter and von Wilmowsky, Cornelius and Rottmair, Andreas and Körner, Carolin and Singer, Robert and Holst, Stefan and Schlegel, Karl and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
doi = {10.1002/jbm.a.31540},
faupublication = {yes},
journal = {Journal of Biomedical Materials Research Part A},
keywords = {Attachment; Differentiation; Electron beam melting; Human osteoblasts; Proliferation; Surface roughness; Titanium},
pages = {1111-1119},
peerreviewed = {Yes},
title = {{Effects} of topographical surface modifications of electron beam melted {Ti}-{6Al}-{4V} titanium on human fetal osteoblasts},
volume = {84},
year = {2008}
}
@inproceedings{faucris.121457204,
address = {Norderstedt},
author = {Schuster, Maria and Maier, Andreas and Kohler, Regina and Nöth, Elmar and Rosanowski, Frank and Eysholdt, Ulrich and Nkenke, Emeka},
booktitle = {Aktuelle phoniatrische Aspekte},
date = {2007-09-28/2007-09-30},
editor = {Gross M., Kruse Friedrich E.},
faupublication = {yes},
pages = {77-78},
peerreviewed = {Yes},
publisher = {Books on Demand GmbH},
title = {{Einflussfaktoren} auf {Sprechstoerungen} bei {T1} und {T2} {Plattenepithelcarcinomen} der {Mundhoehle}},
venue = {Innsbruck},
year = {2007}
}
@article{faucris.107791684,
abstract = {The purpose of this study was to develop decision-making aids and recommendations for dental practitioners regarding the utilization and sharing of sensitive digital patient data. In the current environment of growing digitization, healthcare professionals need detailed knowledge of secure data management to maximize confidentiality and minimize the risks involved in both archiving patient data and sharing it through electronic channels. Despite well-defined legal requirements, an all-inclusive technological solution does not currently exist. The need for a preliminary review and critical appraisal of common practices of data transfer prompted a search of the literature and the Web to identify viable methods of secure data exchange and to develop a flowchart. A strong focus was placed on the transmission of datasets both smaller than and larger than 10 MB, and on secure communication by smartphone. Although encryption of patient-related data should be routine, it is often difficult to implement. Pretty Good Privacy (PGP) and Secure/Multipurpose Internet Mail Extensions (S/MIME) are viable standards for secure e-mail encryption. Sharing of high-volume data should be accomplished with the help of file encryption. Careful handling of sensitive patient data is mandatory, and it is the end-user's responsibility to meet any requirements for encryption, preferably by using free, open-source (and hence transparent) software.},
author = {Detterbeck, Andreas and Kaiser, J and Hirschfelder, Ursula},
faupublication = {yes},
journal = {International Journal of Computerized Dentistry},
note = {EVALuna2:24846},
pages = {45-57},
peerreviewed = {Yes},
title = {{Electronic} transfer of sensitive patient data},
volume = {18},
year = {2015}
}
@article{faucris.251051542,
abstract = {The aim of this study was to investigate intraluminal vessel diameters and endothelial expression levels of pro-inflammatory and -thrombotic mediators in patent and non-patent microvascular anastomoses. Endothelial expression of CD31, VCAM-1, E− and P-Selectin, eNOS, iNOS and PAI-1 was evaluated by immunohistochemistry and compared to non-anastomosed arteries as controls. Intraluminal diameters were determined via H.E.-staining. In 20 human anastomoses (8 patent, 12 non-patent) neither the analysis of endoluminal de-endothelialization (p = 0.966) nor luminal narrowing (p = 0.750) revealed any significant differences between patent and non-patent microanastomoses. Expressions of pro-inflammatory mediators were significantly higher in patent anastomoses compared to controls but did not show any difference compared to non-patent anastomoses (p > 0.050). iNOS was higher in non-patent compared to patent anastomoses (p = 0.030) and controls (p = 0.001), whereas eNOS did not reveal any differences between these groups (p = 0.611 and p = 0.130). In non-patent anastomoses PAI-1 was expressed higher compared to patent anastomoses and controls (p = 0.021 and p < 0.001). Irrespective of their patency, anastomoses are characterized by endothelial dysfunction with a pro-inflammatory and pro-thrombotic milieu. Avoiding endothelial trauma during suturing is essential in order not to aggravate existing endothelial dysfunction in microanastomoses. Additionally, the influence of medication-related changes on anastomoses should be investigated as this is still an indistinctive topic.},
author = {Preidl, Raimund and Reuß, Silvy and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Wehrhan, Falk},
doi = {10.1016/j.jcms.2021.02.006},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
keywords = {Endothelium; Free flap; Microvascular anastomosis},
note = {CRIS-Team Scopus Importer:2021-03-05},
peerreviewed = {Yes},
title = {{Endothelial} inflammatory and thrombogenic expression changes in microvascular anastomoses – {An} immunohistochemical analysis},
year = {2021}
}
@article{faucris.211742569,
abstract = {Introduction: Treatment decisions for fractures of the orbital floor are based on clinical appearance, ophthalmological examination, and computed tomography (CT) scans. In extensive fractures, decisions are easily made between conservative and surgical treatment. However, objective parameters are rare in inconclusive cases.
Materials and methods: Our retrospective study included 106 patients with unilateral isolated orbital floor fractures. Correlations between preoperative ophthalmological examinations and specific CT parameters were performed.
Results: The defect size of the fracture appeared to be significantly associated with the presence of diplopia. CT-morphological parameters and preoperative ophthalmological results showed statistical significance for diplopia and incarceration of inferior rectus muscle (IRM), diplopia and displacement of IRM, decreased mobility and incarceration of IRM, and decreased mobility and displacement of IRM.
Discussion: Our clinical assessment scheme for CT scans of orbital floor fractures is aimed at facilitating treatment decision making using four CT-based variables. As critical size defects of the orbital floor of >= 2 cm(2) are likely to cause clinically significant posterior displacement of the globe, resulting in enophthalmos, the proposed parameters offer a readily accessible and easy to evaluate scheme that helps to identify patients in need of surgical intervention. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.},
author = {Frohwitter, Gesche and Wimmer, Stephan and Goetz, Carolin and Weitz, Jochen and Ulbig, Michael and Kortuem, Karsten U. and Dangelmaier, Julia and Ritschl, Lucas and Doll, Christian and Ristow, Oliver and Kesting, Marco Rainer and Koerdt, Steffen},
doi = {10.1016/j.jcms.2018.06.016},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:35082},
pages = {1550-1554},
peerreviewed = {Yes},
title = {{Evaluation} of a computed-tomography-based assessment scheme in treatment decision-making for isolated orbital floor fractures},
volume = {46},
year = {2018}
}
@article{faucris.230751664,
abstract = {Introduction: Neck dissection is an essential component of oral cancer therapy. Based on a standardised approach to cervical lymph node management, we seek to define the relevance of neck dissection extension in cN + cases. Material and methods: A retrospective analysis from January 2009 to February 2017 identified 84 patients with oral squamous cell carcinoma with a cN + neck or histologically proven lymph node involvement in intraoperative frozen sectioning and who received modified radical neck dissection according to the presented neck dissection algorithm. Results: Overall 11 patients showed lymph node metastasis level IV or V, whereas 19 developed disease recurrence, of which 5 cases were neck recurrences. A total of 30 patients died within the time of observance (overall survival of n = 54). None of those patients with pN + status in levels IV and V reached a 5-year survival. Discussion: With a look to the possibility of a 5-year survival in patients with a N+ status in level IV and V, the justification for a radical approach to the neck appears questionable. However, modified radical neck dissection appears to be a suitable for a high-risk oral cancer subgroup. A randomised controlled trial is needed to define guidelines for the neck dissection extent in c/pN + cases.},
author = {Frohwitter, Gesche and Röckl, Jonas and Rau, Andrea and Wolff, Klaus Dietrich and Kesting, Marco Rainer and Koerdt, Steffen},
doi = {10.1016/j.jcms.2019.11.019},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
keywords = {Disease-free survival; Level IV and V; Modified radical neck dissection; Oral cancer; Overall survival; Supraomohyoid neck dissection},
note = {CRIS-Team Scopus Importer:2019-12-20},
pages = {1963-1967},
peerreviewed = {Yes},
title = {{Evaluation} of neck dissection with frozen section biopsy – {Management} of levels {IV} and {V}},
volume = {47},
year = {2019}
}
@article{faucris.113186084,
author = {Schuster, Maria and Maier, Andreas and Haderlein, Tino and Nkenke, Emeka and Wohlleben, Ulrike and Rosanowski, Frank and Eysholdt, Ulrich and Nöth, Elmar},
doi = {10.1016/j.ijporl.2006.05.016},
faupublication = {yes},
journal = {International Journal of Pediatric Otorhinolaryngology},
pages = {1741-1747},
peerreviewed = {Yes},
title = {{Evaluation} of speech intelligibility for children with cleft lip and palate by means of automatic speech recognition},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2006/Schuster06-EOS.pdf},
volume = {70/2006},
year = {2006}
}
@article{faucris.211742801,
abstract = {Purpose: Safety checklists in medicine have been shown to be effective in the prevention of complications and adverse events in patients undergoing surgery. Such checklists are not as common in dentistry. The aims of this study were to propose a safety checklist for the ambulatory treatment of patients undergoing oral and implant surgery and to assess its impact on patient safety and staff satisfaction.
Materials and Methods: After implementation of a surgical safety checklist in the ambulatory treatment of patients undergoing oral and implant surgeries, a questionnaire regarding staff satisfaction and safety-related parameters was randomly administered. Incidents, complications, and adverse events were documented. Outcomes with (n = 40 surgeries) and without (n = 40 surgeries) use of the checklist were analyzed and compared.
Results: Staff reported high satisfaction with the use of the checklist, which demonstrably improved team communication and lowered stress levels during surgery. There was a statistically significantly higher frequency of reported incidents without the use of the checklist (n = 43) than with the use of the checklist (n = 10; P =.000). Most incidents were reported in the context of pre- and post-procedural processes.
Conclusions: Safety checklists help to improve work processes, optimize communication, and lower stress levels. Their use in clinical dental practice is recommended. (C) 2018 American Association of Oral and Maxillofacial Surgeons},
author = {Schmitt, Christian and Buchbender, Mayte and Musazada, Saida and Bergauer, Bastian and Neukam, Friedrich Wilhelm},
doi = {10.1016/j.joms.2018.03.032},
faupublication = {yes},
journal = {Journal of Oral and Maxillofacial Surgery},
note = {EVALuna2:35086},
pages = {1616-1639},
peerreviewed = {Yes},
title = {{Evaluation} of {Staff} {Satisfaction} {After} {Implementation} of a {Surgical} {Safety} {Checklist} in the {Ambulatory} of an {Oral} and {Maxillofacial} {Surgery} {Department} and its {Impact} on {Patient} {Safety}},
volume = {76},
year = {2018}
}
@article{faucris.123235464,
author = {Rupprecht, Stephan and Bloch-Birkholz, Alexandra and Rosiwal, Stefan and Neukam, Friedrich Wilhelm and Wiltfang, Joerg},
faupublication = {yes},
journal = {International Journal of Oral & Maxillofacial Implants},
keywords = {Dental implant; Diamond; Microwave plasma chemical vapor deposition; Osseointegration; Surface properties},
pages = {778-785},
peerreviewed = {Yes},
title = {{Examination} of the {Bone}-{Metal} {Interface} of {Titanium} {Implants} {Coated} by the {Microwave} {Plasma} {Chemical} {Vapor} {Deposition} {Method}},
url = {https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036834274&origin=inward},
volume = {17},
year = {2002}
}
@article{faucris.262975980,
abstract = {Objectives: Inflammatory bowel disease (IBD) has multiple impacts on soft and hard tissues in the oral cavity. The aim of this study was to analyze the expression of cytokines in biofilm samples from patients suffering from IBD and compare them to healthy patients. It was hypothesized that different cytokine expression levels and clinical associations might be drawn. Material and methods: A total of 56 biofilm samples from three different patient cohorts (group 0 = healthy, HC n = 30; group 1 = Crohn’s disease, CD, n = 19; group 2 = ulcerative colitis, UC, n = 7) were examined for the expression levels of the cytokine interleukins IL-2, -6, and -10; matrix metalloproteinases 7 and 9; and surface antigens CD90/CD11a by quantitative real-time PCR and according to clinical parameters (plaque index, BOP, PD, DMFT, CAL). Relative gene expression was determined using the ∆∆CT method. Results: The mean BOP values (p = 0.001) and PD (p = 0.000) were significantly higher in the CD group compared to controls. Expression of IL-10 was significantly higher in the CD (p = 0.004) and UC groups (p = 0.022). Expression of MMP-7 was significantly higher in the CD group (p = 0.032). IBD patients treated with TNF inhibitors (p = 0.007) or other immunosuppressants (p = 0.014) showed significant overexpression of IL-10 compared to controls. Conclusion: Different expression levels of IL-10 and MMP-7 were detected in plaque samples from IBD patients. As only BOP was significantly increased, we conclude that no clinical impairment of periodontal tissue occurred in IBD patients. Clinical relevance: With the worldwide increasing incidence of IBD, it is important to obtain insights into the effects of the disease on the oral cavity. The study was registered (01.09.2020) at the German clinical trial registry (DRKS00022956). Clinical trial registration: The study is registered at the German clinical trial registry (DRKS00022956).},
author = {Buchbender, Mayte and Fehlhofer, Jakob Paul and Proff, Peter and Möst, Tobias and Ries, Jutta and Hannig, Matthias and Neurath, Markus and Gund, Madline and Atreya, Raja and Kesting, Marco Rainer},
doi = {10.1007/s00784-021-04093-2},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Crohn’s disease; Cytokine expression; Oral biofilm; Periodontitis; Ulcerative colitis},
note = {CRIS-Team Scopus Importer:2021-08-20},
peerreviewed = {Yes},
title = {{Expression} of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients—a preliminary study},
year = {2021}
}
@inproceedings{faucris.238509241,
author = {Ries, Jutta and Wehrhan, Falk and Baran, Christoph and Agaimy, Abbas and Danzer, Eva and Bolzel, Stella and Büttner-Herold, Maike and Kesting, Marco Rainer and Weber, Manuel},
faupublication = {yes},
note = {EVALuna2:216185},
pages = {99-100},
peerreviewed = {Yes},
title = {{Expression} of the {Immune} {Modulators} of the {PD}-1: {PD}-{L1} {Axis} in oral {Leukoplakia}},
volume = {43},
year = {2020}
}
@article{faucris.123580864,
abstract = {Microvascular free tissue transfer is a standard method in head and neck reconstructive surgery. However, previous radiotherapy of the operative region is associated with an increased incidence in postoperative flap-related complications and complete flap loss. As transforming growth factor beta (TGF-?) 1 and galectin-3 are well known markers in the context of fibrosis and lectin-like oxidized low-density lipoprotein 1 (LOX-1) supports vascular atherosclerosis, the aim of this study was to evaluate the expression of TGF-?1 and related markers as well as LOX-1 in irradiated vessels.To evaluate the expression of galectin-3, Smad 2/3, TGF-?1, and LOX-1, 20 irradiated and 20 nonirradiated arterial vessels were used for immunohistochemical staining. We semiquantitatively assessed the ratio of stained cells/total number of cells (labeling index).Expression of galectin-3, Smad 2/3, and TGF-?1 was significantly increased in previously irradiated vessels compared with nonirradiated controls. Furthermore, LOX-1 was expressed significantly higher in irradiated compared with nonirradiated vessels.Fibrosis-related proteins like galectin-3, Smad 2/3, and TGF-?1 are upregulated after radiotherapy and support histopathological changes leading to vasculopathy of the irradiated vessels. Furthermore, postoperative complications in irradiated patients can be explained by increased endothelial dysfunction caused by LOX-1 in previously irradiated patients. Consequently, not only TGF-?1 but also galectin-3inhibitors may decrease complications after microsurgical tissue transfer.},
author = {Preidl, Raimund and Moebius, Patrick and Weber, Manuel and Amann, Kerstin Ute and Neukam, Friedrich Wilhelm and Schlegel, Andreas and Wehrhan, Falk},
doi = {10.1007/s00066-014-0797-8},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
note = {EVALuna2:24387},
pages = {518-524},
peerreviewed = {Yes},
title = {{Expression} of transforming growth factor beta 1-related signaling proteins in irradiated vessels},
volume = {191},
year = {2015}
}
@article{faucris.118526144,
abstract = {This study aimed to compare autologous bone (AB), bovine bone (BB), and equine bone (EB) blocks with regard to de novo bone formation, connective tissue, and residual bone substitute material portions in a standardized defect animal model.In the frontal skull of 20 pigs, 106 standardized cylindrical "critical size defects" were prepared. Defects were randomly filled with AB, BB, and EB blocks. After a healing period of 30 and 60 days, de novo bone formation, residual bone substitute material, and connective tissue portion was assessed by means of histomorphometry (Toluidine blue O staining). Mann-Whitney U-tests were used to evaluate differences between the groups.The de novo bone formation was significantly higher in the AB group in comparison to the xenogeneic groups (p < 0.05). After 30 days, EB showed significantly (p < 0.05) more newly formed bone compared to the BB group. The soft tissue formation was significantly higher in the BB and EB group. Defects augmented with BB showed significantly (p < 0.05) higher portions of bone substitute materials compared to sides augmented with EB after 30 days.In the extra-oral model, AB blocks were superior concerning de novo bone formation. No clinical advantages of EB blocks could be observed.},
author = {Moest, Tobias and Wehrhan, Falk and Lutz, Rainer and Schmitt, Christian Martin and Neukam, Friedrich Wilhelm and Schlegel, Karl Andreas},
doi = {10.1016/j.jcms.2015.02.012},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24399},
pages = {559-66},
peerreviewed = {Yes},
title = {{Extra}-oral defect augmentation using autologous, bovine and equine bone blocks: {A} preclinical histomorphometrical comparative study},
volume = {43},
year = {2015}
}
@article{faucris.115524024,
abstract = {Oral squamous cell carcinoma (OSCC) and its treatment impair speech intelligibility by alteration of the vocal tract. The aim of this study was to identify the factors of oral cancer treatment that influence speech intelligibility by means of an automatic, standardized speech-recognition system. The study group comprised 71 patients (mean age 59.89, range 35-82 years) with OSCC ranging from stage T1 to T4 (TNM staging). Tumours were located on the tongue (n=23), lower alveolar crest (n=27), and floor of the mouth (n=21). Reconstruction was conducted through local tissue plasty or microvascular transplants. Adjuvant radiotherapy was performed in 49 patients. Speech intelligibility was evaluated before, and at 3, 6, and 12 months after tumour resection, and compared to that of a healthy control group (n=40). Postoperatively, significant influences on speech intelligibility were tumour localization (P=0.010) and resection volume (P=0.019). Additionally, adjuvant radiotherapy (P=0.049) influenced intelligibility at 3 months after surgery. At 6 months after surgery, influences were resection volume (P=0.028) and adjuvant radiotherapy (P=0.034). The influence of tumour localization (P=0.001) and adjuvant radiotherapy (P=0.022) persisted after 12 months. Tumour localization, resection volume, and radiotherapy are crucial factors for speech intelligibility. Radiotherapy significantly impaired word recognition rate (WR) values with a progression of the impairment for up to 12 months after surgery.},
author = {Stelzle, Florian and Knipfer, Christian and Schuster, M. and Bocklet, Tobias and Nöth, Elmar and Adler, Werner and Schempf, L. and Vieler, Peter and Riemann, Max and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
doi = {10.1016/j.ijom.2013.05.021},
faupublication = {yes},
journal = {International journal of oral and maxillofacial surgery},
pages = {1377-84},
peerreviewed = {unknown},
title = {{Factors} influencing relative speech intelligibility in patients with oral squamous cell carcinoma: a prospective study using automatic, computer-based speech analysis.},
volume = {42},
year = {2013}
}
@article{faucris.227884531,
abstract = {Purpose: Surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) consists of necrotic bone removal followed by dense mucosal closure. Fluorescence-guided surgery has become a promising tool to intraoperatively distinguish between healthy and necrotic bone. Until now, there has been a lack of histopathological studies correlating the intraoperative fluorescence situation to histopathological analyses of the respective bone areas in order to further validate this method. Materials and methods: Histopathological sections from intraoperatively detected fluorescence- and non−fluorescence-labeled bone were analyzed detecting osteocyte and collagen content, RANK(L) and TRAP expression as well as proportion of immature bone regeneration. Samples were compared with viable-looking bone areas according to the intraoperative clinical situation. Results: Staining revealed a significant decrease of osteocytes and collagen type-I fibers in necrotic, non-fluorescing areas compared to fluorescing bone (R/RGB [%]: 0.56 ± 0.38 (fluorescence positive) vs. 3.18 ± 2.22 (fluorescence negative), p = 0.041). Furthermore, the number of osteocytes was higher in fluorescing, clinically viable bone samples (cell/mm2: 151.26 ± 95.77 (fluorescence positive) vs. 0.56 ± 0.38 (fluorescence negative), p = 0.028). Additionally, the amount of immature bone was substantially increased in luminescent jaw bone (proportion of red [%]: 6.78 ± 7.00 (fluorescence positive) vs. 2.24 ± 1.36 (fluorescence negative), p = 0.442). RANK(L) and TRAP expression did not differ between the investigated areas, resembling a generalized decrease in osteocyte−osteoclast function all over the jaw (RANK(L) −positive cells per mm2: 8.97 ± 7.85 (fluorescence positive) vs. 7.76 ± 6.41 (fluorescence negative), p = 0.793; TRAP-positive cells per mm2: 0.36 ± 0.38 (fluorescence positive) vs. 0.33 ± 0.41 (fluorescence negative), p = 0.887). Conclusion: Intraoperative fluorescence-guided surgery might be more precise in identifying and resecting the necrotic bone compared to previous indicators like bone bleeding, which could be useful to further improve surgical therapy in MRONJ patients.},
author = {Wehrhan, Falk and Weber, Manuel and Neukam, Friedrich Wilhelm and Geppert, Carol-Immanuel and Kesting, Marco Rainer and Preidl, Raimund},
doi = {10.1016/j.jcms.2019.07.012},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
keywords = {Bisphosphonate; Bone fluorescence; BRONJ; Doxycycline; MRONJ},
note = {CRIS-Team Scopus Importer:2019-10-15},
pages = {1600-1607},
peerreviewed = {Yes},
title = {{Fluorescence}-guided bone resection: {A} histological analysis in medication-related osteonecrosis of the jaw},
volume = {47},
year = {2019}
}
@article{faucris.255674520,
abstract = {Purpose: Vestibuloplasty with free gingival grafting is a frequently performed surgical procedure to generate sufficient keratinized mucosa (KM) around dental implants. Avascular porcine collagen matrices (CM) have been proclaimed to be sufficient substitutes as alternatives to free gingival grafts (FGGs). However, the process of graft integration and vascularization is still incompletely understood. Methods: In 18 patients a vestibuloplasty in the lower edentulous jaw situation was performed during implant exposure, either with FGGs from the palate or a porcine CM (mucoderm). Tissue perfusion of the soft tissue grafts was measured using laser-doppler-spectrophotometer intraoperatively and on postoperative days 2, 5, 10, 30 and between days 60 and 90. With graft perfusion expressed by oxygen saturation [SO2%], the relative amount of hemoglobin [rHb], blood flow, and velocity [AU] was detected and compared between groups and the surrounding mucosa. Results: Healing was uneventful in both groups, with mature KM around dental implants after healing. Blood flow and velocity significantly increased until postoperative day 10, comparable to perfusion values of the surrounded mucosa. Intergroup comparisons revelated no significant differences concerning the flow between CM and FGGs. Oxygen saturation also significantly increased within the first 5 postoperative days in both groups. Hemoglobin content did not show any differences during the investigated period. Conclusions: The perfusion mainly progresses within the first postoperative week with only minimal further detectable alterations until the final investigation, comparable in both groups. Although integration of FGGs (revascularized) and the CM (new tissue formation) is biologically different, both transplants show comparable perfusion patterns, leading to sufficient KM.},
author = {Preidl, Raimund and Reichert, Sky Helen and Vallenas Coronel, Talisa and Kesting, Marco Rainer and Wehrhan, Falk and Schmitt, Christian},
doi = {10.1016/j.joms.2020.12.019},
faupublication = {yes},
journal = {Journal of Oral and Maxillofacial Surgery},
note = {CRIS-Team Scopus Importer:2021-04-19},
peerreviewed = {Yes},
title = {{Free} {Gingival} {Graft} and {Collagen} {Matrix} {Revascularization} in an {Enoral} {Open} {Wound} {Situation}},
year = {2021}
}
@article{faucris.265352202,
abstract = {Objectives: This retrospective study evaluates intraoral surgical and conservative treatment need in patients with a chronic kidney end-stage disease, depending on the duration of dialysis treatment and the causative nephrological disease. Material and methods: This study is based on data of patients referred to the Department of Oral and Maxillofacial Surgery of the University Hospital Erlangen, Germany, prior to kidney transplantation between January 2015 and March 2020. The necessity for oral surgical or dental therapy was determined by clinical and radiological examinations. Data on renal replacement therapy, cause of underlying renal disease, lifestyle, and general health were collected. Results: Data of N = 89 patients demonstrated that surgical treatment need depends on dialysis duration (p = 0.042). Patients, who had been dialyzing for 2 to 3 years showed the highest need for surgical intervention (80.0%; p = 0.024), followed by dialysis patients with a dialysis time of more than 3 years (48.1%). Similarly, dialysis patients in the second or third year of dialysis had the highest need for conservative treatment (73.3%; p > 0.05), followed by 55.6% of dialysis patients in the third year of dialysis. Conclusions: Operative and conservative treatment is essential to optimize subsequent kidney transplantation. The greatest necessity could be detected for patients in the second and third years of dialysis. Clinical relevance: Oral health addressing surgical and conservative treatment need depends on the duration of dialysis in patients with a chronic kidney end-stage disease.},
author = {Möst, Tobias and Lutz, Rainer and Jahn, Arne Eric and Heller, Katharina M. and Schiffer, Mario and Adler, Werner and Deschner, James and Weber, Manuel and Kesting, Marco Rainer},
doi = {10.1007/s00784-021-04202-1},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Immunosuppression; Kidney; Oral health; Organ transplantation},
note = {CRIS-Team Scopus Importer:2021-10-22},
peerreviewed = {Yes},
title = {{Frequency} of the necessity of dentoalveolar surgery or conservative treatment in patients before kidney transplantation depending on the duration of dialysis and causative nephrological disease},
year = {2021}
}
@article{faucris.120325744,
author = {Maier, Andreas and Nöth, Elmar and Batliner, Anton and Nkenke, Emeka and Schuster, Maria},
faupublication = {yes},
journal = {Informatica},
pages = {477-482},
peerreviewed = {Yes},
title = {{Fully} {Automatic} {Assessment} of {Speech} of {Children} with {Cleft} {Lip} and {Palate}},
url = {http://ai.ijs.si/informatica/},
year = {2006}
}
@article{faucris.248584692,
author = {Ebker, Tobias and Rech, Jürgen and von Wilmowsky, Cornelius and Neukam, Friedrich Wilhelm and Stockmann, Philipp},
doi = {10.1093/rheumatology/kes351},
faupublication = {yes},
journal = {Rheumatology},
note = {CRIS-Team Scopus Importer:2021-02-03},
pages = {218-220},
peerreviewed = {Yes},
title = {{Fulminant} course of osteonecrosis of the jaw in a rheumatoid arthritis patient following oral bisphosphonate intake and biologic therapy},
volume = {52},
year = {2013}
}
@article{faucris.121007084,
abstract = {Objective: To determine the limits of accuracy of fusion of optical three-dimensional (3D) imaging and computed tomography (CT) with and without metal artefacts in an experimental setting and to show the application of this hybrid system in 3D orthognathic surgery simulation. Methods: Ten plaster casts of dental arches were subjected to a CT scan and optical 3D surface imaging. Subsequently, the first molars in the plaster casts were supplied with metal restorations, bilaterally, and new CT scans and optical surface images were assessed. The registration of the surface data of the two imaging modalities of the study models without and with metal restorations was carried out. The mean distance between the two data sets was calculated. From a patient a CT scan of the skull as well as optical 3D images of plaster casts of the dental arches were acquired. Again the two imaging modalities were registered and virtual orthognathic surgery simulation was carried out. Results: The mean distance between the corresponding data points of CT and optical 3D surface images was 0.1262 ±0.0301 mm and 0.2671±0.0580 mm, respectively, for the plaster casts without and with metal restorations. The differences between these data were statistically significant (P< 0.0005). For the patient case a mean difference of 0.66±0.49 mm and 0.56±0.48 mm for mandible and maxilla, respectively, was calculated between CT and optical surface data. Conclusion: The accuracy of the fusion of 3D CT surface data and optical 3D imaging is significantly reduced by metal artefacts. However, it seems appropriate for virtual orthognathic surgery simulation, as post-operative orthodontics are performed frequently. © 2004 The British Institute of Radiology.},
author = {Nkenke, Emeka and Häusler, Gerd and Lell, Michael and et al.},
author_hint = {Nkenke Emeka, Zachow S., Benz Michaela, Maier Tobias, Veit K., Kramer Marlene, Benz S., Häusler Gerd, Neukam F.W., Lell Michael},
doi = {10.1259/dmfr/27071199},
faupublication = {yes},
journal = {Dentomaxillofacial Radiology},
keywords = {Computed tomography; Image fusion; Metal artefacts; Optical 3D imaging; Phase measuring triangulation},
note = {UnivIS-Import:2015-04-14:Pub.2004.nat.dphy.optik.1optik.fusion},
pages = {226-32},
peerreviewed = {Yes},
support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'},
title = {{Fusion} of computed tomography data and optical {3D} images of the dentition for streak artefact correction in the simulation of orthognathic surgery},
volume = {33},
year = {2004}
}
@article{faucris.119948004,
abstract = {Immunologic factors can promote the progression of oral squamous cell carcinomas (oscc). The phylogenetic highly conserved protein Galectin 3 (Gal3) contributes to cell differentiation and immune homeostasis. There is evidence that Gal3 is involved in the progression of oscc and influences the regulation of macrophage polarization. Macrophage polarization (M1 vs. M2) in solid malignancies like oscc contributes to tumor immune-escape. However, the relationship between macrophage polarization and Gal3 expression in oscc is not yet understood. The current study analyzes the association between histomorphologic parameters (T-, N-, L- Pn-status, grading) and Gal3 expression resp. the ratio between Gal3 expressing cells and CD68 positive macrophages in oscc specimens.Preoperative diagnostic biopsies (n = 26) and tumor resection specimens (n = 34) of T1/T2 oscc patients were immunohistochemically analyzed for Gal3 and CD68 expression. The number of Gal3 expressing cells and the ratio between CD68 and Gal3 expressing cells was quantitatively assessed.In biopsy and tumor resection specimens, the number of Gal3 positive cells as well as the Gal3/CD68 ratio were significantly (p < 0.05) higher in T2 oscc compared to T1 cases. In biopsy specimens, a significantly (p < 0.05) increased Gal3 expression and Gal3/CD68 ratio was associated with the progression marker lymph vessel infiltration (L1). Tumor resection specimens of cases with lymph node metastases (N+) had a significantly (p < 0.05) increased Gal3 expression. Additionally, a high Gal3/CD68 ratio correlated significantly (p < 0.05) with higher grading (G3) in tumor resection specimens.High Gal3 expression in oscc is associated with tumor size (T-status) and parameters of malignancy (N-, L-status, grading). Gal3 might contribute to M2 macrophage mediated local immune tolerance. Gal3 expression shows association with prognosis in oscc and represent a potential therapeutic target.},
author = {Weber, Manuel and Buettner-Herold, Maike and Distel, Luitpold and Ries, Jutta and Möbius, Patrick and Preidl, Raimund and Geppert, Carol-Immanuel and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
doi = {10.1186/s12885-017-3920-2},
faupublication = {yes},
journal = {BMC Cancer},
note = {EVALuna2:24446},
pages = {906},
peerreviewed = {Yes},
title = {{Galectin} 3 expression in primary oral squamous cell carcinomas},
volume = {17},
year = {2017}
}
@article{faucris.208679691,
abstract = {BACKGROUND: Neck dissection is standard in surgical management of oral squamous cell carcinomas (oscc). However, the immunologic link between primary tumor and lymph nodes is insufficiently understood. Galectin 3 (Gal3) promotes M2 polarization of macrophages and contributes to immunosuppression. The current study analyzes the association between Gal3 expression in regional lymph nodes of oscc with histomorphologic parameters (T-, N-, L- Pn-stage, grading) of the primary tumor. Additionally, Gal3 expression is correlated with markers of macrophage polarization (M1 vs. M2).
METHODS: Preoperative diagnostic biopsies (n = 26), tumor resection specimens (n = 34), tumor-free lymph nodes (n = 28) and lymph node metastases (n = 10) of T1/T2 oscc patients were immunohistochemically analyzed for Gal3 and macrophage marker (CD68, CD11c, CD163 and MRC1) expression. The number of positive cells and the expression ratios were quantitatively assessed.
RESULTS: High Gal3 expression in tumor-free regional lymph nodes was significantly (p < 0.05) associated with increased tumor size. The epithelial compartment of lymph node metastases showed a significantly (p < 0.05) increased Gal3 expression compared to biopsies and tumor resection specimens. Cell density of M2 macrophages was significantly (p < 0.05) and positively correlated with the number of Gal3 expressing cells in lymph nodes and tumor specimens.
CONCLUSION: Gal3 expression in regional lymph nodes might be associated with oscc progression. The increased Gal3 expression in regional lymph nodes of larger tumors underlines the need of immunomodulatory treatment concepts in early-stage oscc. Blocking of Gal3 might be a therapeutic option in oral cancer.
},
author = {Wehrhan, Falk and Büttner-Herold, Maike and Distel, Luitpold and Ries, Jutta and Möbius, Patrick and Preidl, Raimund and Geppert, Carol-Immanuel and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.1186/s12885-018-4726-6},
faupublication = {yes},
journal = {BMC Cancer},
note = {EVALuna2:34900},
peerreviewed = {Yes},
title = {{Galectin} 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas},
volume = {18},
year = {2018}
}
@article{faucris.111685684,
abstract = {While the oral health-related quality of life (OHRQoL) is known to be reduced in patients with cleft lip and palate (CLP), its inter-dependency with the soft tissue characteristics of the CLP area remains unclear. This study aimed to evaluate the soft tissue characteristics in the treated cleft area in order to investigate whether gingival esthetics correlate with OHRQoL. Thirty-six patients with unilateral or bilateral CLP (46 cleft areas) were investigated after secondary/tertiary alveolar bone grafting and orthodontic/prosthetic implant treatment using an adapted score to rate gingival esthetics (clinical esthetic score, CES). The patient's OHRQoL was determined using the German short version of the Oral Health Impact Profile questionnaire (OHIP-G14). The results showed a significantly better rating in patients with their own teeth in situ (12.05±1.10) than in patients with implants (6.95±4.78) or prosthetics (4.00±3.58). The best OHRQoL values were achieved by patients with their own teeth integrated into the cleft area (1.32±2.31), followed by patients with implants (2.33±2.33) and prosthetics (3.75±5.87). A significant (P=0.017) correlation was found between OHIP-G14 and CES scores, suggesting an increased OHRQoL in cases with higher oral esthetics in the cleft area. The therapeutic strategy contributes to both gingival esthetics and OHRQoL. The patient's subjective perception of OHRQoL can be attributed to objective gingival esthetic ratings.},
author = {Stelzle, Florian and Rohde, Maximilian and Oetter, Nicolai and Krug, K. and Riemann, Max and Adler, Werner and Neukam, Friedrich Wilhelm and Knipfer, Christian},
doi = {10.1016/j.ijom.2017.03.020},
faupublication = {yes},
journal = {International Journal of Oral and Maxillofacial Surgery},
note = {EVALuna2:24436},
pages = {993-999},
peerreviewed = {Yes},
title = {{Gingival} esthetics and oral health-related quality of life in patients with cleft lip and palate},
volume = {46},
year = {2017}
}
@article{faucris.228296816,
abstract = {Aim To compare 10-month histological and immunohistological outcomes after soft tissue thickening around teeth with a porcine collagen matrix (CM) versus a subepithelial connective tissue graft (SCTG). Material and Methods In eight beagle dogs, soft tissue thickening of the buccal gingiva of upper canines was performed with the SCTG or the CM. Connective tissue thickness (CTT) was histomorphometrically measured in the augmented regions. The augmented connective tissues were also histologically characterized and the collagen I and vascular endothelial growth factor (VEGF) expressions immunohistologically quantified. Results CTT significantly differed between groups (SCTG: 1.32 mm +/- 0.44 mm; CM: 1.06 mm +/- 0.27 mm; p = .008). Descriptive histological analyses revealed mature connective tissue that did not differ between groups. Immunohistological quantification of collagen I and VEGF expressions in the connective tissue also revealed no significant inter-group differences (collagen I: SCTG, 32.64% +/- 7.09% vs. CM, 30.57% +/- 7.83%; VEGF: SCTG, 39.06% +/- 7.27% vs. CM, 37.15% +/- 9.80%). Conclusion SCTG is superior to CM with regard to CTT in this experimental model. The CM and the SCTG lead to comparable connective tissue quality ten months after connective tissue thickening.},
author = {Schmitt, Christian M. and Schlegel, Karl Andreas and Gammel, Lisa and Möst, Tobias},
doi = {10.1111/jcpe.13196},
faupublication = {yes},
journal = {Journal of Clinical Periodontology},
note = {CRIS-Team WoS Importer:2019-10-25},
peerreviewed = {Yes},
title = {{Gingiva} thickening with a porcine collagen matrix in a preclinical dog model: {Histological} outcomes},
year = {2019}
}
@article{faucris.267076146,
abstract = {Background: Halitosis is a relatively inhomogeneous pathology with an extremely high prevalence in the population. Potential risk factors for bad breath include bacterial decomposition of organic material as well as numerous general and systemic diseases. The aim of the present study was to analyze whether certain subgroups of oral and maxillofacial surgery patients have a higher risk of halitosis. Further the impact of halitosis on the patient's quality of life was ascertained.},
author = {Willershausen, Ines and Krautkremer, Franziska and Sagheb, Kawe and Weider, Matthias and Weusmann, Jens and Mittermeier, Fabienna and Erhard, Julia and Sagheb, Keyvan and Gölz, Lina and Walter, Christian},
doi = {10.7754/Clin.Lab.2021.210440},
faupublication = {yes},
journal = {Clinical Laboratory},
note = {CRIS-Team WoS Importer:2021-12-10},
peerreviewed = {Yes},
title = {{Halitosis} in {Oral} and {Maxillofacial} {Surgery} {Patients}-a {Pilot} {Study}},
year = {2021}
}
@article{faucris.111353264,
author = {Häusler, Gerd and Nkenke, Emeka and Neukam, Friedrich Wilhelm and et al.},
author_hint = {Nkenke Emeka, Maier Tobias, Benz Michaela, Wiltfang J., Holbach L.M., Kramer M., Häusler Gerd, Neukam Friedrich Wilhelm},
faupublication = {yes},
journal = {International Journal of Oral and Maxillofacial Surgery},
note = {UnivIS-Import:2015-03-09:Pub.2004.nat.dphy.optik.1optik.hertel},
pages = {125-133},
peerreviewed = {Yes},
support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'},
title = {{Hertel} exophtalmometry versus computed tomography and optical {3D} imaging for the determination of the globe position in zygomatic fractures},
volume = {33},
year = {2004}
}
@article{faucris.123494184,
abstract = {The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease-free survival (DFS)/locoregional recurrence-free survival (LRFS), and distant metastases-free survival (DMFS) in patients with high-risk primary salivary gland carcinoma who underwent surgery and postoperative (chemo)radiotherapy with curative intention.We reviewed data of 63 patients with high-risk primary salivary gland carcinoma in a retrospective single-center audit.At a median follow-up of 31 months (range, 5-145 months), cumulative OS and DFS were 91.7%, 77.6%, and 62.9%, and 82.1%, 65.6%, and 57.7%, respectively, after 1, 2, and 5 years. LRFS and DMFS were 92%, 86%, and 86%, and 83.4%, 70.4%, and 62.3% after 1, 2, and 5 years, respectively. Of all patient-related, tumor-related, and treatment-related factors, high-grade histology (G3) was the only factor in univariate and multivariate analysis that was predictive for a shorter DMFS (low/intermediate vs high-grade: 100%, 100%, and 89.4% vs 72.9%, 54.3%, and 42.8% after 1, 2, and 5 years, respectively) and a shorter DFS (low/intermediate vs high-grade: 100%, 90%, and 84.4% vs 71.2%, 50.1%, and 39.4% after 1, 2, and 5 years, respectively) and OS (low/intermediate vs high-grade: 100%, 100%, and 86.5% vs 86.5%, 63.2%, and 46.5% after 1, 2, and 5 years, respectively).High-grade tumor histology is a highly significant predictor of a shorter DMFS, OS, and DFS in salivary gland carcinoma, irrespective of histological subtype. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2041-E2048, 2016.},
author = {Haderlein, Marlen and Scherl, Claudia and Semrau, Sabine and Lettmaier, Sebastian and Uter, Wolfgang and Neukam, Friedrich Wilhelm and Iro, Heinrich and Agaimy, Abbas and Fietkau, Rainer},
doi = {10.1002/hed.24375},
faupublication = {yes},
journal = {Head and Neck-Journal For the Sciences and Specialties of the Head and Neck},
note = {EVALuna2:5539},
pages = {E2041-8},
peerreviewed = {Yes},
title = {{High}-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype},
volume = {38 Suppl 1},
year = {2016}
}
@article{faucris.272548799,
abstract = {The aim of this study was to assess the inter- and intrarater reliability of a recently proposed scoring system for temporomandibular disorders (TMD), based upon radiological findings from magnetic resonance imaging (MRI). Patients with clinically suspected uni- or bilateral TMD, and subsequently conducted MRI examination of both temporomandibular joints, were included in this study. MRI data were independently evaluated by two experienced radiologists according to the DLJ scoring system proposed by Wurm et al., which includes assessment of the following categories: articular disk (prefix ‘D’), direction of disk luxation (prefix ‘L’), and osseous joint alterations (prefix ‘J’). 60 patients (49 female and 11 male) were eligible for analysis. No significant differences were found between both observers regarding ‘D’ and ‘L’ scores (p = 0.13 and p = 0.59, respectively). Significant differences were found for the assessment of subtle osseous changes (‘J0’ category: p = 0.041; ‘J1’ category: p = 0.018). Almost perfect intra- and interrater agreements were found for ‘D’ and ‘L’ categories (intrarater and interrater agreements for ‘D’: κ = 0.92 and κ = 0.84, respectively; intrarater and interrater agreements for ‘L’: κ = 0.93 and κ = 0.89, respectively). However, the assessment of ‘J’ categories revealed only moderate interrater agreement (κ = 0.49). The DLJ scoring system based upon MRI findings is feasible for routine clinical TMD assessment, and may help to simplify interdisciplinary communication between radiologists and clinicians.},
author = {Willenbrock, Dorina and Lutz, Rainer and Wüst, Wolfgang and Heiß, Rafael and Uder, Michael and Behrends, Tessa and Wurm, Matthias and Kesting, Marco Rainer and Wiesmüller, Marco},
doi = {10.1016/j.jcms.2021.11.010},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
keywords = {DLJ score; Magnetic resonance imaging; MRI; Temporomandibular disorder; TMD},
note = {CRIS-Team Scopus Importer:2022-04-08},
pages = {230-236},
peerreviewed = {Yes},
title = {{Imaging} temporomandibular disorders: {Reliability} of a novel {MRI}-based scoring system},
volume = {50},
year = {2022}
}
@article{faucris.281731110,
abstract = {Background: This study seeks to evaluate the impact of breast cancer (BRCA) gene status on tumor dissemination pattern, surgical outcome and survival in a multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian cancer (rOC).},
author = {Glajzer, Jacek and Castillo-Tong, Dan Cacsire and Richter, Rolf and Vergote, Ignace and Kulbe, Hagen and Vanderstichele, Adriaan and Ruscito, Ilary and Trillsch, Fabian and Mustea, Alexander and Kreuzinger, Caroline and Gourley, Charlie and Gabra, Hani and Taube, Eliane T. and Dorigo, Oliver and Horst, David and Keunecke, Carlotta and Baum, Joanna and Angelotti, Timothy and Sehouli, Jalid and Braicu, Elena Ioana},
doi = {10.1245/s10434-022-12459-3},
faupublication = {yes},
journal = {Annals of Surgical Oncology},
note = {CRIS-Team WoS Importer:2022-09-16},
peerreviewed = {Yes},
title = {{Impact} of {BRCA} {Mutation} {Status} on {Tumor} {Dissemination} {Pattern}, {Surgical} {Outcome} and {Patient} {Survival} in {Primary} and {Recurrent} {High}-{Grade} {Serous} {Ovarian} {Cancer}: {A} {Multicenter} {Retrospective} {Study} by the {Ovarian} {Cancer} {Therapy}-{Innovative} {Models} {Prolong} {Survival} ({OCTIPS}) {Consortium}},
year = {2022}
}
@article{faucris.123900964,
abstract = {Radiotherapy and compromised vital bone and/or surrounding soft tissue can be a challenge to the successful osseointegration of dental implants. We evaluated the long-term results of dental implants in patients with oral cancer.To address the research purpose, we designed and implemented a retrospective cohort study that included patients with oral cancer who had received dental implants from 2003 to 2011. The data were collected from a clinical oncology database. The predictor variables included a set of heterogeneous variables grouped into logical sets of demographics, surgical treatment, dental rehabilitation, radiotherapy type, and tumor entity. The primary outcome variable was implant survival; the secondary outcome variable was peri-implantitis. The descriptive statistics, survival time analysis, Kaplan-Meier implant survival curves, and Cox hazard proportional modeling were computed.The study sample included 59 patients with oral cancer (20 women [33.9%], 39 men [66.1%]; mean age at tumor diagnosis, 55 years), who had had 272 implants placed during the study period. The mean follow-up period was 30.9 months (range 3 to 82). Of the 272 implants, 269 (98.9%) and 264 (97.1%) had survived for 2 and 5 years, respectively. During the observation period, 10 implants were lost (3.7%). Of the implant failures, 82% occurred in transplanted bone (4 fibula flaps, 4 iliac crests, and 2 native mandibles). We observed peri-implantitis caused by insufficiently attached gingiva and bone loss in 182 of the implants (67%). The factors associated with implant failure were peri-implantitis, insufficient soft and hard tissue, muscle dysfunction, and xerostomia.Implant-based rehabilitation in oncology patients can achieve a high long-term success rate, although risk factors such as impaired muscle function and a high frequency of peri-implantitis can affect healing.},
author = {Hessling, Sarah and Wehrhan, Falk and Schmitt, Christian M. and Weber, Manuel and Schlittenbauer, Tilo and Scheer, Martin},
doi = {10.1016/j.joms.2014.11.009},
faupublication = {yes},
journal = {Journal of Oral and Maxillofacial Surgery},
note = {EVALuna2:24394},
pages = {889-96},
peerreviewed = {Yes},
title = {{Implant}-based rehabilitation in oncology patients can be performed with high long-term success},
volume = {73},
year = {2015}
}
@article{faucris.209440322,
abstract = {This concept for the treatment of edentulous patients with implant-retained overdentures or implant-supported fixed bridges combines the current knowledge of the reciprocal action between oral biology, dental technology, and optimal esthetics. To obtain an acceptable esthetic result it is important to carefully plan the treatment and to transfer the desirable situation from the study casts into the oral environment. Additional important factors are: The direction of he imp ant axis, which depends on bone quantity, bone morphology, and the intermaxillary relationship The changeover of long abutments to short ones 4 to 6 weeks after abutment connection The try-in of an acrylic resion provisional restoration to check the vertical dimension, aesthetics, plonetics,and accessibility for patient oral hygiene procedures (only required for bone-anchored fixed bridges). The bone-anchored fixed bridge offers the patient more comfort (stability, bite force, chewing efficacy, psychological factors) than he implant-retained overdenture, but he treatment is far more time-consuming and expensive, and the necessary sills of the dentist and the dental technician are greater. Endosseous oral imp ant therapy is a new and wide-open field. Much basic and clinical research must be done to overcome the esthetic and technical problems associated with the integration of endosseous ora implants and the fabrication of a bone-anchored fixed supra-structure, especially in patients with inadequate bone support.},
author = {Strub, Joerg R. and Neukam, Friedrich Wilhelm and Huerzeler, Markus B. and Wiltowski, Siegbert},
faupublication = {yes},
journal = {Orale Implantologie},
note = {EVALuna2:24449},
pages = {7-25},
peerreviewed = {Yes},
title = {{Implantology} in the edentulous jaw - {An} interdisciplinary treatment concept},
volume = {25},
year = {2017}
}
@article{faucris.117439344,
abstract = {The aim of study paper is to present an overview of osseointegration of dental implants, focusing on tissue response, surface modifications and future perspective.Great progress has been made over the decades in the understanding of osseous peri-implant healing of dental implants, leading to the development of new implant materials and surfaces. However, failures and losses of implants are an indicator that there is room for improvement. Of particular importance is the understanding of the biological interaction between the implant and its surrounding bone.The survival rates of dental implants in bone of over 90 % after 10 years show that they are an effective and well-established therapy option. However, new implant materials and surface modifications may be able to improve osseointegration of medical implants especially when the wound healing is compromised. Advanced techniques of evaluation are necessary to understand and validate osseointegration in these cases. An overview regarding the current state of the art in experimental evaluation of osseointegration of implants and implant material modifications will be given in Part II.},
author = {von Wilmowsky, Cornelius and Moest, Tobias and Nkenke, Emeka and Stelzle, Florian and Schlegel, Andreas},
doi = {10.1007/s10006-013-0398-1},
faupublication = {yes},
journal = {Oral and maxillofacial surgery},
note = {EVALuna2:24353},
pages = {243-57},
peerreviewed = {Yes},
title = {{Implants} in bone: {Part} {I}. {A} current overview about tissue response, surface modifications and future perspectives},
volume = {18},
year = {2014}
}
@article{faucris.123388364,
abstract = {In order to determine whether a newly developed implant material conforms to the requirements of biocompatibility, it must undergo rigorous testing. To correctly interpret the results of studies on implant material osseointegration, it is necessary to have a sound understanding of all the testing methods. The aim of this overview is to elucidate the methods that are used for the experimental evaluation of the osseointegration of implant materials.In recent decades, there has been a constant proliferation of new materials and surface modifications in the field of dental implants. This continuous development of innovative biomaterials requires a precise and detailed evaluation in terms of biocompatibility and implant healing before clinical use. The current gold standard is in vivo animal testing on well validated animal models. However, long-term outcome studies on patients have to follow to finally validate and show patient benefit.No experimental set-up can provide answers for all possible research questions. However, a certain transferability of the results to humans might be possible if the experimental set-up is carefully chosen for the aspects and questions being investigated. To enhance the implant survival rate in the rising number of patients with chronic diseases which compromise wound healing and osseointegration, dental implant research on compromised animal models will further gain importance in future.},
author = {von Wilmowsky, Cornelius and Moest, Tobias and Nkenke, Emeka and Stelzle, Florian and Schlegel, Andreas},
doi = {10.1007/s10006-013-0397-2},
faupublication = {yes},
journal = {Oral and maxillofacial surgery},
note = {EVALuna2:24335},
pages = {355-72},
peerreviewed = {Yes},
title = {{Implants} in bone: {Part} {II}. {Research} on implant osseointegration : {Material} testing, mechanical testing, imaging and histoanalytical methods},
volume = {18},
year = {2014}
}
@article{faucris.248715646,
abstract = {In our daily practice more and more patients show up who have received dental implants thirty or fourty years ahead. These patients are today related as "golden agers". At the same time in our days we can see that age related contraindications for implants are very liberal and no definite age limitation is valide any more. With some cases treated in the own office the reliability and problems of such aged patients should be highlighted. Also the question "quality of life" versus potential risks of these therapy options should be counterbalanced and at least when planning new implant borne rehablitations should be brought into consideration.},
author = {Schlegel, Karl Andreas and Schmitt, Christian and Möst, Tobias},
faupublication = {yes},
journal = {Implantologie},
month = {Jan},
note = {CRIS-Team WoS Importer:2021-02-05},
pages = {157-166},
peerreviewed = {Yes},
title = {{Implants} in the elderly patient},
volume = {28},
year = {2020}
}
@article{faucris.240985626,
abstract = {In our daily practice more and more patients show up who have received dental implants thirty or fourty years ahead. These patients are today related as "golden agers". At the same time in our days we can see that age related contraindications for implants are very liberal and no definite age limitation is valide any more. With some cases treated in the own office the reliability and problems of such aged patients should be highlighted. Also the question "quality of life" versus potential risks of these therapy options should be counterbalanced and at least when planning new implant borne rehablitations should be brought into consideration.},
author = {Schlegel, Karl Andreas and Schmitt, Christian and Möst, Tobias},
faupublication = {yes},
journal = {Implantologie},
keywords = {Age; Complications; Implants; Peri-implant mucositis; Peri-implantitis; Risk analysis},
note = {CRIS-Team Scopus Importer:2020-07-31},
pages = {157-166},
peerreviewed = {Yes},
title = {{Implants} in the elderly patient {Implantate} beim hochbetagten patienten-{Fluch} oder segen?! fallserie hochbetagter patienten},
volume = {28},
year = {2020}
}
@article{faucris.122666544,
abstract = {The aim of the study was to evaluate implant survival of reduced-diameter implants compared to regular-diameter implants. A retrospective evaluation of 154 Straumann Bone Level Roxolid(®) implants (diameter 3.3 mm) with SLActive(®)-surface in 107 patients, which were inserted between 2009 and 2010 in private practice, was performed. The mean observation period was 22.4 ± 8.2 months. 396 Straumann SLActive(®) implants (4.1 mm and 4.8 mm) in 204 patients, with an observation period of 28.4 ± 10.1 months served as control group. Implant survival rate, resonance frequency analysis and patient satisfaction were evaluated. The implant survival rate was 97.4% in the test vs. 98.5% in the control group. Resonance frequency analysis showed statistically significant lower values for the reduced-diameter implants. Patient satisfaction showed no significant difference between the test and the control group. Reduced-diameter implants displayed high survival rates during the period investigated and represent a convincing treatment alternative. Long-term follow-up investigations confirmed the high implant survival rates of 96.8% (after 69.7 ± 12.3 months) in the test group and 98.5% (after 76.0 ± 13.6 months) in the control group.},
author = {Herrmann, Jan and Hentschel, Andreas and Glauche, Ingmar and Vollmer, Armin and Schlegel, Karl Andreas and Lutz, Rainer},
doi = {10.1016/j.jcms.2016.09.007},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24429},
pages = {1940-1944},
peerreviewed = {Yes},
title = {{Implant} survival and patient satisfaction of reduced diameter implants made from a titanium-zirconium alloy: {A} retrospective cohort study with 550 implants in 311 patients},
volume = {44},
year = {2016}
}
@article{faucris.252124149,
abstract = {Background: The programmed cell death ligand 1/programmed cell death receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression of the receptor and its ligands is involved in immunosuppression and the failure of an immune response against tumor cells. PD-1/PD-L1 overexpression in oral squamous cell carcinoma (OSCC) compared to healthy oral mucosa (NOM) has already been demonstrated. However, little is known about its expression in oral precancerous lesions like oral leukoplakia (OLP). The aim of the study was to investigate whether an increased expression of PD-1/PD-L1 already exists in OLP and whether it is associated with malignant transformation. Material and Methods: PD-1 and PD-L1 expression was immunohistologically analyzed separately in the epithelium (E) and the subepithelium (S) of OLP that had undergone malignant transformation within 5 years (T-OLP), in OLP without malignant transformation (N-OLP), in corresponding OSCC and in NOM. Additionally, RT-qPCR analysis for PD-L1 expression was done in the entire tissues. Additionally, the association between overexpression and malignant transformation, dysplasia and inflammation were examined. Results: Compared to N-OLP, there were increased levels of PD-1 protein in the epithelial and subepithelial layers of T-OLP (PE = 0.001; PS = 0.005). There was no significant difference in PD-L1 mRNA expression between T-OLP and N-OLP (p = 0.128), but the fold-change increase between these groups was significant (Relative Quantification (RQ) = 3.1). In contrast to N-OLP, the PD-L1 protein levels were significantly increased in the epithelial layers of T-OLP (p = 0.007), but not in its subepithelial layers (p = 0.25). Importantly, increased PD-L1 levels were significantly associated to malignant transformation within 5 years. Conclusion: Increased levels of PD-1 and PD-L1 are related to malignant transformation in OLP and may represent a promising prognostic indicator to determine the risk of malignant progression of OLP. Increased PD-L1 levels might establish an immunosuppressive microenvironment, which could favor immune escape and thereby contribute to malignant transformation. Hence, checkpoint inhibitors could counteract tumor development in OLP and may serve as efficient therapeutic strategy in patients with high-risk precancerous lesions.},
author = {Ries, Jutta and Agaimy, Abbas and Wehrhan, Falk and Baran, Christoph and Bolze, Stella and Danzer, Eva and Frey, Silke and Jantsch, Jonathan and Möst, Tobias and Büttner-Herold, Maike and Wickenhauser, Claudia and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.3390/biomedicines9020194},
faupublication = {yes},
journal = {Biomedicines},
note = {CRIS-Team WoS Importer:2021-03-19},
peerreviewed = {Yes},
title = {{Importance} of the {PD}-1/{PD}-{L1} {Axis} for {Malignant} {Transformation} and {Risk} {Assessment} of {Oral} {Leukoplakia}},
volume = {9},
year = {2021}
}
@article{faucris.260273388,
abstract = {In this study, topology optimized, patient specific osteosynthesis plates (TOPOS-implants) are evaluated for the mandibular reconstruction using fibula segments. These shape optimized implants are compared to a standard treatment with miniplates (thickness: 1.0 mm, titanium grade 4) in biomechanical testing using human cadaveric specimen. Mandible and fibula of 21 body donors were used. Geometrical models were created based on automated segmentation of CT-scans of all specimens. All reconstructions, including cutting guides for osteotomy as well as TOPOS-implants, were planned using a custom-made software tool. The TOPOS-implants were produced by electron beam melting (thickness: 1.0 mm, titanium grade 5). The fibula-reconstructed mandibles were tested in static and dynamic testing in a multi-axial test system, which can adapt to the donor anatomy and apply side-specific loads. Static testing was used to confirm mechanical similarity between the reconstruction groups. Force-controlled dynamic testing was performed with a sinusoidal loading between 60 and 240 N (reconstructed side: 30% reduction to consider resected muscles) at 5 Hz for up to 5 · 105 cycles. There was a significant difference between the groups for dynamic testing: All TOPOS-implants stayed intact during all cycles, while miniplate failure occurred after 26.4% of the planned loading (1.32 · 105 ± 1.46 · 105 cycles). Bone fracture occurred in both groups (miniplates: n = 3, TOPOS-implants: n = 2). A correlation between bone failure and cortical bone thickness in mandible angle as well as the number of bicortical screws used was demonstrated. For both groups no screw failure was detected. In conclusion, the topology optimized, patient specific implants showed superior fatigue properties compared to miniplates in mandibular reconstruction. Additionally, the patient specific shape comes with intrinsic guiding properties to support the reconstruction process during surgery. This demonstrates that the combination of additive manufacturing and topology optimization can be beneficial for future maxillofacial surgery.},
author = {Lang, Jan J. and Bastian, Mirjam and Foehr, Peter and Seebach, Michael and Weitz, Jochen and Von Deimling, Constantin and Schwaiger, Benedikt J. and Micheler, Carina M. and Wilhelm, Nikolas J. and Grosse, Christian U. and Kesting, Marco Rainer and Burgkart, Rainer},
doi = {10.1371/journal.pone.0253002},
faupublication = {yes},
journal = {PLoS ONE},
note = {CRIS-Team Scopus Importer:2021-06-18},
peerreviewed = {Yes},
title = {{Improving} mandibular reconstruction by using topology optimization, patient specific design and additive manufacturing?-{A} biomechanical comparison against miniplates on human specimen},
volume = {16},
year = {2021}
}
@article{faucris.121930204,
abstract = {It is largely accepted that specific immunological parameters in solid malignancies are associated with patient's prognosis. Recently a correlation of macrophage polarization with histomorphological parameters could also be shown in oral squamous cell carcinoma (oscc). The observed tumor derived peripheral immune tolerance could be associated with the macrophage polarization in regional tumor draining lymph nodes.So far there are no studies analyzing the macrophage polarization in cervical lymph nodes of oscc patients. In the present study we aimed to correlate macrophage polarization in different anatomical lymph node compartments of patients diagnosed with oscc with histopathologic parameters of the primary tumor (T-, N-, L-, V-, Pn-status, grading).Tumor free (n = 37) and metastatic (n = 17) lymph nodes of T1 and T2 oscc patients were processed for immunohistochemistry to detect CD68, CD11c, CD163 and MRC1 positive cells. Samples were digitized using whole slide imaging and the number of cells expressing the aforementioned markers in the region of interest quantitatively analyzed.The malignancy of the primary tumor (defined by T-, L-, Pn-status, grading) correlated with the lymph node macrophage polarization. L1 and Pn1 tumor cases displayed a significantly (p < 0.05) decreased M1 and increased M2 polarization in the sinus of the lymph nodes. G3 cases presented a significantly (p < 0.05) increased M2 polarization in the sinus compared to G2 cases. T2 tumors had significantly (p < 0.05) increased M2 polarization in the interfollicular zone of regional lymph nodes compared to T1 tumors. Metastatic and non-metastatic lymph nodes did not differ regarding their macrophage polarization.The current study revealed for the first time an influence of oscc on the macrophage polarization in regional lymph nodes. Markers of malignant behavior in the primary tumor were associated with a shift of macrophage polarization in lymph nodes from the anti-tumoral M1 type to the tumor-promoting M2 type. As tumor free and metastatic lymph nodes did not differ in terms of their macrophage polarization pattern, there must be other factors influencing the location for lymph node metastasis formation.},
author = {Wehrhan, Falk and Buettner-Herold, Maike and Hyckel, Peter and Moebius, Patrick and Preidl, Raimund and Distel, Luitpold and Ries, Jutta and Amann, Kerstin Ute and Schmitt, Christian and Neukam, Friedrich Wilhelm and Weber, Manuel},
doi = {10.1186/1471-2407-14-522},
faupublication = {yes},
journal = {BMC Cancer},
note = {EVALuna2:18175},
pages = {522},
peerreviewed = {Yes},
title = {{Increased} malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes - an immunohistochemical study},
volume = {14},
year = {2014}
}
@article{faucris.293799858,
abstract = {Human labial glands consist of saliva-secreting cells which are formed by serous and predominantly mucous glandular cells. The following excretory duct system converts the isotonic saliva into a hypotonic fluid. Liquids are transported across the membrane of epithelial cells by paracellular or transcellular mode of action. We studied aquaporins (AQP) and tight junction proteins in the endpieces and duct system of human labial glands of 3–5-month-old infants for the first time. AQP1, AQP3, and AQP5 represent the transcellular transport; tight junction proteins like claudin-1, − 3, − 4, and − 7 regulate the permeability of the paracellular pathway. Specimens of 28 infants were included in this study and analyzed histologically. AQP1 was present in myoepithelial cells and in endothelial cells of small blood vessels. AQP3 showed basolateral plasmamembrane localization in glandular endpieces. AQP5 was localized at the apical cytomembrane in serous and mucous glandular cells and at the lateral membrane in serous cells. Ducts remained unstained with the antibody to AQP1, AQP3, and AQP5. Claudin-1, − 3, − 4, and − 7 were expressed mainly in the lateral plasmamembrane of serous glandular cells. In the ducts, claudin-1, − 4, and − 7 were detected at the basal cell layer, claudin-7 also at the lateral cytomembrane. Our findings provide new insights into the localization of epithelial barrier components necessary for regulating saliva-modification in infantile labial glands.},
author = {Stoeckelhuber, Mechthild and Grill, Florian D. and Wolff, Klaus Dietrich and Kesting, Marco Rainer and Wolff, Constantin T. and Fichter, Andreas M. and Loeffelbein, Denys J. and Schmitz, Christoph and Ritschl, Lucas M.},
doi = {10.1016/j.tice.2023.102052},
faupublication = {yes},
journal = {Tissue & Cell},
keywords = {Aquaporin; Claudin; Epithelial barriers; Human; Salivary gland},
note = {CRIS-Team Scopus Importer:2023-03-24},
peerreviewed = {Yes},
title = {{Infantile} human labial glands: {Distribution} of aquaporins and claudins in the context of paracellular and transcellular pathways},
volume = {82},
year = {2023}
}
@inproceedings{faucris.121427944,
abstract = {In this paper we examine the quality of the prediction of intelligibility scores of human experts. Furthermore, we investigate the differences between subjective expert raters who evaluated speech disorders of laryngectomees and children with cleft lip and palate. We use the recognition rate of a word recognizer and prosodic features to predict the intelligibility score of each individual expert. For each expert and the mean opinion of all experts we present the best features to model their scoring behavior according to the mean rank obtained during a 10-fold cross-validation. In this manner all individual speech experts were modeled with a correlation coefficient of at least r >.75. The mean opinion of all raters is predicted with a correlation of r =.90 for the laryngectomees and r =.86 for the children.},
address = {Berlin},
author = {Maier, Andreas and Haderlein, Tino and Schuster, Maria and Nkenke, Emeka and Nöth, Elmar},
booktitle = {Text, Speech and Dialogue},
date = {2007-09-03/2007-09-07},
editor = {Matousek Vaclav, Mautner Pavel},
faupublication = {yes},
month = {Jan},
pages = {278-285},
peerreviewed = {Yes},
publisher = {Springer},
title = {{Intelligibility} is more than a single word: {Quantification} of speech intelligibility by {ASR} and prosody},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2007/Maier07-IIM.pdf},
venue = {Pilsen},
year = {2007}
}
@inproceedings{faucris.120324424,
address = {Los Alamitos, California, Washington, Tokyo},
author = {Maier, Andreas and Hacker, Christian and Nöth, Elmar and Nkenke, Emeka and Haderlein, Tino and Rosanowski, Frank and Schuster, Maria},
booktitle = {The 18th International Conference on Pattern Recognition},
date = {2006-08-20/2006-08-24},
editor = {Tang Y.Y., Wang S.P., Lorette G., Yeung D.S., Yan H.},
faupublication = {yes},
pages = {274-277},
peerreviewed = {Yes},
publisher = {IEEE Computer Society},
title = {{Intelligibility} of {Children} with {Cleft} {Lip} and {Palate}: {Evaluation} by {Speech} {Recognition} {Techniques}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2006/Maier06-IOC.pdf},
venue = {Hong Kong},
year = {2006}
}
@inproceedings{faucris.120207604,
author = {Wittenberg, Thomas and Nkenke, Emeka and Hornegger, Joachim},
booktitle = {35th Jahrestagung der Gesellschaft fur Informatik e.V. (GI): Informatik LIVE!, INFORMATIK 2005 35th Annual Conference of the German Informatics Society (GI): Informatics LIVE!, INFORMATIK 2005},
faupublication = {yes},
pages = {681.0},
peerreviewed = {unknown},
title = {{Interdisciplinary} research! {Was} it worthwhile?},
url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-84877320097&origin=inward},
venue = {Bonn},
volume = {2},
year = {2005}
}
@article{faucris.265764898,
abstract = {Background: Systemic scleroderma (SSc) has multiple orofacial effects. The aim of this study was to analyze the expression of inflammatory mediators in biofilm samples. It was hypothesized that different expression levels and clinical associations might be drawn. Methods: A total of 39 biofilm samples from group 1 = SSc and group 2 = healthy control were examined for the expression levels of interleukin (IL)-2,-6, and-10; matrix metalloprotease (MMP)-9; and surface antigens CD90 and CD34 by quantitative real-time PCR and clinical parameters. Relative quantitative (RQ) gene expression was determined using the ∆∆CT method. Results: The mean bleeding on probing values (p = 0.006), clinical attachment loss (CAL) (p = 0.009), gingival recession (p = 0.020), limited mouth opening (p = 0.001) and cervical tooth defects (p = 0.011) were significantly higher in group 1. RQ expressions of IL-2 and CD34 were significantly lower, IL-6, MMP-9, and CD90 were significantly higher. There was a significant positive correlation of IL-6/MMP-9 and negative correlation of mouth opening/CAL and IL-6/CAL. Conclusion: Different expression levels of IL-2, IL-6, MMP-9, CD34 and CD90 were detected in biofilm samples from patients with SSc compared to control. An immunological correlation to the clinical parameters of mouth opening and CAL was shown; thus, we conclude that SSc might have an impact on periodontal tissues.},
author = {Buchbender, Mayte and Lugenbühl, Amelie and Fehlhofer, Jakob Paul and Kirschneck, Christian and Ries, Jutta and Lutz, Rainer and Sticherling, Michael and Kesting, Marco Rainer and Ries, Jutta},
doi = {10.3390/life11111145},
faupublication = {yes},
journal = {Life},
keywords = {Biofilm samples; Expression levels of cytokines; Periodontal parameters; Systemic sclero-derma (SSc)},
note = {CRIS-Team Scopus Importer:2021-11-05},
peerreviewed = {Yes},
title = {{Investigation} of the expression of inflammatory markers in oral biofilm samples in patients with systemic scleroderma and the association with clinical periodontal parameters— a preliminary study},
volume = {11},
year = {2021}
}
@article{faucris.111149104,
abstract = {Growing evidence suggests a correlation of alternative polarization of macrophages (M2) with a bad outcome of oral cancer. Macrophage polarization plays a significant role in the progression of hyperlipidemia and atherosclerosis, being influenced from plasma cholesterol. On the other hand plasma lipids have been studied epidemiologically as risk factors in carcinogenesis. Goal of our pilot study was the investigation of a possible association of plasma lipids with tumor outcome through their potential influence on macrophage polarization.17 patients with small pN0 OSCC with different clinical outcome, treated operatively without postoperative R(C)T constituted our patient collective. Plasma lipids (total cholesterol and triglycerides) were studied in relation to macrophage polarization (determined through the expression of CD68, CD11c, CD163 and MRC1 antibodies) and tumor outcome.Patients with pathological chronic course of either plasma cholesterol or triglycerides demonstrated an increased infiltration with alternatively polarized macrophages in their specimens. Patients with pathological chronic course of plasma cholesterol showed moreover a bad tumor outcome.A role of plasma lipids in the tumor outcome via alternative macrophage polarization could be assumed. A larger prospective study is needed to confirm our preliminary results.},
author = {Iliopoulos, Christos and Weber, Manuel and Mitsimponas, Konstantinos and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
doi = {10.1016/j.jcms.2015.11.001},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24403},
pages = {134-41},
peerreviewed = {Yes},
title = {{Investigation} of the interplay between plasma lipids and macrophage polarization in small oral squamous cell carcinomas with different outcome: {A} pilot study of 17 cases},
volume = {44},
year = {2016}
}
@article{faucris.281165679,
abstract = {BACKGROUND: In mucogingival and implant surgery, an autologous soft tissue graft from the palate is the gold standard for reconstructing missing keratinised soft tissue and volume. Previously, presurgical measurements of the graft harvesting site were described with two-dimensional (2D) linear measurements. The present observational clinical study aimed to evaluate a three-dimensional (3D) measurement method for determining the present palatal soft tissue volume for each patient individually. METHODS: Pre-existing cone beam computed tomography (CBCT) scans of 20 patients were converted into 3D Standard Tessellation Language models of the bone surface. Intraoral impressions of the maxilla were taken and digitised to visualise the gingival surface. The resulting virtual models of bone (reference value) and gingival (actual value) surfaces were merged, with tooth surfaces used for registration. The region between the central incisors and the hard palate was subdivided into 5 regions of interest (ROIs). The distance between palatal bone and gingival surface was analysed both volumetrically and linearly, and the results were statistically evaluated for the ROIs. RESULTS: The average gingival surface area on the palate was 19.1 cm2, and the mean volume was 58.2 cm3 (± 16.89). Among the ROIs, the mean linear value was highest in the most distal region, from the second molar to the hard palate (4.0 ± 1.09 mm) and lowest in the canine region (1.9 ± 0.63 mm). For mean distance, significant differences were found for the anterior palate and the most posterior palate in comparison with all other ROIs (p < 0.01). The volume measurements also declined significantly and steadily between the posterior (1.9 ± 1.0 cm3) and anterior palates (0.4 ± 0.2 cm3). CONCLUSIONS: By merging digital data, palatal soft tissue could be quantified virtually. The results were reliable and comparable to previous findings with linear measurement methods. This 3D soft tissue volume analysis method fully exploited the diagnostic potential of data that are frequently collected for presurgical planning in oral surgery (i.e., CBCT + surface scans). This evaluation method might be useful for volumetric and linear measurements in other applications in anatomy and for determining palatal soft tissue dimensions in the planning stage before surgical interventions. TRIAL REGISTRATION: This observational clinical trial was retrospectively registered in the German Clinical Trials Register, reference number: DRKS00023918.},
author = {Seidel, Anna and Schmitt, Christian and Matta, Ragai and Buchbender, Mayte and Wichmann, Manfred and Berger, Lara},
doi = {10.1186/s12903-022-02391-z},
faupublication = {yes},
journal = {BMC Oral Health},
keywords = {Cone-beam computed tomography; Connective tissue; Hard palate; Imaging; Maxilla; Oral surgical procedures; Reference values; Soft palate; Three-dimensional},
note = {CRIS-Team Scopus Importer:2022-09-02},
pages = {361-},
peerreviewed = {Yes},
title = {{Investigation} of the palatal soft tissue volume: a {3D} virtual analysis for digital workflows and presurgical planning},
volume = {22},
year = {2022}
}
@article{faucris.120266784,
abstract = {Layer-by-layer self-assembled films of molecular oligoelectrolytes were used to modify Ti-6Al-4V surfaces in order to test their ability as potential drug delivery system. With regard to medical application the in vitro behavior of the modified material was investigated. The Ti-6Al-4V (6% aluminium, 4% vanadium) material was treated in a layer-by-layer (LbL) process with 2, 4, 6 and 8 layers of molecular oligoelectrolytes 1 and 2 and thereby doped with a fluorescent reporter molecule 2. Human osteoblasts were cultured for a period up to 5 days on the modified material. Ti-6Al-4V surfaces without modification were used as control. In order to investigate the in vitro behavior of the coating as well as the influence of components of the coating on osteoblastic cells, respectively, cell proliferation, differentiation and attachment of hFOB cells were observed by means of cell number, osteoblastic gene expression and fluorescence microscopy. Degradation behavior of the OEM (oligoelectrolyte multilayer film) was examined using optical spectroscopy. Measurement data imply that the layer-by-layer coating was successfully assembled on the Ti surface and endures steam sterilization. The fluorescence signal in cell culture medium increased strictly linear with increasing pre-assembled number of layers on the surface. Proliferation rates of the cells in experimental groups did not differ significantly from each other (P ≥ 0.783). Differentiation pattern was not significantly changed by the coating. The fluorescent reporter component of the film was absorbed by osteoblastic cells and was detected by fluorescence microscopy. © 2009 Springer Science+Business Media, LLC.},
author = {Ponader, Sabine and Rosenlehner, Karin and Vairaktaris, Eleftherios and von Wilmowsky, Cornelius and Schlegel, Karl A. and Neukam, Friedrich Wilhelm and Schmidt, Cordula and Schunk, Torsten and Hirsch, Andreas and Nkenke, Emeka},
doi = {10.1007/s10856-009-3825-y},
faupublication = {yes},
journal = {Journal of Materials Science: Materials in Medicine},
pages = {2455-2463},
peerreviewed = {Yes},
title = {{In} vitro behavior of layer-by-layer deposited molecular oligoelectrolyte films on {Ti}-{6Al}-{4V} surfaces},
volume = {20},
year = {2009}
}
@article{faucris.211700181,
abstract = {With additive manufacturing (AM) individual and biocompatible implants can be generated by using suitable materials. The aim of this study was to investigate the biological effects of polylactic acid (PLA) manufactured by Fused Deposition Modeling (FDM) on osteoblasts in vitro according to European Norm / International Organization for Standardization 10,993-5.Human osteoblasts (hFOB 1.19) were seeded onto PLA samples produced by FDM and investigated for cell viability by fluorescence staining after 24 h. Cell proliferation was measured after 1, 3, 7 and 10 days by cell-counting and cell morphology was evaluated by scanning electron microscopy. For control, we used titanium samples and polystyrene (PS).Cell viability showed higher viability on PLA (95,3% ± 2.1%) than in control (91,7% ±2,7%). Cell proliferation was highest in the control group (polystyrene) and higher on PLA samples compared to the titanium samples. Scanning electron microscopy revealed homogenous covering of sample surface with regularly spread cells on PLA as well as on titanium.The manufacturing of PLA discs from polylactic acid using FDM was successful. The in vitro investigation with human fetal osteoblasts showed no cytotoxic effects. Furthermore, FDM does not seem to alter biocompatibility of PLA. Nonetheless osteoblasts showed reduced growth on PLA compared to the polystyrene control within the cell experiments. This could be attributed to surface roughness and possible release of residual monomers. Those influences could be investigated in further studies and thus lead to improvement in the additive manufacturing process. In addition, further research focused on the effect of PLA on bone growth should follow. In summary, PLA processed in Fused Deposition Modelling seems to be an attractive material and method for reconstructive surgery because of their biocompatibility and the possibility to produce individually shaped scaffolds.},
author = {Wurm, Matthias and Möst, Tobias and Bergauer, Bastian and Rietzel, Dominik and Neukam, Friedrich Wilhelm and Cifuentes, Sandra C. and von Wilmowsky, Cornelius},
doi = {10.1186/s13036-017-0073-4},
faupublication = {yes},
journal = {Journal of Biological Engineering},
note = {EVALuna2:24438},
pages = {29},
peerreviewed = {Yes},
title = {{In}-vitro evaluation of {Polylactic} acid ({PLA}) manufactured by fused deposition modeling},
volume = {11},
year = {2017}
}
@article{faucris.108524724,
abstract = {The overall aim of the study was to investigate a biofunctionalized implant surface with electrochemically deposition of hydroxyapatite and the synthetic peptide (P-15) and its effect on osseointegration.Three modified implant types of ANKYLOS(®) C/X implants were used; (1) machined implants used as negative control (M, n = 20), (2) implants with the FRIADENT(®) plus surface (grit blasted and acid-etched) used as positive control (P, n = 20), and (3) implants with a biomimetic surface consisting of hydroxyapatite and the synthetic 15 aminoacids containing peptide P-15 (BP, n = 40). The implants were randomly inserted in the mandibles of 10 beagle dogs following 4 months after tooth extraction (P1-P4). Three animals were sacrificed 2 and 7 days after implant insertion, respectively, and four animals were sacrificed 6 months post implant insertion. Bone-to-implant contacts (BICs) were analyzed via histomorphometrical analyses at five different region of interests (ROIs); two at the middle part on either side of the implant (ROI 1/4), two at the apical part of the implant at each side (ROI 2/3), and one at the tip of the implant (ROI 5).All implant surfaces showed a high level of osseointegration and osteoconductivity. The cumulative implant survival rate (CSR) was 93.8%, 100% in the M, 85% in the P, and 95% in the BP group. No statistical difference in BICs at ROI 1/4, 2/3, and 5 could be shown between implant types following 2 and 7 days of healing. BIC values increased in all groups over time. After 6 months of healing the BP group showed superiority in BIC in ROI 2/3 (73.2 ± 15.6%) compared to the P (48.3 ± 10.6%) and M group (66.3 ± 30.2%) with a significant difference between BP and P (P = 0.002).It is hypothesized, that the surface biofunctionalization improves peri-implant bone formation and remodeling, leading to an increased bone-to implant contact. However, within the limitations of the study set-up no benefit in the early phase of osseointegration could be established for dental implants with P-15 containing surface in this study.},
author = {Schmitt, Christian and Köpple, Markus and Moest, Tobias and Neumann, Konrad and Weisel, Tamara and Schlegel, Karl Andreas},
doi = {10.1111/clr.12723},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24427},
pages = {1339-1348},
peerreviewed = {Yes},
title = {{In} vivo evaluation of biofunctionalized implant surfaces with a synthetic peptide ({P}-15) and its impact on osseointegration. {A} preclinical animal study},
volume = {27},
year = {2016}
}
@article{faucris.288035746,
abstract = {The aim of this study was to produce an individually shaped medical implant from a 3D database and to evaluate the biological behavior of a laser sintered poly(ether ether ketone) (PEEK) implant with incorporated osteoconductive bone materials in porcine bone defects. Laser sintered PEEK samples containing ß-tricalciumphosphate (ß-TCP) were implanted into critical size defects in the frontal skull of ten pigs. Compression moulded pure PEEK was used as a reference material. The bone-implant interface was histomorphometrically analysed after 6, 12, and 24 weeks. Histomorphometrical evaluations after 24 weeks revealed that the superficially located ß-TCP was in contact with the surrounding bone, whereas the other groups were fibrous encapsulated. Interfacial shear strength was significantly higher for the ß-TCP containing group in comparison to the compression moulded PEEK group (p = 0.004) and the laser sintered PEEK group. The laser sintered PEEK implants seem to be attractive as bone substitutes for reconstructive surgery due to their individually constructed 3D shape and biocompatibility. © 2009 SAGE Publications.},
author = {von Wilmowsky, Cornelius and Lutz, Rainer and Meisel, Ulf and Srour, Safwan and Rupprecht, Stephan and Toyoshima, Takeshi and Nkenke, Emeka and Schlegel, Karl Andreas and Pohle, Dirk and Münstedt, Helmut and Rechtenwald, Thomas and Schmidt, Michael},
doi = {10.1177/0883911508101149},
faupublication = {yes},
journal = {Journal of Bioactive and Compatible Polymers},
keywords = {ß-TCP; 3D shaped implants; Bone reconstruction.; Bone substitution; In vivo; Individually shaped implants; Laser sintering; Poly(ether ether ketone) (PEEK); Sintered PEEK biocompatibility; Tissue engineering},
note = {Created from Fastlane, Scopus look-up},
pages = {169-184},
peerreviewed = {Yes},
title = {{In} vivo evaluation of {B}-{TCP} containing {3D} laser sintered poly(ether ether ketone) composites in pigs},
volume = {24},
year = {2009}
}
@article{faucris.286904453,
abstract = {Objectives. Laser surgery requires feedback to avoid the accidental destruction of critically important tissues. It was the aim of the authors to identify different tissue types in vivo by diffuse reflectance spectroscopy to set the basis for tissue-specific control of laser surgery. Methods. Tissue differentiation was performed on in vivo tissue of rats (skin, fat, muscle, and nerve) by diffuse reflectance spectroscopy between 350 and 650 nm. Data analysis was done using principal components analysis, followed by linear discriminant analysis (LDA). The differentiation performance was evaluated by receiver operating characteristic (ROC) analysis. Results. ROC analysis showed a tissue differentiation of 100%, with a high sensitivity of more than 99%. Only the tissue pair skin/fat showed a reduced differentiation performance and specificity. Conclusion. The results show the general viability of in vivo optical tissue differentiation and create a basis for the further development of a control system for tissue-specific laser surgery. © 2012 The Author(s).},
author = {Stelzle, Florian and Adler, Werner and Zam, Azhar and Knipfer, Christian and Douplik, Alexandre and Schmidt, Michael and Nkenke, Emeka and Tangermann-Gerk, Katja},
doi = {10.1177/1553350611429692},
faupublication = {yes},
journal = {Surgical Innovation},
keywords = {diffuse reflectance; optical tissue differentiation; principal components analysis; remote optical measurement; remote surgical methods; spectra analysis},
note = {Created from Fastlane, Scopus look-up},
pages = {385-393},
peerreviewed = {Yes},
title = {{In} vivo optical tissue differentiation by diffuse reflectance spectroscopy: {Preliminary} results for tissue-specific laser surgery},
volume = {19},
year = {2012}
}
@article{faucris.108344324,
abstract = {Highly porous titanium structures are widely used for maxillofacial and orthopedic surgery because of their excellent mechanical properties similar to those of human bone and their facilitation of bone ingrowth. In contrast to common methods, the generation of porous titanium products by selective electron beam melting (SEBM), an additive manufacturing technology, overcomes difficulties concerning the extreme chemical affinity of liquid titanium to atmospheric gases which consequently leads to strongly reduced ductility of the metal. The purpose of this study was to assess the suitability of a smooth compact and a porous Ti-6Al-4V structure directly produced by the SEBM process as scaffolds for bone formation. SEBM-processed titanium implants were placed into defects in the frontal skull of 15 domestic pigs. To evaluate the direct contact between bone and implant surfaces and to assess the ingrowth of osseous tissue into the porous structure, microradiographs and histomorphometric analyses were performed 14, 30, and 60 days after surgery. Bone ingrowth increased significantly during the period of this study. After 14 days the most outer regions of the implants were already filled with newly formed bone tissue (around 14%). After 30 days the bone volume inside the implants reached almost 30% and after 60 days abundant bone formation inside the implants attained 46%. During the study only scarce bone-implant contact was found around all implants, which did not exceed 9% around compact specimens and 6% around porous specimens after 60 days. This work demonstrates that highly porous titanium implants with excellent interconnectivity manufactured using the SEBM method are suitable scaffolds for bone ingrowth. This technique is a good candidate for orthopedic and maxillofacial applications. © 2009 Wiley Periodicals, Inc.},
author = {Ponader, Sabine and von Wilmowsky, Cornelius and Widenmayer, Martin and Lutz, Rainer and Heinl, Peter and Körner, Carolin and Singer, Robert and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Schlegel, Karl},
doi = {10.1002/jbm.a.32337},
faupublication = {yes},
journal = {Journal of Biomedical Materials Research Part A},
keywords = {Bone ingrowth; Bone regeneration; Porous structures; Selective electron beam melting (SEBM); Titanium alloys},
pages = {56-62},
peerreviewed = {Yes},
title = {{In} vivo performance of selective electron beam-melted {Ti}-{6Al}-{4V} structures},
volume = {92},
year = {2010}
}
@inproceedings{faucris.288032605,
abstract = {Remote laser surgery does not provide haptic feedback to operate layer by layer and preserve vulnerable anatomical structures like nerve tissue or blood vessels. The aim of this study is identification of soft tissue in vivo by diffuse reflectance spectroscopy to set the base for a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery. Various soft tissues can be identified by diffuse reflectance spectroscopy in vivo. The results may set the base for a feedback system to prevent nerve damage during oral and maxillofacial laser surgery. © 2010 Published by Elsevier B.V.},
author = {Zam, Azhar and Stelzle, Florian and Adler, Werner and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Schmidt, Michael and Douplik, Alexandre and Tangermann-Gerk, Katja},
booktitle = {Physics Procedia},
doi = {10.1016/j.phpro.2010.08.095},
faupublication = {yes},
keywords = {Diffuse reflectance; Feedback system; In vivo; Linear discriminant analysis; Soft tissue; Tissue differentiation},
note = {Created from Fastlane, Scopus look-up},
pages = {655-658},
peerreviewed = {unknown},
publisher = {Elsevier B.V.},
title = {{In} vivo soft tissue differentiation by diffuse reflectance spectroscopy: {Preliminary} results},
volume = {5},
year = {2010}
}
@article{faucris.121799524,
abstract = {The significance of keratinized mucosa (KM) around dental implants is still not well explained and has been controversial. The aim of this systematic review was to evaluate the importance of KM around dental implants. The electronic databases Cochrane library, MEDLINE, EMBASE, and Virtual Health Library (VHL) databases were utilized to search original articles from 2006 to March 2013. The inclusion and exclusion criteria used to select the articles were: (1) Human studies published in the English language; (2) Study published in international peer-viewed journals; (3) Studies evaluated the association between KM width and the peri-implant tissue health; (4) Studies that have follow up of greater than 12 months; (5) Publication of studies not older than 10 years. The searches retrieved 285 citations. Seven articles fulfilled all of the inclusion criteria. Out of these, three studies were ranked as presenting high methodological quality, and four were judged to be of moderate quality. This systematic review concludes that the presence of an adequate zone of keratinized tissue may be necessary because it was shown to be related to better peri-implant tissue health. Further randomized controlled trials are necessary to support this statement. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 643-650, 2014.},
author = {Brito, Carlos and Tenenbaum, Howard C. and Wong, Benjamin K. C. and Schmitt, Christian and Nogueira-Filho, Getulio},
doi = {10.1002/jbm.b.33042},
faupublication = {yes},
journal = {Journal of Biomedical Materials Research Part B-Applied Biomaterials},
note = {EVALuna2:24315},
pages = {643-50},
peerreviewed = {Yes},
title = {{Is} keratinized mucosa indispensable to maintain peri-implant health? {A} systematic review of the literature},
volume = {102},
year = {2014}
}
@article{faucris.219404846,
abstract = {Purpose: The aim of this retrospective study was to evaluate the clinical outcome of a previously defined low-risk patient population with completely resected (R0) squamous cell carcinoma of the oral cavity, oropharynx, larynx (pT1–3, pN0–pN2b), hypopharynx (pT1–2, pN0–pN1), and the indication for postoperative radio(chemo)therapy. Patients and methods: According to predefined criteria, 99 patients with head and neck squamous cell carcinoma (SCC) who were treated at our institution from January 1, 2005 to December 31, 2014, were available for analysis. The Kaplan–Meier method was used for calculating survival and incidence rates. For univariate comparative analysis, the log-rank test was used for analyzing prognostic clinicopathologic parameters. Results: Median follow-up was 67 months. Cumulative overall (OS) and disease-free survival (DFS) were 97.9%/94.7%/88.0% and 96.9%/92.6%/84.7% after 1, 2, and 5 years, respectively. Cumulative incidence of loco-regional recurrence (LRR), distant metastases (DM), and second cancer (SC) were 1.0%/1.0%/4.9%, 0.0%/3.4%/5.8%, and 2.1%/4.2%/13.1%, respectively. In univariate comparative analysis, location of the primary tumor in the oropharynx was a significant predictor for increased OS (p = 0.043) and DFS (p = 0.048). Conclusion: Considering the low disease relapse rates and high rates of therapy-induced late side effects, as well as the increased risk of developing SC, a prospective multicentric trial investigating de-escalation of radiotherapy in this clearly defined low-risk patient population was started and is still recruiting patients (DIREKHT-Trial, NCT02528955).},
author = {Onbasi, Yonca and Lettmaier, Sebastian and Hecht, Markus and Semrau, Sabine and Iro, Heinrich and Kesting, Marco Rainer and Fietkau, Rainer and Haderlein, Marlen},
doi = {10.1007/s00066-018-1415-y},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
keywords = {Disease-free survival; Late side effect; Overall survival; Radio(chemo)therapy; Second cancer},
note = {CRIS-Team Scopus Importer:2019-06-04},
pages = {482-495},
peerreviewed = {Yes},
title = {{Is} there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy?},
volume = {195},
year = {2019}
}
@article{faucris.220842220,
abstract = {PURPOSE: The aim of this retrospective study was to evaluate the clinical outcome of a previously defined low-risk patient population with completely resected (R0) squamous cell carcinoma of the oral cavity, oropharynx, larynx (pT1-3, pN0-pN2b), hypopharynx (pT1-2, pN0-pN1), and the indication for postoperative radio(chemo)therapy.
PATIENTS AND METHODS: According to predefined criteria, 99 patients with head and neck squamous cell carcinoma (SCC) who were treated at our institution from January 1, 2005 to December 31, 2014, were available for analysis. The Kaplan-Meier method was used for calculating survival and incidence rates. For univariate comparative analysis, the log-rank test was used for analyzing prognostic clinicopathologic parameters.
RESULTS: Median follow-up was 67 months. Cumulative overall (OS) and disease-free survival (DFS) were 97.9%/94.7%/88.0% and 96.9%/92.6%/84.7% after 1, 2, and 5 years, respectively. Cumulative incidence of loco-regional recurrence (LRR), distant metastases (DM), and second cancer (SC) were 1.0%/1.0%/4.9%, 0.0%/3.4%/5.8%, and 2.1%/4.2%/13.1%, respectively. In univariate comparative analysis, location of the primary tumor in the oropharynx was a significant predictor for increased OS (p = 0.043) and DFS (p = 0.048).
CONCLUSION: Considering the low disease relapse rates and high rates of therapy-induced late side effects, as well as the increased risk of developing SC, a prospective multicentric trial investigating de-escalation of radiotherapy in this clearly defined low-risk patient population was started and is still recruiting patients (DIREKHT-Trial, NCT02528955).},
author = {Onbasi, Yonca and Lettmaier, Sebastian and Hecht, Markus and Semrau, Sabine and Iro, Heinrich and Kesting, Marco Rainer and Fietkau, Rainer and Haderlein, Marlen},
doi = {10.1007/s00066-018-1415-y},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
note = {EVALuna2:184476},
pages = {482-495},
peerreviewed = {Yes},
title = {{Is} there a patient population with squamous cell carcinoma of the head and neck region who might benefit from de-intensification of postoperative radiotherapy?},
volume = {195},
year = {2019}
}
@article{faucris.250567701,
abstract = {Computer-aided simulations have long been of great importance in university teaching; however, to date, there is limited use of such simulations in the dental surgical sector. For this purpose, an oral surgery simulator, “Kobra”, was implemented in student training and was evaluated for dental education. Dental students (group 1, third-year and group 2, fourth-year) and dentists of the faculty (control group) were trained to use the simulator. The outcomes for group 1 (apicoectomy of an upper lateral incisor with Kobra), group 2 (removal of an impacted lower wisdom tooth with Kobra) and the control group (both procedures with Kobra) were evaluated. For evaluation purposes, subjective parameters (improvement of practical skills, comparison between conventional training and Kobra simulation, and implementation of simulation-based teaching) and objective parameters (removal of bone, tooth substance and soft tissue measured while performing the Kobra simulation) were assessed using questionnaires with a scale ranging from 1–5. A total of 49 students (third-year n = 29, with 22 women and 7 men; fourth-year n = 20, with 17 women and 3 men) and 10 dentists (women n = 5 and men n = 5) participated. Compared to the Kobra simulation, the conventional training method with plastic models was still favored (the difference was non-significant). Compared to the dentists, the simulation data showed a less precise surgical performance of the students (the difference was not significant). The Kobra simulation may offer an additional method to conventional surgery training using plastic models, with benefits for students and faculty staff.},
author = {Buchbender, Mayte and Maser, Mathias and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Attia, Sameh and Schmitt, Christian},
doi = {10.3390/ijerph18041827},
faupublication = {yes},
journal = {International Journal of Environmental Research and Public Health},
keywords = {Coronavirus; COVID-19; Oral surgery; Surgery simulator; Surgical skills},
note = {CRIS-Team Scopus Importer:2021-02-26},
pages = {1-11},
peerreviewed = {Yes},
title = {{Kobra} surgery simulator—a possibility to improve digital teaching? {A} case-control study},
volume = {18},
year = {2021}
}
@article{faucris.117942704,
abstract = {The goal was to investigate whether the three-dimensional (3D) reliability of the landmarks defining the Frankfort horizontal plane (FH) can be enhanced by reducing variance with the help of nearby anatomical structures.Twenty multislice computed tomography (MSCT) datasets of evidently symmetrical patients (11 female and 9 male patients, 6.1-16 years old) were selected from 695 datasets archived at our department. In the 3D reconstructions, we located the anthropometric landmarks orbitale and porion, then these were modified with the help of frontomalare temporale, radiculare and the most anterior border of the left and right external acoustic pore. The resultant orbitale* and porion* reference points for the Frankfort horizontal plane were then compared to the original landmarks. Statistical analysis was performed.The superior reliability in the sagittal y-axis and in the transversal x-axis of the new reference points was confirmed. Based on the covariance matrices, the mean maximum standard deviation (square root of the maximum eigenvalue) in the direction of maximum variance was reduced from 0.77/0.94 mm to 0.47/0.48 mm for left/right orbitale, and similar reductions from 0.85/0.92 mm to 0.29/0.30 mm were noted for left/right porion (p < 0.001 for all four points). Vertical reliability did not improve further.The modifications significantly reduced the variance of the orbitale and porion landmarks, thus, clearly increasing the three-dimensional reliability. Hence these optimized reference points are better suited to construct the FH, which arguably is an important spatial reference plane in orthodontics.},
author = {Hofmann, Elisabeth and Fimmers, Rolf and Schmid, Matthias and Hirschfelder, Ursula and Detterbeck, Andreas and Hertrich, Klaus},
doi = {10.1007/s00056-016-0045-1},
faupublication = {yes},
journal = {Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie},
note = {EVALuna2:24852},
pages = {373-83},
peerreviewed = {Yes},
title = {{Landmarks} of the {Frankfort} horizontal plane : {Reliability} in a three-dimensional {Cartesian} coordinate system},
volume = {77},
year = {2016}
}
@article{faucris.124035824,
author = {Nkenke, Emeka},
doi = {10.1016/j.joms.2013.09.018},
faupublication = {yes},
journal = {Journal of Oral and Maxillofacial Surgery},
note = {EVALuna2:24364},
pages = {4},
peerreviewed = {Yes},
title = {{Letter} to the editor},
volume = {72},
year = {2014}
}
@article{faucris.251772618,
abstract = {Expression of signaling proteins in bone cells depends on their embryological mesoderm-derived (e.g. tibia) or cranial neural crest (CNC)-derived (e.g. jaw) origin. Connexin 43 (Cx43) is a gap junction protein that plays an essential role in the mode of action of bisphosphonates (BP). This study aimed to investigate Cx43 expression and the influence of BP application on mesoderm- and CNC-derived bone. Using a rat model, molar extraction and tibia osteotomy with (Group 4) or without (Group 3) previous BP application was performed. Untreated (Group 1) and animals selectively treated with BPs (Group 2) served as controls. Cx43 expression was immunohistochemically determined 12 and 16 weeks postoperatively via a labeling index. Cx43 expression in CNC-derived bone was significantly higher compared with mesodermal bone. BP application decreased Cx43 expression; however, detected expression levels were still higher in jawbone (Group 2 tibia vs jaw: 5.83 ± 5.06 vs 23.52 ± 6.42; p = 0.007). During bone healing after surgical intervention (Group 3) there were no expression differences between tibia and jawbone. BP treatment prior to surgery resulted in significantly lower Cx43 expression in CNC-derived compared with tibia bone (Group 4 tibia vs jaw: 56.84 ± 15.57 vs 16.40 ± 5.66; p < 0.01). Increased Cx43 expression in jaw compared with tibia bone is in line with their embryological origins. A significant Cx43 suppression in jawbone after BP application and surgery might contribute to the selectively altered osseous turnover and development of MRONJ in CNC-derived bone.},
author = {Preidl, Raimund and Amann, Kerstin Ute and Weber, Manuel and Schiller, Martin and Ringler, Manuela and Ries, Jutta and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Geppert, Carol-Immanuel and Wehrhan, Falk},
doi = {10.1016/j.jcms.2021.02.010},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
keywords = {Bisphosphonate; Jawbone; Medication-related osteonecrosis of the jaw (MRONJ)},
note = {CRIS-Team Scopus Importer:2021-03-12},
peerreviewed = {Yes},
title = {{Lineage}-associated connexin 43 expression in bisphosphonate-exposed rat bones},
year = {2021}
}
@article{faucris.211796216,
abstract = {BACKGROUND: Local anesthesia is an important skill and a prerequisite for most dental treatments. However, the step from theory to application on the patient is huge for the novice. Hence, a mannequin training model course was developed and implemented into the existing local anesthesia curriculum in undergraduate dental students. It was the aim of this study to evaluate the relation between training-model and real-life anesthesia performance and to measure whether a gain in skill on the model translates to the actual patient situation.
METHODS: Thirty-six third-year students (14 males, 22 females, age 24 years±2.98) attended the four-day course comprising each 4 h of lectures and practical training. The student cohort gave subjective ratings about the didactical components of the course after attendance by using the TRIL questionnaire (TRIL-mod; University of Trier). At the end of the course the performance of each student in administering an inferior alveolar nerve (IAN) block on the training model as well as on a fellow dental student was investigated using a standardized checklist. To evaluate the successful performance, the in vivo IAN-block was assessed using subjective patient-feeling, the sharp-blunt test and an objective pain- and thermal sensitivity tester (PATH).
RESULTS: The course was rated with an average score of 5.25 ± 0.44 (range 1-6; 6 = best). On the training model, 69.4% of the students successfully performed an IAN-block. The in vivo assessment, objectified by the PATH test, showed a successful anesthesia in 36.9% of the cases. The assessment of local anesthesia by using the sharp blunt test and the subjective patient feeling significantly correlated with these findings (k = 0.453-0.751, p < 0.05). The model performance did not correlate with the performance on the patient (k = 0.137, p = 0.198).
CONCLUSIONS: Although subjective ratings of the course were high, the anesthesia success rate on mannequin models did not imply an equal performance on the in vivo setting. As local anesthesia training models are a valuable didactic complement, the focus of the training should be on to the actual real life situation. Chair side feedback should be offered to the students using one of the presented evaluation methods.},
author = {Knipfer, Christian and Rohde, Maximilian and Oetter, Nicolai and Muench, Tim and Kesting, Marco Rainer and Stelzle, Florian},
doi = {10.1186/s12909-018-1389-6},
faupublication = {yes},
journal = {Bmc Medical Education},
note = {EVALuna2:35693},
peerreviewed = {Yes},
title = {{Local} anaesthesia training for undergraduate students - how big is the step from model to man?},
volume = {18},
year = {2018}
}
@article{faucris.121637384,
abstract = {This investigation focused on long-term changes in graft height, implant survival rate, and peri-implant tissue conditions of dental implants placed in alveolar ridges after augmentation procedures with a follow-up of 10 years.We conducted a retrospective cohort study with prospective long-term follow-up of 25 patients with edentulous severe atrophic maxillary situations who received a vertical augmentation procedure with autologous bone prior to implant placement. The participants were divided into three groups according to whether they underwent sinus elevation, onlay grafting, or a combination of both techniques. After a four-month healing period, 127 implants were inserted in the corresponding regions. Following a six-month healing period, the participants underwent prosthodontic rehabilitation, incorporating a fixed or removable implant denture. The cohort was clinically and radiographically followed up 1, 5, and 10 years after augmentation. The following parameters were measured: radiographic vertical bone changes, implant loss, peri-implant pocket depth (PD), width of keratinized mucosa (KM), sulcus fluid flow rate (SFFR), and the radiographic distance between the implant shoulder and the first visible bone-to-implant contact (DIB).Seven implants were lost during the observation period, resulting in a cumulative 10-year survival rate of 94.48%. Significant bone loss occurred during the first 12 months, after which the resorption slowed down and bone height eventually stabilized. After 10 years, the total vertical bone loss was 27.51% after onlay grafting, 28.14% after sinus elevation, and 30.24% in the combination group, with no statistically significant between-group differences. Peri-implant follow-up examinations revealed a positive correlation between SFFR and PD, respectively, DIB, and a negative correlation between SFFR and KM.The treatment method does not seem to impact vertical bone loss following augmentation using autologous grafts. This approach results in long-term stability of dental implants. A sufficient width of keratinized peri-implant mucosa is important to prevent peri-implant bone loss and inflammation.},
author = {Schmitt, Christian and Karasholi, Tarek and Lutz, Rainer and Wiltfang, Joerg and Neukam, Friedrich Wilhelm and Schlegel, Karl Andreas},
doi = {10.1111/clr.12045},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24344},
pages = {e38-46},
peerreviewed = {Yes},
title = {{Long}-term changes in graft height after maxillary sinus augmentation, onlay bone grafting, and combination of both techniques: a long-term retrospective cohort study},
volume = {25},
year = {2014}
}
@article{faucris.210677739,
abstract = {BACKGROUND: Microvascular free flap reconstruction has become a standard technique in head and neck reconstructive surgery. Pre-operative radiotherapy is associated with a higher incidence of free flap malperfusion and the need for operative revision. Irradiated vessels present characteristic histomorphological and structural changes. Alterations in endothelial cells of irradiated arteries remain incompletely investigated especially with regard to long-term changes in endothelial dysfunction supporting an intraluminal pro-thrombotic and pro-inflammatory milieu.
METHODS: Endothelial expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E‑ and P‑selectin, endothelial NO-synthase (eNOS), thrombomodulin and plasminogen activator inhibitor-1 (PAI-1) in irradiated and non-irradiated arteries was analysed using immunohistochemistry and Remmele scale grading. The average radiation dose was 58.7 ± 7.0 Gy; the time interval between end of radiation and tissue sampling was 106.0 ± 86.8 months.
RESULTS: Endothelial expression of ICAM-1, VCAM-1, E‑ and P‑selectin as well as PAI-1 was significantly increased in previously irradiated arteries compared with non-irradiated controls, whereas thrombomodulin and eNOS expression did not show any differences. However, when comparing non-irradiated free flap arteries with irradiated arteries from the head and neck area in respective individuals, eNOS expression was significantly lower in irradiated vessels whereas ICAM-1, VCAM-1, E‑/p-Selectin and PAI-1 showed significantly higher expression levels.
CONCLUSION: There is ongoing endothelial dysfunction in terms of increased expression of pro-thrombotic and pro-inflammatory markers in irradiated arteries even years after radiotherapy. Treating this endothelial dysfunction might reduce the complication rates associated with microvascular free flap reconstructions in irradiated patients.},
author = {Preidl, Raimund and Möbius, Patrick and Weber, Manuel and Amann, Kerstin Ute and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Geppert, Carol-Immanuel and Wehrhan, Falk},
doi = {10.1007/s00066-018-1382-3},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
note = {EVALuna2:35426},
pages = {52-61},
peerreviewed = {Yes},
title = {{Long}-term endothelial dysfunction in irradiated vessels: an immunohistochemical analysis},
volume = {195},
year = {2019}
}
@article{faucris.216891192,
abstract = {Background: Microvascular free flap reconstruction has become a standard technique in head and neck reconstructive surgery. Pre-operative radiotherapy is associated with a higher incidence of free flap malperfusion and the need for operative revision. Irradiated vessels present characteristic histomorphological and structural changes. Alterations in endothelial cells of irradiated arteries remain incompletely investigated especially with regard to long-term changes in endothelial dysfunction supporting an intraluminal pro-thrombotic and pro-inflammatory milieu. Methods: Endothelial expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E‑ and P‑selectin, endothelial NO-synthase (eNOS), thrombomodulin and plasminogen activator inhibitor-1 (PAI-1) in irradiated and non-irradiated arteries was analysed using immunohistochemistry and Remmele scale grading. The average radiation dose was 58.7 ± 7.0 Gy; the time interval between end of radiation and tissue sampling was 106.0 ± 86.8 months. Results: Endothelial expression of ICAM-1, VCAM-1, E‑ and P‑selectin as well as PAI-1 was significantly increased in previously irradiated arteries compared with non-irradiated controls, whereas thrombomodulin and eNOS expression did not show any differences. However, when comparing non-irradiated free flap arteries with irradiated arteries from the head and neck area in respective individuals, eNOS expression was significantly lower in irradiated vessels whereas ICAM-1, VCAM-1, E‑/p-Selectin and PAI-1 showed significantly higher expression levels. Conclusion: There is ongoing endothelial dysfunction in terms of increased expression of pro-thrombotic and pro-inflammatory markers in irradiated arteries even years after radiotherapy. Treating this endothelial dysfunction might reduce the complication rates associated with microvascular free flap reconstructions in irradiated patients.},
author = {Preidl, Raimund and Möbius, Patrick and Weber, Manuel and Amann, Kerstin Ute and Neukam, Friedrich Wilhelm and Kesting, Marco Rainer and Geppert, Carol-Immanuel and Wehrhan, Falk},
doi = {10.1007/s00066-018-1382-3},
faupublication = {yes},
journal = {Strahlentherapie und Onkologie},
keywords = {Endothelial dysfunction; Free tissue flaps; Radiation dosage; Radiotherapy; Reconstructive surgery},
month = {Jan},
note = {CRIS-Team Scopus Importer:2019-05-03},
pages = {52-61},
peerreviewed = {Yes},
title = {{Long}-term endothelial dysfunction in irradiated vessels: an immunohistochemical analysis {Langzeit}-{Endothelfunktionsstörung} in bestrahlten {Gefäßen}: immunhistochemische {Analyse}},
volume = {195},
year = {2019}
}
@article{faucris.236252036,
abstract = {The atrophic maxilla often requires bone augmentation before implant placement to ensure long-term implant success. A previous prospective clinical trial examined the use of platelet-rich plasma (PRP) during maxillary augmentation. The short-term results showed no positive effect of PRP. The aim of this study was to evaluate the same patient collective of the previous study regarding the PRP long-term impact on the survival and success of dental implants. Fifty-three patients from the previous study diagnosed with maxillary atrophy and augmented with autologous bone grafts from the iliac crest and dental implants, were included in this study. Treatment was carried out on both sides in 34 patients with a split-mouth-design in which one randomly chosen side was treated additionally with PRP, the other side was the control-side. Nineteen patients were treated only on one side and were assigned to the PRP-or the control group randomly. Implant follow-up of the patients from the previous study was performed after an average time of 13 years. Implant success was evaluated using two different success criteria. Thitry-seven patients (25 women and 12 men) were investigated in this study. Seventeen patients (12 female, 5 male) were included in the PRP group, while 20 patients (13 female, 7 male) participated in the control group. A total of 210 implants were inserted. Of these, 102 implants (48.57%) were placed in the PRP group and 108 implants (51.42%) in the control group. Out of 102 investigated implants in the PRP group, 6 were removed (survival rate 94.1%). While two of the 108 implants in the control group were loss (survival rate 98.1%). In the PRP group, the cumulative probability of survival after 15.1 years was 94.1% and in the control group, was 98.1%, with no significant difference between the two groups. Higher significant difference for the control group was found in the cumulative success probability using Albrektson criteria (p = 0.05). Positive impact of PRP on long-term implant survival and success could not be found.},
author = {Attia, Sameh and Narberhaus, Clara and Schaaf, Heidrun and Streckbein, Philipp and Pons-Kuehnemann, Joern and Schmitt, Christian and Neukam, Friedrich Wilhelm and Howaldt, Hans-Peter and Boettger, Sebastian},
doi = {10.3390/jcm9020391},
faupublication = {yes},
journal = {Journal of Clinical Medicine},
note = {CRIS-Team WoS Importer:2020-03-24},
peerreviewed = {Yes},
title = {{Long}-{Term} {Influence} of {Platelet}-{Rich} {Plasma} ({PRP}) on {Dental} {Implants} after {Maxillary} {Augmentation}: {Implant} {Survival} and {Success} {Rates}},
volume = {9},
year = {2020}
}
@article{faucris.236251789,
abstract = {The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated with platelet-rich plasma (PRP) has not been well addressed in the literature yet. This study is based on a collection of patients from a randomized controlled trial (RCT) that did not report any short-term positive effects of PRP on bone healing after sinus lift surgery using autologous iliac crest bone graft. This study aimed to evaluate the long-term impact of PRP regarding clinical and radiological outcomes on the inserted implants in the previous RCT. For this evaluation, we considered the following variables: plaque index, probing depth, bleeding index, mobility grade, Periotest((R)) values, and radiological bone loss. Out of 53 patients (n = 306 implants) included in the previous study we were able to reinvestigate 37 patients (n = 210 implants) in two centers (31 in Giessen, Germany and 6 in Erlangen, Germany). Clinical and radiographic parameters suggested overall healthy conditions of the peri-implant tissue. The PRP-group and the control group did not differ significantly in the majority of the parameters. The overall evaluation showed that result data of the PRP-group was inferior to the control group in 64 percent of the evaluated parameters. The present study cannot provide evidence of a positive effect of PRP on the long-term implant clinical and radiological outcomes. In fact, a tendency towards inferior long-term results in the PRP-group was detected without reaching a significant threshold. Further controlled trials need to be conducted to investigate this correlation.},
author = {Attia, Sameh and Narberhaus, Clara and Schaaf, Heidrun and Streckbein, Philipp and Pons-Kuehnemann, Joern and Schmitt, Christian and Neukam, Friedrich Wilhelm and Howaldt, Hans-Peter and Boettger, Sebastian},
doi = {10.3390/jcm9020355},
faupublication = {yes},
journal = {Journal of Clinical Medicine},
note = {CRIS-Team WoS Importer:2020-03-24},
peerreviewed = {Yes},
title = {{Long}-{Term} {Influence} of {Platelet}-{Rich} {Plasma} ({PRP}) on {Dental} {Implants} after {Maxillary} {Augmentation}: {Retrospective} {Clinical} and {Radiological} {Outcomes} of a {Randomized} {Controlled} {Clinical} {Trial}},
volume = {9},
year = {2020}
}
@article{faucris.119428804,
abstract = {Complete maxillary edentulism and prosthetic rehabilitation with removable full dentures are known to affect speech intelligibility. The aim of this study was to prospectively investigate the long-term effect of time on speech intelligibility in patients being rehabilitated with newly fabricated full maxillary dentures.Speech was recorded in a group of 14 patients (male = 9, female = 5; mean age ± standard deviation [SD] = 66.14 ± 7.03 years) five times within a mean period of 4 years (mean ± SD: 47.50 ± 18.16 months; minimum/maximum: 24/68 months) and in a control group of 40 persons with healthy dentition (male = 30, female = 10; mean age ± SD = 59 ± 12 years). All 14 participants had their inadequate removable full maxillary dentures replaced with newly fabricated dentures. Speech intelligibility was measured by means of a polyphone-based speech recognition system that automatically computed the percentage of accurately spoken words (word accuracy [WA]) at five different points in time: 1 week prior to prosthetic maxillary rehabilitation (both with and without inadequate dentures in situ) and at 1 week, 6 months, and a mean of 48 months after the insertion of newly fabricated full maxillary dentures.Speech intelligibility of the patients significantly improved after 6 months of adaptation to the new removable full maxillary dentures (WA = 66.93% ± 9.21%) compared to inadequate dentures in situ (WA = 60.12% ± 10.48%). After this period, no further significant change in speech intelligibility was observed. After 1 week of adaptation, speech intelligibility of the rehabilitated patients aligned with that of the control group (WA = 69.79% ± 10.60%) and remained at this level during the examination period of 48 months.The provision of new removable full maxillary dentures can improve speech intelligibility to the level of a healthy control group on a long-term basis.},
author = {Stelzle, Florian and Riemann, Max and Klein, Alfred and Oetter, Nicolai and Rohde, Maximilian and Maier, Andreas and Eitner, Stephan and Neukam, Friedrich Wilhelm and Knipfer, Christian},
doi = {10.11607/ijp.5239},
faupublication = {yes},
journal = {International Journal of Prosthodontics},
note = {EVALuna2:24437},
pages = {419-425},
peerreviewed = {Yes},
title = {{Long}-term {Outcome} of {Speech} {Intelligibility} in {Maxillary} {Dental} {Rehabilitation} with {Full} {Dentures}: {A} {Prospective} {Study} {Using} {Automatic} {Speech} {Quantification}},
volume = {30},
year = {2017}
}
@article{faucris.121884664,
abstract = {Porcine collagen matrices are proclaimed being a sufficient alternative to autologous free gingival grafts (FGG) in terms of augmenting the keratinized mucosa. The collagen matrix Mucograft(®) (CM) already showed a comparable clinical performance in the early healing phase, similar histological appearance, and even a more natural appearance of augmented regions. Predictability for long-term stability does not yet exist due to missing studies reporting of a follow-up >6 months.The study included 48 patients with atrophic edentulous or partially edentulous lower jaw situations that had undergone an implant treatment. In the context of implant exposure, a vestibuloplasty was either performed with two FGGs from the palate (n = 21 patients) or with the CM (n = 27 patients). Surgery time was recorded from the first incision to the last suture. Follow-up examinations were performed at the following time points: 10, 30, 90, and 180 days and 1, 2, 3, 4, and 5 years after surgery. The width of keratinized mucosa was measured at the buccal aspect of each implant, and augmented sites were evaluated in terms of their clinical appearances (texture and color).The groups showed similar healing with increased peri-implant keratinized mucosa after surgery (FGG: 13.06 mm ± 2.26 mm and CM: 12.96 mm ± 2.86 mm). The maximum follow-up was 5 years (5 patients per group). After 180 days, the width of keratinized mucosa had decreased to 67.08 ± 13.85% in the FGG group and 58.88 ± 14.62% in the CM group with no statistically significant difference. The total loss of the width of keratinized mucosa after 5 years was significant between the FGG (40.65%) and the CM group (52.89%). The CM group had significantly shorter operation times than the FGG group. Augmented soft tissues had a comparable clinical appearance to adjacent native gingiva in the CM group. FGGs could still be defined after 5 years.The FGG and the CM are both suitable for the regeneration of the peri-implant keratinized mucosa with a sufficient long-term stability. With the CM, tissue harvesting procedures are invalid, surgery time can be reduced, and regenerated tissues have a more esthetic appearance.},
author = {Schmitt, Christian M. and Moest, Tobias and Lutz, Rainer and Wehrhan, Falk and Neukam, Friedrich Wilhelm and Schlegel, Andreas},
doi = {10.1111/clr.12575},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24404},
peerreviewed = {Yes},
title = {{Long}-term outcomes after vestibuloplasty with a porcine collagen matrix ({Mucograft}(®) ) versus the free gingival graft: a comparative prospective clinical trial},
year = {2015}
}
@article{faucris.108462684,
abstract = {Peri-implant hard-tissue augmentation is a widely used clinical procedure.The present review aimed to analyse the current literature regarding medium- and long-term data concerning the stability of peri-implant tissues after hard-tissue augmentation prior or immediately with implant placement.An electronic literature search was performed using Medline (PubMed) databases detecting clinical studies focusing on hard- and soft-tissue stability around dental implants placed either in augmented alveolar ridges or simultaneously with peri-implant bone grafting. The search was limited to articles published between 1995 and December 2014, focusing on clinical studies with a prospective study design assessing peri-implant bone and soft tissue stability over time with a minimum follow-up of 12 months. Recent publications were also searched manually to find any relevant studies that might have been missed using the search criteria noted above.Thirty-seven articles met the inclusion criteria and were included in this systematic review. Since the outcome measures and methods, as well as types of grafts and implants used were so heterogeneous, the performance of meta-analysis was impossible. The highest level of evidence was achieved by randomized clinical trials.Different hard-tissue augmentation procedures seem to show stable peri-implant tissues, although, up to now, long-term stability of the augmented buccal bone is assessed by only few studies. Further research should concentrate on combining three-dimensional radiographic data with non-invasive methods as digital surface measuring techniques or ultrasound evaluation.},
author = {Lutz, Rainer and Neukam, Friedrich Wilhelm and Simion, Massimo and Schmitt, Christian M.},
doi = {10.1111/clr.12635},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24411},
pages = {103-22},
peerreviewed = {Yes},
title = {{Long}-term outcomes of bone augmentation on soft and hard-tissue stability: a systematic review},
volume = {26 Suppl 1},
year = {2015}
}
@article{faucris.106986044,
abstract = {Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a complication of antiresorptive therapy with nitrogen-containing bisphosphonates (BP). With various suggestions as to pathogenesis, the etiology of BRONJ is not sufficiently understood. Osteoclasts and their precursors, that is, macrophages, are the main target cells of BP. BP can repolarize regeneration- and healing-associated M2 macrophages towards the tissue destructive M1-type. The current study aims to elucidate differences in macrophage and osteoclast polarization in BRONJ, osteoradionecrosis (ORN) and healthy control specimens.A total of 39 jaw bone samples (18 BRONJ, 8 ORN and 13 healthy controls) were processed for immunohistochemistry to detect CD68-, CD11c- and CD163-positive cells. Macrophages and osteoclasts were distinguished on the basis of morphological differences. Samples were digitized, and the macrophage and osteoclast cell counts were quantitatively analyzed.In jaw bone affected by BRONJ, a significantly increased macrophage infiltration and M1 polarization of macrophages can be seen. The density of CD68-expressing osteoclasts is significantly increased in BRONJ specimens compared to ORN and to healthy controls.A bisphosphonate-derived shift of macrophage polarization towards M1-polarized macrophages might impair bone tissue homeostasis and thus contribute to the pathogenesis of BRONJ. The observed increase in osteoclast density might be caused by BP-induced prolonged osteoclast survival.},
author = {Wehrhan, Falk and Möbius, Patrick and Amann, Kerstin Ute and Ries, Jutta and Preidl, Raimund and Neukam, Friedrich Wilhelm and Weber, Manuel},
doi = {10.1016/j.jcms.2017.02.023},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24431},
pages = {944-953},
peerreviewed = {Yes},
title = {{Macrophage} and osteoclast polarization in bisphosphonate associated necrosis and osteoradionecrosis},
volume = {45},
year = {2017}
}
@article{faucris.274468197,
abstract = {Non-melanoma skin cancer (NMSC) is a heterogeneous tumor entity that is vastly determined by age and UV-light exposure leading to a great mutational burden in cancer cells. However, the success of immune checkpoint blockade in advanced NMSC and the incidence and disease control rates of NMSC in organ transplant recipients compared to immunologically uncompromised patients point toward the emerging importance of the immunologic activity of NMSC. To gain first insight into the role of T-cell and macrophage infiltration in NMSC of the head and neck and capture their different immunogenic profiles, which appear to be highly relevant for the response to immunotherapy, we conducted a whole slide analysis of 107 basal cell carcinoma (BCC) samples and 117 cutaneous squamous cell carcinoma (cSCC) samples. The CD8+ and CD68+ immune cell expression in both cancer types was evaluated by immunohistochemistry and a topographic distribution profile, and the proportion of both cell populations within the two tumor entities was assessed. The results show highly significant differences in terms of CD8+ T-cell and CD68+ macrophage infiltration in BCC and cSCC and indicate cSCC as a highly immunogenic tumor. Yet, BCC presents less immune cell infiltration; the relation between the immune cells compared to cSCC does not show any significant difference. These findings help explain disparities in local aggressiveness, distant metastasis, and eligibility for immune checkpoint blockade in both tumor entities and encourage further research.},
author = {Frohwitter, Gesche and Kerta, Marie-Theres and Vogl, Christoph and Geppert, Carol-Immanuel and Werry, Jan-Erik and Ries, Jutta and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.3389/fonc.2022.809687},
faupublication = {yes},
journal = {Frontiers in Oncology},
keywords = {cancer immunology; checkpoint; immunotherapy; macrophages; non-melanoma skin cancer; T cells},
note = {CRIS-Team Scopus Importer:2022-05-06},
peerreviewed = {Yes},
title = {{Macrophage} and {T}-{Cell} {Infiltration} and {Topographic} {Immune} {Cell} {Distribution} in {Non}-{Melanoma} {Skin} {Cancer} of the {Head} and {Neck}},
volume = {12},
year = {2022}
}
@article{faucris.116818724,
abstract = {The prognosis of solid malignancies has been shown to depend on immunological parameters, such as macrophage polarisation (M1/M2). Recently, it was reported that preoperative oral surgery leads to a worsening of oral squamous cell carcinomas (OSCC) prognosis. Diagnostic incision biopsies are oral surgery procedures that might lead to healing-associated M2 macrophage polarisation with a potential negative influence on tumour biology. No studies have compared macrophage polarisation in OSCC biopsies and tumour specimens.Preoperative diagnostic incision biopsies (n=25) and tumour resection specimens (n=34) of T1/T2 OSCC were processed for immunohistochemistry to detect CD68-, CD11c-, CD163- and MRC1-positive cells. Samples were digitised using whole-slide imaging, and the expression of macrophage markers was quantitatively analysed.Carcinoma tissues obtained during OSCC tumour resections showed a significantly (P<0.05) increased CD163 cell count (M2 macrophages) compared with tissues obtained during preoperative incision biopsies. Additionally, the CD163/CD68 ratio (an indicator of M2 polarisation) was significantly (P<0.05) higher in tumour resection specimens than in biopsies.This study revealed for the first time an increase in M2 polarisation in samples obtained during OSCC tumour resection surgery compared with preoperative incision biopsies. The biopsy-induced tissue trauma might explain the observed shift in macrophage polarisation towards the tumour-promoting M2 type and could lead to accelerated tumour progression.},
author = {Weber, Manuel and Moebius, P. and Büttner-Herold, M. and Amann, Kerstin Ute and Preidl, Raimund and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
doi = {10.1038/bjc.2015.212},
faupublication = {yes},
journal = {British Journal of Cancer},
note = {EVALuna2:24401},
pages = {510-9},
peerreviewed = {Yes},
title = {{Macrophage} polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas-an immunohistochemical study},
volume = {113},
year = {2015}
}
@article{faucris.106215164,
abstract = {Apical periodontitis can appear clinically as apical granulomas or radicular cysts. There is evidence that immunologic factors are involved in the pathogenesis of both pathologies. In contrast to radicular cysts, the dentigerous cysts have a developmental origin. Macrophage polarization (M1 vs M2) is a main regulator of tissue homeostasis and differentiation. There are no studies comparing macrophage polarization in apical granulomas, radicular cysts, and dentigerous cysts.Forty-one apical granulomas, 23 radicular cysts, and 23 dentigerous cysts were analyzed in this study. A tissue microarray (TMA) of the 87 consecutive specimens was created, and CD68-, CD11c-, CD163-, and MRC1-positive macrophages were detected by immunohistochemical methods. TMAs were digitized, and the expression of macrophage markers was quantitatively assessed.Radicular cysts are characterized by M1 polarization of macrophages while apical granulomas show a significantly higher degree of M2 polarization. Dentigerous cysts have a significantly lower M1 polarization than both analyzed periapical lesions (apical granulomas and radicular cysts) and accordingly, a significantly higher M2 polarization than radicular cysts. Macrophage cell density in dentigerous cysts is significantly lower than in the periapical lesions.The development of apical periodontitis towards apical granulomas or radicular cysts might be directed by macrophage polarization. Radicular cyst formation is associated with an increased M1 polarization of infiltrating macrophages. In contrast to radicular cysts, dentigerous cysts are characterized by a low macrophage infiltration and a high degree of M2 polarization, possibly reflecting their developmental rather than inflammatory origin.As M1 polarization of macrophages is triggered by bacterial antigens, these results underline the need for sufficient bacterial clearance during endodontic treatment to prevent a possible M1 macrophage-derived stimulus for radicular cyst formation.},
author = {Weber, Manuel and Schlittenbauer, Tilo and Möbius, Patrick and Büttner-Herold, Maike and Ries, Jutta and Preidl, Raimund and Geppert, Carol-Immanuel and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
doi = {10.1007/s00784-017-2123-1},
faupublication = {yes},
journal = {Clinical Oral Investigations},
note = {EVALuna2:6886},
peerreviewed = {Yes},
title = {{Macrophage} polarization differs between apical granulomas, radicular cysts, and dentigerous cysts},
year = {2017}
}
@article{faucris.223994031,
abstract = {Leukoplakia is a potential precursor of oral as well as laryngeal squamous cell carcinoma. Risk assessment of malignant transformation based on the grade of dysplasia of leukoplakia often does not lead to reliable results. However, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, and leukoplakia express single or multiple members of the melanoma-associated antigens A (MAGE-A) family, while MAGE-A are absent in healthy mucosal tissue. The present study aimed at determining if there is an association between the expression of MAGE-A in leukoplakia and malignant transformation to oral or laryngeal squamous cell carcinoma. Paraffin-embedded tissues of 205 oral and laryngeal leukoplakia, 90 corresponding tumors, and 40 healthy oral mucosal samples were included in the study. The grade of dysplasia of the leukoplakia samples was determined histopathologically. The leukoplakia samples were divided into lesions that transformed to oral and laryngeal squamous cell carcinoma (n = 91) and lesions that did not (n = 114) during a 5 years follow-up. The expression of MAGE-A3/6 and MAGE-A4 was analyzed by real-time RT-PCR. The expression of MAGE-A 1–4, 6, and 12 was determined by immunohistochemistry. A total of 59.3% of the transforming leukoplakia expressed at least one of the examined antigens as opposed to an expression rate of 3.5% of all non-transforming leukoplakia. There was no MAGE-A expression in healthy oral mucosa. The risk of malignant transformation was statistically significantly associated with MAGE-A expression in immunohistochemistry (p < 0.001) and real-time RT-PCR (MAGE-A3/6, p = 0.001; MAGE-A4, p = 0.002) analyses. There was no significant association between MAGE-A expression and the grade of dysplasia (“low-grade”, D0/D1; “high-grade”, D2/D3) in immunohistochemistry (p = 0.412) and real-time RT-PCR (MAGE-A3/6, p = 0.667; MAGE-A4, p = 0.756). It seems that the analysis of the MAGE-A expression profile may support the identification of leukoplakia at risk for malignant transformation. Therefore, efforts should be made to establish this analysis as a routine procedure in addition to conventional histopathology.},
author = {Baran, Christoph and Agaimy, Abbas and Wehrhan, Falk and Weber, Manuel and Hille, Verena and Brunner, Kathrin and Wickenhauser, Claudia and Siebolts, Udo and Nkenke, Emeka and Kesting, Marco Rainer and Ries, Jutta},
doi = {10.1038/s41379-019-0253-5},
faupublication = {yes},
journal = {Modern Pathology},
note = {CRIS-Team Scopus Importer:2019-08-06},
pages = {1068-1081},
peerreviewed = {Yes},
title = {{MAGE}-{A} expression in oral and laryngeal leukoplakia predicts malignant transformation},
volume = {32},
year = {2019}
}
@article{faucris.232028051,
abstract = {BACKGROUND: Most oral squamous cell carcinomas (OSCC) occur on the basis of oral leukoplakias (OLP). The histologic degree of dysplasia is insufficient for the prediction of OLP malignant transformation. Immunologic parameters are gaining importance for prognostic assessment and therapy of cancer. M2 polarized macrophages were shown to be associated with OSCC progression and inferior prognosis. The current study aims to answer the question if OLP with malignant transformation into OSCC within 5 years differ from OLP without transformation regarding macrophage infiltration and polarization. METHODS: 201 specimens (50 transforming OLP, 53 non-transforming OLP, 49 corresponding OSCC and 49 healthy oral mucosa controls) were processed for immunohistochemistry. Samples were stained for CD68, CD163 and CD11c expression, completely digitalized and computer-assisted cell counting was performed. Epithelial and subepithelial compartments were differentially assessed. Groups were statistically compared using the Mann-Whitney U-test. A cut-off point for the discrimination of transforming and non-transforming OLP was determined and the association between macrophage infiltration and malignant transformation was calculated using the Chi-square test (χ2 test). RESULTS: Macrophage infiltration and M2 polarization in OLP with malignant transformation within 5 years was significantly increased compared to OLP without malignant transformation (p < 0.05). OSCC samples showed the highest macrophage infiltration and strongest M2 polarization (p < 0.05). Additionally, transforming OLP revealed a significant shift of macrophage infiltration towards the epithelial compartment (p < 0.05). χ2 test revealed a significant association of increased macrophage infiltration with malignant transformation (p < 0.05). CONCLUSION: Immunological changes precede malignant transformation of OLP. Increased macrophage infiltration and M2 polarization was associated with the development of oral cancer in OLP. Macrophage infiltration could serve as predictive marker for malignant transformation.},
author = {Weber, Manuel and Wehrhan, Falk and Baran, Christoph and Agaimy, Abbas and Büttner-Herold, Maike and Öztürk, Hatice Kübra and Neubauer, Kristina and Wickenhauser, Claudia and Kesting, Marco Rainer and Ries, Jutta},
doi = {10.1186/s12967-019-02191-0},
faupublication = {yes},
journal = {Journal of Translational Medicine},
keywords = {Carcinogenesis; CD11c; CD163; CD68; M1; M2; Macrophage polarization; Oral cancer; Oral leukoplakia; Oral squamous cell carcinoma; OSCC},
month = {Jan},
note = {CRIS-Team Scopus Importer:2020-01-21},
pages = {11-},
peerreviewed = {Yes},
title = {{Malignant} transformation of oral leukoplakia is associated with macrophage polarization},
volume = {18},
year = {2020}
}
@article{faucris.229748718,
abstract = {Objectives: This prospective, comparative, clinical study analyzed the postoperative bleeding risk of patients on anticoagulation therapy (AT) who were undergoing tooth extractions and osteotomies. Materials and methods: Patients with the following ATs were included (test groups): (1.) platelet aggregation inhibitors (PAIs), (2.) vitamin K inhibitors, (3.) low molecular weight heparin (LMWH), and (4.) direct oral anticoagulants (DOACs). Patients in the control group were not on any AT (non-AT group). Patients were subdivided into the following treatment groups: (1.) single tooth extraction, (2.) serial extraction (≥ 2 adjacent teeth), and (3.) tooth osteotomy. Pre-, intra-, and postoperative data concerning the treatment, extent of the surgery, and bleeding were recorded and statistically evaluated. Results: There were 15 postoperative bleeding events in 838 patients (1.7%): four (0.7%) in the non-AT group (n = 603 patients) and 11 (4.7%) in the AT group (n = 235 patients). The surgical procedure had no statistically significant effect on postoperative bleeding frequencies. Patients taking vitamin K inhibitors had a significantly higher risk of postoperative bleeding compared with patients without AT (p < 0.00001). Four patients were hospitalized due to the severity of the bleeding (vitamin K inhibitor group). Postoperative bleeding events were all controlled with local hemostatic measures. Conclusions: The postoperative bleeding risk after tooth extractions and osteotomies in patients continuing AT is low, and bleeding can be controlled with local hemostatic measures. Clinical relevance: AT should be continued in patients undergoing tooth removal procedures under the provision that local hemostatic measures are applied.},
author = {Schmitt, Christopher and Rusche, Birgit and Clemm, Raphael and Neukam, Friedrich Wilhelm and Buchbender, Mayte},
doi = {10.1007/s00784-019-03124-3},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Anticoagulation therapy; Oral surgery; Osteotomy; Tooth extraction},
note = {CRIS-Team Scopus Importer:2019-11-26},
peerreviewed = {Yes},
title = {{Management} of anticoagulated patients in dentoalveolar surgery: a clinical comparative study},
year = {2019}
}
@article{faucris.252987049,
abstract = {BACKGROUND: The aim of this study was to investigate the occurrence of postoperative bleeding following dentoalveolar surgery in patients with either continued vitamin K antagonist medication or perioperative bridging using heparin. METHODS: A retrospective study was performed analyzing patients who underwent tooth extraction between 2012 and 2017. Patients were retrospectively allocated into two comparative groups: un-paused vitamin K antagonist medication versus bridging using heparin. A healthy, non-anticoagulated cohort with equivalent surgery served as a control group. Main outcome measures were: the occurrence and frequency of postoperative bleeding, the number of removed teeth, the surgical technique of tooth removal (extraction/osteotomy/combined extraction and osteotomy) and the prothrombin time. RESULTS: In total, 475 patients were included in the study with 170 patients in the group of un-paused vitamin K antagonist medication VG, 135 patients in the Bridging group BG and 170 patients in the control group CG. Postoperative bleeding was significant: CG versus VG p = 0.004; CG versus BG p < 0.001, BG versus VG p < 0.001. A significant correlation of number of the extracted teeth in the BG (p = 0.014) and no significance in VG (p = 0.298) and CG (p = 0.210) and in the BG versus VG and CG with p < 0.001 in terms of surgical intervention extraction. No difference observed in terms of prothrombin time. CONCLUSIONS: Bridging with heparin increases the risk for bleeding compared to un-paused vitamin K antagonist medication. The perioperative management of anticoagulated patients requires a well-coordinated interdisciplinary teamwork to minimize or at best avoid both: postoperative bleeding and thromboembolic incidences.},
author = {Buchbender, Mayte and Rößler, Felix and Kesting, Marco Rainer and Frohwitter, Gesche and Adler, Werner and Rau, Andrea},
doi = {10.1186/s12903-021-01464-9},
faupublication = {yes},
journal = {BMC Oral Health},
keywords = {Anticoagulation therapy; Bleeding; Bridging with heparin; Vitamin K antagonist},
note = {CRIS-Team Scopus Importer:2021-03-26},
pages = {96-},
peerreviewed = {Yes},
title = {{Management} of anticoagulated patients in dentoalveolar surgery: a retrospective study comparing bridging with heparin versus unpaused vitamin {K} antagonist medication},
volume = {21},
year = {2021}
}
@article{faucris.124145384,
abstract = {This prospective clinical comparative study aimed to analyze the postoperative bleeding risk of patients continuing their anticoagulation therapy (AT) and undergoing implant surgery and bone grafting procedures.The treatments ranged from the insertion of single or multiple dental implants over implant exposures to sinus floor augmentation and vertical and/or lateral bone grafting with autologous bone grafts. The patients of the test groups (AT groups) were treated with platelet aggregation inhibitors (PAIs), Vitamin-K inhibitors, Vitamin-K inhibitor withdrawal bridged with heparin (LMWH), or new/direct oral anticoagulants (NOACs/DOACs). Patients of the control group were non-anticoagulated (non-AT group). Surgical procedures were performed in the same manner in all groups. Pre, intra, and postoperative data concerning the treatment, extent of the surgery and bleedings was recorded and statistically evaluated.There were seven postoperative bleedings in 564 patients (1.2%), four in the AT groups (3.4%), and three in the non-AT group (0.6%). No thromboembolic complication occurred in the whole observation period. The invasiveness of the surgical procedure had no statistically significant effect on bleeding frequencies. Patients taking Vitamin-K inhibitors had a significantly higher risk of a postoperative bleeding compared to patients without any AT (P = 0.038). Two patients were hospitalized due to the severity of the bleeding as a precautionary measure (one in the non-AT and one in the PAI group). All bleedings were easily controllable with local hemostatic measures. There was no postoperative bleeding recorded for patients taking DOACs.Anticoagulation therapy should be continued in patients undergoing implant surgery and bone grafting procedures avoiding thromboembolic complications. Surgeons should always apply the most minimally invasive approach to reduce postoperative risks and be able to apply local hemostatic measures in terms of a bleeding complication.},
author = {Clemm, Raphael and Neukam, Friedrich Wilhelm and Rusche, Birgit and Bauersachs, A. and Musazada, S. and Schmitt, Christopher},
doi = {10.1111/clr.12732},
faupublication = {yes},
journal = {Clinical Oral Implants Research},
note = {EVALuna2:24426},
pages = {1274-1282},
peerreviewed = {Yes},
title = {{Management} of anticoagulated patients in implant therapy: a clinical comparative study},
volume = {27},
year = {2016}
}
@article{faucris.124026144,
author = {Nkenke, Emeka and Alexiou, Christoph and Iro, Heinrich and Amann, Kerstin Ute and Kirchner, Thomas and Häusler, Gerd and Neukam, Friedrich Wilhelm and Holbach, Benedict},
doi = {10.1016/j.ijom.2005.01.011},
faupublication = {yes},
journal = {International Journal of Oral and Maxillofacial Surgery},
note = {UnivIS-Import:2015-04-14:Pub.2005.nat.dphy.optik.1optik.manage},
pages = {809-11},
peerreviewed = {Yes},
title = {{Management} of spontaneous enophthalmos due to silent sinus syndrome: a case report},
volume = {34},
year = {2005}
}
@article{faucris.222466953,
author = {Pohle, Dirk and Rechtenwald, T. and von Wilmowsky, Cornelius and Neukam, Friedrich Wilhelm and Münstedt, Helmut},
faupublication = {yes},
journal = {BIOmaterialien},
note = {LFT Import::2019-07-16 (1427)},
pages = {106-107},
peerreviewed = {Yes},
title = {{Materialspezifische} {Vorraussetzung} für das {Lasersintern} von {Polyetheretherketonen} als {Knochenersatz} für den {Schädelbereich}},
volume = {2},
year = {2007}
}
@article{faucris.258182989,
abstract = {Objective: The aim of the present study was to assess the effect of water storage on the quasi-static properties and cyclic fatigue behavior of four contemporary CAD/CAM resin composite materials. Methods: The CAD/CAM resin composites Grandio Blocs, LavaTM Ultimate, CerasmartTM and Brilliant Crios, as well as the direct resin composite Grandio SO, were evaluated. Rectangular plates were cut from the blocks or fabricated using a silicon mold to obtain specimens for fracture toughness (KIc, n = 10), biaxial strength (σ0, n = 30) and cyclic fatigue testing (n = 30). Half of the specimens was stored for 24 h in dry conditions and the other half was aged for 60 days in distilled water at 37 °C. KIc was determined using the Compact-Tension (C(T)) method and σ0 and cyclic fatigue were tested using the Ball-on-Three-Balls assembly. Additional disc-shaped specimens (n = 5) were produced to obtain water sorption curves of the materials. Weibull statistics and two-way ANOVA with Tukey's post-hoc test were used for data assessment. Results: The highest water sorption was observed for LavaTM Ultimate (42.6 μg/mm3), whereas Grandio SO displayed the lowest uptake (14 μg/mm3). A statistically significant drop in KIc and σ0 was measured for all materials after water storage, except for the σ0 of CerasmartTM. Water ageing had a dissimilar effect on the cyclic fatigue behavior, increasing the slow crack growth susceptibility of LavaTM Ultimate, but decreasing it for CerasmartTM and Brilliant Crios. Significance: Contemporary CAD/CAM resin composites are susceptible to water driven degradative processes, although differences in filler content and resin matrix constitution play an important role in how it impacts their mechanical properties.},
author = {Wendler, Michael and Stenger, Anja and Ripper, Julian and Priewich, Eva and Belli, Renan and Lohbauer, Ulrich},
doi = {10.1016/j.dental.2021.04.002},
faupublication = {yes},
journal = {Dental Materials},
keywords = {Biaxial strength; CAD/CAM; Cyclic fatigue; Fracture toughness; Hydrolytic degradation; Resin composite; Water sorption},
note = {CRIS-Team Scopus Importer:2021-05-14},
peerreviewed = {Yes},
title = {{Mechanical} degradation of contemporary {CAD}/{CAM} resin composite materials after water ageing},
year = {2021}
}
@article{faucris.211870387,
abstract = {Surgical therapy is the gold standard in head and neck cancer treatment, whereas adjuvant radiation and chemotherapy may be indicated in advanced cases. Frequently, neck dissections, former flap anastomoses and irradiated tissue leave a neck depleted of recipient vessels. If further surgery becomes inevitable the surgeon is faced with a heavily pretreated surgical field asking for highly reliable solutions for microsurgical reconstruction.
From September 2017 until October 2017, a standardised review on the literature of the databases PubMed, Cochrane Library and Web of Science was performed. The primary research led to 1.614 articles, an evaluation by comprehensive content resulted in 26 suitable articles.
Overall, 325 patient cases were included in the study. 112 postsurgical complications were noted (34.5%) and 12 deaths were reported (3.7%). The most common flaps harvested were the anterolateral thigh flap (n = 85, 25.8%), the radial forearm flap (n = 78, 23.7%) and the flaps from the trunk (n = 31, 9.4%). The arteries most frequently used for anastomosis were the internal mammary artery (n = 81; 28%), the transverse cervical artery (n = 46; 15.9%) and the superficial temporal artery (n = 43; 14.9%). The cephalic vein (n = 84; 25.9%), the internal mammary vein (n = 79; 24.4%) and the superficial temporal vein (n = 50; 15.4%) were the most successfully applied veins. (C) 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.},
author = {Frohwitter, Gesche and Rau, Andrea and Kesting, Marco Rainer and Fichter, Andreas},
doi = {10.1016/j.jcms.2018.05.051},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:35083},
pages = {1652-1658},
peerreviewed = {Yes},
title = {{Microvascular} reconstruction in the vessel depleted neck - {A} systematic review},
volume = {46},
year = {2018}
}
@article{faucris.122900184,
abstract = {microRNAs (miRNAs) are aberrantly expressed in the whole blood of patients suffering from different types of cancer. Collection of whole blood samples is a minimally invasive procedure. To date, little is known concerning the altered miRNA expression in patients suffering from oral squamous cell carcinoma (OSCC). The present study aimed to evaluate the difference in miRNA expression in whole blood samples in OSCC patients as compared to healthy volunteers who served as controls. In 20 blood samples from patients and healthy volunteers, the expression patterns of 1,205 human miRNAs were examined by miRNA microarray in order to identify those with the most pronounced differential expression. The results were verified by quantitative RT-PCR (RT-qPCR) for miR-186, miR-3651 and miR-494 using 57 samples of patients and 33 samples of healthy volunteers. Receiver operating characteristic (ROC) curves and the highest Youden index were calculated in order to assess cut-off points (COPs) that allowed the distinguishing of blood samples of OSCC patients from those of healthy volunteers. Significantly different expression rates were found for miR-186 (p=0.01), miR-3651 (p=0.0001) and miR-494 (p=0.004) between the OSCC patients and healthy controls. In the OSCC patients, there was a 2-fold upregulation for miR-494 and miR-3651 and a 2-fold downregulation for miR-186. Based on the determined COPs, significant correlations between miR-3651 overexpression and lymph node status (p=0.04), tumor grade (p=0.02) and clinical stage (p=0.04) were indicated. Aberrant expression levels of miR-186, miR-494 and miR-3651 in whole blood samples of OSCC patients may provide the possibility to establish a minimally invasive screening method for OSCC.},
author = {Ries, Jutta and Vairaktaris, Eleftherios and Agaimy, Abbas and Kintopp, Rita and Baran, Christoph and Neukam, Friedrich Wilhelm and Nkenke, Emeka},
doi = {10.3892/or.2014.2983},
faupublication = {yes},
journal = {Oncology Reports},
note = {EVALuna2:6555},
pages = {1429-36},
peerreviewed = {Yes},
title = {{miR}-186, {miR}-3651 and {miR}-494: {Potential} biomarkers for oral squamous cell carcinoma extracted from whole blood},
volume = {31},
year = {2014}
}
@article{faucris.117941164,
abstract = {To examine the relative usefulness and suitability of magnetic resonance imaging (MRI) in daily clinical practice as compared to various technologies of computed tomography (CT) in addressing questions of orthodontic interest.Three blinded raters evaluated 2D slices and 3D reconstructions created from scans of two pig heads. Five imaging modalities were used, including three CT technologies-multislice (MSCT), cone-beam CT (CBCT), and industrial (µCT)-and two MRI protocols with different scan durations. Defined orthodontic parameters were rated one by one on the 2D slices and the 3D reconstructions, followed by final overall ratings for each modality. A mixed linear model was used for statistical analysis.Based on the 2D slices, the parameter of visualizing tooth-germ topography did not yield any significantly different ratings for MRI versus any of the CT scans. While some ratings for the other parameters did involve significant differences, how these should be interpreted depends greatly on the relevance of each parameter. Based on the 3D reconstructions, the only significant difference between technologies was noted for the parameter of visualizing root-surface morphology. Based on the final overall ratings, the imaging performance of the standard MRI protocol was noninferior to the performance of the three CT technologies.On comparing the imaging performance of MRI and CT scans, it becomes clear that MRI has a huge potential for applications in daily clinical practice. Given its additional benefits of a good contrast ratio and complete absence of ionizing radiation, further studies are needed to explore this clinical potential in greater detail.},
author = {Detterbeck, Andreas and Hofmeister, Michael and Hofmann, Elisabeth and Haddad, Daniel and Weber, Daniel and Hoelzing, Astrid and Zabler, Simon and Schmid, Matthias and Hiller, Karl-Heinz and Jakob, Peter and Engel, Jens and Hiller, Jochen and Hirschfelder, Ursula},
doi = {10.1007/s00056-016-0028-2},
faupublication = {yes},
journal = {Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie},
note = {EVALuna2:24851},
pages = {251-261},
peerreviewed = {Yes},
title = {{MRI} vs. {CT} for orthodontic applications: comparison of two {MRI} protocols and three {CT} (multislice, cone-beam, industrial) technologies},
volume = {77},
year = {2016}
}
@article{faucris.262668408,
abstract = {Background: The treatment of oral cancer remains challenging due to its infiltrative nature and a high tendency for tumour relapse leading to an overall poor prognosis. In the case of early recurrence, the patient’s prognosis deteriorates dramatically, with survival rate dropping to below 30%. Minimal improvements in survival trends in recurrent and advanced stage tumours have been reported in recent decades. Neoadjuvant immunotherapy may represent a new therapeutic approach changing the standard of care in advanced oral cancer therapy. Case Presentation: We describe the case of a woman in her late 30’s who presented in mid-2019 with oral squamous cell carcinoma (OSCC) localized to the floor of the mouth. After initial R0 resection, selective neck dissection, and adjuvant brachytherapy, an early recurrence of OSCC located between the hyoid bone and the mandible was diagnosed at the end of 2019. An off-label treatment regimen was performed with neoadjuvant use of Pembrolizumab 19 days prior to salvage surgery. Radiological and histological assessment of T-cell and programmed cell death protein 1 ligand 1 (PD-L1) expression was performed before and after checkpoint inhibitor application. Neoadjuvant immunotherapy resulted in increased T-cell infiltration and PD-L1 expression, as well as a significant tumour necrosis rate. One cycle of Pembrolizumab led to significant regressive tumour changes with increases in immune infiltration, sclerosis, and necrosis of 75% of the tumour mass with only 25% vital tumour cells remaining. By June 2020, the patient remained without recurrence. Conclusions: The case presented outlines the potential effects of neoadjuvant immunotherapy in recurrent or advanced OSCC prior to definitive surgical tumour treatment. The benefit of additional adjuvant treatment after histologic response will be discussed. The case is also analysed considering ongoing clinical trials of neoadjuvant immunotherapy for head and neck malignancies.},
author = {Olmos, Manuel and Glajzer, Jacek and Büntemeyer, Tjark-Ole and Frohwitter, Gesche and Ries, Jutta and Eckstein, Markus and Hecht, Markus and Lutz, Rainer and Kesting, Marco Rainer and Weber, Manuel},
doi = {10.3389/fonc.2021.720951},
faupublication = {yes},
journal = {Frontiers in Oncology},
keywords = {case report; immune checkpoint inhibitors; immunotherapy; neoadjuvant; oral cancer; OSCC; PD-1 - PD-L1 axis; pembrolizumab},
note = {CRIS-Team Scopus Importer:2021-08-13},
peerreviewed = {Yes},
title = {{Neoadjuvant} {Immunotherapy} of {Oral} {Squamous} {Cell} {Carcinoma}: {Case} {Report} and {Assessment} of {Histological} {Response}},
volume = {11},
year = {2021}
}
@article{faucris.320049729,
abstract = {Background: The first-line treatment of oral squamous cell carcinoma (OSCC) involves surgical tumor resection, followed by adjuvant radio(chemo)therapy (R(C)T) in advanced cases. Neoadjuvant radio- and/or chemotherapy has failed to show improved survival in OSCC. Recently, neoadjuvant immunotherapy has shown promising therapeutic efficacy in phase 2 trials. In this context, the addition of radio- and chemotherapy is being reconsidered. Therefore, a better understanding of the tumor-biologic effects of neoadjuvant RCT would be beneficial. The current study was conducted on a retrospective cohort of patients who received neoadjuvant RCT for the treatment of oral cancer. The aim of the study was to evaluate the influence of neoadjuvant RCT on the immunological tumor microenvironment (TME) and hypoxic and glucose metabolisms. Methods: A cohort of 45 OSSC tissue samples from patients were analyzed before and after RCT (total 50.4 Gy; 1.8 Gy 5× weekly; Cisplatin + 5-Fluorouracil). Immunohistochemistry for CD68, CD163, TGF-β, GLUT-1 and HIF-1α was performed using tissue microarrays and automated cell counting. Differences in expression before and after RCT and associations with histomorphological parameters (T-status, N-status) were assessed using the Mann–Whitney U test. Results: Tumor resection specimens after neoadjuvant RCT showed a significant decrease in CD68 infiltration and a significant increase in CD163 cell density. The CD68/CD163 ratio was significantly lower after RCT, indicating a shift toward M2 polarization. The GLUT-1 and HIF-1α expressions were significantly lower after RCT. Larger tumors (T3/T4) showed a lower GLUT-1 expression. Other biomarkers were not associated with the T- and N-status. Conclusions: Neoadjuvant RCT with 50.4 Gy induced a shift toward the M2 polarization of macrophages in the TME. This change in immune composition is not favorable and may be prognostically negative and counteract immunotherapeutic approaches. In addition, the decreased expressions in GLUT-1 and HIF-1α indicate reductions in the glucose metabolism and hypoxic energy metabolism in response to “high dose” neoadjuvant RCT, which may be therapeutically desirable.},
author = {Weber, Manuel and Ries, Jutta and Braun, Kristina and Wehrhan, Falk and Distel, Luitpold and Geppert, Carol-Immanuel and Lutz, Rainer and Kesting, Marco Rainer and Trumet, Leah},
doi = {10.3390/cells13050397},
faupublication = {yes},
journal = {Cells},
keywords = {head and neck squamous cell carcinoma; HNSCC; hypoxia; immune tolerance; induction therapy; macrophage polarization; metabolism; oral squamous cell carcinoma; OSCC; RCT},
note = {CRIS-Team Scopus Importer:2024-03-22},
peerreviewed = {Yes},
title = {{Neoadjuvant} {Radiochemotherapy} {Alters} the {Immune} and {Metabolic} {Microenvironment} in {Oral} {Cancer}—{Analyses} of {CD68}, {CD163}, {TGF}-β1, {GLUT}-1 and {HIF}-1α {Expressions}},
volume = {13},
year = {2024}
}
@article{faucris.115636884,
abstract = {Objective. Even after adequate surgical and nonsurgical treatment, combined or isolated clefts often cause functional disorders, such as speech disorders. Speech disorders vary widely in extent and can take the form, for example, of specific features of articulation, with altered nasal emission and shifted articulation, leading to reduced speech intelligibility. So far it has not been possible to describe the relationship between cleft type and intelligibility except subjective, categorical evaluation. Methods. Intelligibility of the speech as influenced by cleft palate in 58 children aged 9±2 was quantified objectively and numerically by means of automatic speech recognition technology in speech recordings for the PLAKSS test [test for psycholinguistic analysis of childhood speech impairments]. It was found that 33 children had a unilateral cleft lip and palate (CLP), 9, bilateral CLP, 10, isolated cleft palate, and 6, submucosal cleft palate. As a control group, 84 children aged 9±1 years and with physiological articulation were recruited from a mainstream school. Speech intelligibility is expressed as word accuracy, which means the percentage of correctly recognized words in a word sequence. Results. Word accuracy levels in the control group were between 39% and 84% (mean 62%±10%), while the children with clefts achieved values between 0% and 73% (mean 42%±17%). There was no difference in intelligibility between children with isolated cleft palate and those with combined cleft type. Differences were, however, found between each group and the control group (p<0.01). Conclusion. Speech intelligibility of children with isolated cleft palate does not significantly differ from that of children with combined cleft type including the palate, as has been objectively quantified for the first time by objective methods. In the presence of speech disorders, the need for diagnosis and therapy is just as great in children with isolated cleft palate as in children with combined cleft types. © 2007 Springer Medizin Verlag.},
author = {Vogt, Beate and Maier, Andreas and Batliner, Anton and Nöth, Elmar and Nkenke, Emeka and Eysholdt, Ulrich and Schuster, Maria},
doi = {10.1007/s00106-007-1620-y},
faupublication = {yes},
journal = {HNO},
keywords = {Automatic speech recognition; Cleft lip and palate; Isolated cleft palate; Objective evaluation; Speech intelligibility},
pages = {891-898},
peerreviewed = {Yes},
title = {{Numeric} quantification of intelligibility in schoolchildren with isolated and combined cleft palate},
volume = {55},
year = {2007}
}
@article{faucris.107967244,
author = {Vogt, Beate and Maier, Andreas and Batliner, Anton and Nöth, Elmar and Nkenke, Emeka and Eysholdt, Ulrich and Schuster, Maria},
faupublication = {yes},
journal = {HNO},
pages = {891-898},
peerreviewed = {Yes},
title = {{Numerische} {Quantifizierung} der {Verständlichkeit} von {Schulkindern} mit isolierter und kombinierter {Gaumenspalte}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2007/Vogt07-NQD.pdf},
volume = {55.0},
year = {2007}
}
@inproceedings{faucris.120324644,
address = {Norderstedt},
author = {Schuster, Maria and Maier, Andreas and Vogt, Beate and Nöth, Elmar and Nkenke, Emeka and Holst, Alexandra and Eysholdt, Ulrich and Rosanowski, Frank},
booktitle = {Aktuelle phoniatrisch-pädaudiologische Aspekte 2006},
date = {2006-09-15/2006-09-17},
editor = {Gross Manfred, Kruse Friedrich E.},
faupublication = {yes},
pages = {43-46},
peerreviewed = {Yes},
publisher = {Books On Demand GmbH Norderstedt},
title = {{Objektive} und automatische {Ermittlung} der {Verständlichkeit} von {Kindern} und {Jugendlichen} mit {Lippen}-{Kiefer}-{Gaumenspalten}},
url = {http://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2006/Schuster06-OAE.pdf},
venue = {Heidelberg},
year = {2006}
}
@article{faucris.317561050,
abstract = {Objectives: Management of the neck in patients with oral squamous cell carcinoma (OSCC) is pivotal to oncologic control and survival. However, there is controversy regarding necessity of neck dissection (ND) in patients with clinically node-negative neck. We aimed to assess risk factors for occult metastasis and to explore whether the presence of occult lymph node metastases (LNMs) has an impact on recurrence and survival. Material and methods: A retrospective cohort study was performed including patients with primary OSCC who underwent radical tumor resection and ND in a high-volume center adhering to the prevailing German guideline. The ND was performed according to a standardized approach. Results: Four hundred twenty-one patients with primary surgically treated OSCC were included. The incidence of occult metastasis was 14.49%. A pathological T stage > 1 (multivariate analysis, odds ratio (OR) 3.958, p = 0.042) and the presence of extranodal extension in LNMs (multivariate analysis, OR 0.287, p = 0.020) were identified as independent risk factors for occult metastasis. When comparing patients with and without occult metastasis, there were no significant differences in terms of progression-free survival (log-rank, p = 0.297) and overall survival (log-rank, p = 0.320). There were no cases of ipsilateral neck recurrence. One patient developed contralateral neck metastasis; however, he initially presented with a unilateral pT1 pN0 tumor. Conclusions: Overall, our findings suggest that conducting a standardized approach in ND should be applied in terms of management of the neck in order to maintain survival rates and to prevent neck recurrence in OSCC patients. Clinical relevance. None of the risk factors for occult metastasis can be reliably assessed preoperatively. Although elective ND does not guarantee the complete prevention of neck recurrence, it increases the likelihood of either timely removal of micrometastases or strengthens the justification for adjuvant therapy. Consequently, this approach leads to improvements in clinical outcomes.},
author = {Struckmeier, Ann-Kristin and Buchbender, Mayte and Möst, Tobias and Lutz, Rainer and Agaimy, Abbas and Kesting, Marco Rainer},
doi = {10.1007/s00784-024-05514-8},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Lymph node metastasis; Neck dissection; Occult metastasis; Oral squamous cell carcinoma},
month = {Jan},
note = {CRIS-Team Scopus Importer:2024-02-02},
peerreviewed = {Yes},
title = {{Occult} metastasis is no burden factor in oral squamous cell carcinoma patients when adhering to a standardized approach in neck dissection},
volume = {28},
year = {2024}
}
@article{faucris.213170675,
abstract = {OBJECTIVES: To evaluate, by comparing maxillary sinus volumes, how asymmetries related to oculoauriculovertebral spectrum (OAVS) affect upper-jaw development.
METHODS: From pre-existing multislice spiral computed tomography (MSCT) datasets, we selected 20 cases of 11 female and 9 male patients aged 6.1-24 years who were clinically and radiographically symmetrical (group 1) plus 20 cases of 8 female and 12 male patients aged 5.7-23.9 years who had OAVS (group 2). After three-dimensional reconstruction of the datasets, the volumes of the left and right maxillary sinuses were calculated and compared based on patient groups and based on the sides affected or unaffected by OAVS. To this end, the OAVS patients were subdivided into a group in whom both external acoustic pores were radiographically present (group 2a) and a group in whom the pore on the affected side was congenitally missing (group 2b).
RESULTS: Intrarater reliability was very high (0.997). Significantly larger volumes of the maxillary sinuses, amounting to a mean of 13.4 ml, were observed in the control group than in the asymmetric OAVS groups where the volumes averaged 9.8 ml or 10.3 ml, respectively (p = 0.03). No statistically significant differences in sinus volumes were found between the two OAVS groups (p = 0.557) and between the sides affected or unaffected by the OAVS (p = 0.8311 in group 2a and 0.4961 in group 2b).
CONCLUSIONS: Overall, we found the volumes of both maxillary sinuses to be somewhat smaller in the asymmetric patients than in the symmetric control group. This might indicate that OAVS was associated with a mild generalized hypoplasia of the maxilla, but significantly different sinus volumes were not seen between the affected and unaffected sides.
},
author = {Hofmann, Elisabeth and Detterbeck, Andreas and Chepura, Taras and Kirschneck, Christian and Schmid, Matthias and Hirschfelder, Ursula},
doi = {10.1007/s00056-018-0141-5},
faupublication = {yes},
journal = {Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie},
note = {EVALuna2:36410},
pages = {259-266},
peerreviewed = {Yes},
title = {{Oculoauriculovertebral} spectrum and maxillary sinus volumes : {CT}-based comparative evaluation},
volume = {79},
year = {2018}
}
@article{faucris.286905778,
abstract = {Background: Laser surgery lacks haptic feedback, which is accompanied by the risk of iatrogenic nerve damage. It was the aim of this study to investigate diffuse reflectance spectroscopy for tissue differentiation as the base of a feedback control system to enhance nerve preservation in oral and maxillofacial laser surgery.Methods: Diffuse reflectance spectra of nerve tissue, salivary gland and bone (8640 spectra) of the mid-facial region of ex vivo domestic pigs were acquired in the wavelength range of 350-650 nm. Tissue differentiation was performed using principal component (PC) analysis followed by linear discriminant analysis (LDA). Specificity and sensitivity were calculated using receiver operating characteristic (ROC) analysis and the area under curve (AUC).Results: Five PCs were found to be adequate for tissue differentiation with diffuse reflectance spectra using LDA. Nerve tissue could be differed from bone as well as from salivary gland with AUC results of greater than 88%, sensitivity of greater than 83% and specificity in excess of 78%.Conclusions: Diffuse reflectance spectroscopy is an adequate technique for nerve identification in the vicinity of bone and salivary gland. The results set the basis for a feedback system to prevent iatrogenic nerve damage when performing oral and maxillofacial laser surgery. © 2011 Stelzle et al; licensee BioMed Central Ltd.},
author = {Stelzle, Florian and Zam, Azhar and Adler, Werner and Douplik, Alexandre and Nkenke, Emeka and Schmidt, Michael and Tangermann-Gerk, Katja},
doi = {10.1186/1479-5876-9-20},
faupublication = {yes},
journal = {Journal of Translational Medicine},
note = {Created from Fastlane, Scopus look-up},
peerreviewed = {Yes},
title = {{Optical} {Nerve} {Detection} by {Diffuse} {Reflectance} {Spectroscopy} for {Feedback} {Controlled} {Oral} and {Maxillofacial} {Laser} {Surgery}},
volume = {9},
year = {2011}
}
@article{faucris.107452224,
abstract = {Facial nerve function may be hampered by iatrogenic damage during head and neck laser surgery procedures. Optical techniques can serve as a basis for feedback-controlled tissue-specific laser surgery on the jaw bone and the parotid gland. In order to preserve nerve tissue during laser surgery, the alteration of optical tissue properties through laser-tissue interactions have to be taken into account. It was the aim of this study to evaluate the viability of optical tissue differentiation through diffuse reflectance spectroscopy after exposure to laser light as a basis for a feedback system for tissue-specific laser surgery. Spectra of diffuse reflectance (wavelength, 350-650 nm) of nerves, salivary glands, and cortical and cancellous bone of the midfacial region (ex vivo domestic pig heads) were acquired before/after Er:YAG laser (wavelength, 2.94 ?m) ablation (each 16,800 spectra). Principal component analysis was computed followed by quadratic discriminant analysis. The tissue classification performance as well as area under the curve (AUC) sensitivity and specificity for tissue differentiation was assessed before and after laser-tissue exposure. A high classification performance was observed before laser ablation (total error, 7.74 %). Nerve tissue was differentiated from bone and salivary glands with results greater than 0.96 in AUC, sensitivity and specificity. After laser exposure, a total classification error of 18.61 % was observed. The differentiation of nerve tissue was reduced with an AUC of >0.94, sensitivity of >0.95, and specificity >0.87. Er:YAG laser ablation only slightly reduces the differentiation performance through diffuse reflectance in the investigated tissue types. The results show the general viability of diffuse reflectance spectroscopy in identifying neural structures in the vicinity of salivary glands and bone as a basis for nerve preservation during feedback-controlled laser surgery.},
author = {Stelzle, Florian and Knipfer, Christian and Bergauer, Bastian and Rohde, Maximilian and Adler, Werner and Tangermann-Gerk, Katja and Nkenke, Emeka and Schmidt, Michael},
doi = {10.1007/s10103-014-1569-5},
faupublication = {yes},
journal = {Lasers in Medical Science},
note = {EVALuna2:5449},
pages = {1641-8},
peerreviewed = {Yes},
title = {{Optical} nerve identification in head and neck surgery after {Er}:{YAG} laser ablation},
volume = {29},
year = {2014}
}
@incollection{faucris.118982644,
address = {Bonn},
author = {Häusler, Gerd and Nkenke, Emeka and et al.},
author_hint = {Maier Tobias, Benz Michaela, Häusler Gerd, Veit K., Neukam F.W., Nkenke Emeka},
booktitle = {Informatik 2005 - Informatik live! (35. Jahrestagung der Ges. für Informatik e.V.)},
faupublication = {yes},
note = {UnivIS-Import:2015-04-20:Pub.2005.nat.dphy.optik.1optik.optisc},
pages = {677},
peerreviewed = {Yes},
publisher = {-},
support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'},
title = {{Optische} {3D}-{Messtechnik} in der {Mund}-, {Kiefer}-, {Gesichtschirurgie}},
year = {2005}
}
@article{faucris.265763888,
abstract = {Background: The oral health of organ transplanted patients before organ re-transplantation is largely unknown. This retrospective clinical study evaluates the necessity for intraoral surgical intervention and/or conservative treatment in candidates awaiting organ re-transplantation, both for graft failure and for reasons of another upcoming solid organ transplantation (renal or non-renal). Methods: From January 2015 to March 2020 n = 19 transplant recipients in evaluation on the waiting list for solid organ re-transplantation could be included in the retrospective case series study. Using clinical and radiological examinations, necessity for oral surgical or conservative dental treatment was evaluated. On the basis of anamnesis data, current kidney function, renal replacement treatment (RRT), and medication, a risk profile for several patient subgroups was created. Results: The clinical and radiological examinations showed a conservative and/or surgical treatment need in n = 13 cases (68.42%). In n = 7 cases (36.84%) surgical intervention was recommended due to residual root remnants (n = 5), unclear mucosal changes (n = 1), and periimplantitis (n = 1). In n = 16 recipients (84.2%) RRT (n = 15 hemodialysis; n = 1 peritoneal dialysis) had been performed. N = 14 recipients (73.68%) received immunosuppressants. In n = 1 patient (5.3%) displayed intraoral and n = 4 patients (21.1%) extraoral neoplasms due to drug-induced immunosuppression. Conclusions: Solid organ transplant recipients with renal failure present a complex treatment profile due to a double burden of uremia plus immunosuppressants. In cases of surgical treatment need a hospitalized setting is recommended, where potentially necessary follow-up care and close cooperation with disciplines of internal medicine is possible in order to avoid surgical and/or internal complications.},
author = {Möst, Tobias and Lutz, Rainer and Jahn, Arne Eric and Heller, Katharina M. and Schiffer, Mario and Adler, Werner and Deschner, James and Weber, Manuel and Kesting, Marco Rainer},
doi = {10.1186/s12903-021-01908-2},
faupublication = {yes},
journal = {BMC Oral Health},
keywords = {Immunosuppression; Oral health; Organ transplantation},
note = {CRIS-Team Scopus Importer:2021-11-05},
peerreviewed = {Yes},
title = {{Oral} health of patients suffering from end-stage solid organ insufficiency prior to solid organ re-transplantation: a retrospective case series study},
volume = {21},
year = {2021}
}
@article{faucris.211795523,
abstract = {AIM: In this systematic review, we aimed to assess the impact of endosseous implants on the formation of an osteonecrosis of the jaw, as well as implant survival rates for patients under bisphosphonate (BP), antiresorptive and radiation therapy.
MATERIALS AND METHODS: An electronic search was performed using PubMed, Embase, and Medline databases with the logical operators: "dental implant", "antiresorptive", "bisphosphonate", "irradiation", "radiotherapy", "radiation", "necrosis" and "survival". The search was limited to articles published up to 15 December 2016. Recent publications were also searched manually to find any relevant studies that might have been missed using the search criteria noted above. The outcome variables were the implant survival rate and the frequency of osteonecrosis of the jaws.
RESULTS: In total, 18 studies addressing oral implants in patients with BP or antiresorptive therapy and 23 with radiation therapy met the inclusion criteria and were included in this systematic review. Most of the studies had a retrospective design with a level of evidence (LoE) of III (moderately high risk of bias). Implant survival rate ranged from 92.86% to 100% in patients with BP/antiresorptive therapy (all due to osteoporosis) and 38.5% to 97.9% in patients with radiation therapy. For BP patients, osteonecrosis in relation to oral implants more frequently occurred in patients taking BPs due to malignant diseases. In patients with radiation therapy, an "implant triggered" necrosis is also a potential complication. The lack of data in the current literature concerning this issue does not allow a proper risk assessment to date.
CONCLUSIONS: Within the limits of this systematic review, implant treatment concepts seem to be a valuable approach in patients with radiation therapy and patients with BP therapy due to an osteoporosis. In patients taking BPs due to a malignant disease, implant treatments are not recommended due to the high number of reported implant-related necrosis in this patient cohort. Outcomes of this review should, however, be regarded with caution due to the low level of evidence of the currently existing data.},
author = {Schmitt, Christian and Buchbender, Mayte and Lutz, Rainer and Neukam, Friedrich Wilhelm},
faupublication = {yes},
journal = {European Journal of Oral Implantology},
note = {EVALuna2:35698},
pages = {S93-S111},
peerreviewed = {Yes},
title = {{Oral} implant survival in patients with bisphosphonate ({BP})/antiresorptive and radiation therapy and their impact on osteonecrosis of the jaws. {A} systematic review},
volume = {11 Suppl 1},
year = {2018}
}
@article{faucris.117662864,
abstract = {Prospective speech intelligibility assessments lack objectivity in patients undergoing surgery for oral squamous cell carcinoma (OSCC) of the tongue.Speech intelligibility was measured based on word recognition by means of an automatic and objective speech recognition system preoperatively, and 14 to 20 days, and 3 months, 6 months, and 12 months postoperatively. The study comprised 25 patients with OSCC of the tongue and a healthy control group (n = 40).Patients yielded significant speech impairments compared to the healthy control group both before surgery and after 12 months (p <= .002). The speech intelligibility of the patients decreased significantly 14 to 20 days after surgery (p < .001) but realigned to preoperative values after 12 months (p = .159). Preservation of the tip of the tongue resulted in significantly higher word recognition after 12 months (p = .007; ?word recognition = 16.29).Having OSSC of the tongue results in a significant impairment of speech intelligibility. The preservation of the tip of the tongue seems to be a central factor concerning the recovery of speech. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.},
author = {Riemann, Max and Knipfer, Christian and Rohde, Maximilian and Adler, Werner and Schuster, Maria and Nöth, Elmar and Oetter, Nicolai and Shams, Nima and Neukam, Friedrich Wilhelm and Stelzle, Florian},
doi = {10.1002/hed.23994},
faupublication = {yes},
journal = {Head and Neck-Journal For the Sciences and Specialties of the Head and Neck},
note = {EVALuna2:5479},
peerreviewed = {Yes},
title = {{Oral} squamous cell carcinoma of the tongue: {Prospective} and objective speech evaluation of patients undergoing surgical therapy},
year = {2014}
}
@article{faucris.230869010,
abstract = {Objectives: The aim of the present study was the qualitative and quantitative evaluation of osseous graft consolidation using allogeneic bone blocks for vertical bone augmentation in an animal model. Material and methods: Standardised allogeneic and autologous bone blocks were fixed on the frontal skull of 20 adult female pigs and covered with a resorbable collagen membrane. Animals were sacrificed after 2 and 6 months. Specimens were histologically and histomorphometrically analysed focusing on the amount of vital bone, residual bone substitute material and connective tissue. Furthermore, the amount of expression of bone matrix proteins (collagen type I and osteocalcin) and de novo vessel formation (von Willebrand factor) were quantified by immunohistochemistry. Results: Significantly more allogeneic bone blocks failed for both evaluation time points (p < 0.05). Allogeneic blocks showed significantly less vital bone with more connective tissue formation compared to autologous bone blocks. Increased vessel formation could be detected for both evaluation time points in the contact area of autologous bone with local bone. The expression of collagen type I and osteocalcin was significantly lower in the allogeneic bone graft. Conclusions: Allogeneic cancellous bone blocks showed a significantly higher failure rate compared to autologous bone blocks. Allogeneic bone blocks seemed to negatively affect bone formation or negatively influence the host in the long term, and increased connective tissue formation and block loss should be anticipated. Clinical relevance: In order to maintain patient safety and treatment success clinicians should be persuaded to make a conscious choice of the applied biomaterials with regard to their components and structure.},
author = {Möst, Tobias and Frabschka, Johanna and Kesting, Marco Rainer and Schmitt, Christian and Frohwitter, Gesche and Lutz, Rainer and Schlegel, Karl Andreas},
doi = {10.1007/s00784-019-03151-0},
faupublication = {yes},
journal = {Clinical Oral Investigations},
keywords = {Allogeneic bone block; Animal model; Bone substitutes; Histomorphometry; Immunohistochemistry},
note = {CRIS-Team Scopus Importer:2019-12-27},
peerreviewed = {Yes},
title = {{Osseous} ingrowth in allogeneic bone blocks applied for vertical bone augmentation: a preclinical randomised controlled study},
year = {2019}
}
@article{faucris.213920241,
abstract = {BackgroundWith an increasing indication spectrum of antiresorptive drugs, the medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is continuously gaining clinical relevance. Impaired osteoclast function, accompanied by altered cell morphology and expression of osteoclastic effector proteins, contributes to the pathogenesis of MRONJ (BP). However, the underlying regulatory mechanisms at a transcriptional level are unaddressed so far. These mechanisms are crucial to the development of disease-characteristic osteoclastic anomalies, that contribute to the pathogenesis of MRONJ (BP). NFATc1 is considered a master upstream osteoclastic activator, whereas BCL6 acts as osteoclastic suppressor. The present study aimed to elucidate the NFATc1 and BCL6 mediated osteoclastic regulation and activity in MRONJ (BP) compared to osteoradionecrosis (ORN) and osteomyelitis (OM) and normal jaw bone.MethodsFormalin-fixed jaw bone specimens from 70 patients [MRONJ (BP) n=30; OM: n=15, ORN: n=15, control: n=10] were analyzed retrospectively for osteoclast expression of NFATc1 and BCL6. The specimens were processed for H&E staining and immunohistochemistry. The histological sections were digitalized and analyzed by virtual microscopy.ResultsOsteoclastic expression of NFATc1 and BCL6 was significantly higher in MRONJ (BP) specimens compared to OM and control specimens. NFATc1 and BCL6 labeling indices revealed no significant differences between MRONJ (BP) and ORN. The ratio of nuclear BCL6+ osteoclasts to cytoplasmic BCL6+ osteoclasts revealed significantly higher values for MRONJ (BP) specimens compared to OM and controls.ConclusionThis study displays that osteoclasts in MRONJ (BP) tissues feature increased expression of the higher-level regulators, paradoxically of both NFATc1 and BCL6. These observations can help to explain the genesis of morphologically altered and resorptive inactive osteoclasts in MRONJ (BP) tissues by outlining the transcriptional regulation of the pathomechanically relevant osteoclastic effector proteins. Furthermore, they strengthen the etiological delineation of MRONJ (BP) from OM and extend the osteoclast profiles of MRONJ (BP), OM and ORN and thus could lead to a better histopathological differentiation that can improve treatment decision and motivate new therapeutic concepts.},
author = {Wehrhan, Falk and Gross, Christian and Creutzburg, Kay and Amann, Kerstin Ute and Ries, Jutta and Kesting, Marco Rainer and Geppert, Carol-Immanuel and Weber, Manuel},
doi = {10.1186/s12967-019-1819-1},
faupublication = {yes},
journal = {Journal of Translational Medicine},
note = {CRIS-Team WoS Importer:2019-03-20},
peerreviewed = {Yes},
title = {{Osteoclastic} expression of higher-level regulators {NFATc1} and {BCL6} in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis},
volume = {17},
year = {2019}
}
@article{faucris.121802604,
abstract = {Bisphosphonates have a widespread indication for osteoporosis and are also applied in cancer patients with skeletal-related conditions. Bisphosphonate-associated osteonecrosis of the jaw (BRONJ) is a feared side effect which is hard to treat and often affects patient´s quality of life in an extensive manner. Adalimumab (Humira®), a fully human recombinant antibody specific for tumor necrosis factor- ?, is approved for treatment in patients with Inflammatory Bowel Disease like ulcerative colitis or Crohn's disease.In March 2013, a 36-year-old female presented with right-sided perimandibular swelling, recurrent facial pain and exposed necrotic bone after previous extraction of tooth 47. She had the medical history of Crohn's disease for more than one decade with chronic active enterocolitis, fistula disease as well as previous oral manifestation and was currently treated with Adalimumab since September 2008. Due to steroid-induced osteoporosis, diagnosed in 2004, she received oral Bisphosphonates (Risedronate) from 2004 until 2007 followed by two infusions of Zoledronic acid in 2008 and 2009.This patient with a medical history of Crohn's disease and gastrointestinal remission under Adalimumab therapy presented with osteonecrosis of the jaw after suspended oral and intravenous Bisphosphonate therapy implicating that the biologic therapy with an anti-TNF-? antibody might promote the manifestation of osteonecrosis and compromise oral healing capacity.},
author = {Preidl, Raimund and Ebker, Tobias and Raithel, Martin and Wehrhan, Falk and Neukam, Friedrich Wilhelm and Stockmann, Philipp},
doi = {10.1186/1471-230X-14-6},
faupublication = {yes},
journal = {BMC Gastroenterology},
note = {EVALuna2:1730},
pages = {6},
peerreviewed = {Yes},
title = {{Osteonecrosis} of the jaw in a {Crohn}'s disease patient following a course of {Bisphosphonate} and {Adalimumab} therapy: a case report},
volume = {14},
year = {2014}
}
@article{faucris.121806564,
abstract = {Both Osteoradionecrosis (ORN) and Bisphosphonate associated osteonecrosis of the jaws (BRONJ) present clinically as regions of exposed necrotic bone. The study aimed to demonstrate the histopathological differences behind the observed clinical similarities.Ten ORN specimens and ten BRONJ specimens were used, as well as ten samples of normal mandibular bone as control. Two bone-specific stainings were used, i.e. Sirius Red for the study of the relative presence of collagen types I and III and toluidine blue for the study the osteon density.The Red Green Blue (RGB)-analysis of the specimens stained with Sirius Red identified significant differences between the chromatic patterns observed in bone preparations of patients suffering from ORN when compared to both BRONJ and control samples. Moreover, the osteon density of the BRONJ samples was significantly lower when compared to ORN and normal bone samples.The demonstrated differences in the bone architecture and in the bone collagen content between the two pathological conditions most likely reflect underlying pathophysiological differences.},
author = {Mitsimponas, Konstantinos and Moebius, Patrick and Amann, Kerstin Ute and Stockmann, Philipp and Schlegel, Karl-Andreas and Neukam, Friedrich Wilhelm and Wehrhan, Falk},
faupublication = {yes},
journal = {International Journal of Clinical and Experimental Pathology},
note = {EVALuna2:24379},
pages = {496-508},
peerreviewed = {Yes},
title = {{Osteo}-radio-necrosis ({ORN}) and bisphosphonate-related osteonecrosis of the jaws ({BRONJ}): the histopathological differences under the clinical similarities},
volume = {7},
year = {2014}
}
@article{faucris.242206976,
abstract = {Introduction: The incidence of oral squamous cell carcinoma (OSCC) shows a constant increase, while the long-term outcome remains poor over the last decades. Radical oxygen and nitrogen species (RONS)-initially released by carcinogens, such as alcohol and tobacco, and later maintained by the tumor microenvironment- A ppear to be strongly associated to chronic inflammation, tumor induction, progression, and metastatic spread. The aim of this study was to evaluate the role of oxidative and nitrosative stress in primary OSCC compared to healthy tissue specimens and to identify their impact on tumor carcinogenesis. Materials and Methods: In this basic research study, tissue samples of 30 patients with primary OSCC were evaluated for the expression of pAKT, pERK, 3-NT, NOS1, NOS3, MAPK1, and IP-8 by immunohistochemistry and RT-PCR and compared to those of a healthy control group (n = 30). Results: The results showed a significantly increased expression of pAKT (p < 0.001), pERK (p = 0.01), 3-NT (p = 0.039), NOS1 (p = 0.025), NOS3 (p = 0.046), and MAPK1 (p = 0.032) in OSCC tissue samples compared to healthy controls. Conclusion: The results of this study prove the tested stable degradation products to be suitable for the detection of RONS in OSCC. Moreover, the significantly increased expression underlines the role of RONS in carcinogenesis of OSCC, suggests specific mechanisms of detection, and anticipates supplementary research.},
author = {Frohwitter, Gesche and Zimmermann, Ornella Lisa and Kreutzer, Kilian and Doll, Christian and Rendenbach, Carsten M. and Dommisch, Henrik and Wolff, Klaus Dietrich and Kesting, Marco Rainer and Heiland, Max and Koerdt, Steffen},
doi = {10.1159/000508705},
faupublication = {yes},
journal = {Cells Tissues Organs},
keywords = {Nitrosative stress; Oral cancer; Oral squamous cell carcinoma; Oxidative stress; RONS},
note = {CRIS-Team Scopus Importer:2020-09-04},
peerreviewed = {Yes},
title = {{Oxidative} and {Nitrosative} {Stress} in {Oral} {Squamous} {Cell} {Carcinoma}},
year = {2020}
}
@article{faucris.251068743,
abstract = {Objectives: This study analyzed the expression of the PD1 receptor in tumor tissue and peripheral blood of oral squamous cell carcinoma (OSCC) patients, and correlated it with the PD1 ligands PD-L1 and PD-L2. The currently low response rates of checkpoint inhibitor treatment in OSCC could be increased by a better understanding of immune checkpoint biology. Despite evidence in the literature for upregulation of PD1 checkpoint ligands in OSCC tissue, there has been no correlation analysis of the PD1 receptor with its ligands in tissue specimens and peripheral blood of OSCC patients.},
author = {Wehrhan, Falk and Weber, Manuel and Baran, Christoph and Agaimy, Abbas and Büttner-Herold, Maike and Kesting, Marco Rainer and Ries, Jutta},
doi = {10.1016/j.jcms.2020.12.007},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {CRIS-Team WoS Importer:2021-03-05},
pages = {118-125},
peerreviewed = {Yes},
title = {{PD1} expression and correlation with its ligands in oral cancer specimens and peripheral blood},
volume = {49},
year = {2021}
}
@article{faucris.120011804,
abstract = {Immune checkpoints like programmed cell death-1 (PD-1) and its ligand PD-L1 are involved in immune escape mechanisms of solid tumors including oral squamous cell carcinoma (OSCC). Inhibitors of the pathway are successfully used for treating especially advanced disease. However, the physiological relevance of PD-1/PD-L1-signaling in OSCC is insufficiently understood. The aim of the study was to analyze if PD-L1 expression in tumor tissue and peripheral blood samples of OSCC patients is associated with histomorphological tumor parameters and if PD-L1 expression in patients is different from controls.OSCC tumor specimens showed a significantly higher PD-L1 expression than oral mucosa controls (p < 0.001; upregulation more than 3-fold). Cross-tabulation revealed an association of increased expression of PD-L1 mRNA in tissue specimens with malignancy (p < 0.001).OSCC cases with higher tumor grade and cases with lymph node metastases (N+) were significantly (p < 0.05) associated with increased PD-L1 expression in peripheral blood. Cross-tabulation revealed an significant association with lymph node metastases (N+) (p <= 0.002).PD-L1 mRNA expression was analyzed in tumor specimens and corresponding samples of healthy oral mucosa and peripheral blood of 45 OSCC patients and 36 healthy control persons using RT-qPCR analysis. A Mann-Whitney U-test, a cut-off point analysis and a Chi-square test were carried out.PD-L1 expression in OSCC could contribute to the immunosuppressive local tumor microenvironment. Increased malignant behavior (higher tumor grade, positive nodal status) might be associated with PD-L1 mediated systemic immune tolerance. Thus, PD-L1 expression in peripheral blood might be an indicator of the existence of metastatic disease (N+) in OSCC.},
author = {Weber, Manuel and Wehrhan, Falk and Baran, Christoph and Agaimy, Abbas and Büttner-Herold, Maike and Preidl, Raimund and Neukam, Friedrich Wilhelm and Ries, Jutta},
doi = {10.18632/oncotarget.22576},
faupublication = {yes},
journal = {Oncotarget},
note = {EVALuna2:25563},
pages = {112584-112597},
peerreviewed = {Yes},
title = {{PD}-{L1} expression in tumor tissue and peripheral blood of patients with oral squamous cell carcinoma},
volume = {8},
year = {2017}
}
@article{faucris.275320898,
abstract = {Objectives The present radiological observational controlled study aims to evaluate the impact of secondary hyperparathyroidism (SHPT) due to chronic kidney disease (CKD) as well as the duration of dialysis on the mineralization of the mandible by standardized qualitative evaluation of digital panoramic radiographs. Methods Panoramic radiographs of CKD patients with SHPT and healthy controls were used for the qualitative analysis of the mandibular cortical index (MCI), the trabecular bone pattern (TBP), and calcification and resorption foci. Radiomorphometric indices were correlated to biochemical parameters and the duration of dialysis using the Spearman Rho test. Group comparisons were conducted using the Mann-Whitney U test and Fisher's exact test at a significance level of alpha <= 0.05. Interrater reliability of two physicians was estimated using Cohen's kappa. Results Inclusion and exclusion criteria were fulfilled by N = 41 patients. Statistically significant differences in the MCI (p < 0.001) as well as the TBP (p = 0.002) could be detected for the experimental group in comparison to the healthy control group. Focusing on calcification and resorption foci, no statistically significant difference could be detected between the groups (p = 0.244). The level of the detected parathyroid hormone (PTH) significantly correlated with TBP (Rho = 0.338; p = 0.031), while no significant relationship between TBP and the duration of the dialysis could be found. Conclusions Patients with SHPT due to CKD show statistically significant bone changes in the panoramic radiograph, whereby the grade of trabecular bone change correlates to PTH values.},
author = {Möst, Tobias and Jahn, Arne Eric and Heller, Katharina M. and Schiffer, Mario and Adler, Werner and Rohde, Maximilian and Weber, Manuel and Kesting, Marco Rainer and Lutz, Rainer},
doi = {10.1007/s11282-022-00613-2},
faupublication = {yes},
journal = {Oral Radiology},
note = {CRIS-Team WoS Importer:2022-05-20},
peerreviewed = {Yes},
title = {{Peculiarities} in the panoramic radiograph of patients with secondary hyperparathyroidism due to terminal renal disease: a radiologic controlled comparative study},
year = {2022}
}
@article{faucris.268922167,
abstract = {Background: Intraoral soft tissue deficiency and impaired wound beds are common problems after cleft and tumour surgery or after dental trauma. Frequently, limited defects are overtreated with extensive microvascular reconstruction procedures, but pedicled flaps remain useful, as they are simple to harvest, and they provide a reliable outcome. The buccal flap, first described in the 1970s, has been used for palatine lengthening in cleft patients over decades. In the following, we present an expanded indication in cases of palatal fistula, complex vestibulum, exposed bone in orthognathic surgery, and osteoradionecrosis. Methods: We conducted a retrospective chart review and report on all buccal flaps harvested in our department within the last 3 years with a follow-up period of at least half a year after flap surgery. Patients of all age groups and treatment indications in which a buccal flap was used were implicated in the evaluation. Results: Sixteen buccal flaps were performed in 10 patients. The median age at the time of surgery was 42 years, reaching from 12 up to 66 years. Fourteen buccal flaps were used for upper jaw or palatal coverage; two buccal flaps were used in the mandible. In terms of complications (four flaps; 25%), there were two partial flap failures, one wound dehiscence and one wound dehiscence. There were no failures of the remaining mucosal flap islands after pedicle dissection. Conclusion: The buccal flap is a reliable and straightforward approach to challenging intraoral wound beds with soft tissue deficiency. We thoroughly discuss the additional indications for buccal flap surgery, describe the harvest technique, and provide strategies to prevent intra- and postoperative complications.},
author = {Frohwitter, Gesche and Kesting, Marco Rainer and Rau, Andrea and Weber, Manuel and Baran, Christoph and Nobis, Christopher-Philipp and Büntemeyer, Tjark-Ole and Preidl, Raimund and Lutz, Rainer},
doi = {10.1007/s10006-022-01040-7},
faupublication = {yes},
journal = {Oral and maxillofacial surgery},
keywords = {Backup procedures; Cleft surgery; Oral surgery; Pedicle flaps; Reconstructive surgery},
note = {CRIS-Team Scopus Importer:2022-02-04},
peerreviewed = {unknown},
title = {{Pedicled} buccal flaps as a backup procedure for intraoral reconstruction},
year = {2022}
}
@article{faucris.117760324,
abstract = {In this systematic review, we aimed to compare conical versus nonconical implant-abutment connection systems in terms of their in vitro and in vivo performances. An electronic search was performed using PubMed, Embase, and Medline databases with the logical operators: "dental implant" AND "dental abutment" AND ("conical" OR "taper" OR "cone"). Names of the most common conical implant-abutment connection systems were used as additional key words to detect further data. The search was limited to articles published up to November 2012. Recent publications were also searched manually in order to find any relevant studies that might have been missed using the search criteria noted above. Fifty-two studies met the inclusion criteria and were included in this systematic review. As the data and methods, as well as types of implants used was so heterogeneous, this mitigated against the performance of meta-analysis. In vitro studies indicated that conical and nonconical abutments showed sufficient resistance to maximal bending forces and fatigue loading. However, conical abutments showed superiority in terms of seal performance, microgap formation, torque maintenance, and abutment stability. In vivo studies (human and animal) indicated that conical and nonconical systems are comparable in terms of implant success and survival rates with less marginal bone loss around conical connection implants in most cases. This review indicates that implant systems using a conical implant-abutment connection, provides better results in terms of abutment fit, stability, and seal performance. These design features could lead to improvements over time versus nonconical connection systems. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 552-574, 2014.},
author = {Schmitt, Christian M. and Nogueira-Filho, Getulio and Tenenbaum, Howard C. and Lai, Jim Yuan and Brito, Carlos and Döring, Hendrik and Nonhoff, Jörg},
doi = {10.1002/jbm.a.34709},
faupublication = {yes},
journal = {Journal of Biomedical Materials Research Part A},
note = {EVALuna2:24367},
pages = {552-74},
peerreviewed = {Yes},
title = {{Performance} of conical abutment ({Morse} {Taper}) connection implants: {A} systematic review},
volume = {102},
year = {2014}
}
@article{faucris.272550056,
abstract = {Purpose: Fibula free flap (FFF) is the main reconstructive choice for large mandibular defects. Recent improvements were made regarding planning and surgical procedure, but choice of osteosynthesis material (OSM) for segment-fixation remains controversial. Materials and methods: A retrospective cohort study obtained clinical and radiological data from FFF-patients. Data was screened for OSM, surgical procedure and complications as OSM fractures, loosening, exposure, or insufficient osseous consolidation. Results: 80 patients with FFF were included. Planning was CAD/CAM (n=29), Recon Guide (n=26) or without planning (n=25). OSM was 2.0mm-miniplates in standard (n=26), preformed (n=6), CAD/CAM (n=14) or ReconGuide (n=23) variation and 2.3mm-reconstruction-plates in standard (n=5) or CAD/CAM (n=6) variation. Complications were observed in 21 cases, fractures in 10 times overall, but with low rates for preformed (n=1), ReconGuide (n=3) and none for CAD/CAM. Analysis detected significant correlations between used OSM and plate exposure (p = .000), but none regarding fracture (p = .275), loosening (p = .714) or insufficient osseous consolidation (p = .208). No correlations were observed between complications and OSM (p = .609) or diagnosis (p = .716). Conclusion: Fixation of FFF segments for reconstruction is possible with various OSM providing good clinical outcome. No significant differences were detected regarding prevention of complications by any osteosynthesis material (miniplate vs. macroplate). Although no differences were detected, miniplate usage is advocated whenever clinically reasonable, due to more facile reintervention possibilities and reduced implanted foreign material. Nevertheless, decision for ideal OSM must remain patient-specific and cannot be generalized.},
author = {Nobis, Christopher-Philipp and Lutz, Rainer and Weber, Margarete and Preidl, Raimund and Goetze, Elisabeth and Frohwitter, Gesche and Kesting, Marco Rainer},
doi = {10.1016/j.bjoms.2021.10.013},
faupublication = {yes},
journal = {British Journal of Oral and Maxillofacial Surgery},
keywords = {CAD/CAM; complications; fibula free flap; miniplate; osteosynthesis; ReconGuide},
note = {CRIS-Team Scopus Importer:2022-04-08},
peerreviewed = {Yes},
title = {{Performance} of different osteosynthesis materials in microvascular fibula free flap reconstruction},
year = {2022}
}
@article{faucris.121357984,
abstract = {The study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration.Experimental diabetes was induced in three domestic pigs by streptozotocin. Three animals served as healthy controls. After 12 months four standardized peri-implant dehiscence bone defects were surgically created in the ramus mandibulae. The animals were sacrificed after 90 days. Samples were histologically analyzed to quantify new bone height (NBH), bone-to-implant-contact (BIC), area of newly formed bone (NFB), bone-density (BD), and bone mineralization (BM) in the prepared defect (-D) and in a local control region (-L).After 90 days, diabetic animals revealed a significantly lower BIC (p = 0.037) and BD (p = 0.041) in the defect area (-D). NBH and BM-D differences within the groups were not significant (p > 0.05). Significant more NFB was measured in the healthy control group (p = 0.046). In the region of local bone BIC-L was significant less in the diabetic group (p = 0.028). In the local control region BD-L and BM-L was lower in the diabetic group compared to the healthy control animals (p > 0.05).Histological evidence indicates impaired peri-implant defect regeneration in a diabetic animal model.},
author = {von Wilmowsky, Cornelius and Schlegel, Andreas and Baran, Christoph and Nkenke, Emeka and Neukam, Friedrich Wilhelm and Moest, Tobias},
doi = {10.1016/j.jcms.2016.04.002},
faupublication = {yes},
journal = {Journal of Cranio-Maxillofacial Surgery},
note = {EVALuna2:24420},
pages = {827-34},
peerreviewed = {Yes},
title = {{Peri}-implant defect regeneration in the diabetic pig: {A} preclinical study},
volume = {44},
year = {2016}
}
@article{faucris.122098944,
abstract = {Microsurgical tissue transfer is a well-established way of reconstructing the head and neck, but there are still many postoperative complications that require revision. The aim of this study was to clarify perioperative factors and characteristics of patients that influence the success of the flap and the need for revision. We retrospectively studied 368 patients who were treated with microsurgical free tissue transfer in the head and neck area at the Department of Oral and Maxillofacial Surgery at the University Medical Centre, Erlangen, between 2004 and 2009. Investigations concentrated on patients' characteristics and operative factors. Free scapular or parascapular flaps (n=161, 44%) and radial forearm flaps (n=119, 32%) were predominantly used for the reconstruction of major defects in the mandible and the floor of the mouth. In 39 patients (11%) revision was required, which resulted in a success rate of 96%. There was a significant association between preoperative American Society of Anesthesiologists (ASA) grade and postoperative survival of the flap (p=0.04). Patients previously treated by irradiation required significantly more revisions than those not so treated (p=0.04). The use of vein grafts was also significantly associated with the need for revision (p=0.02). The ASA grade influenced the success rate but was not associated with the number of revisions. These factors must be taken into consideration when intervention is planned to reduce the number of postoperative complications and interventions further.},
author = {Preidl, Raimund and Wehrhan, Falk and Schlittenbauer, T. and Neukam, Friedrich Wilhelm and Stockmann, Philipp},
doi = {10.1016/j.bjoms.2015.03.007},
faupublication = {yes},
journal = {British Journal of Oral and Maxillofacial Surgery},
note = {EVALuna2:24398},
pages = {533-7},
peerreviewed = {Yes},
title = {{Perioperative} factors that influence the outcome of microsurgical reconstructions in craniomaxillofacial surgery},
volume = {53},
year = {2015}
}
@article{faucris.231299894,
abstract = {In cleft care, perioperative treatment strategies like ear nose and throat (ENT) diagnostics as well as postoperative antibiotics, feeding, and duration of inpatient stay are nonstandardized procedures varying between different centers. Likewise, intraoperative choice of suture materials and time of suture removal are performed inconsistently. Therefore, we wanted to collect information on protocols focusing on these topics to summarize and subsume currently approved treatment strategies of centers around the world. We ask members of international cleft centers for their respective treatment strategies and performed descriptive statistics.Absorbable suture material is used for reconstruction of the outer lip skin in 20 of 70 centers. Removal of skin sutures is conducted after 7.0 ± 1.5 days. Suturing of the orbicularis oris muscle, the enoral and nasal mucosa, as well as the palatal musculature is predominantly performed with absorbable suture materials. Intraoperative antibiotic prophylaxis is applied in 82.9% of the participating centers. In contrast, 31.9% of the departments do not apply any antibiotic postoperatively. Postoperative feeding is performed in 27 centers via a nasogastric tube for 4.6 ± 2.3 days on average. Mean length of postoperative inpatient stay is 4.1 ± 2.6 days in children after cleft lip surgery and 4.5 ± 2.7 days after cleft palate surgery. ENT consultation before surgery is routinely conducted in 52.8% of the centers and 82.9% of ENT colleagues investigate middle ear pathologies in the same operation in which cleft repair is performed.Closure of the lip skin is predominantly performed with nonabsorbable suture material followed by a suture removal after 1 week. Intraoperative antibiotic prophylaxis as well as inpatient hospital stay of 4 to 5 days in combination with oral feeding and a preoperative consultation and intraoperative cooperation with the ENT department seems to be well-proven concepts in cleft lip palate patient care. However, this analysis illustrated the variations and differing approaches in perioperative care emphasizing the need to verify perioperative management concepts in cleft surgery-preferably in the context of multicenter studies.},
author = {Preidl, Raimund and Kesting, Marco Rainer and Rau, Andrea},
doi = {10.1097/SCS.0000000000005897},
faupublication = {yes},
journal = {Journal of Craniofacial Surgery},
month = {Jan},
note = {CRIS-Team Scopus Importer:2020-01-10},
pages = {95-101},
peerreviewed = {Yes},
title = {{Perioperative} {Management} in {Patients} {With} {Cleft} {Lip} and {Palate}},
volume = {31},
year = {2020}
}
@article{faucris.287057982,
abstract = {The goal of this study is to explore the feasibility of the PPG sensor for the clinical shock detection by measuring hemodynamic parameters.