% Encoding: UTF-8 @COMMENT{BibTeX export based on data in FAU CRIS: https://cris.fau.de/} @COMMENT{For any questions please write to cris-support@fau.de} @article{faucris.268132065, author = {Berendt, Julia and Gahr, Susanne and Heckel, Maria and Tewes, Mitra and Ostgathe, Christoph}, doi = {10.1055/a-1688-7739}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, month = {Jan}, note = {CRIS-Team WoS Importer:2022-01-14}, pages = {8-9}, peerreviewed = {unknown}, title = {10 {Years} of the {Palliative} {Medicine} {Working} {Group} in the {Network} of {Top} {Oncology} {Centers}}, volume = {23}, year = {2022} } @inproceedings{faucris.243327167, address = {HOBOKEN}, author = {Erb, T. and Mihai, Sidonia and Cipa, Franziska and Herbst, Larissa and Strauss, Richard and Castellanos, Ixchel and Lang, K. and Ganslmayer, Marion and Willam, Carsten and Rath, Anca and Diesch, Katharina and Held, Jürgen}, booktitle = {MYCOSES}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2020-10-02}, pages = {18-18}, peerreviewed = {unknown}, publisher = {WILEY}, title = {(1 -> 3)-beta-{D}-glucan and mannan guided early termination of antifungal therapy in {ICU} patients: a prospective randomized intervention study ({REDUCE}-{AM})}, year = {2020} } @article{faucris.275309237, author = {Scholz, Jens and Schüttler, Jürgen}, faupublication = {yes}, journal = {Anästhesiologie & Intensivmedizin}, note = {CRIS-Team Scopus Importer:2022-05-20}, pages = {138-}, peerreviewed = {Yes}, title = {15 {Jahre} {Deutsches} {Reanimationsregister} – {Die} {DGAI} stärkt die {Notfallversorgung} in {Deutschland}}, volume = {63}, year = {2022} } @article{faucris.275323393, author = {Scholz, Jens and Schüttler, Jürgen}, faupublication = {yes}, journal = {Anästhesiologie & Intensivmedizin}, note = {CRIS-Team WoS Importer:2022-05-20}, peerreviewed = {unknown}, title = {15 {Years} of the {German} {Resuscitation} {Register} - {The} {DGAI} strengthens {Emergency} {Care} in {Germany}}, volume = {63}, year = {2022} } @article{faucris.275325357, abstract = {Modern safety science owes much of its current theories and practical approaches to the critical analysis of sociotechnological disasters in the nuclear, chemical, maritime, and aviation industries at the end of the 1970 s and in the 1980 s. The medical field by contrast, was not challenged by a single high profile event, but by the release of a single report by the Institute of Medicine in 1999: To Err is Human - Building a Safer Health System. The report expanded the level of conversation and concern about patient injuries in health care and led to an unprecedented provision of research grants in patient safety research, essentially launching the academic base for that work. Twenty years later, it is a good time to analyze how this seminal work was received in the academic literature, which authors and institutions had the greatest research activity, which national and international collaborations ensued, and how the ideas presented in To Err Is Human might have affected the academic discourse in the two decades to follow. To meet this aim, a bibliometric analysis was performed on all publications from 2000 to 2019 where the authors referenced To Err Is Human as part of their scientific argument. 20.494 documents were retrieved. The majority of patient safety related research was carried out by researchers from North America, with little international collaboration. Over the years, the thematic scope of the research diversified from the IOM report's initial focus in many directions. Contrary to what might be expected from the IOM report's central objectives, research on a systems approach to patient safety and on incident reporting were underrepresented. From a safety science perspective, the report narrowed the diversity of the patient safety discourse rather than enlarging it by favoring the theoretical framework proposed by James Reason over other, equally valid ones.}, author = {St. Pierre, Michael and Grawe, Petra and Bergstrom, Johan and Neuhaus, Christopher}, doi = {10.1016/j.ssci.2021.105593}, faupublication = {yes}, journal = {Safety Science}, note = {CRIS-Team WoS Importer:2022-05-20}, peerreviewed = {Yes}, title = {20 years after {To} {Err} {Is} {Human}: {A} bibliometric analysis of 'the {IOM} report's' impact on research on patient safety}, volume = {147}, year = {2022} } @article{faucris.228452291, author = {Ostgathe, Christoph and Klein, Carsten}, doi = {10.1007/s00101-019-00665-w}, faupublication = {yes}, journal = {Anaesthesist}, note = {CRIS-Team WoS Importer:2019-10-29}, peerreviewed = {Yes}, title = {62-year-old male with condition following emergency tracheotomy in metastasized hypopharyngeal cancer {Preparation} for the medical specialist examination: part 39}, year = {2019} } @article{faucris.216630771, abstract = {OBJECTIVE: Arden Syntax is a standard for representing and sharing medical knowledge in form of independent modules and looks back on a history of 25 years. Its traditional field of application is the monitoring of clinical events such as generating an alert in case of occurrence of a critical laboratory result. Arden Syntax Medical Logic Modules must be able to retrieve patient data from the electronic medical record in order to enable automated decision making. For patient data with a simple structure, for instance a list of laboratory results, or, in a broader view, any patient data with a list or table structure, this mapping process is straightforward. Nevertheless, if patient data are of a complex nested structure the mapping process may become tedious. Two clinical requirements - to process complex microbiology data and to decrease the time between a critical laboratory event and its alerting by monitoring Health Level 7 (HL7) communication - have triggered the investigation of approaches for providing complex patient data from electronic medical records inside Arden Syntax Medical Logic Modules. METHODS AND MATERIALS: The data mapping capabilities of current versions of the Arden Syntax standard as well as interfaces and data mapping capabilities of three different Arden Syntax environments have been analyzed. We found and implemented three different approaches to map a test sample of complex microbiology data for 22 patients and measured their execution times and memory usage. Based on one of these approaches, we mapped entire HL7 messages onto congruent Arden Syntax objects. RESULTS: While current versions of Arden Syntax support the mapping of list and table structures, complex data structures are so far unsupported. We identified three different approaches to map complex data from electronic patient records onto Arden Syntax variables; each of these approaches successfully mapped a test sample of complex microbiology data. The first approach was implemented in Arden Syntax itself, the second one inside the interface component of one of the investigated Arden Syntax environments. The third one was based on deserialization of Extended Markup Language (XML) data. Mean execution times of the approaches to map the test sample were 497ms, 382ms, and 84ms. Peak memory usage amounted to 3MB, 3MB, and 6MB. CONCLUSION: The most promising approach by far was to map arbitrary XML structures onto congruent complex data types of Arden Syntax through deserialization. This approach is generic insofar as a data mapper based on this approach can transform any patient data provided in appropriate XML format. Therefore it could help overcome a major obstacle for integrating clinical decision support functions into clinical information systems. Theoretically, the deserialization approach would even allow mapping entire patient records onto Arden Syntax objects in one single step. We recommend extending the Arden Syntax specification with an appropriate XML data format.}, author = {Kraus, Stefan and Enders, Martin and Prokosch, Hans-Ulrich and Castellanos, Ixchel and Lenz, Richard and Sedlmayr, Martin}, doi = {10.1016/j.artmed.2015.09.003}, faupublication = {yes}, journal = {Artificial Intelligence in Medicine}, note = {EVALuna2:142}, pages = {95-102}, peerreviewed = {Yes}, title = {{Accessing} complex patient data from {Arden} {Syntax} {Medical} {Logic} {Modules}}, volume = {92}, year = {2018} } @article{faucris.216858110, abstract = {Objective: Evaluate the accuracy and trending ability of the fourth-generation FloTrac/EV1000 (Edwards Lifesciences, Irvine, CA) system in patients with severe aortic valve stenosis by comparing FloTrac/EV1000-derived cardiac output (CCO-FT) with continuous thermodilution pulmonary artery catheter (CCO-PAC) measurements before and after surgical valve replacement. Design: Prospective clinical study. Setting: Anesthesia for cardiac surgery, operating room, single-center university hospital. Participants: Twenty-five patients were included. After exclusion, 20 patients undergoing elective aortic valve replacement were analyzed. Interventions: After induction of general anesthesia, CCO-FT and CCO-PAC values were recorded every 30 seconds before and after aortic valve replacement with a bioprosthesis under cardiopulmonary bypass (CPB). Measurements and Main Results: Data were analyzed separately from skin incision to last suture and before and after CPB. Regression analyses, Bland-Altman analyses, and trending analyses (4-quadrant plot, polar plot) were performed. The percentage errors of the FloTrac/EV1000 were 69.7% and 59.3% before and after CPB, respectively. The concordance rates (CRs) and angular CRs of the FloTrac/EV1000 were 50.9% and 57.1%, and 48.7% and 61.9% before and after CPB, respectively. Conclusion: This study revealed a low level of agreement and poor trending ability of the FloTrac/EV1000 system compared to continuous thermodilution pulmonary artery catheter in patients with severe aortic stenosis. Although there was a slight improvement after surgical valve replacement and CPB, the results were not within acceptable limits to replace CCO-PAC in this patient population.}, author = {Eisenried, Andreas and Klarwein, Raphael and Ihmsen, Harald and Wehrfritz, Andreas and Tandler, René and Heim, Christian and Fechner, Jörg}, doi = {10.1053/j.jvca.2018.09.015}, faupublication = {yes}, journal = {Journal of Cardiothoracic and Vascular Anesthesia}, keywords = {aortic stenosis; cardiac output; pulmonary artery catheter; pulse contour analysis}, note = {CRIS-Team Scopus Importer:2019-05-02}, pages = {1230-1236}, peerreviewed = {Yes}, title = {{Accuracy} and {Trending} {Ability} of the {Fourth}-{Generation} {FloTrac}/{EV1000} {System} in {Patients} {With} {Severe} {Aortic} {Valve} {Stenosis} {Before} and {After} {Surgical} {Valve} {Replacement}}, volume = {33}, year = {2019} } @article{faucris.242007089, abstract = {Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of antidepressants require definition. We investigated the role of the acid sphingomyelinase (Asm)-ceramide system as a target for antidepressants. Therapeutic concentrations of the antidepressants amitriptyline and fluoxetine reduced Asm activity and ceramide concentrations in the hippocampus, increased neuronal proliferation, maturation and survival and improved behavior in mouse models of stress-induced depression. Genetic Asm deficiency abrogated these effects. Mice overexpressing Asm, heterozygous for acid ceramidase, treated with blockers of ceramide metabolism or directly injected with C16 ceramide in the hippocampus had higher ceramide concentrations and lower rates of neuronal proliferation, maturation and survival compared with controls and showed depression-like behavior even in the absence of stress. The decrease of ceramide abundance achieved by antidepressant-mediated inhibition of Asm normalized these effects. Lowering ceramide abundance may thus be a central goal for the future development of antidepressants.}, author = {Gulbins, Erich and Palmada, Monica and Reichel, Martin and Lueth, Anja and Boehmer, Christoph and Amato, Davide and Müller, Christian P. and Tischbirek, Carsten H. and Groemer, Teja W. and Tabatabai, Ghazaleh and Becker, Katrin A. and Tripal, Philipp and Städtler, Sven and Ackermann, Teresa F. and van Brederode, Johannes and Alzheimer, Christian and Weller, Michael and Lang, Undine E. and Kleuser, Burkhard and Grassme, Heike and Kornhuber, Johannes}, doi = {10.1038/nm.3214}, faupublication = {yes}, journal = {Nature Medicine}, note = {Created from Fastlane, Scopus look-up}, pages = {934-938}, peerreviewed = {Yes}, title = {{Acid} sphingomyelinase-ceramide system mediates effects of antidepressant drugs}, volume = {19}, year = {2013} } @article{faucris.216337023, abstract = {
Vital parameters are key indicators for the assessment of health. Conventional methods rely on direct contact with the patients’ skin and can hence cause discomfort and reduce autonomy. This article presents a bistatic 24 GHz radar system based on an interferometric six-port architecture and features a precision of 1 µm in distance measurements. Placed at a distance of 40 cm in front of the human chest, it detects vibrations containing respiratory movements, pulse waves and heart sounds. For the extraction of the respiration rate, time-domain approaches like autocorrelation, peaksearch and zero crossing rate are compared to the Fourier transform, while template matching and a hidden semi-Markov model are utilized for the detection of the heart rate from sphygmograms and heart sounds. A medical study with 30 healthy volunteers was conducted to collect 5.5 h of data, where impedance cardiogram and electrocardiogram were used as gold standard for synchronously recording respiration and heart rate, respectively. A low root mean square error for the breathing rate (0.828 BrPM) and a high overall F1 score for heartbeat detection (93.14%) could be achieved using the proposed radar system and signal processing.}, author = {Michler, Fabian and Shi, Kilin and Schellenberger, Sven and Steigleder, Tobias and Malessa, Anke and Hameyer, Laura and Neumann, Nina and Lurz, Fabian and Ostgathe, Christoph and Weigel, Robert and Kölpin, Alexander}, doi = {10.3390/s19112492}, faupublication = {yes}, journal = {Sensors}, peerreviewed = {Yes}, title = {{A} {Clinically} {Evaluated} {Interferometric} {Continuous}-{Wave} {Radar} {System} for the {Contactless} {Measurement} of {Human} {Vital} {Parameters}}, url = {https://www.mdpi.com/1424-8220/19/11/2492}, volume = {19}, year = {2019} } @inproceedings{faucris.106234964, abstract = {Vital sign monitoring systems play a crucial role in the medical environment. Patients in palliative and intensive care can especially benefit from continuous observation by detecting sudden changes in health status allowing the medical staff to promptly provide intensified symptom amelioration at the end-of-life. However, machine based monitoring like electrocardiography requires the patient being permanently wired to the device. This circumstance severely restricts the independence and mobility of the patient, leading to a decrease in the quality of life. For this reason, palliative care stations currently usually avoid continuous monitoring. After a comprehensive literature survey and background research, this paper presents a novel approach by using a single radar system to perform continuous and above all contactless monitoring of respiration and heartbeat. A continuous wave radar using the Six-Port technology is introduced and its feasibility, performance and real-time capability are validated in long-term measurements on different test persons. In comparison to gold standard reference devices a correlation of 97.6% was achieve}, author = {Shi, Kilin and Will, Christoph and Steigleder, Tobias and Michler, Fabian and Weigel, Robert and Ostgathe, Christoph and Kölpin, Alexander}, booktitle = {2018 Annual IEEE International Systems Conference (SysCon)}, date = {2018-04-23/2018-04-26}, doi = {10.1109/SYSCON.2018.8369507}, faupublication = {yes}, peerreviewed = {unknown}, title = {{A} {Contactless} {System} for {Continuous} {Vital} {Sign} {Monitoring} in {Palliative} and {Intensive} {Care}}, venue = {Vancouver, Kanada}, year = {2018} } @article{faucris.247772090, abstract = {SARS-CoV-2, causing the lethal disease COVid-19, is a public health emergency in the 2020 global pandemic. The outbreak and fast spreading of SARS-CoV-2 have a high morbidity and mortality specifically in elder patients with chronic diseases such as diabetes mellitus, arterial hypertension, chronic kidney disease, and organ transplanted patients with immunosuppressive therapy. Preliminary results support different treatments such as chloroquine and convalescent plasma infusion in severe cases, with good outcome. On the other hand, the efficacy of supplementation with active vitamin D, an immunomodulator hormone with antiinflammatory and antimicrobial effects, is unproven. A recent study reported that vitamin D attains antiviral effects, via blocking viral replication directly. SARS-CoV-2 primarily uses the immune evasion process during infection via the envelope spike glycoprotein, which is followed by a cytokine storm, causing severe acute respiratory disease syndrome and death. SARS-CoV-2, by using the well-known angiotensin-converting enzyme 2 by the protein spike, as the host receptor to enter into alveolar, myocardial, and renal epithelial cells, can be disrupted by vitamin D. However, the correlation between vitamin D levels and COVID-19 deaths in previous studies was insignificant. Retrospective studies demonstrated a correlation between vitamin D status and COVID-19 severity and mortality, while other studies did not find this correlation. Studies have shown that, vitamin D reduces the risk of acute viral respiratory tract infections and pneumonia via direct inhibition of viral replication, antiinflammatory and immunomodulatory effects. The data available today regarding the beneficial protective effect of vitamin D is unclear and with conflicting results. Large randomized control trials are necessary to test this hypothesis. In this review, we will explain the cross talk between the active vitamin D and the angiotensin-converting enzyme 2, and summarize the data from the literature.}, author = {Farid, Nakhoul and Rola, Nakhoul and Koch, Elias and Nakhoul, Nakhoul}, doi = {10.1007/s11845-020-02452-8}, faupublication = {yes}, journal = {Irish Journal of Medical Science}, keywords = {Angiotensin converting enzyme 2; COVID-19; Renin; SARS-CoV-2; Vitamin D}, note = {CRIS-Team Scopus Importer:2021-01-15}, peerreviewed = {Yes}, title = {{Active} vitamin {D} supplementation and {COVID}-19 infections: review}, year = {2021} } @article{faucris.112196524, abstract = {The voltage-gated sodium channel subtype NaV1.8 is expressed in the peripheral nervous system in primary afferent nociceptive C-fibers and is essential for noxious cold signaling. We utilized functional magnetic resonance imaging on NaV1.8-deficient (NaV1.8(-/-)) compared with wildtype (WT) mice to identify brain structures decoding noxious cold and/or heat signals. In NaV1.8(-/-) mice functional activity patterns, activated volumes and BOLD signal amplitudes are significantly reduced upon noxious cold stimulation whereas differences of noxious heat processing are less pronounced. Graph-theoretical analysis of the functional connectivity also shows dramatic alterations in noxious cold sensation in NaV1.8(-/-) mice and clearly reduced interactions between certain brain structures. In contrast, upon heat stimulation qualitatively quite the same functional connectivity pattern and consequently less prominent connectivity differences were observed between NaV1.8(-/-) and WT mice. Thus, the fact that NaV1.8(-/-) mice do not perceive nociceptive aspects of strong cooling in contrast to their WT littermates seems not only to be a pure peripheral phenomenon with diminished peripheral transmission, but also consists of upstream effects leading to altered subsequent nociceptive processing in the central nervous system and consequently altered connectivity between pain-relevant brain structures.}, author = {Heindl-Erdmann, Cornelia and Zimmermann, Katharina and Reeh, Peter and Brune, Kay and Heß, Andreas}, doi = {10.1038/s41598-017-00524-x}, faupublication = {yes}, journal = {Scientific Reports}, note = {EVALuna2:2489}, pages = {543}, peerreviewed = {Yes}, title = {{Activity} and connectivity changes of central projection areas revealed by functional magnetic resonance imaging in {NaV1}.8-deficient mice upon cold signaling}, volume = {7}, year = {2017} } @article{faucris.290031801, author = {Jentschke, Elisabeth and Roch, Carmen and Reinholz, Ulrike and Gahr, Susanne and Gaertner, Jan and Lewerenz, Jan and Mayer-Steinacker, Regine and Oechsle, Karin and Villalobos, Matthias}, doi = {10.1007/s00761-022-01281-x}, faupublication = {yes}, journal = {Die Onkologie}, month = {Jan}, note = {CRIS-Team WoS Importer:2023-03-03}, peerreviewed = {Yes}, title = {{Acute} confusional states and delirium in palliative care}, year = {2023} } @article{faucris.263245267, abstract = {Background: Palliative care phases (stable, unstable, deteriorating, terminal and bereavement) are routinely used in Australia and the UK to describe the clinical situation of patients and their families and to evaluate the associated care plan. In addition, it serves as a benchmark developed by the Australian Palliative Care Outcome Collaboration (PCOC) and is used nationwide for comparisons between services. In Germany, the concept is not used consistently due to various translations. Furthermore, there is no nationwide systematic approach to routinely assess clinical outcomes in palliative care. The study aims to develop a German version of the palliative care phase definitions by adapting them culturally, and to examine the inter-rater reliability of the adjusted definitions with healthcare professionals. Methods: Mixed-methods approach: Cognitive interview study using ‘think aloud’ and verbal probing techniques and a consecutive multi-center cross-sectional study with two clinicians independently assigning the phase definitions. Interviewees/participants were selected through convenience and purposive sampling in specialist palliative care inpatient units, advisory and community services and in three specialist palliative care units with doctors, nursing staff and allied health professionals. Results: Fifteen interviews were conducted. Identified difficulties were: Some translated terms were 1) not self-explanatory (e.g. ‘family/carer’ or ‘care plan’) and (2) too limited to the medical dimension neglecting the holistic approach of palliative care. (3) Problems of comprehension regarding the concept in general occurred, e.g. in differentiating between the ‘unstable’ and ‘deteriorating’ phase. Inter-rater reliability was moderate (kappa = 0.44; 95% CI = 0.39–0.52). The assignment of the phase ‘deteriorating’ has caused the most difficulties. Conclusion: Overall, the adapted palliative care phases are suitable to use in the German specialist palliative care setting. However, the concept of the phases is not self-explanatory. To implement it nationwide for outcome measurement/benchmarking, it requires further education, on-the-job training and experience as well as the involvement of healthcare professionals in implementation process. For the use of international concepts in different healthcare systems, a deeper discussion and cultural adaptation is necessary besides the formal translation.}, author = {Lehmann, Eva and Hodiamont, Farina and Landmesser, Mirjam and Knobloch, Carina and Nauck, Friedemann and Ostgathe, Christoph and Gruene, Bettina and Bausewein, Claudia}, doi = {10.1186/s12904-021-00825-z}, faupublication = {yes}, journal = {BMC Palliative Care}, keywords = {Cognitive interviewing; Inter-rater reliability; Outcome measurement; Palliative care; Palliative care phases; Quality of healthcare; Reproducibility of results}, note = {CRIS-Team Scopus Importer:2021-08-27}, peerreviewed = {Yes}, title = {{Adaptation} of the {Australian} {Palliative} {Care} {Phase} concept to the {German} palliative care context: a mixed-methods approach using cognitive interviews and cross-sectional data}, volume = {20}, year = {2021} } @article{faucris.242322780, abstract = {Using Radar it is possible to measure vital signs through clothing or a mattress from the distance. This allows for a very comfortable way of continuous monitoring in hospitals or home environments. The dataset presented in this article consists of 24 h of synchronised data from a radar and a reference device. The implemented continuous wave radar system is based on the Six-Port technology and operates at 24 GHz in the ISM band. The reference device simultaneously measures electrocardiogram, impedance cardiogram and non-invasive continuous blood pressure. 30 healthy subjects were measured by physicians according to a predefined protocol. The radar was focused on the chest while the subjects were lying on a tilt table wired to the reference monitoring device. In this manner five scenarios were conducted, the majority of them aimed to trigger hemodynamics and the autonomic nervous system of the subjects. Using the database, algorithms for respiratory or cardiovascular analysis can be developed and a better understanding of the characteristics of the radar-recorded vital signs can be gaine}, author = {Schellenberger, Sven and Shi, Kilin and Steigleder, Tobias and Malessa, Anke and Michler, Fabian and Hameyer, Laura and Neumann, Nina and Lurz, Fabian and Weigel, Robert and Ostgathe, Christoph and Kölpin, Alexander}, doi = {10.1038/s41597-020-00629-5}, faupublication = {yes}, journal = {Scientific Data}, keywords = {Vital signs; Radar; Database; Reference signals}, peerreviewed = {Yes}, title = {{A} dataset of clinically recorded radar vital signs with synchronised reference sensor signals}, url = {https://www.nature.com/articles/s41597-020-00629-5}, year = {2020} } @article{faucris.275158124, abstract = {Radar systems allow for contactless measurements of vital signs such as heart sounds, the pulse signal, and respiration. This approach is able to tackle crucial disadvantages of state-of-the-art monitoring devices such as the need for permanent wiring and skin contact. Potential applications include the employment in a hospital environment but also in home care or passenger vehicles. This dataset consists of synchronised data which are acquired using a Six-Port-based radar system operating at 24 GHz, a digital stethoscope, an ECG, and a respiration sensor. 11 test subjects were measured in different defined scenarios and at several measurement positions such as at the carotid, the back, and several frontal positions on the thorax. Overall, around 223 minutes of data were acquired at scenarios such as breath-holding, post-exercise measurements, and while speaking. The presented dataset contains reference-labeled ECG signals and can therefore easily be used to either test algorithms for monitoring the heart rate, but also to gain insights about characteristic effects of radar-based vital sign monitoring.}, author = {Shi, Kilin and Schellenberger, Sven and Will, Christoph and Steigleder, Tobias and Michler, Fabian and Fuchs, Jonas and Weigel, Robert and Ostgathe, Christoph and Koelpin, Alexander}, doi = {10.1038/s41597-020-0390-1}, faupublication = {yes}, journal = {Scientific Data}, note = {EVALuna2:415941}, peerreviewed = {Yes}, title = {{A} dataset of radar-recorded heart sounds and vital signs including synchronised reference sensor signals.}, volume = {7}, year = {2020} } @article{faucris.310127706, abstract = {While the number and types of indoor air pollutants is rising, much is suspected but little is known about the impact of their potentially synergistic interactions, upon human health. Gases, particulate matter, organic compounds but also allergens and viruses, fall within the ‘pollutant’ definition. Distinct populations, such as children and allergy and asthma sufferers are highly susceptible, while a low socioeconomic background is a further susceptibility factor; however, no specific guidance is available. We spend most of our time indoors; for children, the school environment is of paramount importance and potentially amenable to intervention. The interactions between some pollutant classes have been studied. However, a lot is missing with respect to understanding interactions between specific pollutants of different classes in terms of concentrations, timing and sequence, to improve targeting and upgrade standards. SynAir-G is a European Commission-funded project aiming to reveal and quantify synergistic interactions between different pollutants affecting health, from mechanisms to real life, focusing on the school setting. It will develop a comprehensive and responsive multipollutant monitoring system, advance environmentally friendly interventions, and disseminate the generated knowledge to relevant stakeholders in accessible and actionable formats. The aim of this article it to put forward the SynAir-G hypothesis, and describe its background and objectives.}, author = {Papadopoulos, Nikolaos G. and Akdis, Cezmi and Akdis, Mubeccel and Damialis, Athanasios and Esposito, Giuseppina and Fergadiotou, Ioana and Goroncy, Christian and Guitton, Pierre and Gotua, Maia and Erotokritou, Kleanthis and Jartti, Tuomas and Murray, Clare and Nenes, Athanasios and Nikoletseas, Sotirios and Finotto, Susetta and Pandis, Spyros N. and Ramiconi, Valeria and Simpson, Angela and Soudunsaari, Aki and Stårbröst, Anna and Staiano, Maria and Varriale, Antonio and Xepapadaki, Paraskevi and Zuberbier, Torsten and Annesi-Maesano, Isabella}, doi = {10.1111/all.15857}, faupublication = {yes}, journal = {Allergy}, keywords = {aerobiology; allergy; artificial intelligence; asthma; biosensors; children; school; virus; volatile organic compounds}, note = {CRIS-Team Scopus Importer:2023-09-08}, peerreviewed = {Yes}, title = {{Addressing} adverse synergies between chemical and biological pollutants at schools—{The} ‘{SynAir}-{G}’ hypothesis}, year = {2023} } @article{faucris.218417635, abstract = {Background: Stressful situations during intraoperative emergencies have negative impact on human cognitive functions. Consequently, task performance may decrease and patient safety may be compromised. Cognitive aids can counteract these effects and support anesthesiologists in their crisis management. The Professional Association of German Anesthesiologists set up a project to develop a comprehensive set of digital cognitive aids for intraoperative emergencies. A parallel development for several software platforms and stationary and mobile devices will accommodate the inhomogeneity of the information technology infrastructure within German anesthesia departments.}, author = {Schild, Stefanie and Sedlmayr, Brita and Schumacher, Ann-Kathrin and Sedlmayr, Martin and Prokosch, Hans-Ulrich and St. Pierre, Michael}, doi = {10.2196/13226}, faupublication = {yes}, journal = {JMIR mHealth and uHealth}, note = {CRIS-Team WoS Importer:2019-05-24}, peerreviewed = {Yes}, title = {{A} {Digital} {Cognitive} {Aid} for {Anesthesia} to {Support} {Intraoperative} {Crisis} {Management}: {Results} of the {User}-{Centered} {Design} {Process}}, volume = {7}, year = {2019} } @article{faucris.273232272, abstract = {Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM) and alcohol abuse, emotional behavior, and bone defects were discovered and multiple mechanisms were identified for females. Here we report strong sex-dimorphisms for central, but not for peripheral mechanisms of NSM action in mouse models. Reduced NSM activity resulted in enhanced alcohol consumption in males, but delayed conditioned rewarding effects. It enhanced the acute dopamine response to alcohol, but decreased monoaminergic systems adaptations to chronic alcohol. Reduced NSM activity increased depression- and anxiety-like behavior, but was not involved in alcohol use for the self-management of the emotional state. Constitutively reduced NSM activity impaired structural development in the brain and enhanced lipidomic sensitivity to chronic alcohol. While the central effects were mostly opposite to NSM function in females, similar roles in bone-mediated osteocalcin release and its effects on alcohol drinking and emotional behavior were observed. These findings support the view that the NSM and multiple downstream mechanism may be a source of the sex-differences in alcohol use and emotional behavior.}, author = {Kalinichenko, Liubov and Mühle, Christiane and Jia, Tianye and Anderheiden, Felix and Datz, Maria and Eberle, Anna-Lisa and Eulenburg, Volker and Granzow, Jonas and Hofer, Martin Jürgen and Hohenschild, Julia and Huber, Sabine and Kämpf, Stefanie and Kogias, Georgios and Lacatusu, Laura and Lugmair, Charlotte and Taku, Stephen Mbu and Meixner, Doris and Sembritzki, Nina-Kristin and Praetner, Marc and Rhein, Cosima and Sauer, Christina and Scholz, Jessica and Ulrich, Franziska and Valenta, Florian and Weigand, Esther and Werner, Markus and Tay, Nicole and Mc Veigh, Conor J. and Haase, Jana and Wang, An-Li and Abdel-Hafiz, Laila and Huston, Joseph P. and Smaga, Irena and Frankowska, Malgorzata and Filip, Malgorzata and Lourdusamy, Anbarasu and Kirchner, Philipp and Ekici, Arif Bülent and Marx, Lena M. and PULIPARAMBIL SURESH, NEERAJA and Frischknecht, Renato and Fejtová, Anna and Saied, Essa M. and Arenz, Christoph and Bozec, Aline and Wank, Isabel and Kreitz, Silke and Heß, Andreas and Bäuerle, Tobias and Ledesma, Maria Dolores and Mitroi, Daniel N. and Miranda, Andre M. and Oliveira, Tiago Gil and Lenz, Bernd and Schumann, Gunter and Kornhuber, Johannes and Müller, Christian P.}, doi = {10.1093/cercor/bhac106}, faupublication = {yes}, journal = {Cerebral Cortex}, keywords = {neutral sphingomyelinase; osteocalcin; depression; alcohol; anxiety}, note = {CRIS-Team WoS Importer:2022-04-15}, peerreviewed = {Yes}, title = {{Adult} alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males}, year = {2022} } @article{faucris.273550739, abstract = {Background: Advance Care Planning including living wills and durable powers of attorney for healthcare is a highly relevant topic aiming to increase patient autonomy and reduce medical overtreatment. Data from patients with head and neck cancer (HNC) are not currently available. The main objective of this study was to survey the frequency of advance directives (AD) in patients with head and neck cancer. Methods: In this single center cross-sectional study, we evaluated patients during their regular follow-up consultations at Germany’s largest tertiary referral center for head and neck cancer, regarding the frequency, characteristics, and influencing factors for the creation of advance directives using a questionnaire tailored to our cohort. The advance directives included living wills, durable powers of attorney for healthcare, and combined directives. Results: Four hundred and forty-six patients were surveyed from 07/01/2019 to 12/31/2019 (response rate = 68.9%). The mean age was 62.4 years (SD 11.9), 26.9% were women (n = 120). 46.4% of patients (n = 207) reported having authored at least one advance directive. These documents included 16 durable powers of attorney for healthcare (3.6%), 75 living wills (16.8%), and 116 combined directives (26.0%). In multivariate regression analysis, older age (OR ≤ 0.396, 95% CI 0.181–0.868; p = 0.021), regular medication (OR = 1.896, 95% CI 1.029–3.494; p = 0.040), and the marital status (“married”: OR = 2.574, 95% CI 1.142–5.802; p = 0.023; and “permanent partnership”: OR = 6.900, 95% CI 1.312–36.295; p = 0.023) emerged as significant factors increasing the likelihood of having an advance directive. In contrast, the stage of disease, the therapeutic regimen, the ECOG status, and the time from initial diagnosis did not correlate with the presence of any type of advance directive. Ninety-one patients (44%) with advance directives created their documents before the initial diagnoses of head and neck cancer. Most patients who decide to draw up an advance directive make the decision themselves or are motivated to do so by their immediate environment. Only 7% of patients (n = 16) actively made a conscious decision not create an advance directive. Conclusion: Less than half of head and neck cancer patients had created an advance directive, and very few patients have made a conscious decision not to do so. Older and comorbid patients who were married or in a permanent partnership had a higher likelihood of having an appropriate document. Advance directives are an essential component in enhancing patient autonomy and allow patients to be treated according to their wishes even when they are unable to consent. Therefore, maximum efforts are advocated to increase the prevalence of advance directives, especially in head and neck cancer patients, whose disease often takes a crisis-like course.}, author = {Allner, Moritz and Gostian, Magdalena and Rupp, Robin and Allner, Clarissa and Mantsopoulos, Konstantinos and Ostgathe, Christoph and Iro, Heinrich and Hecht, Markus and Gostian, Antoniu-Oreste and Balk, Matthias}, doi = {10.1186/s12904-022-00932-5}, faupublication = {yes}, journal = {BMC Palliative Care}, keywords = {Advance care planning; Advance directive; Head and neck Cancer; Living will; Patient autonomy; Power of attorney for healthcare}, note = {CRIS-Team Scopus Importer:2022-04-22}, peerreviewed = {Yes}, title = {{Advance} directives in patients with head and neck cancer - status quo and factors influencing their creation}, volume = {21}, year = {2022} } @article{faucris.122880824, abstract = {The fear of airway problems often leads to prolonged attempts to obtain neuroaxial (spinal anesthesia or epidural anesthesia) anesthesia in obstetric anesthesia. The aim of this institutional quality management study was to revisit existing anesthesia care in the obstetric department, focusing on the frequency of delayed or failed neuroaxial anesthesia as well as the risk of airway problems in parturient and non-obstetric patients.The clinical records from 8 consecutive years (2005-2013) were analyzed retrospectively. Cases of cesarean delivery with general anesthesia were analyzed and compared with an age-matched group of female patients undergoing non-obstetric abdominal or gynecological surgery with rapid sequence induction. Poor laryngeal visualization (Cormack-Lehane grade III or IV) and failed intubation were recorded.The records of 6393 cesarean deliveries including 851 with general anesthesia were analyzed. In 175 cases insufficient or delayed onset of regional anesthesia led to requirement for general anesthesia. The rate of poor laryngoscopic view in parturient women undergoing cesarean delivery was 14/851, and 4/814 in the reference group (P = 0.023). Failed intubation occurred in three patients undergoing cesarean delivery (0.4%) and in one non-obstetric patient (0.1%; P = 0.339).The rate of failed intubations in patients undergoing cesarean delivery may be equivalent to non-obstetric patients. In time-challenging cesarean deliveries, delay of conversion from non-successful neuroaxial anesthesia to general anesthesia in order to avoid adverse airway events does not appear to be justified.}, author = {Heinrich, Stefan and Irouschek, Andrea and Prottengeier, Johannes and Ackermann, Andreas and Schmidt, Joachim}, doi = {10.1111/jog.12677}, faupublication = {yes}, journal = {Journal of Obstetrics and Gynaecology Research}, note = {EVALuna2:16690}, pages = {1032-9}, peerreviewed = {Yes}, title = {{Adverse} airway events in parturient compared with non-parturient patients. {Is} there a difference? {Results} from a quality management project}, volume = {41}, year = {2015} } @inproceedings{faucris.231369697, author = {Koch, Sonja and Springel, R. and Knipfer, Lisa and Wirtz, Stefan and Finotto, Susetta}, faupublication = {yes}, note = {EVALuna2:207770}, pages = {259-259}, peerreviewed = {Yes}, title = {{Affected} differentiation and function of innate lymphoid cells type 2 in the absence of the {Th2}-and {Th1}-associated transcription factor {NIP45}}, volume = {73}, year = {2018} } @article{faucris.109665864, abstract = {The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion channel family can regulate their function by modulating their expression at the plasma membrane (PM) through rapid vesicular translocation and fusion. The mechanisms underlying this regulation are not completely understood, and the contribution of vesicular trafficking to physiological function is unknown. TRPM8 receptors are expressed in mammalian peripheral sensory neurons and are essential for the detection of cold temperatures. Previously, we showed that TRPM8-containing vesicles are segregated into three main pools, immobile at the PM, simple diffusive and corralled-hopping. Here, we show that channel expression at the PM is modulated by TRPM8 agonists in F11 and HEK293T cells. Our results support a model in which the activation of TRPM8 channels, located at the PM, induces a short-lived recruitment of a TRPM8-containing vesicular pool to the cell surface causing a transitory increase in the number of functional channels, affecting intrinsic properties of cold receptor responses. We further demonstrate the requirement of intact vesicular trafficking to support sustained cold responses in the skin of mice.}, author = {Toro, Carlos A. and Eger, Stephanie and Veliz, Luis and Sotelo-Hitschfeld, Pamela and Cabezas, Deny and Castro, Maite A. and Zimmermann, Katharina and Brauchi, Sebastian}, doi = {10.1523/JNEUROSCI.3820-13.2015}, faupublication = {yes}, journal = {The Journal of Neuroscience}, note = {EVALuna2:2487}, pages = {571-82}, peerreviewed = {Yes}, title = {{Agonist}-dependent modulation of cell surface expression of the cold receptor {TRPM8}}, volume = {35}, year = {2015} } @article{faucris.211610159, abstract = {Background: The obstructive sleep apnea syndrome (OSAS) is characterized by temporary cerebral hypoxia which can cause cognitive dysfunction. On the other hand, hypoxia induced neurocognitive deficits are detectable after general anesthesia. The objective of this study was to evaluate the impact of a high risk of OSAS on the postoperative cognitive dysfunction after intravenous anesthesia. Methods: In this single center trial between June 2012 and June 2013 43 patients aged 55 to 80 years with an estimated hospital stay of at least 3 days undergoing surgery were enrolled. Patients were screened for a high risk of OSAS using the STOP-BANG test. The cognitive function was assessed using a neuropsychological test battery, including the DemTect test for cognitive impairment and the RMBT test for memory, the day before surgery and within 36 h after extubation. Results: Twenty-two of the 43 analyzed patients were identified as patients with a high risk of OSAS. Preoperatively, OSAS patients showed a significant worse performance only for the DemTect (p = 0.0043). However, when comparing pre- and postoperative test results, the OSAS patients did not show a significant loss in any test but significantly improved in RMBT test, whereas the control group showed a significant worse performance in three of eight tests. In five tests, we found a significant difference between the two groups with respect to the change from pre- to postoperative cognitive function. Conclusion: Patients with a high risk of OSAS showed a less impairment of memory function and work memory performance after intravenous anesthesia. This might be explained by a beneficial effect of intrinsic hypoxic preconditioning in these patients.}, author = {Wagner, Sören and Quente, Jörg and Städtler, Sven and Koch, Katharina and Richter-Schmidinger, Tanja and Kornhuber, Johannes and Ihmsen, Harald and Schüttler, Jürgen}, doi = {10.1186/s12871-018-0602-9}, faupublication = {yes}, journal = {BMC Anesthesiology}, note = {EVALuna2:35845}, peerreviewed = {Yes}, title = {{A} high risk of sleep apnea is associated with less postoperative cognitive dysfunction after intravenous anesthesia: results of an observational pilot study}, volume = {18}, year = {2018} } @article{faucris.315096515, author = {Klein, Carsten and Ostgathe, Christoph}, doi = {10.1007/s15006-023-3146-y}, faupublication = {yes}, journal = {MMW Fortschritte der Medizin}, note = {CRIS-Team Scopus Importer:2023-12-15}, pages = {58-61}, peerreviewed = {unknown}, title = {{Aktuelle} {Empfehlungen} für die gezielte {Sedierung} am {Lebensende}}, volume = {165}, year = {2023} } @article{faucris.121078584, abstract = {Automated perioperative measurements such as cardiovascular monitoring data are commonly compared to established upper and lower thresholds, but could also allow for more complex interpretations. Analyzing such time series in extensive electronic medical records for research purposes may itself require customized automation, so we developed a set of algorithms for quantifying different aspects of temporal fluctuations. We implemented conventional measures of dispersion, summaries of absolute gradients between successive values, and Poincaré plots. We aggregated the severity and duration of hypotensive episodes by calculating the average area under different mean arterial pressure (MAP) thresholds. We applied these methods to 30,452 de-identified MAP series, and analyzed the similarity between alternative indices via hierarchical clustering. To explore the potential utility of these propositional metrics, we computed their statistical association with presumed complications due to cardiovascular instability. We observed that hierarchical clustering reliably segregated features that had been designed to quantify dissimilar aspects. Summaries of temporary hypotension turned out to be significantly increased among patient subgroups with subsequent signs of a complicated recovery. These associations were even stronger for measures that were specifically geared to capturing short-term MAP variability. These observations suggest the potential capability of our proposed algorithms for quantifying heterogeneous aspects of short-term MAP fluctuations. Future research might also target a wider selection of outcomes and other attributes that may be subject to intraoperative variability.}, author = {Toddenroth, Dennis and Ganslandt, Thomas and Drescher, Caroline and Weith, Thomas and Prokosch, Hans-Ulrich and Schüttler, Jürgen and Münster, Tino}, doi = {10.3233/978-1-61499-678-1-532}, faupublication = {yes}, journal = {Studies in health technology and informatics}, keywords = {Advanced algorithmic analyses; Clinical times series; EMR reuse}, note = {EVALuna2:161}, pages = {532-536}, peerreviewed = {Yes}, title = {{Algorithmic} {Summaries} of {Perioperative} {Blood} {Pressure} {Fluctuations}}, volume = {228}, year = {2016} } @article{faucris.217910960, author = {Peters, Joachim and Dykes, Nathan and Heckel, Maria and Ostgathe, Christoph and Habermann, Mechthild}, doi = {10.1089/jpm.2019.0027}, faupublication = {yes}, journal = {Journal of Palliative Medicine}, peerreviewed = {Yes}, title = {{A} {Linguistic} {Model} of {Communication} {Types} in {Palliative} {Medicine}: {Effects} of {Multidrug}-{Resistant} {Organisms} ({MDRO}) {Colonization} or {Infection} and {Isolation} {Measures} in {End} of {Life} on {Family} {Caregivers}’ {Knowledge}, {Attitude} and {Practices}.}, url = {https://www.liebertpub.com/doi/pdf/10.1089/jpm.2019.0027}, volume = {22}, year = {2019} } @inproceedings{faucris.225158227, address = {HOBOKEN}, author = {Kölle, Julia and Haag, Patricia and Vuorinen, T. and Kiefer, Alexander and Papadopoulos, N. G. and Finotto, Susetta}, booktitle = {ALLERGY}, date = {2019-06-01/2019-06-05}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2019-08-27}, pages = {4-5}, peerreviewed = {unknown}, publisher = {WILEY}, title = {{Allergen} and rhinovirus ({RV}) regulation of {PD}-{L1}/{PD1} in allergic asthma}, venue = {Lisbon}, year = {2019} } @inproceedings{faucris.241755431, address = {LONDON}, author = {Liu, Mao and Andreev, D. and Kachler, K. and Koelle, J. and Rauber, S. and Ramming, Andreas and Finotto, Susetta and Schett, G. and Bozec, A.}, booktitle = {ANNALS OF THE RHEUMATIC DISEASES}, date = {2020-06-03}, doi = {10.1136/annrheumdis-2020-eular.4479}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2020-08-21}, pages = {86-86}, peerreviewed = {unknown}, publisher = {BMJ PUBLISHING GROUP}, title = {{ALLERGIC} {ASTHMA} {INDUCES} {THE} {ACCUMULATION} {OF} {SYNOVIAL} {RESIDENT} {EOSINOPHILS}, {TRIGGERING} {THE} {RESOLUTION} {OF} {INFLAMMATORY} {ARTHRITIS}}, venue = {, ELECTR NETWORK}, year = {2020} } @article{faucris.123400684, abstract = {Over 1.5 billion people lack the skeletal muscle fast-twitch fibre protein alpha-actinin-3 due to homozygosity for a common null polymorphism (R577X) in the ACTN3 gene. alpha-Actinin-3 deficiency is detrimental to sprint performance in elite athletes and beneficial to endurance activities. In the human genome, it is very difficult to find single-gene loss-of-function variants that bear signatures of positive selection, yet intriguingly, the ACTN3 null variant has undergone strong positive selection during recent evolution, appearing to provide a survival advantage where food resources are scarce and climate is cold. We have previously demonstrated that alpha-actinin-3 deficiency in the Actn3 KO mouse results in a shift in fast-twitch fibres towards oxidative metabolism, which would be more "energy efficient" in famine, and beneficial to endurance performance. Prolonged exposure to cold can also induce changes in skeletal muscle similar to those observed with endurance training, and changes in Ca2+ handling by the sarcoplasmic reticulum (SR) are a key factor underlying these adaptations. On this basis, we explored the effects of alpha-actinin-3 deficiency on Ca2+ kinetics in single flexor digitorum brevis muscle fibres from Actn3 KO mice, using the Ca2+-sensitive dye fura-2. Compared to wild-type, fibres of Actn3 KO mice showed: (i) an increased rate of decay of the twitch transient; (ii) a fourfold increase in the rate of SR Ca2+ leak; (iii) a threefold increase in the rate of SR Ca2+ pumping; and (iv) enhanced maintenance of tetanic Ca2+ during fatigue. The SR Ca2+ pump, SERCA1, and the Ca2+-binding proteins, calsequestrin and sarcalumenin, showed markedly increased expression inmuscles of KO mice. Together, these changes in Ca2+ handling in the absence of a-actinin-3 are consistent with cold acclimatisation and thermogenesis, and offer an additional explanation for the positive selection of the ACTN3 577X null allele in populations living in cold environments during recent evolutio}, author = {Head, Stewart I. and Chan, Stephen and Houweling, Peter J. and Quinlan, Kate G. R. and Murphy, Robyn and Wagner, Sören and Friedrich, Oliver and North, Kathryn N.}, doi = {10.1371/journal.pgen.1004862}, faupublication = {yes}, journal = {PLoS Genetics}, month = {Jan}, peerreviewed = {Yes}, title = {{Altered} {Ca2}+ {Kinetics} {Associated} with alpha-{Actinin}-3 {Deficiency} {May} {Explain} {Positive} {Selection} for {ACTN3} {Null} {Allele} in {Human} {Evolution}}, volume = {11}, year = {2015} } @article{faucris.211543482, abstract = {Airway management in the prehospital setting is a particular challenge. Even with numerous alternative devices, endotracheal intubation still represents the gold standard. Limited knowledge and experience of the user in addition to a critical patient's condition, special environmental conditions and limited material resources at the out of hospital emergency, are major causes of an increased incidence of difficult airways in the preclinical setting. For the management of the difficult airway emergency physicians can use alternatives to tracheal intubation such as extraglottic airway devices, videolaryngoscopy and cricothyroidotomy. Both direct laryngoscopy as well as the use of alternative devices require experience and continuous training.}, author = {Martin, Christoph and Nefzger, Tobias and Lotz, Goesta}, doi = {10.1055/s-0041-103153}, faupublication = {yes}, journal = {AINS - Anästhesiologie. Intensivmedizin. Notfallmedizin. Schmerztherapie.}, note = {EVALuna2:35473}, pages = {254-262}, peerreviewed = {Yes}, title = {{Alternative} airway management in the pre hospital setting}, volume = {51}, year = {2016} } @article{faucris.229192153, abstract = {Searching for patient cohorts in electronic patient data often requires the definition of temporal constraints between the selection criteria. However, beyond a certain degree of temporal complexity, the non-graphical, form-based approaches implemented in current translational research platforms may be limited when modeling such constraints. In our opinion, there is a need for an easily accessible and implementable, fully graphical method for creating temporal queries. We aim to respond to this challenge with a new graphical notation. Based on Allen's time interval algebra, it allows for modeling temporal queries by arranging simple horizontal bars depicting symbolic time intervals. To make our approach applicable to complex temporal patterns, we apply two extensions: with duration intervals, we enable the inference about relative temporal distances between patient events, and with time interval modifiers, we support counting and excluding patient events, as well as constraining numeric values. We describe how to generate database queries from this notation. We provide a prototypical implementation, consisting of a temporal query modeling frontend and an experimental backend that connects to an i2b2 system. We evaluate our modeling approach on the MIMIC-III database to demonstrate that it can be used for modeling typical temporal phenotyping queries. Data availability statement The source code (licensed under the GNU General Public License v3.0) is available on GitHub (https://github.com/sebmate/AllenGUI and https://github.com/sebmate/AllenSPARQL). Also supplied are the development i2b2 dataset (with the 13 artificial patients) and the SQL scripts to populate the i2b2 system with the MIMIC-III data. Please note that the software is of prototypical character and provided “as is”, without any warranties.}, author = {Mate, Sebastian and Bürkle, Thomas and Kapsner, Lorenz and Toddenroth, Dennis and Kampf, Marvin and Sedlmayr, Martin and Castellanos, Ixchel and Prokosch, Hans-Ulrich and Kraus, Stefan}, doi = {10.1016/j.jbi.2019.103314}, faupublication = {yes}, journal = {Journal of Biomedical Informatics}, keywords = {Data integration; Data retrieval; Patient cohort identification; Phenotyping; Phenotyping algorithms; Temporal queries}, note = {CRIS-Team Scopus Importer:2019-11-15}, peerreviewed = {Yes}, title = {{A} method for the graphical modeling of relative temporal constraints}, volume = {100}, year = {2019} } @article{faucris.122099164, author = {Kienle, Florian and Münster, Tino and Wurm, Jochen and Prottengeier, Johannes}, doi = {10.1097/EJA.0000000000000349}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:16683}, pages = {888-9}, peerreviewed = {Yes}, title = {{Anaesthesia} and orphan disease: 22q11.2 microdeletion disorder ({DiGeorge} syndrome)}, volume = {32}, year = {2015} } @article{faucris.109821624, author = {Eberhardt, Esther and Münster, Tino and Wurm, Jochen and Prottengeier, Johannes}, doi = {10.1097/EJA.0000000000000451}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:16727}, pages = {547-9}, peerreviewed = {Yes}, title = {{Anaesthesia} and orphan disease: {Bloom}'s syndrome}, volume = {33}, year = {2016} } @article{faucris.124077624, author = {Prottengeier, Johannes and Münster, Tino and Wintermeyer, Philip and Schmidt, Joachim}, doi = {10.1097/EJA.0000000000000058}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:16670}, pages = {338-40}, peerreviewed = {Yes}, title = {{Anaesthesia} for orphan disease: {Haddad} syndrome ({Ondine}-{Hirschsprung} disease)}, volume = {31}, year = {2014} } @article{faucris.236674401, abstract = {Disease summary: Camp(t)omelic dysplasia (CD) is an autosomal dominantly inherited disorder of the SOX9 gene (17p24.3-q25.1), caused by de novo mutation or defective chromosomal recombination [1,2,3]. The SOX9 gene encodes a transcription factor that affects chondrogenesis, testicular development and determines phenotypic sex characteristics [4,5]. Pathological findings can be grouped in osseous and non-osseous disorders. Osseous features are the naming bowed femora and tibia (campomel = bent limb; camptomel bowed limb), short stature, vertebral abnormalities with cervical instability and possible cord compression (paraplegia), only eleven rib pairs, facial dysmorphia (Pierre Robin sequence, short neck), cleft palate, progressive scoliosis, club feet and dislocatable hips. Non-osseous features include laryngotracheobronchomalacia with respiratory compromise, ambiguous genitalia with sex reversal (female external genitalia with 46 XY karyotype), congenital heart disease (ventricular septal defect, VSD), hypotonia, kidney malformation (hydronephrosis) and neurological disorders including hydrocephalus and hearing impairment [6,7]. No clinical feature is obligatory. When femora and tibia are not affected, it is termed as acamp(t)omelic camp(t)omelic dysplasia (ACD). The estimated prevalence ranges from 1:10,000 to <1:1,000,000 [8,9]. Because of the rare occurrence of CD, an exact prevalence is uncertain. Currently, only symptomatic therapy is available. Most affected patients die in the neonatal period due to respiratory insufficiency [10]. Operative treatment is performed if individuals reach infancy.}, author = {Albermann, Matthias and Prottengeier, Johannes}, doi = {10.19224/ai2020.s067}, faupublication = {yes}, journal = {Anästhesiologie & Intensivmedizin}, keywords = {Camp(t)omelic dwarfism; Camp(t)omelic syndrome}, note = {CRIS-Team Scopus Importer:2020-03-31}, pages = {S67-S73}, peerreviewed = {Yes}, title = {{Anaesthesia} recommendations for {Camp}(t)omelic dysplasia}, volume = {61}, year = {2020} } @article{faucris.239306987, abstract = {Loss-of-function mutations of NaV1.7 lead to congenital insensitivity to pain, a rare condition resulting in individuals who are otherwise normal except for the inability to sense pain, making pharmacological inhibition of NaV1.7 a promising therapeutic strategy for the treatment of pain. We characterized a novel mouse model of NaV1.7-mediated pain based on intraplantar injection of the scorpion toxin OD1, which is suitable for rapid in vivo profiling of NaV1.7 inhibitors. Intraplantar injection of OD1 caused spontaneous pain behaviors, which were reversed by co-injection with NaV1.7 inhibitors and significantly reduced in NaV1.7−/− mice. To validate the use of the model for profiling NaV1.7 inhibitors, we determined the NaV selectivity and tested the efficacy of the reported NaV1.7 inhibitors GpTx-1, PF-04856264 and CNV1014802 (raxatrigine). GpTx-1 selectively inhibited NaV1.7 and was effective when co-administered with OD1, but lacked efficacy when delivered systemically. PF-04856264 state-dependently and selectively inhibited NaV1.7 and significantly reduced OD1-induced spontaneous pain when delivered locally and systemically. CNV1014802 state-dependently, but non-selectively, inhibited NaV channels and was only effective in the OD1 model when delivered systemically. Our novel model of NaV1.7-mediated pain based on intraplantar injection of OD1 is thus suitable for the rapid in vivo characterization of the analgesic efficacy of NaV1.7 inhibitors.
nervous system (ANS) and provides crucial information on the health status of a person, would
provide great benefits for both patients and doctors during prevention and aftercare. However, gold
standard devices to record the HRV, such as the electrocardiograph, have the common disadvantage
that they need permanent skin contact with the patient. Being connected to a monitoring device
by cable reduces the mobility, comfort, and compliance by patients. Here, we present a contactless
approach using a 24 GHz Six-Port-based radar system and an LSTM network for radar heart sound
segmentation. The best scores are obtained using a two-layer bidirectional LSTM architecture. To
verify the performance of the proposed system not only in a static measurement scenario but also
during a dynamic change of HRV parameters, a stimulation of the ANS through a cold pressor test is
integrated in the study design. A total of 638 minutes of data is gathered from 25 test subjects and
is analysed extensively. High F-scores of over 95% are achieved for heartbeat detection. HRV indices
such as HF norm are extracted with relative errors around 5%. Our proposed approach is capable to
perform contactless and convenient HRV monitoring and is therefore suitable for long-term recordings
in clinical environments and home-care scenario}, author = {Shi, Kilin and Steigleder, Tobias and Schellenberger, Sven and Michler, Fabian and Malessa, Anke and Lurz, Fabian and Rohleder, Nicolas and Ostgathe, Christoph and Weigel, Robert and Kölpin, Alexander}, doi = {10.1038/s41598-021-81101-1}, faupublication = {yes}, journal = {Scientific Reports}, keywords = {hrv, radar, vitalparameter, herztöne, berührungslos, herzratenvariabilität}, peerreviewed = {Yes}, title = {{Contactless} analysis of heart rate variability during cold pressor test using radar interferometry and bidirectional {LSTM} networks}, url = {https://www.nature.com/articles/s41598-021-81101-1}, volume = {11}, year = {2021} } @inproceedings{faucris.202749417, abstract = {Cardiovascular diseases are one of the major causes of death. Regular checkups and preventive actions can drastically help reducing fatal incidences. This can be achieved by monitoring the carotid artery or rather the carotid pulse signal. Commonly, ultrasound devices are used for that purpose. However, these devices are costly, mostly stationary and their usage requires training and experience. This paper investigates the possible usage of radar systems as a contactless and low-cost alternative for carotid pulse measurements. Theoretical investigations reveal a linear relationship between the measurands of both devices and synchronous recordings from three test persons further confirm the feasibility of using radar systems as a potential device for monitoring cardiovascular disease}, author = {Shi, Kilin and Schellenberger, Sven and Steigleder, Tobias and Michler, Fabian and Lurz, Fabian and Weigel, Robert and Kölpin, Alexander}, booktitle = {2018 Asia-Pacific Microwave Conference}, date = {2018-11-06/2018-08-09}, doi = {10.23919/apmc.2018.8617522}, faupublication = {yes}, peerreviewed = {unknown}, title = {{Contactless} {Carotid} {Pulse} {Measurement} {Using} {Continuous} {Wave} {Radar}}, venue = {Kyoto}, year = {2018} } @inproceedings{faucris.314595737, abstract = {Continuous wave (CW) radar has been used to detect motions in various scenarios. In this paper, we first present a data-driven method to classify in-bed movement from various scales with CW radar. Data augmentation techniques are used to address the small sample size problem, resulting in a significant improvement of over 10% in accuracy. Three machine learning classifiers, namely random forest, k-nearest neighbor (k-NN), and multilayer perceptron (MLP), are evaluated, with random forest demonstrating the highest accuracy of 81.94% and relative improvement of 22.5% compared to k-NN. The movement sitting up from the bed can be classified with 97.5% accuracy. Additionally, the method can classify two types of movements involving only arm and leg movements, which are not visible to the radar, by detecting small-scale joint movements from the back with an accuracy of 74.8%.}, author = {Lu, Hui and Wenzel, Marvin and Steigleder, Tobias and Klinger, Isabell and Ostgathe, Christoph and Koelpin, Alexander}, booktitle = {20th European Radar Conference, EuRAD 2023}, date = {2023-09-20/2023-09-22}, doi = {10.23919/EuRAD58043.2023.10289241}, faupublication = {yes}, isbn = {9782874870743}, keywords = {continuous wave radar; data augmentation; feature selection; machine learning; movement classification}, note = {CRIS-Team Scopus Importer:2023-12-01}, pages = {306-309}, peerreviewed = {unknown}, publisher = {Institute of Electrical and Electronics Engineers Inc.}, title = {{Contactless} {In}-{Bed} {Movement} in {Various} {Scales} {Classification} with {CW} {Radar}}, venue = {Berlin}, year = {2023} } @article{faucris.214995474, abstract = {BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association with viral/microbial exposures and immunological responses. We present the cohort design and demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls. At baseline, detailed information on demographics, asthma and allergy-related disease activity, exposures, and lifestyle were recorded. Lung function, airway inflammation, and immune responses were also assessed. Power analysis confirmed that the cohort is adequate to answer the initial hypothesis. RESULTS: A total of 167 asthmatic children (102 males) and 66 healthy controls (30 males) were included. Groups were homogeneous in respect to most baseline characteristics, with the exception of male gender in cases (61%) and exposure to tobacco smoke. Comorbidities and number and duration of infections were significantly higher in asthmatics than controls. 55.7% of asthmatic children had at least one positive skin prick test to aeroallergens (controls: 33.3%, P = .002). Spirometric and exhaled nitric oxide values were within normal limits; only baseline FEV0.5 and FEV1 reversibility values were significantly different between groups. Viral infections were the most common triggers (89.2%) independent of severity, control, or atopy; however, overlapping phenotypes were also common. Severity and control clustered together in an unsupervised analysis, separating moderate from mild disease. CONCLUSIONS: The PreDicta cohort presented no differences in non-asthma related measures; however, it is well balanced regarding key phenotypic characteristics representative of "preschool asthma". }, author = {Xepapadaki, Paraskevi and Bachert, Claus and Finotto, Susetta and Jartti, Tuomas and Konstantinou, George N. and Kiefer, Alexander and Kowalski, Marek and Lewandowska-Polak, Anna and Lukkarinen, Heikki and Roumpedaki, Eirini and Sobanska, Anna and Sintobin, Ina and Vuorinen, Tytti and Zhang, Nan and Zimmermann, Theodor and Papadopoulos, Nikolaos G.}, doi = {10.1111/pai.12881}, faupublication = {yes}, journal = {Pediatric Allergy and Immunology}, note = {EVALuna2:52975}, pages = {383-393}, peerreviewed = {Yes}, title = {{Contribution} of repeated infections in asthma persistence from preschool to school age: {Design} and characteristics of the {PreDicta} cohort}, volume = {29}, year = {2018} } @article{faucris.297259495, abstract = {Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide. Although immunotherapy has increased the overall survival of patients with lung cancer, there is the need to improve this treatment. At this regard, blood lipid levels are thought to be linked to cancer risk and thus a preventive intervention through regulation of the nutrition of patients with lung cancer is gaining much attention. In this study, we therefore asked about the contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression. We measured different serum lipids and analyzed cholesterol synthesis enzymes 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) and acetyl-coenzyme A cholesterol acetyltransferase 1 (ACAT1) as well as the cholesterol cellular export protein ATP-binding cassette (ABC) A-1 mRNA by quantitative PCR (qPCR) in the control and tumoral regions of post-surgery lung tissues to analyze the accumulation of cholesterol in cancer cells in a cohort of patients with lung adenocarcinoma (LUAD). We found that triglycerides in serum directly correlated with the body mass index (BMI) in patients with LUAD. By contrast, we found that high-density lipoprotein (HDL) cholesterol inversely correlated with the BMI, C-reactive protein (CRP) and overall survival and total cholesterol inversely correlated with the tumor diameter, serum CRP and overall survival in these LUAD patients. Functionally, the role of cholesterol is indispensable for the growth and development of normal animal cells where it is tightly regulated. Excess of cellular cholesterol regulated by HMGCR is converted to cholesteryl esters by the enzyme ACAT1 and exported extracellularly by the cholesterol transporter ABCA1. Here we found HMGCR and ACAT1 upregulated and ABCA1 downregulated in the lung's tumoral region of our LUAD cohort, indicating cholesterol dysregulated cellular export in lung tumor cells.}, author = {Hartmann, Philipp and Trufa, Denis and Hohenberger, Katja and Tausche, Patrick and Trump, Sonja and Mittler, Susanne and Geppert, Carol-Immanuel and Rieker, Ralf and Schieweck, Oliver and Sirbu, Horia and Hartmann, Arndt and Neurath-Finotto, Susetta}, doi = {10.1038/s41598-023-31575-y}, faupublication = {yes}, journal = {Scientific Reports}, note = {CRIS-Team Scopus Importer:2023-04-21}, pages = {5662-}, peerreviewed = {Yes}, title = {{Contribution} of serum lipids and cholesterol cellular metabolism in lung cancer development and progression}, volume = {13}, year = {2023} } @article{faucris.281399636, abstract = {Following the publication of the original article [1], the author reported that the given name and family name of all authors were erroneously transposed. The author group has been updated above and the original article [1] has been corrected.}, author = {Kurkowski, Sandra and Heckel, Maria and Pfaller, Larissa and Peters, Joachim and Bazata, Jeremias and Schildmann, Eva and Ostgathe, Christoph}, doi = {10.1186/s12904-022-00990-9}, faupublication = {yes}, journal = {BMC Palliative Care}, note = {CRIS-Team Scopus Importer:2022-09-09}, peerreviewed = {Yes}, title = {{Correction}: {Possible} age-related differences in healthcare professionals’ perspectives on younger and older patients’ autonomy and decision-making in the context of sedation in specialised palliative care: exploratory secondary qualitative content and linguistic conversation analysis of interviews with healthcare professionals ({BMC} {Palliative} {Care}, (2022), 21, 1, (71), 10.1186/s12904-022-00963-y)}, volume = {21}, year = {2022} } @article{faucris.265050596, abstract = {The article “Dynamic changes in the signal-averaged electrocardiogram are associated with the long-term outcomes after ablation of ischemic ventricular tachycardia”, written by Borislav Dinov, Lisa Schramm, Sebastian Koenig, Sabrina Oebel, Andreas Bollmann, Gerhard Hindricks, Arash Arya and Kerstin Bode was originally published Online First without Open Access. After publication in volume 60, issue 1, page 125–134 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4.0. The original article has been corrected.}, author = {Dinov, Borislav and Schramm, Lisa and Koenig, Sebastian and Oebel, Sabrina and Bollmann, Andreas and Hindricks, Gerhard and Arya, Arash and Bode, Kerstin}, doi = {10.1007/s10840-021-01038-3}, faupublication = {yes}, journal = {Journal of Interventional Cardiac Electrophysiology}, note = {CRIS-Team Scopus Importer:2021-10-15}, pages = {217-}, peerreviewed = {Yes}, title = {{Correction} to: {Dynamic} changes in the signal-averaged electrocardiogram are associated with the long-term outcomes after ablation of ischemic ventricular tachycardia ({Journal} of {Interventional} {Cardiac} {Electrophysiology}, (2021), 60, 1, (125-134), 10.1007/s10840-020-00708-y)}, volume = {62}, year = {2021} } @article{faucris.254726322, abstract = {An amendment to this paper has been published and can be accessed via the original article.}, author = {Gombert, Sara and Rhein, Mathias and Winterpacht, Andreas and Münster, Tino and Hillemacher, Thomas and Leffler, Andreas and Frieling, Helge}, doi = {10.1186/s13148-021-01059-9}, faupublication = {yes}, journal = {Clinical Epigenetics}, note = {CRIS-Team Scopus Importer:2021-04-09}, peerreviewed = {Yes}, title = {{Correction} to: {Transient} receptor potential ankyrin 1 promoter methylation and peripheral pain sensitivity in {Crohn}’s disease ({Clinical} {Epigenetics}, (2020), 12, 1, (1), 10.1186/s13148-019-0796-9)}, volume = {13}, year = {2021} } @article{faucris.283162068, abstract = {Background: Cognitive Aids (checklists) are a common tool to improve patient safety. But the factors for their successful implementation and continuous use are not yet fully understood. Recent publications suggest safety culture to play a key role in this context. However, the effects on the outcome of implementation measures remain unclear. Hospitals and clinics that are involved in cognitive aid development and research might have significantly different safety cultures than their counterparts, resulting in skewed assessments of proper implementation. Therefore, the objective of this study was to assess the correlation between cognitive aid implementation and safety attitudes of staff members in early adopting and later adopting clinics. Methods: An online survey of the Safety Attitudes Questionnaire (SAQ) was carried out in German anaesthesiology departments during the initial implementation of a new checklist for emergencies during anesthesia (“eGENA” app). Subsequently an analysis between subgroups (“eGENA” app usage and occupation), with Kruskal–Wallis- and Mann–Whitney-U-Tests was carried out for the general SAQ, as well as it six subscales. Results: Departments that introduced “eGENA” app (Median 3,74, IQR 0,90) reported a significantly higher median SAQ (U (NeGENA = 6, Nnon eGENA = 14) = 70,0, z = 2,31, p = 0,02, r = 0,516) than their counterparts (Median 2,82, IQR 0,77) with significant differences in the dimensions teamwork climate, work satisfaction, perception of management and working conditions. Conclusion: Early adopters of cognitive aids are likely to show a significantly higher perception of safety culture in the SAQ. Consequently, successful implementation steps from these settings might not be sufficient in different clinics. Therefore, further investigation of the effects of safety culture on cognitive aid implementation should be conducted.}, author = {Wegener, Justus and St. Pierre, Michael and Keil, Oliver and Eismann, Hendrik}, doi = {10.1186/s12913-022-08581-3}, faupublication = {yes}, journal = {BMC Health Services Research}, keywords = {Checklist implementation; Cognitive Aid implementation; Elektronische Gedächtnis- und Entscheidungshilfe für Notfälle in der Anästhesiologie (eGENA); Safety Attitudes Questionnaire (SAQ)}, note = {CRIS-Team Scopus Importer:2022-10-14}, peerreviewed = {Yes}, title = {{Correlation} between safety attitudes and early adoption of cognitive aids in the {German} culture sphere: a multicenter survey study}, volume = {22}, year = {2022} } @article{faucris.235493265, abstract = {Purpose: Noninvasive cerebral optical spectrometry is a promising candidate technology for the objective assessment physiological changes during pain perception. This study's primary objective was to test if there was a significant correlation between the changes in physiological parameters as measured by a cerebral optical spectrometry-based algorithm (real-time objective pain assessment [ROPA]) and subjective pain ratings obtained from volunteers and laboring women. Secondary aims were performance assessment using linear regression and receiver operating curve (ROC) analysis. Patients and methods: Prospective cohort study performed in Human Pain Laboratory and Labor and Delivery Unit. After institutional review board approval, we evaluated ROPA in volunteers undergoing the cold pressor test and in laboring women before and after epidural or combined spinal epidural placement. Linear regression was performed to measure correlations. ROCs and corresponding areas under the ROCs (AUC), as well as Youden's indices, as a measure of diagnostic effectiveness, were calculated. Results: Correlations between numeric rating scale or visual analog scale and ROPA were significant for both volunteers and laboring women. AUCs for both volunteers and laboring women with numeric rating scale and visual analog scale subjective pain ratings as ground truth revealed at least good (AUC: 70%-79%) to excellent (AUC >90%) distinction between clinically meaningful pain severity differentiations (no/mild-moderate-severe). Conclusion: Cerebral Optical Spectrometry-based ROPA significantly correlated with subjectively reported pain in volunteers and laboring women, and could be a useful monitor for clinical circumstances where direct assessment is not available, or to complement patient-reported pain scores.}, author = {Eisenried, Andreas and Austin, Naola and Cobb, Benjamin and Akhbardeh, Alireza and Carvalho, Brendan and Yeomans, David C. and Tzabazis, Alexander Z.}, doi = {10.2147/JPR.S162839}, faupublication = {yes}, journal = {Journal of Pain Research}, note = {EVALuna2:36284}, pages = {1991-1998}, peerreviewed = {Yes}, title = {{Correlation} of changes in hemodynamic response as measured by cerebral optical spectrometry with subjective pain ratings in volunteers and patients: a prospective cohort study}, volume = {11}, year = {2018} } @article{faucris.267253629, abstract = {In the original article, the authors neglected to include the funder Collaborative Research Centre (CRC) 1181 (Erlangen), grant number TP-B08 N to authors Zuqin Yang and Susetta Finotto. In the original article, there was an error. The scientific meaning of the following sentence was unclear owing to poor syntax: “In asthma, are predominantly induced ILC2 producing type 2 cytokine IL-4, IL-5, IL-13, and IL-9”. A correction has been made to Innate Immune Response in Asthma, Innate Lymphoid Cells (ILC2), Paragraph 1. The sentence should read: “In asthma, ILC2 producing type 2 cytokine IL-4, IL-5, IL-13, and IL-9 are predominantly induced”. The same is true of the following sentence: “After RV16 infection, in Tregs were induced both in healthy control and asthmatic subjects with upregulated anti-viral gene expression, such as IFI44L, MX1, ISG15, IRF and STAT1”. A correction has been made to Adaptive Immune Response in Asthma, Treg, Paragraph 2. The sentence should read: “After RV16 infection, Tregs were induced both in healthy control and asthmatic subjects with upregulated anti-viral gene expression, such as IFI44L, MX1, ISG15, IRF and STAT1”. The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.}, author = {Yang, Zuqin and Mitländer, Hannah and Vuorinen, Tytti and Finotto, Susetta}, doi = {10.3389/fimmu.2021.800020}, faupublication = {yes}, journal = {Frontiers in Immunology}, keywords = {asthma; host defense; immune evasion; interferon type I; rhinovirus}, note = {CRIS-Team Scopus Importer:2021-12-17}, peerreviewed = {Yes}, title = {{Corrigendum}: {Mechanism} of {Rhinovirus} {Immunity} and {Asthma}, ({Front}. {Immunol}, (2021), 12, (731846), 10.3389/fimmu.2021.731846)}, volume = {12}, year = {2021} } @article{faucris.223562135, abstract = {The authors regret an incorrect information in the “Material and Methods” section concerning the mentioned German breeding company (‘Breeding Company Renner, Franconia’). The correct breeding company is the ‘National Centre for Agricultural Research and Innovation’ (Nemzeti Agrárkutatási és Innovácios Központ Állattenyésztési, Takarmányozási és Húsipari Kutatóintézet, 2053 Herceghalom Gesztenyés u. 1., Hungary). The study has been performed in Hungary and the mentioned number belongs to the ‘Pest country government department for food safety and animal health, Hungary’. The authors would like to apologise for any inconvenience caused.}, author = {Nonhoff, J. and Möst, Tobias and Schmitt, Christopher and Weisel, T. and Bauer, S. and Schlegel, K. A.}, doi = {10.1016/j.jcms.2019.05.005}, faupublication = {yes}, journal = {Journal of Cranio-Maxillofacial Surgery}, note = {EVALuna2:203644}, pages = {1317-1317}, peerreviewed = {No}, title = {{Corrigendum} to “{Establishment} of a new pull-out strength testing method to quantify early osseointegration - {An} experimental pilot study” [{J} {Cranio}-{Maxillofacial} {Surg} 43 (10) ({December} 2015) 1966–1973]({S1010518215003364})(10.1016/j.jcms.2015.10.005)}, volume = {47}, year = {2019} } @article{faucris.226685078, abstract = {The study deals with the financial impact of the occurrence of multidrug-resistant pathogens on a palliative care unit of a German university hospital. Aims of the study are an analysis of the cost drivers as well as a cost comparison between MDRO-positive and -negative patients.}, author = {Adelhardt, Thomas and Hessemer, Stefanie and Heckel, Maria and Herbst, Franziska A. and Stiel, Stephanie and Ostgathe, Christoph and Schöffski, Oliver}, doi = {10.1055/a-0651-6448}, faupublication = {yes}, journal = {Gesundheitsökonomie und Qualitätsmanagement}, note = {CRIS-Team WoS Importer:2019-09-17}, pages = {185-190}, peerreviewed = {No}, title = {{Costs} associated with multidrug-resistance in inpatient palliative care}, volume = {24}, year = {2019} } @article{faucris.106836224, author = {Adelhardt, Thomas and Hessemer, Stefanie and Docter, Katrin and Sieber, Cornel and Ostgathe, Christoph and Schöffski, Oliver}, doi = {10.1055/s-0043-101517}, faupublication = {yes}, journal = {Gesundheitswesen}, keywords = {cost analysis; end-of-life; geriatrics; methicillin-resistant staphylococcus aureus; MRSA}, peerreviewed = {Yes}, title = {{Costs} of {Medial} {Care} of {MRSA} {Patients} at the {End}-of-{Life} in a {Geriatric} {Ward} {Die} {Kosten} von {MRSA} in der stationären geriatrischen {Versorgung} von {Patienten} am {Lebensende} ({End}-of-{Life} {Care})}, year = {2017} } @article{faucris.211553371, abstract = {OBJECTIVE: The present study addresses the financial effects of incidences of MRSA in the geriatric ward of a German hospital on patients receiving end-of-life care. The main cost drivers will be identified and the costs calculated. METHODOLOGY: A retrospective analysis for a period of one year was conducted for the geriatric ward of a German hospital. In addition to the duration of the patient's stay and the total costs of his/her case, individual cost categories such as personnel and material costs were also examined. In order to enable a cost comparison of MRSA-positive and MRSA-negative patients, matching was used. T-tests were used for purposes of comparison with the case groups. FINDINGS: A total of 107 cases were included in the study; in 27 of these cases, MRSA was detected. Patients with MRSA were found to have a longer average stay and to incur higher average costs. There were no statistically significant differences in the duration of hospital stay between MRSA-positive and MRSA-negative patients. Furthermore, no statistically significant differences were seen in the total costs per case. Significantly higher daily personnel costs for nursing staff were observed for MRSA-positive patients in the case group of patients with lower than average total costs. For MRSA-positive patients, these costs amounted to € 97.18, while MRSA-negative patients incurred € 80.44 in costs. Costs of doctors, medical technicians and non-medical personnel and material costs for infrastructure showed an opposite tendency. If the case groups for different total costs are not considered, no significant differences between MRSA-positive and MRSA-negative patients were found for the individual cost categories examined. CONCLUSIONS: Although we demonstrated that MRSA-positive patients had longer stays and caused higher overall costs in the geriatric ward, we did not find any statistically significant differences between MRSA-positive and MRSA-negative patients. One of the main cost drivers in the care of MRSA-positive patients was identified as the daily personnel costs for nursing staff. Analysing processes related to patients' nursing care can be the first step in attempts to make care for MRSA-positive patients more effective and efficient.}, author = {Adelhardt, Thomas and Hessemer, Stefanie and Docter, Katrin and Sieber, Cornel and Ostgathe, Christoph and Schöffski, Oliver}, doi = {10.1055/s-0043-101517}, faupublication = {yes}, journal = {Gesundheitswesen}, note = {EVALuna2:35552}, pages = {910-915}, peerreviewed = {Yes}, title = {{Costs} of {Medical} {Care} of {MRSA} {Patients} at the {End}-of-{Life} in a {Geriatric} {Ward}}, volume = {80}, year = {2018} } @article{faucris.277084164, abstract = {Background: During the SARS-CoV-2 pandemic's initial waves, bans on visiting and isolation measures placed limits on providing services for seriously ill and dying people and their relatives. Pandemic response teams at governmental level (macro), at federal state and municipal level (meso) and in healthcare facilities (micro) played their role in pandemic management procedures. Aim: To explore pandemic-related challenges and solutions of pandemic response teams regarding the provision of care to seriously ill and dying people and their relatives. Findings were to be integrated into a national strategy (PallPan). Design: Semi-structured expert interviews (10/2020-2/2021) analysed via structured content analysis. Setting/Participants: We interviewed 41 members, who discussed the work of 43 German pandemic response teams (micro n = 23; meso n = 20; no members were available at macro level) from 14 German federal states. Results: Twenty-nine of 43 teams took account of the needs of seriously ill and dying. Their main challenges resulted from pandemic-related legal requirements in hospitals and long-term care facilities. The implementation of such was in the remits of the meso level. Dysfunctional or non-existent communication between the levels was reported to be challenging. To foster patient-related solutions the micro level pandemic response teams supported individual decisions to enable patient-relative contact for example, visiting and saying goodbye outside, meeting via digital solutions. Conclusions: Pandemic response teams evidently struggled to find appropriate solutions to ease pandemic-related impact on the care of seriously ill and dying patients and their relatives. We recommend bringing palliative care expertise on board.}, author = {Klinger, Isabell and Heckel, Maria and Shahda, Sophie and Kriesen, Ursula and Schneider, Carolin and Kurkowski, Sandra and Junghanss, Christian and Ostgathe, Christoph}, doi = {10.1177/02692163221099114}, faupublication = {yes}, journal = {Palliative Medicine}, keywords = {Qualitative research; palliative care; COVID-19; public health; SARS-CoV-2}, note = {CRIS-Team WoS Importer:2022-06-24}, peerreviewed = {Yes}, title = {{COVID}-19: {Challenges} and solutions for the provision of care to seriously ill and dying people and their relatives during {SARS}-{CoV}-2 pandemic - perspectives of pandemic response team members: {A} qualitative study on the basis of expert interviews (part of {PallPan})}, year = {2022} } @article{faucris.266800490, abstract = {Background In the current pandemic regarding the infection with the SARS-CoV-2-virus and COVID-19 as the disease, concerns about pregnant women, effects on childbirth and the health of the newborn remain high. Initially, due to the early manifestation of the disease in younger patients, high numbers of COVID-19 patients in women needing peripartum care were expected. Objective This article aims to provide a general overview over the beginning of the pandemic as well as the second wave of infections in Germany and Switzerland, regarding SARS-CoV-2 positive pregnant women hospitalized for childbirth. We therefore launched a registry to gain timely information over the dynamic situation during the SARS-CoV-2 pandemic in Germany. Material and methods As part of the COVID-19-related Obstetric Anesthesia Longitudinal Assessment (COALA) registry, centers reported weekly birth rates, numbers of suspected SARS-CoV-2 cases, as well as the numbers of confirmed cases between 16 March and 3 May 2020. Data acquisition was continued from 18 October 2020 till 28 February 2021. The data were analyzed regarding distribution of SARS-CoV-2 positive pregnant women hospitalized for childbirth between centers, calendar weeks and birth rates as well as maternal characteristics, course of disease and outcomes of SARS-CoV-2 positive pregnant women. Results A total of 9 German centers reported 2270 deliveries over 7 weeks during the first wave of infections including 3 SARS-CoV-2 positive cases and 9 suspected cases. During the second survey period, 6 centers from Germany and Switzerland reported 41 positive cases out of 4897 deliveries. One woman presented with a severe and ultimately fatal course of the disease, while another one needed prolonged ECMO treatment. Of the women 28 presented with asymptomatic infections and 6 neonates were admitted to a neonatal intensive care unit for further treatment. There was one case of neonatal SARS-CoV-2 infection. Conclusion The number of pregnant women infected with SARS-CoV-2 was at a very low level at the time of delivery, with only sporadic suspected or confirmed cases. Due to the lack of comprehensive testing in the first survey period, however, a certain number of asymptomatic cases are to be assumed. Of the cases 68% presented as asymptomatic or as mild courses of disease but the data showed that even in young healthy patients without the presence of typical risk factors, serious progression can occur. These outcomes should raise awareness for anesthesiologists, obstetricians, pediatricians and intensive care physicians to identify severe cases of COVID-19 in pregnant women during childbirth and to take the necessary precautions to ensure the best treatment of mother and neonate. The prospective acquisition of data allowed a timely assessment of the highly dynamic situation and gain knowledge regarding this vulnerable group of patients.}, author = {Sitter, Magdalena and Schlesinger, Tobias and Reinhold, Ann-Kristin and Scholler, Axel and Von Heymann, Christian and Welfle, Sabine and Bartmann, Catharina and Woeckel, Achim and Kleinschmidt, Stefan and Schneider, Sven and Gottschalk, Andre and Greve, Susanne and Wermelt, Julius Z. and Wiener, Roland and Schulz, Frank and Chappell, Daniel and Brunner, Maya and Neumann, Claudia and Meybohm, Patrick and Kranke, Peter}, doi = {10.1007/s00101-021-01068-6}, faupublication = {yes}, journal = {Anaesthesist}, note = {CRIS-Team WoS Importer:2021-12-03}, peerreviewed = {Yes}, title = {{COVID}-19 in obstetric anesthesia {Prospective} surveillance of peripartum infections with {SARS}-{CoV}-2 and peripartum course of disease in affected women}, year = {2021} } @article{faucris.274944503, abstract = {Background and aim. Germany has a federal state system. Pandemic response teams are key instruments of pandemic management. The aim of this article is to describe the structures and powers of pandemic response teams that were explored during a study on the care of the critically ill and dying in times of a pandemic (Pall Pan). The focus is on health-related pandemic response teams on the national state level (macrolevel) and federal and community level (mesolevel) as well as pandemic response teams in healthcare facilities (microlevel).}, author = {Klinger, Isabell and Heckel, Maria and Shahda, Sophie and Krisen, Ursula and Stellmacher, Silke and Kurkowski, Sandra and Junghanss, Christian and Ostgathe, Christoph}, doi = {10.1007/s00103-022-03542-x}, faupublication = {yes}, journal = {Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz}, note = {CRIS-Team WoS Importer:2022-05-13}, peerreviewed = {Yes}, title = {{COVID}-19 pandemic response teams: organization, competencies, and challenges-understanding and using structural realities}, year = {2022} } @inproceedings{faucris.208411038, author = {Kölle, Julia and Haag, Patricia and Vuorinen, T. and Kiefer, Alexander and Zimmermann, Theodor and Papadopoulos, N. G. and Finotto, Susetta}, faupublication = {yes}, note = {EVALuna2:34821}, pages = {301-302}, peerreviewed = {Yes}, title = {{CTLA4} induction by {Rhinovirus} ({RV}) in pediatric asthma}, volume = {73}, year = {2018} } @article{faucris.312691383, author = {Ostgathe, Christoph and Jäger, Christian}, doi = {10.1007/s15006-023-2881-4}, faupublication = {yes}, journal = {MMW Fortschritte der Medizin}, note = {CRIS-Team Scopus Importer:2023-10-13}, pages = {32-35}, peerreviewed = {unknown}, title = {{Current} legal aspects of physician-assisted suicide in {Germany} {Aktuelles} zum ärztlich assistierten {Suizid} in {Deutschland}}, volume = {165}, year = {2023} } @article{faucris.211613454, abstract = {Introduction Migraine is characterized by cycling phases (interictal, preictal, ictal and postictal) with differing symptoms, while in chronic tension type headache pain phases are fluctuating. The question we asked is whether these phases are associated with changes in parameters of somatosensation and axon-reflex erythema. Methods Patients with episodic migraine and chronic tension type headache were examined psychophysically in the interictal, preictal and ictal phase and healthy subjects on five different test days. Thresholds and suprathreshold ratings of pressure and electrical pain were assessed on three different regions of the head. In migraine patients and in healthy controls, electrically induced axon-reflex erythema was measured in the area of the first trigeminal branch. All migraine patients filled out questionnaires about prodromal symptoms at every visit. Results The axon-reflex erythema was always larger in patients with migraine in contrast to healthy subjects. The pressure pain threshold was lower in migraine patients and chronic tension type headache in comparison to healthy subjects. Electrical pain thresholds did not differ between headache patients and healthy subjects and showed no changes between the phases. However, suprathreshold pain ratings showed less habituation solely in the preictal phase of migraine. The number of prodromal symptoms in migraine patients was increased in the preictal and ictal phase. Discussion Reduced habituation was the unique sign of the preictal phase in migraine patients, independently of prodromal symptoms, whereas a larger axon-reflex erythema and higher pressure pain sensitivity are constitutional and non-phase dependent properties of migraine. Reduced inhibitory mechanisms in the preictal phase may contribute to trigger headache attacks in migraine.}, author = {Strupf, Marion and Fraunberger, Britta and Meßlinger, Karl and Namer, Barbara}, doi = {10.1177/0333102418793641}, faupublication = {yes}, journal = {Cephalalgia}, note = {EVALuna2:35831}, peerreviewed = {Yes}, title = {{Cyclic} changes in sensations to painful stimuli in migraine patients}, year = {2018} } @article{faucris.276359781, abstract = {Background Migraine shows a cyclic pattern with an inter-ictal-, a pre-ictal, an ictal- and a post-ictal phase. We aimed to examine changes in psychophysical parameters during the migraine cycle. Methods The perception of nociceptive and non-nociceptive stimuli and an electrically induced axon-reflex-erythema were assessed in 20 healthy controls and 14 migraine patients on five consecutive days according to different phases of the migraine cycle. Pain was rated three times during a 10-second electrical stimulus. The size of the axon-reflex-erythema was determined using laser-Doppler-imaging. Intensity and hedonic estimates of odours presented by Sniffin' Sticks were rated. Results In healthy controls, no significant changes over the test days were observed. In migraine patients pain thresholds at the head decreased with an ictal minimum. Less habituation after five seconds of stimulation at the head was found pre-ictally, whereas reduced habituation to 10-second electrical stimulation was present in all phases. The axon-reflex-erythema size showed an inter-ictal-specific minimum at the head. odours were perceived ictally as more unpleasant and intense. Conclusions Somatosensory functions, pain thresholds and habituation as predominantly central parameters, axon-reflex-erythema as a peripheral function of trigeminal neurons and odour perception as a predominantly extra-thalamic sensation change specifically over the migraine cycle indicating complex variations of neuronal signal processing.}, author = {Helfenstein, Carolin and Strupf, Marion and Stefke, Andrea and Fraunberger, Britta and Renner, Bertold and Suchantke, Insa and Rothermel, Markus and Meßlinger, Karl and Decol, Roberto and Namer, Barbara}, doi = {10.1177/03331024221097932}, faupublication = {yes}, journal = {Cephalalgia}, note = {CRIS-Team WoS Importer:2022-06-03}, peerreviewed = {Yes}, title = {{Cyclic} changes of sensory parameters in migraine patients}, year = {2022} } @inproceedings{faucris.261570492, address = {HEIDELBERG}, author = {Becker, Ina and Denzler, M. and Heim, Lisanne and Klemt, Insa and Voloshin, Y. Z. and Selin, R. and Mokhir, Andriy and Fietkau, Rainer and Gaipl, Udo and Frey, Benjamin}, booktitle = {STRAHLENTHERAPIE UND ONKOLOGIE}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-07-16}, pages = {S210-S211}, peerreviewed = {unknown}, publisher = {SPRINGER HEIDELBERG}, title = {{Cytotoxic} and immunogenic {Potential} of {Iron} ({II}) {Clathrochelates} and {Irradiation} on {Lung} {Cancer} {Cell} {Lines}}, year = {2021} } @article{faucris.236515158, abstract = {OBJECTIVE: The aim of this study is to define data model requirements supporting the development of a digital cognitive aid (CA) for intraoperative crisis management in anesthesia, including medical emergency text modules (text elements) and branches or loops within emergency instructions (control structures) as well as their properties, data types, and value ranges. METHODS: The analysis process comprised three steps: reviewing the structure of paper-based CAs to identify common text elements and control structures, identifying requirements derived from content, design, and purpose of a digital CA, and validating requirements by loading exemplary emergency checklist data into the resulting prototype data model. RESULTS: The analysis of paper-based CAs identified 19 general text elements and two control structures. Aggregating these elements and analyzing the content, design and purpose of a digital CA revealed 20 relevant data model requirements. These included checklist tags to enable different search options, structured checklist action steps (items) in groups and subgroups, and additional information on each item. Checklist and Item were identified as two main classes of the prototype data model. A data object built according to this model was successfully integrated into a digital CA prototype. CONCLUSION: To enable consistent design and interactivity with the content, presentation of critical medical information in a digital CA for crisis management requires a uniform structure. So far it has not been investigated which requirements need to be met by a data model for this purpose. The results of this study define the requirements and structure that enable the presentation of critical medical information. Further research is needed to develop a comprehensive data model for a digital CA for crisis management in anesthesia, including supplementation of requirements resulting from simulation studies and feasibility analyses regarding existing data models. This model may also be a useful template for developing data models for CAs in other medical domains.}, author = {Schild, Stefanie and Gründner, Julian and Gulden, Christian and Prokosch, Hans-Ulrich and St. Pierre, Michael and Sedlmayr, Martin}, doi = {10.1055/s-0040-1703015}, faupublication = {yes}, journal = {Applied Clinical Informatics}, month = {Jan}, note = {CRIS-Team Scopus Importer:2020-03-27}, pages = {190-199}, peerreviewed = {Yes}, title = {{Data} {Model} {Requirements} for a {Digital} {Cognitive} {Aid} for {Anesthesia} to {Support} {Intraoperative} {Crisis} {Management}}, volume = {11}, year = {2020} } @inproceedings{faucris.283173681, address = {CLARE}, author = {Kruse, A. and Bischof, Erik and Raaz-Schrauder, D. and Achenbach, Susanne and Dietel, B. and Tauchi, Miyuki and Urschel, K.}, booktitle = {ATHEROSCLEROSIS}, doi = {10.1016/j.atherosclerosis.2022.06.585}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2022-10-14}, pages = {E203-E203}, peerreviewed = {unknown}, publisher = {ELSEVIER IRELAND LTD}, title = {{DECREASING} {GPLD} 1-{LEVELS} {IN} {PATIENTS} {AFTER} {ST}-{ELEVATED} {MYOCARDIAL} {INFARCTION}}, year = {2022} } @article{faucris.282229185, abstract = {Delirium occurs in 20 - 50 % of hospitalized elderly patients. An age > 65 years is one of the factors predisposing to the development of delirium, which is a common syndrome in geriatric medicine. Two clinical guidelines on this condition were published in 2010: NICE clinical guideline 103, Delirium: diagnosis, prevention, management and the German guideline S3-Leitlinie Analgesie, Sedierung und Delirmanagement in der Intensivmedizin. The article gives an overview of new aspects of delirium in the clinical context. © Georg Thieme Verlag KG Stuttgart - New York.}, author = {Singler, K. and Singler, Boris and Heppner, Hans Jürgen}, doi = {10.1055/s-0031-1274563}, faupublication = {yes}, journal = {Deutsche Medizinische Wochenschrift}, keywords = {CAM-Score; delirium; geriatrics}, note = {CRIS-Team Scopus Importer:2022-09-26}, pages = {681-684}, peerreviewed = {Yes}, title = {{Delirium} in the elderly {Akute} {Verwirrtheit} im {Alter}}, volume = {136}, year = {2011} } @article{faucris.111079144, abstract = {Desires for hastened death (DHD; wish to hasten death is also in use) are prevalent in terminally ill patients. Studies show that health professionals (HP) are often underprepared when presented with DHD. HPs in specialized palliative care (SPC-HP) often encounter DHD. This study aimed to identify SPC-HP responses to DHD in daily practice and their corresponding functions.Narrative interviews were conducted with 19 SPC-HPs at four German University Hospitals. Transcripts were analyzed using the documentary method. An inventory of established responses to DHD was compiled, and their corresponding functions in the context of the patient-SPC-HP interaction were reconstructed.Twelve response categories and six corresponding functions were identified. On the patient level, responses categorized as symptom control, exploring the reasons and generating perspective, reorientation, and hope were particularly used to ease the patient's burden. On the interaction level, creating a relationship was fundamental. On the SPC-HP level, various methods served the functions self-protection and showed professional expertise.Profound personal and professional development is necessary to respond to the inherent challenges presented by DHD. Establishing helpful relationships with patients is essential regardless of SPC-HP specialization. SPC-HPs should maximize their skills in establishing and maintaining relationships as well as strengthening their own resilience, possibly in specific training courses. Copyright © 2015 John Wiley & Sons, Ltd.}, author = {Galushko, M. and Frerich, G. and Perrar, K. M. and Golla, H. and Radbruch, L. and Nauck, F. and Ostgathe, Christoph and Voltz, R.}, doi = {10.1002/pon.3959}, faupublication = {yes}, journal = {Psycho-Oncology}, note = {EVALuna2:26205}, pages = {536-43}, peerreviewed = {Yes}, title = {{Desire} for hastened death: how do professionals in specialized palliative care react?}, volume = {25}, year = {2016} } @inproceedings{faucris.202377694, author = {Schellenberger, Sven and Shi, Kilin and Mai, Melanie and Wiedemann, Jan Philipp and Steigleder, Tobias and Eskofier, Björn and Weigel, Robert and Kölpin, Alexander}, booktitle = {Computing in Cardiology}, date = {2018-09-23/2018-09-26}, doi = {10.22489/cinc.2018.104}, faupublication = {yes}, peerreviewed = {Yes}, title = {{Detecting} {Respiratory} {Effort}-{Related} {Arousals} in {Polysomnographic} {Data} {Using} {LSTM} {Networks}}, venue = {MECC Maastricht}, year = {2018} } @inproceedings{faucris.217809694, address = {HEIDELBERG}, author = {Raithel, Martin and Krischke, Eugenia and Kressel, Juergen and Krischke, Frederick and Albrecht, Heinz and Hotfiel, Katharina and Schultis, Wolfgang and Hagel, Alexander}, booktitle = {INTERNIST}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2019-05-17}, pages = {S37-S38}, peerreviewed = {unknown}, publisher = {SPRINGER HEIDELBERG}, title = {{Detection} of {Local} {Intestinal} {IgE} {Antibodies} to {Foods} in {Irritable} {Bowel} {Syndrome} and {Effect} of an {Antigen}-{Specific} {Diet} on {Irritable} {Bowel} {Syndrome} ({IBS}) {Type}, {Severity}, and {Symptoms}}, year = {2019} } @article{faucris.298202901, abstract = {Purpose: The Ad26.COV2.S vaccine is a replication-incompetent human adenovirus type 26 vector encoding the SARS-CoV-2 spike protein. In a phase 1-2a trial, a single dose of Ad26.COV2.S induced SARS-CoV-2 spike-specific antibodies in ≥ 96% of healthy adults. To investigate vaccine immunogenicity in HIV-1-infection, we measured SARS-CoV-2 spike-specific antibodies in Ad26.COV2.S vaccinated HIV-1-infected patients and analyzed the presence of pre-existing Ad26 neutralizing antibodies. Methods: We included all Ad26.COV2.S vaccinated HIV-1-infected patients of Erlangen HIV cohort fulfilling all inclusion criteria. The study cohort consisted of 15 HIV-1-infected patients and three HIV-1-uninfected subjects who received the Ad26.COV2.S vaccine between April and November 2021. Pre-vaccination sera were collected between October 2014 and June 2021, post-vaccination sera between June and December 2021. Neutralizing antibodies towards Ad26 were determined by a FACS-based inhibition assay measuring the expression of SARS-CoV-2 spike and adenoviral proteins in HEK293T cells after in-vitro transduction with Ad26.COV2.S or the control ChAdOx1-S. Results: Six out of 15 HIV-1-infected patients failed to develop SARS-CoV-2-specific antibodies and four patients developed weak antibody responses after vaccination with Ad26.COV2.S. Pre-vaccination sera of four of the six vaccine non-responders showed neutralizing activity towards Ad26.COV2.S but not toward the ChAdOx1-S vaccine at 1:50 dilution. After Ad26.COV2.S vaccination, 17 of the 18 subjects developed strong Ad26-neutralizing activity and only one of the 18 subjects showed neutralizing activity towards the ChAdOx1-S vaccine. Conclusion: Ad26.COV2.S vaccination showed a high failure rate in HIV-1-infected patients. Pre-existing immunity against Ad26 could be an important contributor to poor vaccine efficacy in a subgroup of patients.}, author = {Schmidt, Katja and Harrer, Ellen and Schönau, Verena and Simon, David and Kleyer, Arnd and Steininger, Philipp and Korn, Klaus and Schett, Georg and Knobloch, Carina and Nganou-Makamdop, Krystelle and Harrer, Thomas}, doi = {10.1007/s15010-023-02035-6}, faupublication = {yes}, journal = {Infection}, keywords = {Ad26.COV2.S; Adenovirus 26; HIV-1; Neutralizing antibodies; SARS-CoV-2; SARS-CoV-2 vaccine}, note = {CRIS-Team Scopus Importer:2023-04-28}, peerreviewed = {Yes}, title = {{Detection} of pre-existing neutralizing antibodies against {Ad26} in {HIV}-1-infected individuals not responding to the {Ad26}.{COV2}.{S} vaccine}, year = {2023} } @article{faucris.114065424, abstract = {For the quantification of propofol total and unbound drug concentrations a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated. To separate unbound propofol an ultrafiltration step before sample preparation was performed. Both the ultrafiltrate and plasma samples were extracted with solid-phase extraction and substituted with deuterated propofol as an internal standard. Separation was performed by gradient elution using UPLC-like system and analyzed by MS/MS consisting of an electrospray ionization source. To detect low and high concentration levels of propofol two calibration curves were identified and showed linearity within the range of 1-50ng/ml and 50-20000ng/ml. The lower limit of quantification was 1ng/ml. Intra- and interassay precision and accuracy did not exceed ±15%. The method was applied to a clinical study during intensive care treatment of patients after coronary artery bypass grafting.}, author = {Eisenried, Andreas and Wehrfritz, Andreas and Ihmsen, Harald and Schüttler, Jürgen and Jeleazcov, Christian}, doi = {10.1016/j.jpba.2016.04.026}, faupublication = {yes}, journal = {Journal of Pharmaceutical and Biomedical Analysis}, note = {EVALuna2:16713}, pages = {148-55}, peerreviewed = {Yes}, title = {{Determination} of total and unbound propofol in patients during intensive care sedation by ultrafiltration and {LC}-{MS}/{MS}}, volume = {126}, year = {2016} } @article{faucris.280967481, abstract = {Background: The SARS-CoV-2 pandemic is a constant challenge for health care systems, also in Germany. Care of seriously ill and dying people and their relatives is often neglected and suffering increased due to sub-optimal symptom management, visiting restrictions and lonely dying. The project "Palliative Care in Pandemics (PallPan)" intended to develop a national strategy including evidence- and consensus-based recommendations for the care of seriously ill and dying people and their relatives during pandemic times in Germany. Aim: To reach consensus on evidence-based recommendations for the care of seriously ill and dying people and their relatives in pandemics. Methods: Three-step consensus process comprising two online Delphi rounds and an expert workshop conducted from April to June 2021. One hundred twenty experts from various areas of healthcare, administration, and politics in Germany were included. Results: During the consensus-process, pre-formulated evidence-based recommendations were refined step-by-step. This resulted in consensus on 33 recommendations on the topics of "supporting patients and their relatives," "supporting staff," and "supporting and maintaining structures and provision of palliative care." The recommendations address professional carers and various responsibilities on a governmental, federal state and municipal level, and in healthcare facilities. Conclusion: We provide evidence and consensus-based recommendations for the care of seriously ill and dying people and their relatives in pandemics in Germany. This is an important step towards a pandemic preparedness and hopefully improves the future palliative care response to pandemics.}, author = {Gauder, Sonja and Pralong, Anne and Remi, Constanze and Hodiamont, Farina and Klinger, Isabell and Heckel, Maria and Simon, Steffen T. and Bausewein, Claudia}, doi = {10.1177/02692163221114536}, faupublication = {yes}, journal = {Palliative Medicine}, note = {CRIS-Team WoS Importer:2022-08-26}, peerreviewed = {Yes}, title = {{Development} of a national strategy with recommendations for the care of seriously ill and dying people and their relatives in pandemics: {A} modified {Delphi} study}, year = {2022} } @article{faucris.282051595, abstract = {Introduction A range of referral criteria and scores have been developed in recent years to help with screening for the need of specialist palliative care (SPC) in advanced, incurable cancer patients. However, referral criteria have not yet been widely implemented in oncology, as they usually need to be revised by physicians or nurses with limited time resources. To develop an easily applicable screening for the need for SPC in incurable cancer inpatients, we aim to (a) test inter-rater reliability of multiprofessional expert opinion as reference standard for SPC need (phase I) and (b) explore the diagnostic validity of selected patient-reported outcome measures (PROMs) and routine data for the need of SPC (phase II). Methods and analysis Inclusion criteria for patients are metastatic or locally advanced, incurable cancer, >= 18 years of age and informed consent by patient or proxy. (Exclusion criteria: malignant haematological disease as main diagnosis). In phase I, three palliative care consultation teams (PCTs) of three German university hospitals assess the SPC need of 20 patient cases. Fleiss' Kappa will be calculated for inter-rater reliability. In phase II, 208 patients are consecutively recruited in four inpatient oncology wards of Freiburg University Hospital. The PCT will provide assessment of SPC need. As potential referral criteria, patients complete PROMs and a selection of routine data on person, disease and treatment is documented. Logistic regression models and ROC analyses are employed to test their utility in screening for SPC need. Ethics and dissemination Our findings will be published in peer-reviewed journals and presented at national and international scientific meetings and congresses. Ethical approval was granted by the Ethics Committee of Albert-Ludwigs-University Freiburg, Germany (approval no. 20-1103).}, author = {Mueller, Evelyn and Mueller, Michael Josef and Boehlke, Christopher and Ramsenthaler, Christina and Jaeger, Helga and Schaefer, Henning and Ostgathe, Christoph and Klein, Carsten and Simon, Steffen and Becker, Gerhild}, doi = {10.1136/bmjopen-2021-059598}, faupublication = {yes}, journal = {BMJ Open}, note = {CRIS-Team WoS Importer:2022-09-23}, peerreviewed = {Yes}, title = {{Development} of a screening tool for the need of specialist palliative care in oncologic inpatients: study protocol for the {ScreeningPALL} {Study}}, volume = {12}, year = {2022} } @article{faucris.209655187, abstract = {BACKGROUND: Internationally, efforts are underway to develop coordinated and standardized approaches for palliative care service delivery by improving service quality in hospice and palliative care networks. German legal regulations explicitly demand networking between hospice and palliative care providers. However, there is little research on models of cooperation and the building and development of hospice and palliative care networks. Research-based recommendations for network building and advancement are lacking. OBJECTIVE: The study aim was to develop empirical recommendations for the building of new and advancement of existing hospice and palliative care networks in Bavaria, Germany. METHODS: The project utilized a qualitative approach. The research project was structured in six sequential phases: 1) semi-structured individual interviews on status quo of networks, 2) a workshop including a focus group to develop definitions of key terms and prioritize major network themes, 3) semi-structured face-to-face interviews on factors enabling and inhibiting cooperation, 4) drafting of a recommendation for regional hospice and palliative care networks, 5) an online consensus survey questionnaire to rate relevance and feasibility of the draft recommendation and an internal consensus meeting to revise the draft, and 6) an expert workshop to develop examples of realization. Coordinators and chairpersons of 12 hospice and palliative care networks constitute the study population for study phases 1 to 3, 5, and 6. Network representatives partook in one (n=6), two (n=6), three (n=4), four (n=2), or all five (n=1) of the study phases 1, 2, 3, 5, and 6. Further experts participated in one (n=10) or both (n=1) of the phases 5 and 6. RESULTS: Recommendations were drafted for six thematic fields: (i) missions and aims, (ii) roles and responsibilities, (iii) coordination, (iv) communication and information channels, (v) public visibility, and (vi) funding. The whole set of recommendations was rated by 90% of the participants to be fully or somewhat important for network building and development. A total of 22 recommendations was approved. CONCLUSIONS: The call for establishing and developing standards for hospice and palliative care networks was situated within the current policy climate of Germany and the broader international community. The present recommendations can aid implementation of this request and have a strong relevance for practice.}, author = {Herbst, Franziska A. and Heckel, Maria and Stiel, Stephanie and Ostgathe, Christoph}, doi = {10.1016/j.zefq.2018.11.007}, faupublication = {yes}, journal = {Zeitschrift für Evidenz, Fortbildung und Qualitat im Gesundheitswesen}, note = {EVALuna2:35124}, peerreviewed = {Yes}, title = {{Development} of empirical recommendations for regional hospice and palliative care networks in {Germany}: {A} qualitative study}, year = {2018} } @article{faucris.221133855, abstract = {Background: Making the right diagnosis plays an important role in emergency departments, but objective indicators to investigate diagnostic quality are rarely available. Methods: By systematically comparing the main admission diagnosis (AD), the main discharge diagnosis (ED) and the main hospital diagnosis (HD), the diagnostic agreement (dÜ), -sensitivity (dSe), -specifity (dSp) and efficiency (dEff) were calculated for 28 time-critical diagnoses. Results: During the study period, 21,512 emergency department inpatients (average 63 years; min 0, max 104, standard deviation [SD] ± 21.4) were treated with 599 different main admission diagnoses. The diagnostic agreement (dÜ) and sensitivity (dSe) over all time-critical diagnoses reached 66.5 and 70.0%, the diagnostic specificity (dSp) 51.5%. The diagnostic sensitivity (dSe) was highest (100%) among patients with aortic aneurysm and dissection (dSp 72%). Inpatients with Intracranial injury reached the highest diagnostic specificity (dSp) of 94% (dSe 92%), while patients with vascular disorders of intestine had the largest gap between diagnostic sensitivity (dSe) and diagnostic specificity (dSp) (82 and 13%). The diagnostic efficiency over all emergency diagnoses (dEff) was 0.37/minute (min 0.03, max 92, SD ± 1.22), whereas the subgroup of patients with cardiac arrest reached highest diagnostic efficiency (dEff) of 1.04/minute (min 0.42, max 9.17, SD ± 1.41, dSe 55%). Conclusion: Quality indicators for time-critical diagnoses could be determined by routine data of the hospital information systems. By linking outcome- and process indicators diagnostic quality of an emergency department can be objectified.}, author = {Wilk, Florian and Grosse, F. and Liebel, J. and Wagner, M. and Dormann, H.}, doi = {10.1007/s10049-019-0611-3}, faupublication = {yes}, journal = {Notfall und Rettungsmedizin}, keywords = {Central emergency room; Diagnostic quality; Process optimization; Quality indicators; Quality management}, note = {CRIS-Team Scopus Importer:2019-06-21}, peerreviewed = {Yes}, title = {{Diagnosen} einer {Zentralen} {Notaufnahme} als {Qualitätsindikator}}, year = {2019} } @article{faucris.209033035, author = {Larkin, P. J. and Cherny, N. I. and La Carpia, D. and Guglielmo, M. and Ostgathe, Christoph and Scotte, F. and Ripamonti, C. I.}, doi = {10.1093/annonc/mdy148}, faupublication = {yes}, journal = {Annals of Oncology}, note = {EVALuna2:34945}, pages = {iv111-iv125}, peerreviewed = {Yes}, title = {{Diagnosis}, assessment and management of constipation in advanced cancer: {ESMO} {Clinical} {Practice} {Guidelines}}, volume = {29}, year = {2018} } @inproceedings{faucris.211728082, author = {Peters, Joachim and Heckel, Maria and Ostgathe, Christoph and Habermann, Mechthild}, booktitle = {12. Kongress der Deutschen Gesellschaft für Palliativmedizin}, date = {2018-09-05/2018-09-08}, doi = {10.1055/s-0038-1669222}, faupublication = {yes}, peerreviewed = {unknown}, title = {{Die} {Entstehung} einer professionalisierten {Fachkultur} in der {Palliativmedizin} - sprachwissenschaftliche {Perspektiven}}, venue = {Berlin}, year = {2018} } @article{faucris.252100178, abstract = {The global COVID-19 pandemic has led to drastic changes in the management of patients with rheumatic diseases. Due to the imminent risk of infection, monitoring intervals of rheumatic patients have prolonged. The aim of this study is to present insights from patients, rheumatologists, and digital product developers on the ongoing digital health transition in rheumatology. A qualitative and participatory semi-structured fishbowl approach was conducted to gain detailed insights from a total of 476 participants. The main findings show that digital health and remote care are generally welcomed by the participants. Five key themes emerged from the qualitative content analysis: (1) digital rheumatology use cases, (2) user descriptions, (3) adaptation to different environments of rheumatology care, and (4) potentials of and (5) barriers to digital rheumatology implementation. Codes were scaled by positive and negative ratings as well as on micro, meso, and macro levels. A main recommendation resulting from the insights is that both patients and rheumatologists need more information and education to successfully implement digital health tools into clinical routine.}, author = {Müehlensiepen, Felix and Kurkowski, Sandra and Krusche, Martin and Mucke, Johanna and Prill, Robert and Heinze, Martin and Welcker, Martin and Schulze-Koops, Hendrik and Vuillerme, Nicolas and Schett, Georg and Knitza, Johannes}, doi = {10.3390/ijerph18052636}, faupublication = {yes}, journal = {International Journal of Environmental Research and Public Health}, keywords = {Chronic disease; Content analysis; Digital health; EHealth; Fishbowl discussion; Patient perspective; Qualitative research; Remote care; Rheumatology; Telemedicine}, note = {CRIS-Team Scopus Importer:2021-03-19}, pages = {1-11}, peerreviewed = {Yes}, title = {{Digital} health transition in rheumatology: {A} qualitative study}, volume = {18}, year = {2021} } @article{faucris.275143424, abstract = {Objectives: To describe three coronavirus disease 2019 patients suffering from acute respiratory distress syndrome under venovenous extracorporeal membrane oxygenation therapy and tight anticoagulation monitoring presenting a novel pattern of multifocal brain hemorrhage in various degrees in all cerebral and cerebellar lobes. Design: Clinical observation of three patients. Post mortem examinations. Setting: Two ICUs at the University Hospital Erlangen. Patients: Three patients (medium age 56.6 yr, two male with hypertension and diabetes, one female with no medical history) developed severe acute respiratory distress syndrome on the basis of a severe acute respiratory syndrome coronavirus 2 infection. All required mechanical ventilation and venovenous extracorporeal membrane oxygenation support. Interventions: Clinical observation, CT, data extraction from electronic medical records, and post mortem examinations. Main Results: We report on an unusual multifocal bleeding pattern in the white matter in three cases with severe acute respiratory distress syndrome due to coronavirus disease 2019 undergoing venovenous extracorporeal membrane oxygenation therapy. Bleeding pattern with consecutive herniation was found in CT scans as well as in neuropathologic post mortem examinations. Frequency for this unusual brain hemorrhage in coronavirus disease 2019 patients with extracorporeal membrane oxygenation therapy at our hospital is currently 50%, whereas bleeding events in extracorporeal membrane oxygenation patients generally occur at 10-15%. Conclusions: Multifocality and high frequency of the unusual white matter hemorrhage pattern suggest a coherence to coronavirus disease 2019. Neuropathological analyses showed circumscribed thrombotic cerebrovascular occlusions, which eventually led to microvascular and later on macrovascular disseminated bleeding events. However, signs of cerebrovascular inflammation could not be detected. Polymerase chain reaction analyses of brain tissue or cerebrospinal fluid remained negative. Increased susceptibility for fatal bleeding events should be taken into consideration in terms of systemic anticoagulation strategies in coronavirus disease 2019.}, author = {Bihlmaier, Karl and Coras, Roland and Willam, Carsten and Grampp, Steffen and Jabari, Samir and Eichhorn, Philip and Haller, Florian and Kuramatsu, Joji and Schwab, Stefan and Castellanos, Ixchel and Birkholz, Torsten and Schüttler, Jürgen and Altmeppen, Jürgen and Schiffer, Mario and Herbst, Larissa}, doi = {10.1097/CCE.0000000000000218}, faupublication = {yes}, journal = {Critical Care Explorations}, keywords = {acute respiratory distress syndrome; cerebral microhemorrhage; coronavirus disease 2019; extracorporeal membrane oxygenation; intracerebral bleeding}, note = {EVALuna2:313697}, peerreviewed = {Yes}, title = {{Disseminated} {Multifocal} {Intracerebral} {Bleeding} {Events} in {Three} {Coronavirus} {Disease} 2019 {Patients} on {Extracorporeal} {Membrane} {Oxygenation} {As} {Rescue} {Therapy}.}, volume = {2}, year = {2020} } @article{faucris.286632572, abstract = {Distortion or whiplash trauma of the cervical spine is an injury pattern associated with motor vehicle collisions and typically occurs after rear impact collisions, but is not limited to this type of collision and accident. The vast majority of these injuries are low-grade injuries according to the Quebec Task Force (QTF) classification, whereby no objective morphological correlates can be determined in clinical and radiological examinations. The prognosis is predominantly favorable and the condition is self-limiting; however, care must be taken with respect to complex courses with chronic pain and the manifestation of neuropsychiatric complaints. Due to the mechanism of the accident this injury pattern is particularly frequent in accidents associated with third party liability insurance claims. The discrepancy between subjective complaints and the presence of objective findings is a particular challenge for the assessment by the medical expert.}, author = {Wagner, Sören and Renner, Nina and Krause, J. and Perl, Markus}, doi = {10.1007/s00113-022-01248-y}, faupublication = {yes}, journal = {Die Unfallchirurgie}, note = {CRIS-Team WoS Importer:2022-12-16}, peerreviewed = {Yes}, title = {{Distortion} of the cervical spine {Pathophysiology}, diagnostics, treatment and assessment}, year = {2022} } @article{faucris.302901894, abstract = {Objective: To identify and describe requirements, recommendations, and templates for the documentation of sedation in adult palliative care.Introduction: International literature shows inconsistency in clinical practice regarding sedation in palliative care accompanied by legal, ethical, and medical uncertainties. Documentation in general serves as proof for previous treatments. In the context of intentional sedation to relieve suffering at the end of life, documentation provides a clear demarcation against practices of euthanasia.Inclusion Criteria: Articles with full-text version published in English or German since 2000, covering documentation requirements, recommendations, monitoring parameters or templates for sedation in adult palliative care were included.Methods: Scoping review following the JBI methodology. Search in online databases, websites of professional associations in palliative care, reference lists of relevant publications, the archive of the German "Journal of Palliative Medicine" and databases for unpublished literature were used. Search terms included "palliative care,' "sedation," and "documentation." The search was conducted from January 2022 to April 2022 with an initial hand search in November 2021. Data were screened and charted by one reviewer after conducting a pilot test of the criteria.Results: From the initial 390 articles (database search), 22 articles were included. In addition, 15 articles were integrated from the hand search. The results can be clustered in two sets of items, regarding either the documentation before or during sedation. The documentation requirements referred both to inpatient and homecare settings but in many cases, a clear assignment was missing.Conclusions: The guidelines analyzed in this study rarely cover setting-specific differences in documentation and often treat documentation as minor topic. Further research is needed addressing legal and ethical concerns of health care teams and, therefore, help to improve treatment of patients suffering from otherwise intractable burden at the end of life.}, author = {Kauzner, Saskia and Heckel, Maria and Ostgathe, Christoph and Schneider, Manuela and Bausewein, Claudia and Schildmann, Eva and Kremling, Alexander and Ziegler, Kerstin and Klein, Carsten}, doi = {10.1089/jpm.2022.0476}, faupublication = {yes}, journal = {Journal of Palliative Medicine}, note = {CRIS-Team WoS Importer:2023-05-26}, peerreviewed = {Yes}, title = {{Documentation} of {Sedation} in {Palliative} {Care}: {A} {Scoping} {Review} of {Requirements}, {Recommendations}, and {Templates}}, year = {2023} } @article{faucris.209236459, abstract = {BACKGROUND: Lack of familiarity with the content of current guidelines is a major factor associated with non-compliance by clinicians. It is conceivable that cognitive aids with regularly updated medical content can guide clinicians' task performance by evidence-based practices, even if they are unfamiliar with the actual guideline. Acute hyponatraemia as a consequence of TURP syndrome is a rare intraoperative event, and current practice guidelines have changed from slow correction to rapid correction of serum sodium levels. The primary objective of this study was to compare the management of a simulated severe gynaecological transurethral resection of the prostate (TURP) syndrome under spinal anaesthesia with either: an electronic cognitive aid, or with management from memory alone. The secondary objective was to assess the clinical relevance and participant perception of the usefulness of the cognitive aid. METHODS: Anaesthetic teams were allocated to control (no cognitive aid; n = 10) or intervention (cognitive aid provided; n = 10) groups. We identified eight evidence-based management tasks for severe TURP syndrome from current guidelines and subdivided them into acute heart failure (AHF)/pulmonary oedema tasks (5) and acute hyponatraemia tasks (3). Implementation of the treatment steps was measured by scoring task items in a binary fashion (yes/no). To assess whether or not the cognitive aid had prompted a treatment step, participants from the cognitive aid group were questioned during debriefing on every single treatment step. At the end of the simulation, session participants were asked to complete a survey. RESULTS: Teams in the cognitive aid group considered evidence-based treatment steps significantly more often than teams of the control group (96% vs. 50% for 'AHF/pulmonary oedema' p < 0.001; 79% vs. 12% for 'acute hyponatraemia' p < 0.001). Without the cognitive aid, performance would have been comparable across both groups. Nurses, trainees, and consultants derived equal benefit from the cognitive aid. CONCLUSIONS: The cognitive aid improved the implementation of evidence-based practices in a simulated intraoperative scenario. Cognitive aids with current medical content could help to close the translational gap between guideline publication and implementation in acute patient care. It is important that the cognitive aid should be familiar, in a format that has been used in practice and training.}, author = {St. Pierre, Michael and Breuer, Georg and Strembski, Dieter and Schmitt, Christopher and Lütcke, Björn}, doi = {10.1186/s12871-017-0365-8}, faupublication = {yes}, journal = {BMC Anesthesiology}, note = {EVALuna2:35110}, peerreviewed = {Yes}, title = {{Does} an electronic cognitive aid have an effect on the management of severe gynaecological {TURP} syndrome? {A} prospective, randomised simulation study}, volume = {17}, year = {2017} } @article{faucris.119977484, abstract = {Simulation-based training with a focus on non-technical skills can have a positive influence on safety relevant attitudes of participants. If an organization succeeds in training sufficient staff, it may experience a positive change in the safety climate. As the effects of a single training are of a transient nature, annual training sessions may lead to an incremental improvement of safety relevant attitudes of employees over time. In spring 2012 the Department of Anesthesia at the University Hospital of Erlangen established an annual simulation-based training for staff members (e.g. consultants, trainee anesthetists and nurse anesthetists).The study aimed to test whether an annual simulation-based training would result in an incremental longitudinal improvement in attitudes towards teamwork, safety and stress recognition.A survey comprising three domains (teamwork climate, safety climate and stress recognition) of the safety attitudes questionnaire (SAQ) and items addressing briefing and speaking up was distributed to all participants in an annual in-house simulation training. Participants filled out the questionnaire in the morning of each training day. The attitudes were measured before the first training series in 2012, 6 months after the first training and then every year (2013-2016). Participants generated a personalized identification code which allowed individuals to be anonymously tracked over time. Results of the 5-point Likert scale were transformed to a 100-point scale. Results were calculated at the group level and at the individual level. Univariable linear regression was used to calculate mean changes per year.Over a period of 5 years (2012-2016) a total of 255 individuals completed the questionnaire. Each year, 14-20% of all nurse anesthetists and 81-90% of all anesthetists participated in the simulation-based training. As a result of annual staff turnover 16-24% of participants were new staff members. A personalized code allowed the before and after comparison of 99 staff members who had participated twice or more. Physicians had a higher mean score for teamwork climate before the first training (+8.7 p < 0.001). Mean teamwork climate and safety climate scores before the first training increased over a period of 5 years (3.11 for teamwork climate, p < 0.001 and 2.73 for safety climate, p < 0.001). Repeat participation led to a bigger mean change of individual attitudes in nurse anesthetists: teamwork climate 5.2 (nurses) vs. 1.4 (physicians) and safety climate 5.3 (nurses) vs. 2.8 (physicians) without reaching significance. Participants acknowledged the importance of briefings but confirmed their existence in less than half of the cases. The frequency of briefings increased over the 5-year period. There were no changes in attitude towards speaking up.Over a 5-year period, small positive changes in attitudes towards teamwork and safety occurred. Low participation of nurse anesthetists as well as personnel turnover may have weakened the impact of simulation-based training on the safety climate.}, author = {St. Pierre, Michael and Gall, Christine and Breuer, Georg and Schüttler, Jürgen}, doi = {10.1007/s00101-017-0371-8}, faupublication = {yes}, journal = {Anaesthesist}, note = {EVALuna2:198}, pages = {910-923}, peerreviewed = {Yes}, title = {{Does} annual simulation training influence the safety climate of a university hospital? : {Prospective} 5-year investigation using dimensions of the safety attitude questionnaire}, volume = {66}, year = {2017} } @article{faucris.118441884, abstract = {Depending on the specific national emergency medical systems, venous cannulations may be performed by physicians, paramedics or both alike. Difficulties in the establishment of vascular access can lead to delayed treatment and transport. Our study investigates possible inter-professional differences in the difficulties of prehospital venous cannulation.Paramedics were interviewed for their personal attitudes towards and experiences in venous access. We analysed 47 candidate predictor variables in terms of cannulation failure and exceedance of a 2 min time threshold. Multivariable logistic regression models were fitted for variables of potential predictive value (P<0.25) and evaluated by the area under the curve (AUC>0.60) of their respective receiver operating characteristic curve. Results were compared with previously published data from emergency physicians.A total of 552 cannulations were included in our study. All 146 participants voted that paramedics should be eligible to perform venous catheterizations. Despite ample experience in the task, almost half of them considered prehospital venous cannulations more difficult than those performed in hospital. However, the multivariable logistic regression found only patient-related and puncture site factors to be predictive of cannulation failure (patient age, vein palpability with tourniquet, insufficient ambient lighting: model AUC: 0.72) or cannulation delay (vein palpability with tourniquet: model AUC: 0.60).Our study shows that venous cannulation is well established among paramedics. It presents itself with similar difficulties across medical professions. Not the numerous specific circumstances of prehospital emergency care, but universal factors inherent to the task will influence the success at venous catheterization.}, author = {Prottengeier, Johannes and Maier, Jan-Niklas and Gall, Christine and Heinrich, Sebastian and Schmidt, Joachim and Birkholz, Torsten}, doi = {10.1097/MEJ.0000000000000386}, faupublication = {yes}, journal = {European Journal of Emergency Medicine}, note = {EVALuna2:16736}, peerreviewed = {Yes}, title = {{Does} it matter who places the intravenous? {An} inter-professional comparison of prehospital intravenous access difficulties between physicians and paramedics}, year = {2016} } @article{faucris.211638876, abstract = {BACKGROUND: Since 2015, more than 3 million refugees have reached the European Union. In order to receive and integrate them, societies heavily rely on relief organizations and private initiatives. Yet the well-being, work-satisfaction and possible health implications for refugee helpers have not been adequately addressed. METHODS: In a German national cross-sectional study, we gathered socio-demographic data on refugee helpers. Work satisfaction was examined by means of Neuberger and Allerbeck's Work Description Inventory. We screened for depression by using the 5-item WHO Well-Being Index (WHO-5), and for post-traumatic stress disorder (PTSD) using the PTSD Short Screening Scale (PTSD-7). 1712 questionnaires were analyzed. RESULTS: Females accounted for 73.4% (1235), the mean age was 52.0 years (SD: 14.4). 61.6% were academics (1042). 87.0% (1454) were voluntary helpers who invested 9.4 hours (SD: 8.9) per week. Refugee helpers were more satisfied with the content than with the conditions or the organization of their work. Their work satisfaction and overall life satisfaction reached higher values than in representative samples. The mean WHO-5 index for refugee helpers was 68.2 points (SD: 19.0). Positive depression screening was found in 17.3% (226). 982 (57.4%) had experienced a traumatic event in their past or witnessed it during their work in refugee aid. 33 (2.8%) of the helpers had a positive PTSD screening. CONCLUSIONS: Refugee helpers deliver invaluable services to migrants and receiving communities. Our data indicates above average well-being as well as work-satisfaction. Psychological traumatization is found frequently but fortunately PTSD is rare. All efforts should be made to uphold helpers' keen spirit and contributions. They should be screened regularly with regards to work satisfaction, well-being and mental health. As part of a comprehensive health promotion strategy they should be instructed about depression, psychological trauma, PTSD and ways to find help. }, author = {Jobst, Eva and Gall, Christine and Eiche, Christian and Birkholz, Torsten and Prottengeier, Johannes}, doi = {10.1371/journal.pone.0209697}, faupublication = {yes}, journal = {PLoS ONE}, note = {EVALuna2:35653}, peerreviewed = {Yes}, title = {{Do} good, stay well. {Well}-being and work satisfaction among {German} refugee helpers: {A} national cross-sectional study}, volume = {13}, year = {2018} } @article{faucris.122786884, author = {Bernhard, Michael and Hossfeld, Bjoern and Kumle, Bernhard and Becker, Torben K. and Boettiger, Bernd and Birkholz, Torsten}, doi = {10.1097/EJA.0000000000000426}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:16728}, pages = {553-6}, peerreviewed = {No}, title = {{Don}'t forget to ventilate during cardiopulmonary resuscitation with mechanical chest compression devices}, volume = {33}, year = {2016} } @article{faucris.107516684, author = {Rohde, Doris and Schmitt, Heike and Winterpacht, Andreas and Münster, Tino}, doi = {10.1097/EJA.0000000000000053}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:9224}, pages = {341-2}, peerreviewed = {Yes}, title = {{Duchenne} muscular dystrophy and malignant hyperthermia: a genetic study of the ryanodine receptor in 47 patients}, volume = {31}, year = {2014} } @article{faucris.236516641, abstract = {Purpose: Signal-averaged ECG (SAECG) can detect inhomogeneous myocardial conduction in patients presenting with ventricular tachycardia (VT) after myocardial infarction. Radiofrequency ablation (RFCA) aims at elimination of the endocardial late potentials and non-inducibility of VT. Previously, we demonstrated that abnormal SAECG at baseline can return to normal after a successful VT ablation. The present research investigates the post-ablation changes in SAECG after RFCA of VT and their relation to the procedural long-term outcomes. Methods: Thirty-three patients (31 male; age 68 ± 9 years; EF 36 ± 12%) with ischemic VT were prospectively enrolled to receive RFCA. One VT (range 1–7) per patient was ablated using substrate-guided RFCA and complete success was achieved in 28 (85%) cases. SAECG was performed before (t1), immediately after (t2), and at least 6 months (t3) after the RFCA. Results: After RFCA, the amount of patients showing abnormal SAECG decreased from 82% initially (t1) to 57.6% post-interventionally (t2); P = 0.008; and remained unchanged thereafter in 57% (t3). Patients who experienced VT recurrence (VT+) during the follow-up period had broader averaged QRS (t2): (VT+) 150 ± 26 vs. (VT−) 129 ± 21 ms; P = 0.015, as well as longer LAS40 (t2): (VT+) 60 ± 26 vs. (VT−) 43 ± 18 ms; P = 0.03. Abnormal SAECG (t2) was a strong predictor for VT recurrence: HR 5.4; 95% CI 1.5–21. SAECG detected more late potentials in patients with inferior than in those with anterior scars: 95% vs. 58%; P = 0.016. Conclusions: RFCA of VT in the left ventricle can improve an abnormal SAECG in some patients after myocardial infarction. Normal SAECG after RFCA of VT is associated with a lower risk for VT recurrence and death.}, author = {Dinov, Borislav and Schramm, Lisa and Koenig, Sebastian and Oebel, Sabrina and Bollmann, Andreas and Hindricks, Gerhard and Arya, Arash and Bode, Kerstin}, doi = {10.1007/s10840-020-00708-y}, faupublication = {yes}, journal = {Journal of Interventional Cardiac Electrophysiology}, keywords = {Catheter ablation; Ischemic heart disease; Late potentials; Long-term follow-up; Signal-averaged ECG; Ventricular tachycardia}, note = {CRIS-Team Scopus Importer:2020-03-27}, peerreviewed = {Yes}, title = {{Dynamic} changes in the signal-averaged electrocardiogram are associated with the long-term outcomes after ablation of ischemic ventricular tachycardia}, year = {2020} } @article{faucris.247777303, author = {Ostgathe, Christoph}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, month = {Jan}, note = {CRIS-Team WoS Importer:2021-01-15}, pages = {5-6}, peerreviewed = {unknown}, title = {{EAPC} 2020 {Research} {Congress}: {From} {Palermo} to virtual}, volume = {22}, year = {2021} } @article{faucris.121306944, abstract = {The aim of this study is to describe how models of early integration (EI) of specialized palliative care (SPC) are applied to German comprehensive cancer center (CCCs).Heads of SPC departments of the 15 German CCCs were asked by email to describe the situation of early SPC in their CCC. The responses were analyzed using MAXQDA.Thirteen answers were allowed to be analyzed. Most of the department heads report that EI models of SPC are partially applied in the CCC (responses with "yes" or "partly," n = 10). Though they often describe that the models' implementation needs optimization and depends on temporary and financial restrictions or it has a pilot character. Models compromise structures like SPC unit, inpatient/outpatient SPC consultation team, and participation of members of SPC team in tumor boards. Moreover, other EI models of SPC quoted by the participants were standard operating procedures (SOP), screening tools, and information material for physicians, patients, and their related persons.Currently, German CCC models of EI of SPC are not applied in a standardized way. Approaches are still very diverse.}, author = {Berendt, Julia and Stiel, Stephanie and Nauck, Friedemann and Ostgathe, Christoph}, doi = {10.1007/s00520-017-3667-y}, faupublication = {yes}, journal = {Supportive Care in Cancer}, note = {EVALuna2:26212}, pages = {2577-2580}, peerreviewed = {Yes}, title = {{Early} palliative care: current status of integration within {German} comprehensive cancer centers}, volume = {25}, year = {2017} } @article{faucris.269449203, author = {Finotto, Susetta and Jartti, Tuomas and Johnston, Sebastian L.}, doi = {10.3389/fimmu.2021.826363}, faupublication = {yes}, journal = {Frontiers in Immunology}, keywords = {air pollution; allergic asthma; children; interferons; rhinovirus}, month = {Jan}, note = {CRIS-Team Scopus Importer:2022-02-11}, peerreviewed = {Yes}, title = {{Editorial}: {Type} {I} and {Type} {III} {Interferon} {Immune} {Responses} in {Asthma}}, volume = {12}, year = {2022} } @article{faucris.313477437, author = {Bose, Tanima and Medina-Contreras, Oscar and Fernandez, Carmen and Finotto, Susetta}, doi = {10.3389/fimmu.2023.1282709}, faupublication = {yes}, journal = {Frontiers in Immunology}, keywords = {environment; fibrosis; IgGFc-binding protein; microbiome; SLE; vaccination}, note = {CRIS-Team Scopus Importer:2023-11-03}, peerreviewed = {Yes}, title = {{Editorial}: {Women} in mucosal immunity}, volume = {14}, year = {2023} } @article{faucris.284506362, abstract = {Background: Haemophilus influenzae (H. influenzae), Streptococcus pneumoniae (pneumococcus) and influenza vaccines are administered in children to prevent infections caused by these pathogens. The benefits of vaccination for asthma control in children and the elicited immune response are not fully understood. This study aimed to investigate the impact of these vaccinations on respiratory infections, asthma symptoms, asthma severity and control status, pathogen colonization and in vitro immune responses to different stimulants mimicking infections in asthmatic children. Methods: Children aged 4–6 years were recruited into the multicentre prospective PreDicta study conducted across five European countries. Information about vaccination history, infections, antibiotic use, inhaled corticosteroid (ICS) use and asthma symptoms in the last 12 months were obtained from questionnaires of the study. Nasopharyngeal samples were collected at the first visit to assess bacterial and viral colonization, and venous blood for isolation of peripheral blood mononuclear cells (PBMCs). The PBMCs were stimulated with phytohemagglutinin, R848, Poly I:C and zymosan. The levels of 22 cytokines and chemokines were measured in cell culture supernatants using a luminometric multiplex assay. Results: One-hundred and forty asthmatic preschool children (5.3 ± 0.7 years) and 53 healthy children (5.0 ± 0.8 years) from the PreDicta cohort were included in the current study. Asthmatic children were associated with more frequent upper and lower respiratory infections, and more frequent and longer duration of antibiotic use compared with healthy children. In asthmatic children, sufficient H. influenzae vaccination was associated with a shorter duration of upper respiratory infection (URI) and overall use and average dose of ICS. The airway colonization was characterized by less pneumococcus and more rhinovirus. Pneumococcal vaccination was associated with a reduction in the use rate and average dose of ICS, improved asthma control, and less human enterovirus and more H. influenzae and rhinovirus (RV) airway colonization. Influenza vaccination in the last 12 months was associated with a longer duration of URI, but with a decrease in the occurrence of lower respiratory infection (LRI) and the duration of gastrointestinal (GI) infection and antibiotic use. Asthmatic preschoolers vaccinated with H. influenzae, pneumococcus or influenza presented higher levels of Th1-, Th2-, Th17- and regulatory T cells (Treg)-related cytokines in unstimulated PBMCs. Under stimulation, PBMCs from asthmatic preschoolers with pneumococcal vaccination displayed a predominant anti-inflammatory immune response, whereas PBMCs from asthmatic children with sufficient H. influenzae or influenza vaccination were associated with both pro- and anti-inflammatory immune responses. Conclusion: In asthmatic preschoolers, the standard childhood vaccinations to common respiratory pathogens have beneficial effects on asthma control and may modulate immune responses relevant to asthma pathogenesis.}, author = {Gao, Ya-Dong and Xepapadaki, Paraskevi and Cui, Yan-Wen and Stanic, Barbara and Maurer, Debbie J. and Bachert, Claus and Zhang, Nan and Finotto, Susetta and Chalubinski, Maciej and Lukkarinen, Heikki and Passioti, Maria and Graser, Anna and Jartti, Tuomas and Kowalski, Marek and Ogulur, Ismail and Shi, Zi-Wei and Akdis, Mubeccel and Papadopoulos, Nikolaos G. and Akdis, Cezmi A.}, doi = {10.1111/all.15551}, faupublication = {yes}, journal = {Allergy}, keywords = {asthma; Haemophiluse influenzae; immune response; influenza; pneumococcus}, note = {CRIS-Team Scopus Importer:2022-11-04}, peerreviewed = {Yes}, title = {{Effect} of {Haemophilus} influenzae, {Streptococcus} pneumoniae and influenza vaccinations on infections, immune response and asthma control in preschool children with asthma}, year = {2022} } @inproceedings{faucris.212384902, author = {Yeomans, D. C. and Meidahl, A. and Eisenried, Andreas and Klukinov, M. and Tzabazis, A.}, faupublication = {yes}, note = {EVALuna2:36281}, pages = {1336-1336}, peerreviewed = {Yes}, title = {{Effect} of {Nasal} {Oxytocin} on {Pain} {Following} {Traumatic} {Brain} {Injury} in {Rats}}, volume = {58}, year = {2018} } @article{faucris.111174844, abstract = {After surgical procedures, anesthesia itself may affect pain perception. Particularly, there is increasing evidence that opioids not only have analgesic effects but also provoke pronociceptive changes, that is, opioid-induced hyperalgesia. We investigated the effect of different anesthetic regimens on pain processing in volunteers using a transdermal electrical pain model. In this model, stimulation of epidermal nerve fibers representing mainly peptidergic C-nociceptors leads to secondary hyperalgesia and habituation to the stimulus.Forty-eight healthy volunteers underwent conditioning noxious stimulation (CS) over 5 days. On day 2, the volunteers were randomized into 4 groups: control group (no anesthesia) and 3 groups receiving anesthesia before CS in anesthetic doses: propofol (P), propofol/remifentanil (PR), and propofol/remifentanil/S-ketamine (PRK). Quantitative sensory testing was performed on days 1 through 5 and on day 22.In every group, CS was associated with short- and long-term habituation to the electrical stimulus. Repetitive CS resulted in unmodified short-term sensitization with stable areas of hyperalgesia. Although the PR group showed a trend toward increased areas of hyperalgesia on day 2, no significant differences were detectable between the groups. In contrast, anesthesia resulted in decreased intensity of the electrically evoked pain on day 2. Finally, the mechanical pain threshold before CS on day 5 was increased in all groups and remained elevated 3 weeks after the first CS, consistent with a long-term antinociceptive effect after CS.The results suggest a short-term analgesic effect of general anesthesia. Furthermore, the conditioning stimulation over several days induced differential modulation of pro- and antinociceptive systems.}, author = {Nickel, Franziska and Ott, Stephan and Möhringer, Susanne and Münster, Tino and Rieß, Simon and Filitz, Joerg and Koppert, Wolfgang and Maihoefner, Christian}, doi = {10.1111/papr.12326}, faupublication = {yes}, journal = {Pain Practice}, note = {EVALuna2:16707}, pages = {820-30}, peerreviewed = {Yes}, title = {{Effects} of {Different} {Anesthetics} on {Pain} {Processing} in an {Experimental} {Human} {Pain} {Model}}, volume = {16}, year = {2016} } @inproceedings{faucris.266781827, address = {BETHESDA}, author = {Gähler, Alexander and Hohenberger, Katja and Tausche, Patrick and Chiriac, Mircea-Teodor and Rauh, Manfred and Trufa, Denis and Geppert, Carol-Immanuel and Rieker, Ralf and Sirbu, Horia and Neurath-Finotto, Susetta}, booktitle = {JOURNAL OF IMMUNOLOGY}, doi = {10.4049/jimmunol.206.supp.56.09}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-12-03}, peerreviewed = {unknown}, publisher = {AMER ASSOC IMMUNOLOGISTS}, title = {{Effects} of glucose concentration in the tumor microenvironment on {Non} {Small} {Lung} {Cancer} ({NSCLC}) {Progression}}, year = {2021} } @article{faucris.242197751, abstract = {A class of Group III muscle afferent neurons has branching sensory terminals in the connective tissue between layers of mouse abdominal muscles (“CT3 muscle afferents”). These sensory endings are both mechanosensitive and metabosensitive. In the present study, responses of CT3 afferents to lactate ions and changes in temperature were recorded. Raising muscle temperature from 32.7°C to 37°C had no consistent effects on CT3 afferent basal firing rate or responses to either von Frey hair stimulation or to an applied load. Superfusion with lactate ions (15 mM, pH 7.4) was associated with an increase in firing from 6 ± 0.7 Hz to 11.7 ± 6.7 Hz (14 units, n = 13, P < 0.05, P = 0.0484) but with considerable variability in the nature and latency of response. Reducing the concentration of extracellular divalent cations, which mimicked the chelating effects of lactate, did not increase firing. Raised concentrations of divalent cations (to compensate for chelation) did not block excitatory effects of lactate on CT3 afferents, suggesting that effects via ASIC3 were not involved. Messenger RNA for the G-protein coupled receptor, hydroxyl carboxylic acid receptor 1 (HCAR1) was detected in dorsal root ganglia and HCAR1-like immunoreactivity was present in spinal afferent nerve cell bodies retrogradely labeled from mouse abdominal muscles. HCAR1-like immunoreactivity was also present in axons in mouse abdominal muscles. This raises the possibility that some effects of lactate on group III muscle afferents may be mediated by HCAR1.}, author = {Peterson, Rochelle A. and König, Christine and Zimmermann, Katharina and Barry, Christine M. and Wiklendt, Lukasz and Brookes, Simon J.H.}, doi = {10.3389/fncel.2020.00215}, faupublication = {yes}, journal = {Frontiers in Cellular Neuroscience}, keywords = {ergoreceptor; HCAR1; lactate; lactic acid; metaboreceptor}, note = {CRIS-Team Scopus Importer:2020-09-04}, peerreviewed = {Yes}, title = {{Effects} of {Lactate} on {One} {Class} of {Group} {III} ({CT3}) {Muscle} {Afferents}}, volume = {14}, year = {2020} } @article{faucris.119646384, abstract = {Little is known about the experiences of family caregivers of hospitalized patients with confirmed methicillin-resistant Staphylococcus aureus/multiresistant gram-negative bacteria (MRSA/MRGN) diagnosis at the end of life. The study at hand is a subproject of an interdisciplinary cooperation project that aims at developing a patient-, family-, and team-centered approach in dealing with MRSA/MRGN-positive hospitalized patients in palliative and geriatric care.The present study aimed to assess the individual effects of the patient's MRSA/MRGN colonization or infection and isolation measures on family caregivers.Between April 2014 and September 2015, all known family caregivers associated with an MRSA/MRGN-positive patient from a palliative care unit, a hospital palliative care support team, and a geriatric ward were considered for study participation. A qualitative interview study with family caregivers and an additional focus group was conducted. Data were analyzed using the principles of Grounded Theory.Family caregivers (N = 62) raised suggestions regarding the provision of information and communication on the MRSA/MRGN diagnosis and hygiene measures from staff members and the consistency of hygiene procedures. Family caregivers requested not to be stigmatized or being disadvantaged due to the MRSA/MRGN diagnosis of the patient, and they wished to receive psychosocial and emotional support.Staff members and institutional stakeholders should be aware that family caregivers might be burdened and upset by positive MRSA/MRGN diagnosis and the required hygiene measures. The need for detailed and understandable information on MRSA/MRGN, adequate communication between staff members and family caregivers, and support for family caregivers should be of special attention in particular in end-of-life care.}, author = {Heckel, Maria and Sturm, Alexander and Herbst, Franziska A. and Ostgathe, Christoph and Stiel, Stephanie}, doi = {10.1089/jpm.2016.0301}, faupublication = {yes}, journal = {Journal of Palliative Medicine}, note = {EVALuna2:26215}, pages = {273-281}, peerreviewed = {Yes}, title = {{Effects} of {Methicillin}-{Resistant} {Staphylococcus} aureus/{Multiresistant} {Gram}-{Negative} {Bacteria} {Colonization} or {Infection} and {Isolation} {Measures} in {End} of {Life} on {Family} {Caregivers}: {Results} of a {Qualitative} {Study}}, volume = {20}, year = {2017} } @article{faucris.106291504, abstract = {To investigate long-term effects of staff training and electronic clinical decision support (CDS) on adherence to lung-protective ventilation recommendations.In 2012, group instructions and workshops at two surgical intensive care units (ICUs) started, focusing on standardized protocols for mechanical ventilation and volutrauma prevention. Subsequently implemented CDS functions continuously monitor ventilation parameters, and from 2015 triggered graphical notifications when tidal volume (VT) violated individual thresholds. To estimate the effects of these educational and technical interventions, we retrospectively analyzed nine years of VT records from routine care. As outcome measures, we calculated relative frequencies of settings that conform to recommendations, case-specific mean excess VT, and total ICU survival.Assessing 571,478 VT records from 10,241 ICU cases indicated that adherence during pressure-controlled ventilation improved significantly after both interventions; the share of conforming VT records increased from 61.6% to 83.0% and then 86.0%. Despite increasing case severity, ICU survival remained nearly constant over time.Staff training effectively improves adherence to lung-protective ventilation strategies. The observed CDS effect seemed less pronounced, although it can easily be adapted to new recommendations. Both interventions, which futures studies could deploy in combination, promise to improve the precision of mechanical ventilation.}, author = {Castellanos, Ixchel and Martin, Marcus and Kraus, Stefan and Bürkle, Thomas and Prokosch, Hans-Ulrich and Schüttler, Jürgen and Toddenroth, Dennis}, doi = {10.1016/j.jcrc.2017.06.027}, faupublication = {yes}, journal = {Journal of Critical Care}, note = {EVALuna2:184}, pages = {13-20}, peerreviewed = {Yes}, title = {{Effects} of staff training and electronic event monitoring on long-term adherence to lung-protective ventilation recommendations}, volume = {43}, year = {2017} } @article{faucris.309432186, abstract = {PURPOSE: Microvascular blood flow (MBF) and its intramuscular regulation are of importance for physiological responsiveness and adaptation. The quantifiable in-vivo monitoring of MBF after cycling or systemic cold-water exposure may reveal new insights into capillary regulatory mechanisms. This study aimed to assess the role of exercise and cold therapy on MBF by using contrast-enhanced ultrasound (CEUS). METHODS: Twenty healthy athletes were recruited and randomly assigned to an intervention (IG) or a control group (CG). MBF was quantified in superficial (rectus femoris, RF) and deep muscle layers (vastus intermedius, VI). Representative perfusion parameters (peak enhancement (PE) and wash-in area under the curve (WiAUC)) were measured after a standardized measurement protocol for both groups at resting conditions (t0) and after cycling (20 min., 70% Watt max, t1) for both groups, after cold-water immersion exposure for IG (15 min., 12°C) or after precisely 15 minutes of rest for CG (t2) and for both groups after 60 minutes of follow-up (t3). RESULTS: At t1, MBF in VI increased significantly compared to resting conditions in both groups in VI (p= 0.02). After the cold-water exposure (t2), there were no statistically significant changes in perfusion parameters as well as after 60 minutes of follow-up (t3) (p = 0.14). CONCLUSION: Cycling leads to an upregulation of MBF. However, cold exposure does not change the MBF. The implementation of CEUS during different physiological demands may provide deeper insight into intramuscular perfusion regulation and regenerative processes.}, author = {Huettel, Moritz and Schroeter, Sarah and Heiß, Rafael and Lutter, Christoph and Golditz, Tobias and Hoppe, Matthias Wilhelm and Forst, Raimund and Hafez, Hossam and Engelhardt, Martin and Grim, Casper and Hotfiel, Thilo}, doi = {10.1055/a-2080-2937}, faupublication = {yes}, journal = {Ultraschall in der Medizin}, note = {CRIS-Team Scopus Importer:2023-08-18}, pages = {e191-e198}, peerreviewed = {Yes}, title = {{Effekte} von körperlicher {Belastung} und {Kaltwasserexposition} auf die mikrovaskuläre {Muskelperfusion} {Effects} of exercise and cold-water exposure on microvascular muscle perfusion}, volume = {44}, year = {2023} } @article{faucris.315951868, abstract = {IMPORTANCE: The proportion of VREfm among all Enterococcus faecium isolated from blood cultures in German hospitals has increased in the period 2015-2020 from 11.9% to 22.3% with a country-wide spread of the clonal lineage ST117/CT71 vanB. In this study, we provided useful information about the genetic diversity of invasive strains of E. faecium. Moreover, our findings confirm the nosocomial spread of novel ST1299 vanA lineages, which recently had a rapid expansion in Austria and the south-eastern part of Germany.}, author = {Valenza, Giuseppe and Eisenberger, David and Voigtländer, Sven and Alsalameh, Rayya and Gerlach, Roman and Koch, Sonja and Kunz, Bernd and Held, Jürgen and Bogdan, Christian}, doi = {10.1128/spectrum.02962-23}, faupublication = {yes}, journal = {Microbiology Spectrum}, keywords = {bloodstream Infection; core genome multilocus sequence typing; Enterococcus faecium; ST1299 vanA; vancomycin resistance}, note = {CRIS-Team Scopus Importer:2023-12-29}, pages = {e0296223-}, peerreviewed = {Yes}, title = {{Emergence} of novel {ST1299} {vanA} lineages as possible cause for the striking rise of vancomycin resistance among invasive strains of {Enterococcus} faecium at a {German} university hospital}, volume = {11}, year = {2023} } @article{faucris.109355004, abstract = {Next-generation sequencing (NGS) provides unrestricted access to the genome, but it produces 'big data' exceeding in amount and complexity the classical analytical approaches. We introduce a bioinformatics-based classifying biomarker that uses emergent properties in genetics to separate pain patients requiring extremely high opioid doses from controls. Following precisely calculated selection of the 34 most informative markers in the OPRM1, OPRK1, OPRD1 and SIGMAR1 genes, pattern of genotypes belonging to either patient group could be derived using a k-nearest neighbor (kNN) classifier that provided a diagnostic accuracy of 80.6±4%. This outperformed alternative classifiers such as reportedly functional opioid receptor gene variants or complex biomarkers obtained via multiple regression or decision tree analysis. The accumulation of several genetic variants with only minor functional influences may result in a qualitative consequence affecting complex phenotypes, pointing at emergent properties in genetics.The Pharmacogenomics Journal advance online publication, 3 May 2016; doi:10.1038/tpj.2016.28.}, author = {Kringel, D. and Ultsch, A. and Zimmermann, M. and Jansen, J. P. and Ilias, W. and Freynhagen, R. and Grießinger, Norbert and Kopf, A. and Stein, C. and Doehring, A. and Resch, E. and Lötsch, J.}, doi = {10.1038/tpj.2016.28}, faupublication = {yes}, journal = {Pharmacogenomics Journal}, note = {EVALuna2:16735}, peerreviewed = {Yes}, title = {{Emergent} biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses}, year = {2016} } @article{faucris.106477184, abstract = {The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal therapeutic target. In this study, we demonstrate elevated ASM activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC). RNAi-mediated attenuation of SMPD1 in human NSCLC cells rendered them resistant to serum starvation-induced apoptosis. In a murine model of lung adenocarcinoma, ASM deficiency reduced tumor development in a manner associated with significant enhancement of Th1-mediated and cytotoxic T-cell-mediated antitumor immunity. Our findings indicate that targeting ASM in NSCLC can act by tumor cell-intrinsic and -extrinsic mechanisms to suppress tumor cell growth, most notably by enabling an effective antitumor immune response by the host. Cancer Res; 77(21); 5963-76. ©2017 AACR.}, author = {Kachler, Katerina and Bailer, Maximilian and Heim, Lisanne and Schumacher, Fabian and Reichel, Martin and Holzinger, Corinna D. and Trump, Sonja and Mittler, Susanne and Monti, Juliana and Trufa, Denis and Rieker, Ralf and Hartmann, Arndt and Sirbu, Horia and Kleuser, Burkhard and Kornhuber, Johannes and Finotto, Susetta}, doi = {10.1158/0008-5472.CAN-16-3313}, faupublication = {yes}, journal = {Cancer Research}, note = {EVALuna2:4034}, pages = {5963-5976}, peerreviewed = {Yes}, title = {{Enhanced} {Acid} {Sphingomyelinase} {Activity} {Drives} {Immune} {Evasion} and {Tumor} {Growth} in {Non}-{Small} {Cell} {Lung} {Carcinoma}}, volume = {77}, year = {2017} } @article{faucris.212664228, abstract = {Entrustable professional activities (EPAs) are characterized as self-contained units of work in a given typical clinical context, which may be entrusted to a trainee for independent execution at a certain point of training. An example could be the intraoperative anesthesia management of an ASA 1 patient for an uncomplicated surgical intervention as an EPA in early postgraduate anesthesia training. The EPAs can be described as an evolution of a competency-based medical educational concept, applying the concept of the competencies of a person to specific workplace contexts. In this way the expected level of skills and supervision at a certain stage of training have a more practical meaning and the danger of fragmentation of individual competencies in the competence-based model is avoided. It is a more holistic view of a trainee. Experience with this new concept is so far limited, therefore, further studies are urgently needed to determine whether and how EPAs can contribute to improvements in further training. }, author = {Breckwoldt, Jan and Beckers, S. K. and Breuer, Georg and Marty, A.}, doi = {10.1007/s00101-018-0420-y}, faupublication = {yes}, journal = {Anaesthesist}, note = {EVALuna2:36219}, pages = {452-457}, peerreviewed = {Yes}, title = {{Entrustable} professional activities : {Promising} concept in postgraduate medical education}, volume = {67}, year = {2018} } @inproceedings{faucris.242719216, abstract = {Fragestellung: Der Bedarf an spezialisierter ambulanter Palliativversorgung (SAPV) steigt bei abnehmenden Ressourcen. Um eine flächendeckende Versorgung zu gewährleisten, können digitale Systeme Patienten und Fachpersonal unterstützen. Wir erforschen eine Smartphone Applikation (App) und Web-Interface (WI) die gewährleisten sollen, dass Patienten und SAPV Zugriff auf biometrische und psychometrische Daten haben, um die Versorgung möglichst Ressourcen-effizient zu gestalten.
Studiendesign: Explorative Anwendungs- und Proof-of-Concept-Studie mit Probanden
Methodik: App und WI Entwurf nach klinisch-medizinischen Vorgaben von erfahrenen Palliativmedizinern integriert psychometrische (MIDOS{\_}2) und exemplarische biometrische Messung (Körpergewicht (KG), Körperflüssigkeitsanteil (KFA), Blutdruck (BD)) mit automatischer (Bluetooth) und manueller Eingabe; Evaluation des ersten Design-Modells der App in begleitender Beobachtung; offenes Interview mit n = 2 Probanden (männlich, Alter 70-85);Implementierung des Feedbacks; Pilotierung mit n = 6 Probanden (2 weiblich, Alter 23-30);
Ergebnis: Erster Entwurf nach klinisch-medizinischen Vorgaben: App: KG des Patienten wird automatisch und KF, BD, MIDOS{\_}2 manuell eingegeben. Die Daten werden in App und WI visuell individuell anpassbar dargestellt. App wurde nach begleitender Beobachtung hinsichtlich Akzeptanz und Nutzbarkeit überarbeitet: vereinfachte Nutzerschnittstelle. Pilotierung mit Probanden: Dateneingabe, -übertragung, -abruf und webbasierter Zugriff erfolgten in 100 % der Fälle fehlerfrei. Anwendungsdauer für KG, KFA, BD, MIDOS{\_}2 betrug im Durchschnitt 4 min.
Diskussion: Austausch von psychometrischen und biometrischen Daten zwischen Patient (App) und SAPV-Team (WI) werden ermöglicht und so können SAPV Teams bei ihrer Behandlungsplanung unterstützet werden.
Take Home Message für die Kongressbesucher: App und WI kann die SAPV effizienter gestalten. Weitere Untersuchungen mit Patienten sind notwendi},
author = {Sternemann, Ulla and Suchantke, Insa and Schmidt, Klaus-Günther and Höfner, Patrick and Wagner, Daniel and Ollenschläger, Malte and Heckel, Maria and Ostgathe, Christoph and Eskofier, Björn and Steigleder, Tobias},
booktitle = {Zeitschrift für Palliativmedizin 2020; 21(05)},
date = {2020-09-09/2020-09-12},
doi = {10.1055/s-0040-1714998},
faupublication = {yes},
keywords = {Palliativmedizin; SAPV; Smartphone},
peerreviewed = {unknown},
publisher = {Georg Thieme Verlag KG},
title = {{Entwicklung} einer {Applikation} zum {Home}-{Monitoring} des {Gesundheitszustandes} von {Palliativpatienten} - eine {Proof}-of-{Concept}-{Studie}},
url = {https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1714998#info},
venue = {Wiesbaden},
year = {2020}
}
@article{faucris.223998950,
abstract = {Background: Prioritisation competence has relevance beyond emergency medical education and training. Two teaching strategies were compared in this study on the basis of the triage of injured persons. The aim was to describe the teaching method that successfully convey “priority” to novices. Methodology: 96 students categorised case vignettes after an introductory lecture and joint development of allocation categorisation (SK) using the “Amberg-Schwandorf-Algorithmus für die Vorsichtung” (ASAV) in a four-member team. In the traditional teaching method (TL), the SK was only voiced by one participant as the result of his own assessment. In a new teaching approach to be compared here, the SK was named, justified and discussed (reasoning reflection; BR). Finally, an individual success check (EK 1) and 14 days later (EK 2) (long-term effect) were carried out. In addition, subjective learning success was recorded. Results: 1920 initial assessment procedures were recorded in EK 1. Correctness was 69.6% (TL) and 70.5% (BR), the undertriage 25.9% and 26.8%, the overtriage 4.5% and 2.7%, respectively. In the delayed test with 740 initial assessment procedures, the correctness was 67.38% and 72.5% respectively, the lower triage 21.9 vs. 15.94%, the upper triage 10.71 vs. 11.56%. No method was statistically superior (χ2 test). The teaching method with reasoned reflection led to a higher subjective learning satisfaction. Discussion: Both teaching/learning conditions led to comparable results. With regard to the quality of the sighting results, the performance would be rather unsatisfactory. The medical complexity of a caution algorithm is rather low in comparison to other, e.g. intensive care decision situations, so that limited expert knowledge would generally be sufficient for successful implementation. The learning satisfaction was higher with justification reflection. The hypothesis that the learning method with the higher learning satisfaction produces a more lasting learning effect and a higher transfer performance should be the subject of further investigations.},
author = {Lütcke, Björn and Birkholz, Torsten and Dittmar, M. S. and Breuer, G.},
doi = {10.1007/s10049-019-0619-8},
faupublication = {yes},
journal = {Notfall und Rettungsmedizin},
keywords = {Cooperative learning; Curriculum; Mass casualty attack; Rescue services; Teaching methods},
note = {CRIS-Team Scopus Importer:2019-08-06},
peerreviewed = {Yes},
title = {{Erlernen} von {Priorisierungskompetenz} medizinischer {Hilfeleistungen} am {Beispiel} der {Sichtung}: {Vergleich} zweier {Lehrstrategien}},
year = {2019}
}
@article{faucris.285803390,
author = {Bierhaus, Angelika and Fleming, Thomas and Stoyanov, Stoyan and Leffler, Andreas and Babes, Alexandru and Neacsu, Cristian and Sauer, Susanne and Schnölzer, Martina and Lasischka, Felix and Eberhardt, Mirjam and Neuhuber, Winfried and Kichko, Tatjana I. and Konrade, Ilze and Elvert, Ralf and Mier, Walter and Pirags, Valdis and Lukic, Ivan K. and Morcos, Michael and Dehmer, Thomas and Rabbani, Naila and Thornalley, Paul J. and Edelstein, Diane and Nau, Carla and Forbes, Josephine and Humpert, Per M. and Schwaninger, Markus and Ziegler, Dan and Stern, David M. and Cooper, Mark E. and Haberkorn, Uwe and Brownlee, Michael and Reeh, Peter and Nawroth, Peter P.},
doi = {10.1038/nm0912-1445c},
faupublication = {yes},
journal = {Nature Medicine},
note = {CRIS-Team Scopus Importer:2022-11-28},
pages = {1445-},
peerreviewed = {Yes},
title = {{Erratum}: {Methylglyoxal} modification of {Na} v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy ({Nature} {Medicine} (2012) 18 (926-933))},
volume = {18},
year = {2012}
}
@article{faucris.118557164,
author = {Schuler, M. and Grießinger, Norbert},
doi = {10.1007/s00482-015-0064-7},
faupublication = {yes},
journal = {Schmerz},
note = {EVALuna2:16689},
pages = {530},
peerreviewed = {No},
title = {{Erratum} to: {Opioids} for noncancer pain in the elderly},
volume = {29},
year = {2015}
}
@article{faucris.233239508,
author = {Klein, Carsten and Wittmann, C. and Wendt, K. N. and Ostgathe, Christoph and Stiel, S.},
doi = {10.1007/s00101-020-00729-2},
faupublication = {yes},
journal = {Anaesthesist},
note = {CRIS-Team Scopus Importer:2020-02-04},
peerreviewed = {Yes},
title = {{Erratum} to: {Palliative} sedation: {Development} and consensus of a {German} language documentation template ({Der} {Anaesthesist}, (2018), 67, 7, (504-511), 10.1007/s00101-018-0451-4) {Erratum} zu: {Palliative} {Sedierung}: {Entwicklung} und {Konsentierung} einer deutschsprachigen {Dokumentationsvorlage} ({Der} {Anaesthesist}, (2018), 67, 7, (504-511), 10.1007/s00101-018-0451-4)},
year = {2020}
}
@article{faucris.217945099,
author = {Palmaers, T. and Frank, P. and Eismann, H. and Sieg, L. and Leffler, A. and Schmitt, Hubert and Scholler, A.},
doi = {10.1007/s00101-019-0593-z},
faupublication = {yes},
journal = {Anaesthesist},
note = {CRIS-Team Scopus Importer:2019-05-21},
pages = {308-},
peerreviewed = {Yes},
title = {{Erratum} zu: {Vena}-subclavia-{Katheter} und {Pneumothoraxrisiko}: {Maschinelle} {Beatmung} erhöht das {Pneumothoraxrisiko} während infraklavikulärer landmarkengestützter {V}.‑subclavia-{Punktion}: eine prospektiv randomisierte {Studie} ({Der} {Anaesthesist}, (2019), 68, 5, (309-316), 10.1007/s00101-019-0579-x)},
volume = {68},
year = {2019}
}
@article{faucris.108610744,
abstract = {Very few microsurgical courses have been offered for medical students in Germany to date. To raise early interest in this technique, which is essential for plastic and reconstructive surgery, and to guide eligible medical students to choose plastic surgery as their specialist field, the Department of Plastic and Hand Surgery, supported by the Faculty of Medicine of the Friedrich-Alexander-University of Erlangen-Nuremberg, implemented a microsurgical course for students in 2011. This study describes the implementation of that course and evaluates its impact on the subsequent choice of the participants' specialist fields.Since the summer of 2011, the microsurgery course for medical students has taken place regularly 3 times per term. It is free of charge for participants and is guided by senior physicians of the Department of Plastic and Hand Surgery together with student tutors from the Faculty of Medicine. The arterial end-to-end anastomosis in the fresh chicken leg is used as a training model. Based on a questionnaire survey the participants were evaluated and statistically analysed regarding their course satisfaction, self-assessment of their own eligibility before and after the course, the anticipated future choice of their medical specialist field and how their choice was influenced by this course.After the successful implementation of the microsurgical course in 2011, a significant number of students were interested in microsurgery. According to the questionnaire, the level of enthusiasm was high among all participants. The self-assessment of microsurgical skills improved significantly after the course compared with the pre-course assessment. In 82% of the participants, the course had a strong positive influence on the future choice of their specialist field.The regular implementation of a microsurgical course for students in the form described here is practicable and possible without undue personnel and cost of materials. The ongoing interest among students in such an offer is enormous and the satisfaction of the participants is very high. This might be a way to recruit future plastic surgeons by raising early enthusiasm for microsurgery. These future plastic surgeons, in turn, would be given the chance to experience a very fascinating aspect of plastic surgery, which might help them to decide on their specialisation within that field at a later point in their career.},
author = {Beier, Justus and Horch, Raymund E. and Boos, Anja and Taeger, Christian and Breuer, Georg and Arkudas, Andreas},
doi = {10.1055/s-0041-108196},
faupublication = {yes},
journal = {Handchirurgie, Mikrochirurgie, Plastische Chirurgie},
note = {EVALuna2:15603},
pages = {400-7},
peerreviewed = {Yes},
title = {{Establishment} and {Evaluation} of a {Microsurgery} {Course} for {Medical} {Students}},
volume = {47},
year = {2015}
}
@article{faucris.316387656,
abstract = {During the COVID 19 pandemic, advanced age, scoring systems, and a shortage of ICU beds were used as cut-offs for ICU admission. This case report describes the epicrisis of an elderly patient who was almost mistakenly not treated in an ICU.},
author = {Wehrfritz, Andreas and Schmidt, Joachim and Bremer, Frank Felix and Lang, Anne-Katharina and Welzer, Jacob and Castellanos, Alvaro Ixchel},
doi = {10.1002/ccr3.7710},
faupublication = {yes},
journal = {Clinical Case Reports},
note = {EVALuna2:547214},
peerreviewed = {Yes},
title = {{Ethical} conflicts associated with {COVID}-19 pandemic, triage and frailty-unexpected positive disease progression in a 90-year-old patient: {A} case report.},
volume = {11},
year = {2023}
}
@article{faucris.225151101,
abstract = {Kaum ein Medikament in der prahospitalen Notfallmedizin ist so umstritten und dennoch so weit verbreitet wie das Hypnotikum Etomidat. Regelma ss ig kommt es zu hei ss en Diskussionen und Kollegen zitieren Studien, die eindeutige Ergebnisse zeigen wurden. Leider ist in der Medizin und insbesondere in der Notfallmedizin selten die Datenlage klar und erlaubt nur eine Interpretation. Im folgenden Artikel sollen daher Argumente fur und gegen den Einsatz von Etomidat in der Notfallmedizin im Sinne einer Pro- und Contra-Debatte dargestellt und diskutiert werden. So kann sich jeder Leser sein eigenes Bild uber die aktuelle Studienlage zu diesem Medikament machen und fur die eigene Praxis entsprechende Konsequenzen ziehen.},
author = {Schmidt, Joachim and Schüttler, Jürgen and Knapp, Jürgen and Bernhard, Michael},
doi = {10.1055/a-0891-6315},
faupublication = {yes},
journal = {Notarzt},
note = {CRIS-Team Scopus Importer:2019-08-27},
pages = {195-198},
peerreviewed = {Yes},
title = {{Etomidat} in der {Notfallmedizin} – {Pro} und {Contra}},
volume = {35},
year = {2019}
}
@article{faucris.113264184,
abstract = {Background: The necessity to translate eligibility criteria from free text into decision rules that are compatible with data from the electronic health record (EHR) constitutes the main challenge when developing and deploying clinical trial recruitment support systems. Recruitment decisions based on case-based reasoning, i.e. using past cases rather than explicit rules, could dispense with the need for translating eligibility criteria and could also be implemented largely independently from the terminology of the EHR's database. We evaluated the feasibility of predictive modeling to assess the eligibility of patients for clinical trials and report on a prototype's performance for different system configurations. Methods. The prototype worked by using existing basic patient data of manually assessed eligible and ineligible patients to induce prediction models. Performance was measured retrospectively for three clinical trials by plotting receiver operating characteristic curves and comparing the area under the curve (ROC-AUC) for different prediction algorithms, different sizes of the learning set and different numbers and aggregation levels of the patient attributes. Results: Random forests were generally among the best performing models with a maximum ROC-AUC of 0.81 (CI: 0.72-0.88) for trial A, 0.96 (CI: 0.95-0.97) for trial B and 0.99 (CI: 0.98-0.99) for trial C. The full potential of this algorithm was reached after learning from approximately 200 manually screened patients (eligible and ineligible). Neither block- nor category-level aggregation of diagnosis and procedure codes influenced the algorithms' performance substantially. Conclusions: Our results indicate that predictive modeling is a feasible approach to support patient recruitment into clinical trials. Its major advantages over the commonly applied rule-based systems are its independency from the concrete representation of eligibility criteria and EHR data and its potential for automation. © 2013 Köpcke et al.; licensee BioMed Central Ltd.},
author = {Köpcke, Felix and Lubgan, Dorota and Fietkau, Rainer and Scholler, Axel and Nau, Carla and Stürzl, Michael and Croner, Roland S. and Prokosch, Hans-Ulrich and Toddenroth, Dennis},
doi = {10.1186/1472-6947-13-134},
faupublication = {yes},
journal = {BMC Medical Informatics and Decision Making},
note = {UnivIS-Import:2015-04-14:Pub.2013.tech.IMMD.infome.evalua{\_}3},
pages = {134},
peerreviewed = {Yes},
title = {{Evaluating} predictive modeling algorithms to assess patient eligibility for clinical trials from routine data},
url = {http://www.biomedcentral.com/1472-6947/13/134/abstract},
volume = {13},
year = {2013}
}
@article{faucris.245470441,
abstract = {Introduction: In 2017, a national recommendation on multidrug-resistant bacterial microorganisms (MDRO) in end-of-life care was published. In order to monitor the implementation in a hospital-based palliative care unit, a dedicated multidisciplinary working group on MDRO was established. It developed a standard operating procedure and a documentation template (checklist). The aim of the present study is to evaluate the implementation status after one year. Methods: A mixed-methods approach was selected. The status of implementation was identified through a survey among staff members. A retrospective routine data analysis was performed. A focus group discussion with members of the working group focused on previous steps, factors conducive to implementation and on remaining problems. Results: Almost all (18 out of 20) participants (20 out of 29 eligible staff members) knew the national recommendations. Twelve out of 27 recommendations had a high degree of implementation after one year, another 13 recommendations were seen as at least partly integrated into daily routine. For two recommendations the degree of implementation was rated low: (i) ”Taking into account any additional time constraint imposed by protection and isolation measures when planning for personnel and bed occupancy”, and (ii) ”Facilitating the patient's ability to distinguish and recognize team members and family caregivers”. Working group members reported improvements since the implementation, whilst reporting some uncertainty prevailing among both staff members and visitors. Inhibitory factors were said to include the complexity of the standard operating procedure, inadequate usage and poor usability of the checklist. Behavioural and cognitive barriers such as anxieties related to transmission and the sense of security caused by the routine use of protective clothing were considered to be strong. Improving the checklist and the standard operating procedure as well as anchoring procedures in daily routine were considered to be the next important steps. Discussion: The implementation of recommendations is an iterative process and requires the ongoing development of appropriate measures for implementation in the respective institution. A multidisciplinary working group with monitoring tasks is an advantage.},
author = {Heckel, Maria and Illig, Annabell and Brunner, Sarah and Ostgathe, Christoph},
doi = {10.1016/j.zefq.2020.10.005},
faupublication = {yes},
journal = {Zeitschrift für Evidenz, Fortbildung und Qualitat im Gesundheitswesen},
keywords = {End-of-life care; Evaluation research; Infection control; Palliative care; Patient safety},
note = {CRIS-Team Scopus Importer:2020-11-20},
peerreviewed = {Yes},
title = {{Evaluating} the implementation of national recommendations on multidrug-resistant bacterial microorganisms in end-of-life care},
year = {2020}
}
@article{faucris.270416012,
abstract = {BACKGROUND Remifentanil is an effective drug in peri-operative pain therapy, but it can also induce and aggravate hyperalgesia. Supplemental administration of N2O may help to reduce remifentanil-induced hyperalgesia.},
author = {Wehrfritz, Andreas and Bauer, Marcus and Noel, Nathalie and Ramirez-Gil, Juan Fernando and Ihmsen, Harald and Prottengeier, Johannes and Schüttler, Jürgen and Bessiere, Baptiste},
doi = {10.1097/EJA.0000000000001468},
faupublication = {yes},
journal = {European Journal of Anaesthesiology},
note = {CRIS-Team WoS Importer:2022-03-04},
pages = {1230-1241},
peerreviewed = {Yes},
title = {{Evaluation} of antihyperalgesic and analgesic effects of 35% nitrous oxide when combined with remifentanil {A} randomised phase 1 trial in volunteers},
volume = {38},
year = {2021}
}
@article{faucris.275206681,
abstract = {Preparations for anesthesiological management of patients build on preoperative patient self-reports concerning risk factors and comorbidities. In this setting, electronic documentation could facilitate innovative computerized functions, although patient-facing digital questionnaires require appropriate tools that patients can access effectively. To explore the feasibility of an electronic application for preoperative data acquisition directly from patients, a digital, tablet-based prototypical application has been developed within a user-centered design process in order to replace a previously used paper-based anamnesis sheet for perioperative risk evaluation. The implemented prototype has been extensively tested and iteratively improved to progressively provide an easy-to-use data entry function. To assess the suitability of this tool for everyday data acquisition by patients and physicians and to identify usability problems, the stepwise development process was accompanied by a heuristic evaluation as well as a think-aloud evaluation, while another 56 participating patients completed a feedback sheet according to ISO 9241/10. The latter method detected additional usability problems that occurred during the use of the application, which contributed to iterative improvements of the prototype. Throughout the development process, 81 issues were identified and largely resolved. After these revisions of the prototype, the number of problems found per tester decreased from 4.75 to 0.96, while the overall rating increased to 6.14 out of 7 points (SD = 1.2). These improvements demonstrate the value and efficiency of such a user-centered design process and illustrate that a user-friendly patient-facing digital data entry can replace preoperative paper questionnaires for anesthesiological management.},
author = {Mang, Jonathan and Schild, Stefanie and Prokosch, Hans-Ulrich and Jeleazcov, Christian and Heinrich, Anne and Toddenroth, Dennis},
faupublication = {yes},
journal = {Studies in health technology and informatics},
note = {EVALuna2:209490},
pages = {201-205},
peerreviewed = {unknown},
title = {{Evaluation} of a {Patient}-{Facing} {Digital} {Prototype} for {Perioperative} {Risk} {Assessment}.},
volume = {258},
year = {2019}
}
@inproceedings{faucris.217157361,
abstract = {Preparations for anesthesiological management of patients build on preoperative patient self-reports concerning risk factors and comorbidities. In this setting, electronic documentation could facilitate innovative computerized functions, although patient-facing digital questionnaires require appropriate tools that patients can access effectively. To explore the feasibility of an electronic application for preoperative data acquisition directly from patients, a digital, tablet-based prototypical application has been developed within a user-centered design process in order to replace a previously used paper-based anamnesis sheet for perioperative risk evaluation. The implemented prototype has been extensively tested and iteratively improved to progressively provide an easy-to-use data entry function. To assess the suitability of this tool for everyday data acquisition by patients and physicians and to identify usability problems, the stepwise development process was accompanied by a heuristic evaluation as well as a think-aloud evaluation, while another 56 participating patients completed a feedback sheet according to ISO 9241/10. The latter method detected additional usability problems that occurred during the use of the application, which contributed to iterative improvements of the prototype. Throughout the development process, 81 issues were identified and largely resolved. After these revisions of the prototype, the number of problems found per tester decreased from 4.75 to 0.96, while the overall rating increased to 6.14 out of 7 points (SD = 1.2). These improvements demonstrate the value and efficiency of such a user-centered design process and illustrate that a user-friendly patient-facing digital data entry can replace preoperative paper questionnaires for anesthesiological management.},
address = {Amsterdam},
author = {Mang, Jonathan and Schild, Stefanie and Prokosch, Hans-Ulrich and Jeleazcov, Christian and Heinrich, Anne and Toddenroth, Dennis},
booktitle = {ICT for Health Science Research - Proceedings of the EFMI 2019 Special Topic Conference},
doi = {10.3233/978-1-61499-959-1-201},
editor = {Amnon Shabo, Inge Madsen, Thomas M. Deserno, Matthias Lobe, Kristiina Hayrinen, Hans-Ulrich Prokosch, Fernando Martin-Sanchez, Klaus-Hendrik Wolf},
faupublication = {yes},
keywords = {Anesthesiologic patient history; Digital questionnaire; ISO 9241; Usability evaluation},
note = {CRIS-Team Scopus Importer:2019-05-09},
pages = {201-205},
peerreviewed = {unknown},
publisher = {IOS Press},
title = {{Evaluation} of a patient-facing digital prototype for perioperative risk assessment},
volume = {258},
year = {2019}
}
@article{faucris.117321644,
abstract = {Heart rate variability (HRV) analysis is increasingly used in anaesthesia and intensive care monitoring of spontaneous breathing and mechanical ventilated patients. In the frequency domain, different estimation methods of the power spectral density (PSD) of RR-intervals lead to different results. Therefore, we investigated the PSD estimates of fast Fourier transform (FFT), autoregressive modeling (AR) and Lomb-Scargle periodogram (LSP) for 25 young healthy subjects subjected to metronomic breathing. The optimum method for determination of HRV spectral parameters under paced respiration was identified by evaluating the relative error (RE) and the root mean square relative error (RMSRE) for each breathing frequency (BF) and spectral estimation method. Additionally, the sympathovagal balance was investigated by calculating the low frequency/high frequency (LF/HF) ratio. Above 7 breaths per minute, all methods showed a significant increase in LF/HF ratio with increasing BF. On average, the RMSRE of FFT was lower than for LSP and AR. Therefore, under paced respiration conditions, estimating RR-interval PSD using FFT is recommend.},
author = {Schaffer, Thorsten and Hensel, Bernhard and Weigand, Christian and Schüttler, Jürgen and Jeleazcov, Christian},
doi = {10.1007/s10877-013-9447-4},
faupublication = {yes},
journal = {Journal of Clinical Monitoring and Computing},
note = {EVALuna2:16636},
pages = {481-6},
peerreviewed = {Yes},
title = {{Evaluation} of techniques for estimating the power spectral density of {RR}-intervals under paced respiration conditions},
volume = {28},
year = {2014}
}
@inproceedings{faucris.243346323,
address = {HOBOKEN},
author = {Xepapadaki, P. and Korovessi, P. and Bachert, C. and Finotto, Susetta and Jartti, T. and Lakoumentas, J. and Kowalski, M. L. and Lewandowska-Polak, A. and Lukkarinen, H. and Zhang, N. and Zimmermann, Theodor and Papadopoulos, N. G.},
booktitle = {ALLERGY},
doi = {10.3390/jcm9010187},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2020-10-02},
pages = {399-399},
peerreviewed = {unknown},
publisher = {WILEY},
title = {{Evolution} of airway inflammation in preschoolers with asthma-results of a two-year longitudinal study},
venue = {London},
year = {2020}
}
@article{faucris.234051981,
abstract = {Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here, we assess the characteristics of FeNO from preschool to school age, in parallel with asthma activity. A total of 167 asthmatic children and 66 healthy, age-matched controls were included in the 2-year prospective PreDicta study evaluating wheeze/asthma persistence in preschool-aged children. Information on asthma/rhinitis activity, infections and atopy was recorded at baseline. Follow-up visits were performed at 6-month intervals, as well as upon exacerbation/cold and 4-6 weeks later in the asthmatic group. We obtained 539 FeNO measurements from asthmatics and 42 from controls. At baseline, FeNO values did not differ between the two groups (median: 3.0 ppb vs. 2.0 ppb, respectively). FeNO values at 6, 12, 18 and 24 months (4.0, CI: 0.0-8.6; 6.0, CI: 2.8-12.0; 8.0, CI: 4.0-14.0; 8.5, CI: 4.4-14.5 ppb, respectively) increased with age (correlation p ≤ 0.001) and atopy (p = 0.03). FeNO was non-significantly increased from baseline to the symptomatic visit, while it decreased after convalescence (p = 0.007). Markers of disease activity, such as wheezing episodes and days with asthma were associated with increased FeNO values during the study (p < 0.05 for all). Age, atopy and disease activity were found to be important FeNO determinants in preschool children. Longitudinal and individualized FeNO assessment may be valuable in monitoring asthmatic children with recurrent wheezing or mild asthma.},
author = {Xepapadaki, Paraskevi and Korovessi, Paraskevi and Bachert, Claus and Neurath-Finotto, Susetta and Jartti, Tuomas and Lakoumentas, John and Kowalski, Marek L. and Lewandowska-Polak, Anna and Lukkarinen, Heikki and Zhang, Nan and Zimmermann, Theodor and Papadopoulos, Nikolaos G.},
doi = {10.3390/jcm9010187},
faupublication = {yes},
journal = {Journal of Clinical Medicine},
note = {EVALuna2:211404},
peerreviewed = {Yes},
title = {{Evolution} of {Airway} {Inflammation} in {Preschoolers} with {Asthma}-{Results} of a {Two}-{Year} {Longitudinal} {Study}},
volume = {9},
year = {2020}
}
@article{faucris.204702470,
abstract = {OBJECTIVE: Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of Crohn's disease. Nevertheless, approximately 40% of patients display failure to anti-TNF therapy. Here, we characterised molecular mechanisms that are associated with endoscopic resistance to anti-TNF therapy.
DESIGN: Mucosal and blood cells were isolated from patients with Crohn's disease prior and during anti-TNF therapy. Cytokine profiles, cell surface markers, signalling proteins and cell apoptosis were assessed by microarray, immunohistochemistry, qPCR, ELISA, whole organ cultures and FACS.
RESULTS: Responders to anti-TNF therapy displayed a significantly higher expression of TNF receptor 2 (TNFR2) but not IL23R on T cells than non-responders prior to anti-TNF therapy. During anti-TNF therapy, there was a significant upregulation of mucosal IL-23p19, IL23R and IL-17A in anti-TNF non-responders but not in responders. Apoptosis-resistant TNFR2+IL23R+ T cells were significantly expanded in anti-TNF non-responders compared with responders, expressed the gut tropic integrins α4β7, and exhibited increased expression of IFN-γ, T-bet, IL-17A and RORγt compared with TNFR2+IL23R- cells, indicating a mixed Th1/Th17-like phenotype. Intestinal TNFR2+IL23R+ T cells were activated by IL-23 derived from CD14+ macrophages, which were significantly more present in non-responders prior to anti-TNF treatment. Administration of IL-23 to anti-TNF-treated mucosal organ cultures led to the expansion of CD4+IL23R+TNFR2+ lymphocytes. Functional studies demonstrated that anti-TNF-induced apoptosis in mucosal T cells is abrogated by IL-23.
CONCLUSIONS: Expansion of apoptosis-resistant intestinal TNFR2+IL23R+ T cells is associated with resistance to anti-TNF therapy in Crohn's disease. These findings identify IL-23 as a suitable molecular target in patients with Crohn's disease refractory to anti-TNF therapy.},
author = {Schmitt, Heike and Billmeier, Ulrike and Dieterich, Walburga and Rath, Timo and Sonnewald, Sophia and Reid, Stephen and Hirschmann, Simon and Hildner, Kai and Waldner, Maximilian and Mudter, Jonas and Hartmann, Arndt and Grützmann, Robert and Neufert, Clemens and Münster, Tino and Neurath, Markus and Atreya, Raja},
doi = {10.1136/gutjnl-2017-315671},
faupublication = {yes},
journal = {Gut},
note = {EVALuna2:34305},
peerreviewed = {Yes},
title = {{Expansion} of {IL}-23 receptor bearing {TNFR2}+ {T} cells is associated with molecular resistance to anti-{TNF} therapy in {Crohn}'s disease},
year = {2018}
}
@article{faucris.310439343,
abstract = {Background: The use of sedative drugs and intentional sedation in end-of-life care is associated with clinical, ethical and legal challenges. In view of these and of the issue’s great importance to patients undergoing intolerable suffering, we conducted a project titled SedPall (“From anxiolysis to deep continuous sedation – Development of recommendations for sedation in palliative care“) with the purpose of developing best practice recommendations on the use of sedative drugs and intentional sedation in specialist palliative care and obtaining feedback and approval from experts in this area. Design: Our stepwise approach entailed drafting the recommendations, obtaining expert feedback, conducting a single-round Delphi study, and convening a consensus conference. As an interdisciplinary group, we created a set of best practice recommendations based on previously published guidance and empirical and normative analysis, and drawing on feedback from experts, including patient representatives and of public involvement participants. We set the required agreement rate for approval at the single-round Delphi and the consensus conference at ≥80%. Results: Ten experts commented on the recommendations’ first draft. The Delphi panel comprised 50 experts and patient and public involvement participants, while 46 participants attended the consensus conference. In total, the participants in these stages of the process approved 66 recommendations, covering the topics “indications”, “intent/purpose [of sedation]”, “decision-making”, “information and consent”, “medication and type of sedation”, “monitoring”, “management of fluids and nutrition”, “continuing other measures”, “support for relatives”, and “team support”. The recommendations include suggestions on terminology and comments on legal issues. Conclusion: Further research will be required for evaluating the feasibility of the recommendations’ implementation and their effectiveness. The recommendations and the suggested terminology may serve as a resource for healthcare professionals in Germany on the use of sedative drugs and intentional sedation in specialist palliative care and may contribute to discussion on the topic at an international level. Trial Registration: DRKS00015047 (German Clinical Trials Register)},
author = {Ostgathe, Christoph and Bausewein, Claudia and Schildmann, Eva and Bazata, Jeremias and Handtke, Violet and Heckel, Maria and Klein, Carsten and Kremling, Alexander and Kurkowski, Sandra and Meesters, Sophie and Seifert, Andreas and Torres Cavazos, Jorge and Ziegler, Kerstin and Jäger, Christian and Schildmann, Jan},
doi = {10.1186/s12904-023-01243-z},
faupublication = {yes},
journal = {BMC Palliative Care},
keywords = {Community-based participatory research; Empirical research; Hypnotics and sedatives; Palliative care; Practice guidelines; Terminal care},
note = {CRIS-Team Scopus Importer:2023-09-15},
peerreviewed = {Yes},
title = {{Expert}-approved best practice recommendations on the use of sedative drugs and intentional sedation in specialist palliative care ({SedPall})},
volume = {22},
year = {2023}
}
@inproceedings{faucris.266785796,
address = {HOBOKEN},
author = {Krammer, Susanne and Yang, Zuqin and Gutu, Sicorschi C. and Grund, Janina and Mitländer, Hannah and Zirlik, Sabine and Finotto, Susetta},
booktitle = {ALLERGY},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2021-12-03},
pages = {109-109},
peerreviewed = {unknown},
publisher = {WILEY},
title = {{Expression} of {IFN} lambda and its receptor in human adult asthma cohort {AZCRA}},
year = {2021}
}
@article{faucris.118159184,
abstract = {We recently developed a new population pharmacokinetic model for hydromorphone in patients including age and bodyweight as covariates. The aim of the present study was to evaluate prospectively the predictive performance of this new model during postoperative pain therapy.This was a prospective, single-blinded, randomized, single-center study with two parallel arms. Fifty patients aged 40-85 years undergoing cardiac surgery involving thoracotomy were enrolled. Hydromorphone was administered postoperatively on the intensive care unit as target controlled infusion (TCI) for patient controlled analgesia (TCI-PCA) using the new pharmacokinetic model, or as conventional patient controlled analgesia (PCA). Arterial blood samples were taken for measurement of the hydromorphone plasma concentration. The predictive performance of the pharmacokinetic model was assessed by the median performance error (MDPE), the median absolute performance error (MDAPE), wobble and divergence. For comparison, the performance indices were also determined for three older models from the literature.903 plasma concentrations of 41 patients were analyzed. The mean values (95 % CI) of MDPE, MDAPE, wobble and divergence for the new pharmacokinetic model were 11.2 % (3.9 to 18.7 %), 28.5 % (23.9 to 33.0 %), 21.4 % (18.0 to 24.9 %) and -1.6 %/h (-2.3 to -0.8 %/h). When compared with older models from the literature, performance was better with less overshoot after bolus doses.The new pharmacokinetic model of hydromorphone showed a good precision and a better performance than older models. It is therefore suitable for TCI with hydromorphone during postoperative pain therapy.EudraCT 2013-002875-16, Clinical Trials NCT02035709.},
author = {Ihmsen, Harald and Rohde, Doris and Schüttler, Jürgen and Jeleazcov, Christian},
doi = {10.1007/s13318-015-0318-x},
faupublication = {yes},
journal = {European Journal of Drug Metabolism and Pharmacokinetics},
note = {EVALuna2:16706},
pages = {17-28},
peerreviewed = {Yes},
title = {{External} {Validation} of a {Recently} {Developed} {Population} {Pharmacokinetic} {Model} for {Hydromorphone} {During} {Postoperative} {Pain} {Therapy}},
volume = {42},
year = {2017}
}
@article{faucris.106686184,
abstract = {BACKGROUND
Extracorporeal perfusion (EP) is moving into focus of research in reconstructive and transplantation medicine for the preservation of amputates and free tissue transplants. The idea behind EP is the reduction of ischemia-related cell damage between separation from blood circulation and reanastomosis of the transplant. Most experimental approaches are based on a complex system that moves the perfusate in a circular course.
OBJECTIVE AND METHODS
In this study, we aimed to evaluate if a simple perfusion by an infusion bag filled with an electrolyte solution can provide acceptable results in terms of flow stability, oxygen supply and viability conservation for EP of a muscle transplant. The results are compared to muscles perfused with a pump system as well as muscles stored under ischemic conditions with a one-time intravasal flushing with Jonosteril.
RESULTS
With this simple method a sufficient oxygen supply could be achieved and functionality could be maintained between 3.35 times and 4.60 times longer compared to the control group. Annexin V positive nuclei, indicating apoptosis, increased by 9.7% in the perfused group compared to 24.4% in the control group.
CONCLUSIONS
Overall, by decreasing the complexity of the system, EP by one-way infusion can become more feasible in clinical situation},
author = {Taeger, Christian Dirk and Friedrich, Oliver and Horch, Raymund E. and Drechsler, Caroline and Weigand, Annika and Hopf, Fabio and Geppert, Carol-Immanuel and Münch, Frank and Birkholz, Torsten and Wenzel, Carina and Geis, Sebastian and Prantl, Lukas and Buchholz, Rainer and Präbst, Konstantin},
doi = {10.3233/CH-170298},
faupublication = {yes},
journal = {Clinical hemorheology and microcirculation},
peerreviewed = {Yes},
title = {{Extracorporeal} perfusion - reduced to a one-way infusion.},
year = {2017}
}
@article{faucris.121311344,
abstract = {Genome-wide association studies (GWAS) associated Family with sequence similarity 13, member A (FAM13A) with non-small cell lung cancer (NSCLC) occurrence. Here, we found increased numbers of FAM13A protein expressing cells in the tumoral region of lung tissues from a cohort of patients with NSCLC. Moreover, FAM13A inversely correlated with CTLA4 but directly correlated with HIF1? levels in the control region of these patients. Consistently, FAM13A RhoGAP was found to be associated with T cell effector molecules like HIF1? and Tbet and was downregulated in immunosuppressive CD4(+)CD25(+)Foxp3(+)CTLA4(+) T cells. TGF?, a tumor suppressor factor, as well as siRNA to FAM13A, suppressed both isoforms of FAM13A and inhibited tumor cell proliferation. RNA-Seq analysis confirmed this finding. Moreover, siRNA to FAM13A induced TGF? levels. Finally, in experimental tumor cell migration, FAM13A was induced and TGF? accelerated this process by inducing cell migration, HIF1?, and the FAM13A RhoGAP isoform. Furthermore, siRNA to FAM13A inhibited tumor cell proliferation and induced cell migration without affecting HIF1?. In conclusion, FAM13A is involved in tumor cell proliferation and downstream of TGF? and HIF1?, FAM13A RhoGAP is associated with Th1 gene expression and lung tumor cell migration. These findings identify FAM13A as key regulator of NSCLC growth and progression.},
author = {Eisenhut, Felix and Heim, Lisanne and Trump, Sonja and Mittler, Susanne and Sopel, Nina and Andreev, Katerina and Ferrazzi, Fulvia and Ekici, Arif Bülent and Rieker, Ralf and Springel, Rebekka and Assmann, Vera Elisabeth and Lechmann, Matthias and Koch, Sonja and Engelhardt, Marina and Warnecke, Christina and Trufa, Denis and Sirbu, Horia and Hartmann, Arndt and Finotto, Susetta},
doi = {10.1080/2162402X.2016.1256526},
faupublication = {yes},
journal = {OncoImmunology},
note = {EVALuna2:6835},
pages = {e1256526},
peerreviewed = {Yes},
title = {{FAM13A} is associated with non-small cell lung cancer ({NSCLC}) progression and controls tumor cell proliferation and survival},
volume = {6},
year = {2017}
}
@article{faucris.241995442,
abstract = {Background: Critical incident reporting systems (CIRS) serve to sensitize organizations and individuals to unknown events relevant to patient safety and therefore help in developing safer systems; however, the use and impact of these systems in healthcare has recently been questioned for a variety of reasons, among them unclear and imprecise reporting criteria. Some authors claim that fundamental aspects of successful CIRS have been misunderstood, misapplied or entirely missed during the adaptation to the healthcare context. The aim of this study was the analysis of all reports accumulated over 10 years in the German system CIRSmedical Anesthesiology (CIRS-AINS) as a basis for improved reporting guidelines, user training and generation of further hypotheses. Methods: In a retrospective analysis all reports from CIRS-AINS entered between April 2010 and June 2019 were analyzed for structure and content. Results: A total of 6013 reports were filed consisting of 3492 incidents (58.1%), 1734 near misses (28.8%) and 787 others (13.1%). Those other reports contained 21 interpersonal conflicts (0.4%), 102 general complaints (1.7%), 89 stress or workload complaints (1.5%) and 575 reports that did not contain any critical incident or safety-related content (9.6%). Since 2015 these other reports have increased 2.8-fold from 7.4% to 20.8%. Of the reports 20.1% contained information about technical problems and 27.7% about certified medical devices. Medication was mentioned in 10.7% of reports, 47.8% of inpatient incidents concerned the perioperative setting, 24.6% were reported from intensive care units (ICU) and postanesthesia care units (PACU). Of the cases 198 (3.3%) explicitly mentioned communication issues, 346 cases (5.8%) concerned incomplete or inadequate documentation involving orders, blood products or laboratory tests. Of the reports 36.1% were analyzed and commented on by the CIRS team of the German Society of Anesthesiologists (BDA). Conclusion: The analysis provides insights into reporting practices and can influence both reporting guidelines as well as user training. Report format, content and context are of utmost importance for further analysis: A distinction has to be made between reports that contain locally rational information and cannot be understood without further context and reports that may help inform about patient safety activities on a national level. Especially in light of the limited resources for incident analysis, the content should be critically reflected upon by the user when submitting a report to support a wise allocation of available capacities. In this respect, the increase of non-CIRS reports has to be considered in the future implementation of nationwide IRS. Also, it has to be questioned whether adequate alternative means of communication for these non-CIRS reports exist. The majority of reports were made by physicians, which is in contrast to international experiences with increased engagement of nursing staff and underlines the need for increased interprofessional collaboration with incident reporting and analysis activities in Germany. Reports containing workload complaints, while constituting important signals on a local level, usually fail to address the idea of learning from others inherent to the philosophy of national IRS.},
author = {Neuhaus, C. and Holzschuh, M. and Lichtenstern, C. and St. Pierre, Michael},
doi = {10.1007/s00101-020-00829-z},
faupublication = {yes},
journal = {Anaesthesist},
keywords = {Accident prevention; Critical incident reporting; Patient safety; Reporting systems; Safety management},
note = {CRIS-Team Scopus Importer:2020-08-28},
peerreviewed = {Yes},
title = {{Findings} from 10 years of {CIRS}-{AINS}: {An} analysis of usepatterns and insights into new challenges {Erkenntnisse} aus 10 {Jahren} {CIRS}‑{AINS}: {Eine} {Analyse} von {Nutzerverhalten} und {Ausblick} auf neue {Herausforderungen}},
year = {2020}
}
@article{faucris.106682004,
abstract = {Retrograde fluorescent labeling of dental primary afferent neurons (DPANs) has been described in rats through crystalline fluorescent DiI, while in the mouse, this technique was achieved with only Fluoro-Gold, a neurotoxic fluorescent dye with membrane penetration characteristics superior to the carbocyanine dyes. We reevaluated this technique in the rat with the aim to transfer it to the mouse because comprehensive physiologic studies require access to the mouse as a model organism. Using conventional immunohistochemistry, we assessed in rats and mice the speed of axonal dye transport from the application site to the trigeminal ganglion, the numbers of stained DPANs, and the fluorescence intensity via 1) conventional crystalline DiI and 2) a novel DiI formulation with improved penetration properties and staining efficiency. A 3-dimensional reconstruction of an entire trigeminal ganglion with 2-photon laser scanning fluorescence microscopy permitted visualization of DPANs in all 3 divisions of the trigeminal nerve. We quantified DPANs in mice expressing the farnesylated enhanced green fluorescent protein (EGFPf) from the transient receptor potential cation channel subfamily M member 8 (TRPM8EGFPf/+) locus in the 3 branches. We also evaluated the viability of the labeled DPANs in dissociated trigeminal ganglion cultures using calcium microfluorometry, and we assessed the sensitivity to capsaicin, an agonist of the TRPV1 receptor. Reproducible DiI labeling of DPANs in the mouse is an important tool 1) to investigate the molecular and functional specialization of DPANs within the trigeminal nociceptive system and 2) to recognize exclusive molecular characteristics that differentiate nociception in the trigeminal system from that in the somatic system. A versatile tool to enhance our understanding of the molecular composition and characteristics of DPANs will be essential for the development of mechanism-based therapeutic approaches for dentine hypersensitivity and inflammatory tooth pain.},
author = {Kadala, A. and Sotelo-Hitschfeld, Pamela and Ahmad, Ziad and Tripal, Philipp and Schmid, Benjamin and Mueller, A. and Bernal, L. and Winter, Zoltan and Brauchi, S. and Lohbauer, Ulrich and Meßlinger, Karl and Lennerz, J. K. and Zimmermann, Katharina},
doi = {10.1177/0022034517740577},
faupublication = {yes},
journal = {Journal of Dental Research},
note = {EVALuna2:24704},
pages = {22034517740577},
peerreviewed = {Yes},
title = {{Fluorescent} {Labeling} and 2-{Photon} {Imaging} of {Mouse} {Tooth} {Pulp} {Nociceptors}},
year = {2017}
}
@article{faucris.124172664,
abstract = {Simulation has been increasingly used in medicine. In 2003 German university departments of anesthesiology were provided with a full-scale patient simulator, designated for use with medical students. Meanwhile simulation courses are also offered to physicians and nurses. Currently, the national model curriculum for residency programs in anesthesiology is being revised, possibly to include mandatory simulation training.To assess the status quo of full-scale simulation training for medical school, residency and continuing medical education in German anesthesiology.All 38 German university chairs for anesthesiology as well as five arbitrarily chosen non-university facilities were invited to complete an online questionnaire regarding their centers' infrastructure and courses held between 2010 and 2012.The overall return rate was 86 %. In university simulation centers seven non-student staff members, mainly physicians, were involved, adding up to a full-time equivalent of 1.2. All hours of work were paid by 61 % of the centers. The median center size was 100 m(2) (range 20-500 m(2)), equipped with three patient simulators (1-32). Simulators of high or very high fidelity are available at 80 % of the centers. Scripted scenarios were used by 91 %, video debriefing by 69 %. Of the participating university centers, 97 % offered courses for medical students, 81 % for the department's employees, 43 % for other departments of their hospital, and 61 % for external participants. In 2012 the median center reached 46 % of eligible students (0-100), 39 % of the department's physicians (8-96) and 16 % of its nurses (0-56) once. For physicians and nurses from these departments that equals one simulation-based training every 2.6 and 6 years, respectively. 31 % made simulation training mandatory for their residents, 29 % for their nurses and 24 % for their attending physicians. The overall rates of staff ever exposed to simulation were 45 % of residents (8-90), and 30 % each of nurses (10-80) and attendings (0-100). Including external courses the average center trained 59 (4-271) professionals overall in 2012. No clear trend could be observed over the three years polled. The results for the non-university centers were comparable.Important first steps have been taken to implement full-scale simulation in Germany. In addition to programs for medical students courses for physicians and nurses are available today. To reach everyone clinically involved in German anesthesiology on a regular basis the current capacities need to be dramatically increased. The basis for that to happen will be new concepts for funding, possibly supported by external requirements such as the national model curriculum for residency in anesthesiology.},
author = {Baschnegger, H. and Meyer, O. and Zech, A. and Urban, B. and Rall, M. and Breuer, Georg and Prueckner, S.},
doi = {10.1007/s00101-016-0251-7},
faupublication = {yes},
journal = {Anaesthesist},
note = {EVALuna2:16741},
pages = {11-20},
peerreviewed = {Yes},
title = {{Full}-scale simulation in {German} medical schools and anesthesia residency programs : {Status} quo},
volume = {66},
year = {2017}
}
@article{faucris.239307377,
abstract = {This review aims to create an overview of the currently available results of site-directed mutagenesis studies on transient receptor potential vanilloid type 1 (TRPV1) receptor. Systematization of the vast number of data on the functionally important amino acid mutations of TRPV1 may provide a clearer picture of this field, and may promote a better understanding of the relationship between the structure and function of TRPV1. The review summarizes information on 112 unique mutated sites along the TRPV1, exchanged to multiple different residues in many cases. These mutations influence the effect or binding of different agonists, antagonists, and channel blockers, alter the responsiveness to heat, acid, and voltage dependence, affect the channel pore characteristics, and influence the regulation of the receptor function by phosphorylation, glycosylation, calmodulin, PIP2, ATP, and lipid binding. The main goal of this paper is to publish the above mentioned data in a form that facilitates in silico molecular modelling of the receptor by promoting easier establishment of boundary conditions. The better understanding of the structure-function relationship of TRPV1 may promote discovery of new, promising, more effective and safe drugs for treatment of neurogenic inflammation and pain-related diseases and may offer new opportunities for therapeutic interventions.
= 56 years of age, younger vaccinated participants had a higher risk of systemic reactions after the first (OR 1.35 (1.07-1.70)) and second vaccination (OR 2.08 (1.64-2.63)) and were more often unable to work after dose 2 (OR 2.20 (1.67-2.88)). We also recorded four anaphylactic reactions and received two reports of severe adverse effects indicative of vaccine complications. After the first and second vaccination, 7.9% and 34.7% of the survey participants, respectively, were temporarily unable to work, which added up to 1700 days of sick leave in this cohort. These real-life data extend previous results on the reactogenicity and safety of BNT162b2. Loss of working time due to vaccine-related adverse effects was substantial, but was outweighed by the potential benefit of prevented cases of COVID-19.},
author = {Niekrens, Valentin and Esse, Jan and Held, Jürgen and Knobloch, Carina and Steininger, Philipp and Kunz, Bernd and Seggewies, Christof and Bogdan, Christian},
doi = {10.3390/vaccines10050650},
faupublication = {yes},
journal = {Vaccines},
note = {CRIS-Team WoS Importer:2022-06-10},
peerreviewed = {Yes},
title = {{Homologous} {COVID}-19 {BNT162b2} {mRNA} {Vaccination} at a {German} {Tertiary} {Care} {University} {Hospital}: {A} {Survey}-{Based} {Analysis} of {Reactogenicity}, {Safety}, and {Inability} to {Work} among {Healthcare} {Workers}},
volume = {10},
year = {2022}
}
@article{faucris.217951273,
abstract = {Background: Auditory training is an established intervention in adult cochlear implant (CI) aural rehabilitation. In most cases, training is implemented in an individual therapy setting. Increasing patient numbers and the associated time-economic and cost-related demands as well as psychosocial and communicative aspects support the use of aural group interventions. Objectives: This study aimed 1) to describe concepts and contents of group interventions for adult CI users and 2) to present results of a questionnaire-based evaluation. Methods: Group interventions have been offered at the CI Centre Erlangen CICERO for several years. In Auditory Training Groups, exercises have priority, while Thematic Group Workshops focus on psychosocial aspects and provide information for the participants. The Auditory Training Groups were evaluated based on a patient questionnaire. Additionally, the reliability of the questionnaire was analyzed. Results: The median overall satisfaction of CI users participating in Auditory Training Groups was rated as good. Training of speech perception in noise as well as communicative exchange are of great importance for CI users. They rated the therapeutic design as very good to good. Reliability analysis showed significant positive intercorrelations of the questionnaire items. Conclusion: Group interventions are well accepted by CI users and represent a useful complement to individual therapy during the rehabilitation process. As group interventions place special demands on patients and therapists, structured and well-proven concepts should be used in practice.},
author = {Glaubitz, Cynthia and Lehmann, E. K. and Weber, Lena and Kulke, A. ‑.M. and Hoppe, Ulrich},
doi = {10.1007/s00106-019-0672-0},
faupublication = {yes},
journal = {HNO},
keywords = {Auditory training; Aural therapy; Cochlear implant; Group therapy; Questionnaire evaluation},
note = {CRIS-Team Scopus Importer:2019-05-21},
peerreviewed = {Yes},
title = {{Hörtherapeutische} {Gruppenkonzepte} in der {Cochleaimplantat}-{Rehabilitation} bei {Erwachsenen}},
year = {2019}
}
@article{faucris.246697522,
abstract = {Background: Palliative care strives to improve quality of life for patients with incurable diseases. This approach includes adequate support of the patients' loved ones. Consequently, loved ones have personal experiences of providing end-of-life care for their next. This is a resource for information and may help to investigate the loved ones' perspectives on need for improvements. Aim: To identify further quality aspects considered important by loved ones to improve the quality of care at the end of life as an addition to quantitative results from the Care of the Dying Evaluation for the German-speaking area (CODE-GER) questionnaire. Design: Within the validation study of the questionnaire â € Care of the Dying Evaluation' (CODETM) GER, loved ones were asked to comment (free text) in parallel on each item of the CODE-GER. These free-text notes were analysed with the qualitative content analysis method by Philipp Mayring. Setting/participants: Loved ones of patients (n=237), who had died an expected death in two university hospitals (palliative and non-palliative care units) during the period from April 2016 to March 2017. Results: 993 relevant paragraphs were extracted out of 1261 free-text notes. For loved ones, important aspects of quality of care are information/communication, respect of the patient's and/or loved one's will, involvement in decision-making at the end of life (patient's volition) and having the possibility to say goodbye. Conclusions: It is important for loved ones to be taken seriously in their sorrows, to be informed, that the caregivers respect the patients' will and to be emotionally supported. Trial registration number: This study was registered at the German Clinical Trials Register (DRKS00013916).},
author = {Kurkowski, Sandra and Radon, Johannes and Vogt, Annika R. and Weber, Martin and Stiel, Stephanie and Ostgathe, Christoph and Heckel, Maria},
doi = {10.1136/bmjspcare-2020-00239},
faupublication = {yes},
journal = {BMJ Supportive & Palliative Care},
keywords = {hospital care; quality of life; service evaluation; social care; supportive care; terminal care},
note = {CRIS-Team Scopus Importer:2020-12-11},
peerreviewed = {Yes},
title = {{Hospital} end-of-life care: {Families}' free-text notes},
year = {2020}
}
@article{faucris.241984964,
abstract = {BACKGROUND: The development of expertise in anaesthesia requires personal contact between a mentor and a learner. Because mentors often are experienced clinicians, they may find it difficult to understand the challenges novices face during their first months of clinical practice. As a result, novices' perspectives may be an important source of pedagogical information for the expert. The aim of this study was to explore novice and expert anaesthetists understanding of expertise in anaesthesia using qualitative methods. METHODS: Semi-structured interviews were conducted with 9 novice and 9 expert anaesthetists from a German University Hospital. Novices were included if they had between 3 and 6 months of clinical experience and experts were determined by peer assessment. Interviews were intended to answer the following research questions: What do novices think expertise entails and what do they think they will need to become an expert? What do experts think made them the expert person and how did that happen? How do both groups value evidence-based standards and how do they negotiate following written guidance with following one's experience? RESULTS: The clinical experience in both groups differed significantly (novices: 4.3 mean months vs. experts: 26.7 mean years; p < 0.001). Novices struggled with translating theoretical knowledge into action and found it difficult to talk about expertise. Experts no longer seem to remember being challenged as novice by the complexity of routine tasks. Both groups shared the understanding that the development of expertise was a socially embedded process. Novices assumed that written procedures were specific enough to address every clinical contingency whereas experts stated that rules and standards were essentially underspecified. For novices the challenge was less to familiarise oneself with written standards than to learn the unwritten, quasi-normative rules of their supervising consultant(s). Novices conceptualized decision making as a rational, linear process whereas experts added to this understanding of tacit knowledge and intuitive decision making. CONCLUSIONS: Major qualitative differences between a novice and an expert anaesthetist's understanding of expertise can create challenges during the first months of clinical training. Experts should be aware of the problems novices may have with negotiating evidence-based standards and quasi-normative rules.},
author = {St Pierre, Michael and Nyce, James M.},
doi = {10.1186/s12909-020-02180-8},
faupublication = {yes},
journal = {Bmc Medical Education},
keywords = {Decision making; Expertise; Mentoring; Professionalism; Qualitative research; Tacit knowledge},
note = {CRIS-Team Scopus Importer:2020-08-28},
pages = {262-},
peerreviewed = {Yes},
title = {{How} novice and expert anaesthetists understand expertise in anaesthesia: a qualitative study},
volume = {20},
year = {2020}
}
@article{faucris.260537150,
abstract = {In this concise Mini-Review we will summarize ongoing developments of new techniques to study physiology and pathophysiology of the peripheral sensory nervous system in human stem cell derived models. We will focus on recent developments of reprogramming somatic cells into induced pluripotent stem cells, neural differentiation towards neuronal progenitors and human sensory neurons. We will sum up the high potential of this new technique for disease modelling of human neuropathies with a focus on genetic pain syndromes, such as gain- and loss-of-function mutations in voltage-gated sodium channels. The stem cell derived human sensory neurons are used for drug testing and we will summarize their usefulness for individualized treatment identification in patients with neuropathic pain. The review will give an outlook on potential application of this technique as companion diagnostics and for personalized medicine.},
author = {Lampert, Angelika and Bennett, David L. and McDermott, Lucy A. and Neureiter, Anika and Eberhardt, Esther and Winner, Beate and Zenke, Martin},
doi = {10.1016/j.ynpai.2020.100055},
faupublication = {yes},
journal = {Neurobiology of pain (Cambridge, Mass.)},
keywords = {Disease modelling; iPSC; Pain; Peripheral neuron; Stem cell differentiation},
note = {Created from Fastlane, Scopus look-up},
peerreviewed = {Yes},
title = {{Human} sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine},
volume = {8},
year = {2020}
}
@article{faucris.122632884,
abstract = {In the field of free flap transfer in reconstructive surgery, the trans- or replanted tissue always undergoes cell damage during ischemia to a more or less strong extent. In previous studies we already showed that conserving muscle transplants by means of extracorporeal perfusion over a period of 6 hours by using a crystalloid solution for perfusion. However, we observed significant edema formation. In this study we aimed at reducing the edema formation by using an iso-oncotic colloid as perfusion solution. This way we want to evaluate a possible new application of hydroxyl-ethyl starch in an extracorporeal setup to exploit potential benefits of the colloid.Examined parameters include the muscles' functionality with external field stimulation, histological examination and edema formation. Perfused muscles showed a statistically significant higher ability to exert force compared to nonperfused ones. These findings can be confirmed using Annexin V as marker for cell damage, perfusion of muscle tissue limits damage significantly compared to nonperfused tissue. Substituting the electrolyte perfusion solution with a colloidal one shows the tendency to reduce the edema formation but without statistical significance.},
author = {Taeger, Christian and Friedrich, Oliver and Drechsler, Caroline and Weigand, Annika and Hobe, Frieder and Geppert, Carol-Immanuel and Münch, Frank and Birkholz, Torsten and Buchholz, Rainer and Horch, Raymund E. and Präbst, Konstantin and Buchholz, Rainer},
doi = {10.3233/CH-162049},
faupublication = {yes},
journal = {Clinical hemorheology and microcirculation},
peerreviewed = {Yes},
title = {{Hydroxyethyl} starch solution for extracorporeal tissue perfusion},
year = {2016}
}
@article{faucris.109151504,
abstract = {Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass, but early detection of postoperative AKI remains challenging. Protein biomarkers predict AKI excellently in homogeneous cohorts but are less reliable in patients suffering from various comorbidities. We employed nuclear magnetic resonance spectroscopy in a prospective study of 85 adult cardiac surgery patients to identify metabolites prognostic of AKI in plasma specimens collected 24 h after surgery. Postoperative AKI of stages 1-3, as defined by the Acute Kidney Injury Network (AKIN), developed in 33 cases. A random forests classifier trained on the NMR spectra prognosticated AKI across all stages, with an average accuracy of 80 ± 0.9% and an area under the receiver operating characteristic curve of 0.87 ± 0.01. Prognostications were based, on average, on 24 ± 2.8 spectral features. Among the set of discriminative ions and molecules identified were Mg(2+), lactate, and the glucuronide conjugate of propofol. Using creatinine, Mg(2+), and lactate levels to derive an AKIN index score, we found AKIN 1 disease to be largely indistinguishable from AKIN 0, in concordance with the rather mild nature of AKIN 1 disease.},
author = {Zacharias, Helena U. and Hochrein, Jochen and Vogl, Franziska C. and Schley, Gunnar and Mayer, Friederike and Jeleazcov, Christian and Eckardt, Kai-Uwe and Willam, Carsten and Oefner, Peter J. and Gronwald, Wolfram},
doi = {10.1021/acs.jproteome.5b00219},
faupublication = {yes},
journal = {Journal of Proteome Research},
note = {EVALuna2:3784},
pages = {2897-905},
peerreviewed = {Yes},
title = {{Identification} of {Plasma} {Metabolites} {Prognostic} of {Acute} {Kidney} {Injury} after {Cardiac} {Surgery} with {Cardiopulmonary} {Bypass}},
volume = {14},
year = {2015}
}
@article{faucris.222396614,
abstract = {Background: One challenge in caring for cancer patients with incurable disease is the adequate identification of those in need for specialized palliative care (SPC). The study's aim was to validate an easy to use phenomenological screening tool. Methods: The German tool is based on the National Comprehensive Cancer Network (NCCN) Palliative Care guidelines and contains ten items in five domains that focus e.g. on diagnosis, functional status, complications, comorbidities, and palliative care relevant problems such as symptom management, distress, and support of family and team members. Sum score ranges from 0 to 14 (no need to great need). Assessment to identify SPC needs was done in university hospital wards between 1 and 08/2017 by health care professionals on admission of the patient if the disease was incurable and expected prognosis < 12 months. The Integrated Palliative Outcome Scale (IPOS, staff version), an outcome assessment instrument for palliative care that consists of ten items, served as external criterion; in sub samples inter-rater/test-retest were performed. Results: Data from 208 patients with incurable disease and life expectancy < 12 months (54.8% female; average age 63.5 years, range 21-96) were assessed using the tool. The tool has good convergent validity; the correlation between the sum scores of IPOS and our tool showed a significant and substantial effect. The sum score was independent of the patient's age, gender and primary diagnosis. Patients who already were in contact with SPC had significantly higher screening scores than patients without. With a cut point of ≥ 5, 80.8% of the screened patients were in need for SPC. Cronbach's alpha was α =.600. Rater agreement (inter-rater, test-retest) varied between single items. Correlation coefficients showed significant substantial effects. Conclusions: This is the first validation of a screening procedure in German language identifying SPC needs of adult patients with advanced cancer and the first using filter questions as a pre-screening. Proxy assessment of SPC needs by physicians in cancer care settings is feasible and the suggested tool presents a valid instrument to trigger a PC consultation. Trial registration: The study was not registered.},
author = {Ostgathe, Christoph and Wendt, Kim N. and Heckel, Maria and Kurkowski, Sandra and Klein, Carsten and Krause, Stefan and Fuchs, Florian and Bayer, Christian M. and Stiel, Stephanie},
doi = {10.1186/s12885-019-5809-8},
faupublication = {yes},
journal = {BMC Cancer},
keywords = {Cancer; Delivery of health care; Needs assessment; Palliative care; Psychometric properties},
note = {CRIS-Team Scopus Importer:2019-07-16},
peerreviewed = {Yes},
title = {{Identifying} the need for specialized palliative care in adult cancer patients - {Development} and validation of a screening procedure based on proxy assessment by physicians and filter questions},
volume = {19},
year = {2019}
}
@article{faucris.109213984,
abstract = {We analysed the influence of rhinovirus (RV) in nasopharyngeal fluid (NPF) on type I and III interferon (IFN) responses (e.g. IFN-? and IFN -: ?) and their signal transduction, at baseline and during disease exacerbation, in cohorts of pre-school children with and without asthma.At the time of recruitment into the Europe-wide study PreDicta, and during symptoms, NPF was collected and the local RV colonisation was analysed. Peripheral blood mononuclear cells (PBMCs) were challenged in vitro with RV or not. RNA was analysed by quantitative real-time PCR and gene arrays. Serum was analysed with ELISA for IFNs and C-reactive protein.We found that PBMCs from asthmatic children infected in vitro with the RV1b serotype upregulated MYD88, IRF1, STAT1 and STAT2 mRNA, whereas MYD88, IRF1, STAT1 and IRF9 were predominantly induced in control children. Moreover, during symptomatic visits because of disease exacerbation associated with RV detection in NPF, IFN-? production was found increased, while IFN-? secretion was already induced by RV in asthmatic children at baseline.During asthma exacerbations associated with RV, asthmatic children can induce IFN-? secretion, indicating a hyperactive immune response to repeated respiratory virus infection.},
author = {Bergauer, Annika and Sopel, Nina and Kross, Bettina and Vuorinen, Tytti and Xepapadaki, Paraskevi and Weiss, Scott T. and Blau, Ashley and Sharma, Himanshu and Kraus, Cornelia and Springel, Rebekka and Rauh, Manfred and Mittler, Susanne and Graser, Anna and Zimmermann, Theodor and Melichar, Volker O. and Kiefer, Alexander and Kowalski, Marek L. and Sobanska, Anna and Jartti, Tuomas and Lukkarinen, Heikki and Papadopoulos, Nikolaos G. and Finotto, Susetta},
doi = {10.1183/13993003.00969-2016},
faupublication = {yes},
journal = {European Respiratory Journal},
note = {EVALuna2:9365},
peerreviewed = {Yes},
title = {{IFN}-α/{IFN}-λ responses to respiratory viruses in paediatric asthma},
year = {2016}
}
@article{faucris.110673024,
author = {Bergauer, Annika and Sopel, Nina and Kross, Bettina and Vuorinen, Tytti and Xepapadaki, Paraskevi and Weiss, Scott T. and Blau, Ashley and Sharma, Himanshu and Kraus, Cornelia and Springel, Rebekka and Rauh, Manfred and Mittler, Susanne and Graser, Anna and Zimmermann, Theodor and Melichar, Volker O. and Kiefer, Alexander and Kowalski, Marek L. and Sobanska, Anna and Jartti, Tuomas and Lukkarinen, Heikki and Papadopoulos, Nikolaos G. and Finotto, Susetta},
doi = {10.1183/13993003.00006-2017},
faupublication = {yes},
journal = {European Respiratory Journal},
note = {EVALuna:34061},
peerreviewed = {Yes},
title = {{IFN}-α/{IFN}-λ responses to respiratory viruses in paediatric asthma},
volume = {49},
year = {2017}
}
@article{faucris.121798864,
abstract = {Human studies demonstrated that allergen-specific immunotherapy (IT) represents an effective treatment for allergic diseases. IT involves repeated administration of the sensitizing allergen, indicating a crucial contribution of T cells to its medicinal benefit. However, the underlying mechanisms of IT, especially in a chronic disease, are far from being definitive. In the current study, we sought to elucidate the suppressive mechanisms of IT in a mouse model of chronic allergic asthma. OVA-sensitized mice were challenged with OVA or PBS for 4 wk. After development of chronic airway inflammation, mice received OVA-specific IT or placebo alternately to airway challenge for 3 wk. To analyze the T cell-mediated mechanisms underlying IT in vivo, we elaborated the role of T-bet-expressing Th1 cells, T cell-derived IL-10, and Ag-specific thymic as well as peripherally induced Foxp3(+) regulatory T (Treg) cells. IT ameliorated airway hyperresponsiveness and airway inflammation in a chronic asthma model. Of note, IT even resulted in a regression of structural changes in the airways following chronic inhaled allergen exposure. Concomitantly, IT induced Th1 cells, Foxp3(+), and IL-10-producing Treg cells. Detailed analyses revealed that thymic Treg cells crucially contribute to the effectiveness of IT by promoting IL-10 production in Foxp3-negative T cells. Together with the peripherally induced Ag-specific Foxp3(+) Treg cells, thymic Foxp3(+) Treg cells orchestrate the curative mechanisms of IT. Taken together, we demonstrate that IT is effective in a chronic allergic disease and dependent on IL-10 and thymic as well as peripherally induced Ag-specific Treg cells.},
author = {Bohm, Livia and Maxeiner, Joachim and Meyer-Martin, Helen and Reuter, Sebastian and Finotto, Susetta and Klein, Matthias and Schild, Hansjorg and Schmitt, Edgar and Bopp, Tobias and Taube, Christian},
doi = {10.4049/jimmunol.1401612},
faupublication = {yes},
journal = {Journal of Immunology},
note = {EVALuna2:25968},
pages = {887-97},
peerreviewed = {Yes},
title = {{IL}-10 and regulatory {T} cells cooperate in allergen-specific immunotherapy to ameliorate allergic asthma},
volume = {194},
year = {2015}
}
@article{faucris.314060386,
abstract = {Objective: We sought to investigate the role of interleukin (IL)-20 in IBD and experimental colitis. Design: Experimental colitis was induced in mice deficient in components of the IL-20 and signal transducer and activator of transcription (STAT)2 signalling pathways. In vivo imaging, high-resolution mini-endoscopy and histology were used to assess intestinal inflammation. We further used RNA-sequencing (RNA-Seq), RNAScope and Gene Ontology analysis, western blot analysis and co-immunoprecipitation, confocal microscopy and intestinal epithelial cell (IEC)-derived three-dimensional organoids to investigate the underlying molecular mechanisms. Results were validated using samples from patients with IBD and non-IBD control subjects by a combination of RNA-Seq, organoids and immunostainings. Results: In IBD, IL20 levels were induced during remission and were significantly higher in antitumour necrosis factor responders versus non-responders. IL-20RA and IL-20RB were present on IECs from patients with IBD and IL-20-induced STAT3 and suppressed interferon (IFN)-STAT2 signalling in these cells. In IBD, experimental dextran sulfate sodium (DSS)-induced colitis and mucosal healing, IECs were the main producers of IL-20. Compared with wildtype controls, Il20-/-, Il20ra-/- and Il20rb-/- mice were more susceptible to experimental DSS-induced colitis. IL-20 deficiency was associated with increased IFN/STAT2 activity in mice and IFN/STAT2-induced necroptotic cell death in IEC-derived organoids could be markedly blocked by IL-20. Moreover, newly generated Stat2ΔIEC mice, lacking STAT2 in IECs, were less susceptible to experimental colitis compared with wildtype controls and the administration of IL-20 suppressed colitis activity in wildtype animals. Conclusion: IL-20 controls colitis and mucosal healing by interfering with the IFN/STAT2 death signalling pathway in IECs. These results indicate new directions for suppressing gut inflammation by modulating IL-20-controlled STAT2 signals.},
author = {Chiriac, Mircea-Teodor and Hracsko, Zsuzsanna and Günther, Claudia and Gonzalez Acera, Miguel and Atreya, Raja and Stolzer, Iris and Wittner, Leonie and Dressel, Anja and Schickedanz, Laura and Gámez Belmonte, Maria de los Reyes and Erkert, Lena and Hundorfean, Gheorghe and Zundler, Sebastian and Rath, Timo and Vetrano, Stefania and Danese, Silvio and Sturm, Gregor and Trajanoski, Zlatko and Kühl, Anja A. and Siegmund, Britta and Hartmann, Arndt and Wirtz, Stefan and Siebler, Jürgen and Neurath-Finotto, Susetta and Becker, Christoph and Neurath, Markus},
doi = {10.1136/gutjnl-2023-329628},
faupublication = {yes},
journal = {Gut},
keywords = {experimental colitis; inflammatory bowel disease; interferon; interleukins; signal transduction},
note = {CRIS-Team Scopus Importer:2023-11-17},
peerreviewed = {Yes},
title = {{IL}-20 controls resolution of experimental colitis by regulating epithelial {IFN}/{STAT2} signalling},
year = {2023}
}
@inproceedings{faucris.209691856,
author = {Schmitt, H. and Billmeier, Ulrike and Dieterich, Walburga and Rath, T. and Sonnewald, Sophia and Reid, Stephen and Hirschmann, S. and Hildner, Kai and Waldner, Maximilian and Mudter, J. and Hartmann, Arndt and Grützmann, Robert and Neufert, Clemens and Münster, Tino and Neurath, Markus and Atreya, Raja},
doi = {10.1093/ecco-jcc/jjx180.011},
faupublication = {yes},
note = {EVALuna2:34077},
pages = {S9-S9},
peerreviewed = {Yes},
title = {{IL}-23 is centrally involved in mediating molecular resistance to anti-{TNF} therapy in {Crohn}'s disease patients},
volume = {12},
year = {2018}
}
@inproceedings{faucris.266782570,
address = {BETHESDA},
author = {Hohenberger, Katja and Trufa, Denis and Geppert, Carol-Immanuel and Rieker, Ralf and Sirbu, Horia and Neurath-Finotto, Susetta},
booktitle = {JOURNAL OF IMMUNOLOGY},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2021-12-03},
peerreviewed = {unknown},
publisher = {AMER ASSOC IMMUNOLOGISTS},
title = {{IL}-2 decreased {PU}.1 and {PD}-1 expression in {NK}-cells in {NSCLC} patients},
year = {2021}
}
@article{faucris.122663024,
abstract = {Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of pre-school asthmatic children, nasopharyngeal colonization with Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis was found to be associated with the highest interferon beta (IFN?) and IL-33 levels in the nasal pharyngeal fluids (NPF). IL33R-ST2 was found induced in the blood of asthmatic children with additional Gram + bacteria in the nasopharynx (Gr+/-). Furthermore, asthmatic children had more episodes of infection that required antibiotic therapy than the control group. Treatment with antibiotics associated with reduced ST2 in blood cells of both asthmatic and control children and reduced IL-33 levels in the airways of asthmatic children. In the absence of Staphylococcus (S.) aureus in NPF, antibiotic therapy associated with decreased IL-33 levels in the NPF and lower ST2 values in the blood of control children but not of asthmatic children. These data suggest that, in asthmatic children, Gram- bacteria, which persist after antibiotic therapy, contributes to IL-33 locally and associated with Gr + bacteria colonization in the airways, inhibited IFN-? and in the absence of Staphylococcus (S.) aureus, induced ST2 bearing cells in their blood.},
author = {Hentschke, Isabell and Graser, Anna and Melichar, Volker O. and Kiefer, Alexander and Zimmermann, Theodor and Kross, Bettina and Haag, Patricia and Xepapadaki, Paraskevi and Papadopoulos, Nikolaos G. and Bogdan, Christian and Finotto, Susetta},
doi = {10.1038/srep43426},
faupublication = {yes},
journal = {Scientific Reports},
note = {EVALuna2:7728},
pages = {43426},
peerreviewed = {Yes},
title = {{IL}-33/{ST2} immune responses to respiratory bacteria in pediatric asthma},
volume = {7},
year = {2017}
}
@article{faucris.312725851,
abstract = {IL-3 has been reported to be involved in various inflammatory disorders, but its role in inflammatory bowel disease (IBD) has not been addressed so far. Here, we determined IL-3 expression in samples from patients with IBD and studied the impact of Il3 or Il3r deficiency on T cell-dependent experimental colitis. We explored the mechanical, cytoskeletal and migratory properties of Il3r -/- and Il3r +/+ T cells using real-time deformability cytometry, atomic force microscopy, scanning electron microscopy, fluorescence recovery after photobleaching and in vitro and in vivo cell trafficking assays. We observed that, in patients with IBD, the levels of IL-3 in the inflamed mucosa were increased. In vivo, experimental chronic colitis on T cell transfer was exacerbated in the absence of Il-3 or Il-3r signalling. This was attributable to Il-3r signalling-induced changes in kinase phosphorylation and actin cytoskeleton structure, resulting in increased mechanical deformability and enhanced egress of Tregs from the inflamed colon mucosa. Similarly, IL-3 controlled mechanobiology in human Tregs and was associated with increased mucosal Treg abundance in patients with IBD. Collectively, our data reveal that IL-3 signaling exerts an important regulatory role at the interface of biophysical and migratory T cell features in intestinal inflammation and suggest that this might be an interesting target for future intervention.},
author = {Ullrich, Karen and Derdau, Julia and Baltes, Carsten and Battistella, Alice and Rosso, Gonzalo and Uderhardt, Stefan and Schulze, Lisa and Liu, Lijuan and Dedden, Mark and Spocinska, Marta and Kainka, Lucina and Kubánková, Markéta and Müller, Tanja and Schmidt, Nina Maria and Becker, Emily and Ben Brahim, Oumaima and Atreya, Imke and Neurath-Finotto, Susetta and Prots, Iryna and Wirtz, Stefan and Weigmann, Benno and Lopez Posadas, Rocío and Atreya, Raja and Ekici, Arif Bülent and Lautenschläger, Franziska and Guck, Jochen and Neurath, Markus and Zundler, Sebastian},
doi = {10.1136/gutjnl-2023-329818},
faupublication = {yes},
journal = {Gut},
note = {EVALuna2:539503},
pages = {2081-2094},
peerreviewed = {Yes},
title = {{IL}-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory {T} cells.},
volume = {72},
year = {2023}
}
@article{faucris.121144144,
abstract = {IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced asthma in particular. Here we found an inverse correlation between T-bet and Il-6 mRNA expression in asthmatic children. Moreover, experimental subcutaneous immunotherapy (SIT) in T-bet((-/-)) mice inhibited IL-6, IL-21R and lung TH17 cells in a setting of asthma. Finally, local delivery of an anti-IL-6R antibody in T-bet((-/-)) mice resulted in the resolution of this allergic trait. Noteworthy, BATF, crucial for the immunoglobulin-class-switch and TH2,TH17 development, was found down-regulated in the lungs of T-bet((-/-)) mice after SIT and after treatment with anti-IL-6R antibody, indicating a critical role of IL-6 in controlling BATF/IRF4 integrated functions in TH2, TH17 cells and B cells also in a T-bet independent fashion in allergic asthma.},
author = {Mousset, Stephanie and Koch, Sonja and Mousset, Stephanie and Graser, Anna and Reppert, Sarah and Uebel, Caroline and Reinhardt, Cornelia and Zimmermann, Theodor and Rieker, Ralf and Lehr, Hans A. and Finotto, Susetta},
doi = {10.1038/srep01754},
faupublication = {yes},
journal = {Scientific Reports},
pages = {1754},
peerreviewed = {unknown},
title = {{IL}-6 activated integrated {BATF}/{IRF4} functions in lymphocytes are {T}-bet-independent and reversed by subcutaneous immunotherapy},
volume = {3},
year = {2013}
}
@article{faucris.275307729,
abstract = {Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune evasion in non-small cell lung cancer (NSCLC). We found increased IL-9 and IL-21 production by T cells in the tumoral region of the lung of patients with NSCLC, suggesting the presence of Th9 cells in the lung tumor microenvironment. Moreover, we noted IL-9 producing Tregs in NSCLC. IL-9 target cells in NSCLC consisted of IL-9R+ tumor cells and tumor-infiltrating lymphocytes. In two murine experimental models of NSCLC, and in vitro, IL-9 prevented cell death and controlled growth of lung adenocarcinoma cells. Targeted deletion of IL-9 resulted in successful lung tumor rejection in vivo associated with an induction of IL-21 and reduction of Treg cells. Finally, anti-IL-9 antibody immunotherapy resulted in suppression of tumor development even in established experimental NSCLC and was associated with reduced IL-10 production in the lung. In conclusion, our findings indicate that IL-9 drives immune escape of lung tumor cells via effects on tumor cell survival and tumor infiltrating T cells. Thus, strategies blocking IL-9 emerge as a new approach for clinical therapy of lung cancer.},
author = {Heim, Lisanne and Yang, Zuqin and Tausche, Patrick and Hohenberger, Katja and Chiriac, Mircea-Teodor and Kölle, Julia and Geppert, Carol-Immanuel and Kachler, Katerina and Miksch, Sarah and Graser, Anna and Friedrich, Juliane and Kharwadkar, Rakshin and Rieker, Ralf and Trufa, Denis and Sirbu, Horia and Neurath, Markus and Kaplan, Mark H. and Neurath-Finotto, Susetta},
doi = {10.3389/fimmu.2022.859738},
faupublication = {yes},
journal = {Frontiers in Immunology},
keywords = {IL-9; immune escape; NSCLC; TIL; tumor immunotherapy},
note = {CRIS-Team Scopus Importer:2022-05-20},
peerreviewed = {Yes},
title = {{IL}-9 {Producing} {Tumor}-{Infiltrating} {Lymphocytes} and {Treg} {Subsets} {Drive} {Immune} {Escape} of {Tumor} {Cells} in {Non}-{Small} {Cell} {Lung} {Cancer}},
volume = {13},
year = {2022}
}
@article{faucris.123269344,
abstract = {Recent studies have highlighted a crucial regulatory role of the cytokine IL-9 in driving immune responses in chronic inflammatory and autoimmune diseases at mucosal surfaces. IL-9 activates various types of immune and non-immune cells carrying the membrane bound IL-9R. IL-9 signaling plays a pivotal role in controlling the differentiation and activation of these cells by inducing the Jak/STAT pathway. In particular, IL-9 induces activation of T helper cells and affects the function of various tissue resident cells such as mast cells and epithelial cells in the mucosa. Importantly, recent findings suggest that blockade of IL-9 signaling is effective in treating experimental models of autoimmune and chronic inflammatory diseases such as inflammatory bowel diseases, allergic disorders such as food allergy and asthma. Thus, blockade of IL-9 and IL-9R signaling emerges as potentially novel approach for therapy of inflammatory diseases in the mucosal immune system.},
author = {Neurath, Markus and Finotto, Susetta},
doi = {10.1016/j.cytogfr.2016.02.002},
faupublication = {yes},
journal = {Cytokine & Growth Factor Reviews},
note = {EVALuna2:2054},
pages = {93-9},
peerreviewed = {Yes},
title = {{IL}-9 signaling as key driver of chronic inflammation in mucosal immunity},
volume = {29},
year = {2016}
}
@article{faucris.215697324,
abstract = {Acid sphingomyelinase (ASM) is one of the enzymes that catalyzes the breakdown of sphingomyelin to ceramide and phosphorylcholine. In this study, we aimed at elucidating the role of ASM in allergic asthma. We used an ovalbumin-induced murine model of asthma where we compared wild-type and ASM-deficient mice. In wild-type mice, secretory ASM activity in the bronchoalveolar lavage fluid was increased in the acute ovalbumin model, but not in a tolerogenic model. Furthermore, in the absence of ASM, the serum IgE level was reduced, compared with wild-type mice, while an accumulation of interstitial macrophages and foreign antigen-induced regulatory T cells along with exhausted CD4(+) PD1(+) T cells was observed in the lungs of ASM(-/-) mice. In conclusion, in the absence of ASM, we observed an accumulation of immunosuppressive antigen-induced regulatory T cells expressing Foxp3 and CTLA4 in the lung as well as multinucleated interstitial macrophages and exhausted CD4(+) PD1(+) T cells associated with inhibition of serum IgE in asthma.},
author = {Sopel, Nina and Kölle, Julia and Dumendiak, Sonja and Koch, Sonja and Reichel, Martin and Rhein, Cosima and Kornhuber, Johannes and Finotto, Susetta},
doi = {10.1111/imm.13035},
faupublication = {yes},
journal = {Immunology},
note = {CRIS-Team WoS Importer:2019-04-09},
pages = {373-383},
peerreviewed = {Yes},
title = {{Immunoregulatory} role of acid sphingomyelinase in allergic asthma},
volume = {156},
year = {2019}
}
@inproceedings{faucris.208465659,
author = {Koch, Sonja and Maeding, N. and Karwot, R. and Mirzakhani, H. and Springel, R. and Mittler, S. and Zimmermann, Theodor and Melichar, V. O. and Knipfer, Lisa and Wirtz, Stefan and Weiss, S. T.},
faupublication = {yes},
note = {EVALuna2:33897},
pages = {181-182},
peerreviewed = {Yes},
title = {{Immunoregulatory} role of {NFAT}-interacting protein ({NIP}) 45 in adaptive and innate immune responses in allergic asthma},
volume = {72},
year = {2017}
}
@article{faucris.121805904,
abstract = {In spite of modern therapies for non-small-cell lung cancer (NSCLC), prognosis for many patients is still poor and survival rates are low. Immunotherapy is the possibility to improve the lung immune response surrounding the tumour. However, this approach requires detailed understanding of the local immune-responses of NSCLC patients.We analysed samples from three different regions within the lungs of NSCLC patients, whereas we distinguished between patients suffering from adenocarcinoma and squamous cell carcinoma. Expression of type 1 T helper (Th1)/type 1 cytotoxic (Tc1) factors was assessed by quantitative real-time PCR, western blot analyses or immunohistochemistry. Cytotoxic cell activity of CD8(+) T cells was determined via co-culture with autologous tumour cells and apoptosis assay.We found decreased levels of the transcription factor T-box expressed in T cells (T-bet or Tbx21) and of the downstream activated IFN-?-dependent pSTAT1? isoform in the lung tumour areas of patients with NSCLC as compared with tumour-free control regions. In these patients, reduced T-bet and pSTAT1? levels were found associated with increased immunosuppressive markers like cytotoxic T lymphocyte-associated protein 4, programmed cell death 1 and with a suppression of the Th1 cell cytokine production and Tc1 cell activity.These findings confirm a central role of T-bet in targeted immunotherapy for patients with NSCLC.},
author = {Andreev, Katerina and Trufa, Denis and Siegemund, Raphaela and Rieker, Ralf and Hartmann, Arndt and Schmidt, Joachim and Sirbu, Horia and Finotto, Susetta},
doi = {10.1038/bjc.2015.255},
faupublication = {yes},
journal = {British Journal of Cancer},
note = {EVALuna2:6728},
pages = {902-13},
peerreviewed = {Yes},
title = {{Impaired} {T}-bet-{pSTAT1}? and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma},
volume = {113},
year = {2015}
}
@article{faucris.211546246,
abstract = {Patient data management systems (PDMS) enable digital documentation on intensive care units (ICU) and have positive effects on completness, quality and quantity of documented information. A commercial PDMS was implemented in a 25-bed ICU replacing paper-based patient charting. The ICU electronic patient record is completely managed inside the PDMS. IT compiles data from vital signs monitors, ventilators and further medical devices and facilitates some drug dose and fluid balance calculations as well as data reuse for administrative purposes. Ventilation time and patient severity scoring as well as coding of diagnoses and procedures is supported. Billing data transferred via interface to the central billing system of the hospital. Such benefits should show in measurable parameters, such as documented ventilator time, number of coded diagnoses and procedures and others. These parameters influence reimbursement in the German DRG system. Therefore, measurable changes in cost and reimbursement data of the ICU were expected.A retrospective analysis of documentation quality parameters, cost data and mortality rate of a 25-bed surgical ICU within a German university hospital 3 years before (2004-2006) and 5 years after (2007-2011) PDMS implementation. Selected parameters were documented electronically, consistently and reproducibly for the complete time span of 8 years including those years where no electronic patient recording was available. The following parameters were included: number of cleared DRG, cleared ventilator time, case mix (CM), case mix index (CMI), length of stay, number of coded diagnoses and procedures, detailed overview of a specific procedure code based on daily Apache II and TISS Core 10 scores, mortality, total ICU costs and revenues and partial profits for specific ICU procedures, such as renal replacement therapy and blood products.Systematic shifts were detected over the study period, such as increasing case numbers and decreasing length of stay as well as annual fluctuations in severity of disease seen in the CM and CMI. After PDMS introduction, the total number of coded diagnoses increased but the proportion of DRG relevant diagnoses dropped significantly. The number of procedures increased (not significantly) and the number of procedures per case did not rise significantly. The procedure 8-980 showed a significant increase after PDMS introduction whereas the DRG-relevant proportion of those procedures dropped insignificantly. The number of ventilator-associated DRG cases as well as the total ventilator time increased but not significantly. Costs and revenues increased slightly but profit varied considerably from year to year in the 5 years after system implementation. A small increase was observed per case, per nursing day and per case mix point. Additional revenues for specific ICU procedures increased in the years before and dropped after PDMS implementation. There was an insignificant increase in ICU mortality rate from 7.4 % in the year 2006 (before) to 8.5 % in 2007 (after PDMS implementation). In the following years mortality dropped below the base level.The implementation of the PDMS showed only small effects on documentation of reimbursement-relevant parameters which were too small to set off against the total investment. The method itself, a long-term follow-up of different parameters proved successful and can be adapted by other organizations. The quality of results depends on the availability of long-term parameters in good quality. No significant influence of PDMS on mortality was found.},
author = {Castellanos, Ixchel and Ganslandt, Thomas and Prokosch, Hans-Ulrich and Schüttler, Jürgen and Bürkle, Thomas},
doi = {10.1007/s00101-013-2239-x},
faupublication = {yes},
journal = {Anaesthesist},
note = {EVALuna2:113},
pages = {887-97},
peerreviewed = {Yes},
title = {{Implementation} of a patient data management system : {Effects} on intensive care documentation},
volume = {62},
year = {2013}
}
@article{faucris.227176815,
abstract = {Background From 2014 to 2017, the Palliative Medicine Working Group developed and published best practice recommendations for the integration of palliative care in Comprehensive Cancer Centers (CCCs) in Germany. To evaluate the implementation level of these recommendations in the CCCs an online survey was performed. Based on the results of this study, strategic tandem partnerships between CCCs should be built in order to foster further local development. Materials and Methods Directors of all CCCs were contacted by e-mail between December 2017 and February 2018. At the time of the survey, 15 CCCs were funded by the German Cancer Aid. The level of implementation of the recommendations in individual CCCs was established using a transtheoretical model. Results Between December 2017 and February 2018, all 15 contacted directors or their representatives of the CCCs took part in the survey. More than two thirds of the CCCs have a palliative service as well as a day clinic and palliative outpatient clinic. Regional networking and the provision of a palliative care unit were approved by all CCCs. Conclusion The publication of best practice recommendations was a milestone for the integration of palliative care in the CCCs. The majority of the German CCCs already fulfill essential organizational and structural requirements. There is a particular need for optimization in the provision of a basic qualification for general palliative care and emergency admission personnel. Implications for Practice In 2017, the Palliative Medicine Working Group in the network of the German Comprehensive Cancer Centers (CCCs) published the best practice recommendations it had developed for the integration of palliative medicine in CCCs in Germany. In order to evaluate the level of implementation of the recommendations, an online survey of the CCC directors was established. The majority of German CCCs fulfil elementary organizational and structural requirements. However, there is still room for improvement in the provision of a basic qualification for general palliative care and emergency admission personnel.},
author = {Gahr, Susanne and Lödel, Sarah and Berenot, Julia and Thomas, Michael and Ostgathe, Christoph},
doi = {10.1634/theoncologist.2019-0126},
faupublication = {yes},
journal = {Oncologist},
note = {CRIS-Team WoS Importer:2019-09-27},
peerreviewed = {Yes},
title = {{Implementation} of {Best} {Practice} {Recommendations} for {Palliative} {Care} in {German} {Comprehensive} {Cancer} {Centers}},
year = {2019}
}
@article{faucris.233847573,
abstract = {We investigated whether the integration of machine learning (ML) into MRI interpretation can provide accurate decision rules for the management of suspicious breast masses. A total of 173 consecutive patients with suspicious breast masses upon complementary assessment (BI-RADS IV/V: n = 100/76) received standardized breast MRI prior to histological verification. MRI findings were independently assessed by two observers (R1/R2: 5 years of experience/no experience in breast MRI) using six (semi-)quantitative imaging parameters. Interobserver variability was studied by ICC (intraclass correlation coefficient). A polynomial kernel function support vector machine was trained to differentiate between benign and malignant lesions based on the six imaging parameters and patient age. Ten-fold cross-validation was applied to prevent overfitting. Overall diagnostic accuracy and decision rules (rule-out criteria) to accurately exclude malignancy were evaluated. Results were integrated into a web application and published online. Malignant lesions were present in 107 patients (60.8%). Imaging features showed excellent interobserver variability (ICC: 0.81–0.98) with variable diagnostic accuracy (AUC: 0.65–0.82). Overall performance of the ML algorithm was high (AUC = 90.1%; BI-RADS IV: AUC = 91.6%). The ML algorithm provided decision rules to accurately rule-out malignancy with a false negative rate <1% in 31.3% of the BI-RADS IV cases. Thus, integration of ML into MRI interpretation can provide objective and accurate decision rules for the management of suspicious breast masses, and could help to reduce the number of potentially unnecessary biopsies.
Gerade bei der Behandlung von Menschen am Ende des Lebens ergibt sich hieraus ein Spannungsverhältnis zwischen Effizienz auf der einen und bestmöglicher Pflege bzw. Begleitung von Patienten auf der anderen Seite. Untersuchungen zeigten auch, dass auf Palliativstationen die Prävalenz von multiresistenten Erregern wie zum Beispiel MRSA-Kolonisationen gegenüber dem Krankenhausdurchschnitt deutlich erhöht ist.
Eine systematische Literaturrecherche zu diesem Thema ergab, dass mit Ausnahme einer Studie keine Publikationen zur Analyse der durch multiresistente Erreger zusätzlich verursachten Kosten im palliativen bzw. geriatrischen Kontext existieren. Die benannte Veröffentlichung betrachtet dabei die Kostensituation bei der Behandlung von Patienten am Lebensende auf einer geriatrischen Station. Anhand der hier vorliegenden Studie werden die zusätzlich durch MRE entstehenden Kosten bei der Behandlung von Patienten am Ende des Lebens auf einer Palliativstation analysiert und mögliche Kostentreiber identifiziert.
Die vorliegende Analyse wurde im Rahmen des multizentrischen Projekts „Untersuchung der Auswirkungen von Infektionen oder Kolonisationen mit MRSA oder anderen multiresistenten Erregern auf Patienten am Lebensende“ durchgeführt. Hintergrund des Gesamtprojektes, „MRSA in End-of-Life Care“ (M-EndoL, BMBF-Projektnummer 01GY1314), ist die Entwicklung eines wissenschaftlich fundierten, patienten- und familienzentrierten Ansatzes zum Umgang mit hospitalisierten Patienten mit MRE-Nachweis am Lebensend}, author = {Adelhardt, Thomas and Hessemer, Stefanie and Heckel, Maria and Herbst, Franziska A. and Stiel, Stephanie and Ostgathe, Christoph and Schöffski, Oliver}, doi = {10.1055/a-0651-6448}, faupublication = {yes}, journal = {Gesundheitsökonomie und Qualitätsmanagement}, peerreviewed = {Yes}, title = {{Kosten} von multiresistenten {Erregern} in der stationären {Palliativversorgung}}, year = {2018} } @article{faucris.218995303, abstract = {Background Modern palliative medicine is a young discipline that has developed its independent profile with specific guiding concepts, goals and values. The history of the subject and the development of a palliative vocabulary can be explored by analysing specialised publications.}, author = {Peters, Joachim and Heckel, Maria and Habermann, Mechthild and Ostgathe, Christoph}, doi = {10.1055/a-0873-4234}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, note = {CRIS-Team WoS Importer:2019-05-28}, pages = {125-131}, peerreviewed = {No}, title = {{Language} in {Motion} - {Time}-{Typical} {Vocabulary} of {Palliative} {Medicine}}, volume = {20}, year = {2019} } @article{faucris.209508705, abstract = {The avoidance of neuromuscular blocking agents (NMBA) for endotracheal intubation is associated with a higher incidence of laryngeal discomfort and lesions, but could impair effectiveness of intra operative recurrent laryngeal nerve monitoring (IONM).In a retrospective quality assessment study over a period of 30 months, a collective that had been intubated without NMBA was compared with a group, which had received NMBA. Endolaryngeal EMG was accomplished with a MagStim(®)-EMG-electrode.Out of the 127 patients with 224 nerves at risk (NAR; NMBA 102 NAR, no NMBA 122 NAR), more than 90% received a total intravenous anaesthesia with propofol, and 88% had remifentanil. Laryngeal side effects and damage scores did not differ significantly.In this special setting of IONM and thyroid surgery, avoidance of NMBA for endotracheal intubation seems not to increase the incidence of laryngeal side effects and lesions. If endotracheal intubation without NMBA is required, the authors suggest a standardized approach using induction agents as propofol and remifentanil.}, author = {Birkholz, Torsten and Irouschek, Andrea and Saalfrank-Schardt, Christina and Klein, Peter and Schmidt, Joachim}, doi = {10.1016/j.anl.2011.07.001}, faupublication = {yes}, journal = {Auris Nasus Larynx}, note = {EVALuna2:15058}, pages = {288-93}, peerreviewed = {Yes}, title = {{Laryngeal} morbidity after intubation with or without neuromuscular block in thyroid surgery using recurrent laryngeal nerve monitoring}, volume = {39}, year = {2012} } @inproceedings{faucris.249344655, address = {SHEFFIELD}, author = {Yang, Zuqin and Li, Nina and Kölle, Julia and Rieker, Ralf and Finotto, Susetta}, booktitle = {EUROPEAN RESPIRATORY JOURNAL}, doi = {10.1183/13993003.congress-2020.4080}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-02-12}, peerreviewed = {unknown}, publisher = {EUROPEAN RESPIRATORY SOC JOURNALS LTD}, title = {{Late} {Breaking} {Abstract} - {GATA}-3 in lung {CD4}+{T} cells drives {Interleukin}-10 deficiency-induced lung inflammation in asthma}, year = {2020} } @inproceedings{faucris.249344407, address = {SHEFFIELD}, author = {Neurath, Laura and Trufa, Denis and Geppert, Carol-Immanuel and Rieker, Ralf and Sirbu, Horia and Finotto, Susetta}, booktitle = {EUROPEAN RESPIRATORY JOURNAL}, doi = {10.1183/13993003.congress-2020.3937}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-02-12}, peerreviewed = {unknown}, publisher = {EUROPEAN RESPIRATORY SOC JOURNALS LTD}, title = {{Late} {Breaking} {Abstract} - {Induction} of the transcriptional repressor {B} lymphocytes-induced maturation protein-1 ({Blimp}-1) in lung cancer}, year = {2020} } @inproceedings{faucris.249345896, address = {SHEFFIELD}, author = {Krammer, Susanne and Li, Nina and Yang, Zuqin and Kölle, Julia and Geppert, Carol-Immanuel and Rieker, Ralf and Graham, Gerard and Finotto, Susetta}, booktitle = {EUROPEAN RESPIRATORY JOURNAL}, doi = {10.1183/13993003.congress-2020.306}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-02-12}, peerreviewed = {unknown}, publisher = {EUROPEAN RESPIRATORY SOC JOURNALS LTD}, title = {{Late} {Breaking} {Abstract} - {The} {Role} of the chemokine receptor {CCR3} in {House} {Dust} {Mite} ({HDM}) induced experimental asthma}, year = {2020} } @article{faucris.209600556, abstract = {The world of medicine is becoming from year to year more complex. This necessitates efficient learning processes, which incorporate the principles of adult education but with unchanged periods of further education. The subject matter must be processed, organized, visualized, networked and comprehended. The learning process should be voluntary and self-driven with the aim of learning the profession and becoming an expert in a specialist field. Learning is an individual process. Despite this, the constantly cited learning styles are nowadays more controversial. An important factor is a healthy mixture of blended learning methods, which also use new technical possibilities. These include a multitude of e‑learning options and simulations, which partly enable situative learning in a "shielded" environment. An exemplary role model of the teacher and feedback for the person in training also remain core and sustainable aspects in medical further education.}, author = {Breuer, Georg and Lütcke, Björn and St. Pierre, Michael and Hüttl, Stephan}, doi = {10.1007/s00101-017-0278-4}, faupublication = {yes}, journal = {Anaesthesist}, note = {EVALuna2:35116}, pages = {137-150}, peerreviewed = {Yes}, title = {{Learning} how to learn for specialist further education}, volume = {66}, year = {2017} } @article{faucris.312957341, abstract = {Concomitant LAA occlusion has been shown to be an effective and safe treatment for patients with atrial fibrillation during cardiac surgery to prevent embolic stroke. Minimally invasive procedures are challenging due to restricted access to and visibility of the surgical site. Also, aortic endoclamping has been developed as an alternative surgical approach to exoclamping. The aim of this article is to demonstrate the method of beating heart LAA occlusion with the Atriclip® (AtriCure, Mason, OH, USA) device during minimally invasive mitral valve surgery while using the endoclamping alternative for aortic cross-clamping.}, author = {Suleiman, Mathieu and Kaemmerer, Ann-Sophie and Fechner, Jörg and Nooh, Ehab and Weyand, Michael and Heim, Christian}, doi = {10.3390/jcm12196325}, faupublication = {yes}, journal = {Journal of Clinical Medicine}, keywords = {AtriClip; IntraClude Device; minimally invasive surgery; mitral valve prolapse; mitral valve replacement}, note = {CRIS-Team Scopus Importer:2023-10-20}, peerreviewed = {Yes}, title = {{Left} {Atrial} {Appendage} {Occlusion} on a {Beating} {Heart} during {Minimally} {Invasive} {Valve} {Surgery} {Using} an {Aortic} {Endoclamp}: {A} {Case} {Report}}, volume = {12}, year = {2023} } @inproceedings{faucris.265271345, author = {Becker, Linda and Kauzner, Saskia and Pretscher, Anna and Rohleder, Nicolas}, booktitle = {78th Annual Meeting of the American Psychosomatic Society: Conference canceled due to COVID-19}, faupublication = {yes}, peerreviewed = {unknown}, title = {{Life} satisfaction buffers the effects of inflammation on cognitive aging}, year = {2020} } @article{faucris.242009361, abstract = {Lysosomes accumulate many drugs several fold higher compared to their extracellular concentration. This mechanism is believed to be responsible for many pharmacological effects. So far, uptake and release kinetics are largely unknown and interactions between concomitantly administered drugs often provoke mutual interference. In this study, we addressed these questions in a cell culture model. The molecular mechanism for lysosomal uptake kinetics was analyzed by live cell fluorescence microscopy in SY5Y cells using four drugs (amantadine, amitriptyline, cinnarizine, flavoxate) with different physicochemical properties. Drugs with higher lipophilicity accumulated more extensively within lysosomes, whereas a higher pKa value was associated with a more rapid uptake. The drug-induced displacement of LysoTracker was neither caused by elevation of intra-lysosomal pH, nor by increased lysosomal volume. We extended our previously developed numerical single cell model by introducing a dynamic feedback mechanism. The empirical data were in good agreement with the results obtained from the numerical model. The experimental data and results from the numerical model lead to the conclusion that intra-lysosomal accumulation of lipophilic xenobiotics enhances lysosomal membrane permeability. Manipulation of lysosomal membrane permeability might be useful to overcome, for example, multi-drug resistance by altering subcellular drug distribution. © 2010 Wiley-Liss, Inc.}, author = {Kornhuber, Johannes and Henkel, Andreas W. and Groemer, Teja W. and Städtler, Sven and Welzel, Oliver and Tripal, Philipp and Rotter, Andrea and Bleich, Stefan and Trapp, Stefan}, doi = {10.1002/jcp.22112}, faupublication = {yes}, journal = {Journal of Cellular Physiology}, note = {Created from Fastlane, Scopus look-up}, pages = {152-164}, peerreviewed = {Yes}, title = {{Lipophilic} cationic drugs increase the permeability of lysosomal membranes in a cell culture system}, volume = {224}, year = {2010} } @article{faucris.123402224, author = {Will, Christoph and Shi, Kilin and Schellenberger, Sven and Steigleder, Tobias and Michler, Fabian and Weigel, Robert and Ostgathe, Christoph and Kölpin, Alexander}, doi = {10.1109/JERM.2017.2766567}, faupublication = {yes}, journal = {IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology}, pages = {81-89}, peerreviewed = {Yes}, title = {{Local} {Pulse} {Wave} {Detection} using {Continuous} {Wave} {Radar} {Systems}}, volume = {1}, year = {2017} } @article{faucris.279008235, abstract = {The long-term stability of drugs under normal laboratory storage conditions (-20 degrees C) for years is important for research purposes, clinical re-evaluation, and also for forensic toxicology. To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. Blood samples were disposed using solid-phase extraction with an additional substitution of stable isotope labelled hydromorphone as an internal standard. Hydromorphone concentrations were determined by ultra-performance liquid chromatography (UPLC) with gradient elution, followed by tandem mass spectrometry with electrospray ionization. Calibration curves demonstrated linearity of the assay in the concentration range of 0.3-20 ng/mL hydromorphone. The limit of detection of the hydromorphone plasma concentration was 0.001 ng/mL, and the lower limit of quantification was 0.3 ng/mL. Intra- and interassay errors did not exceed 16%. The percentage deviation of the measured hydromorphone plasma concentrations between the reanalysis and the first analysis was -1.07% +/- 14.8% (mean +/- SD). These results demonstrate that hydromorphone concentration in human plasma was stable when the samples were frozen at -20 degrees C over three years. This finding is of value for re-evaluations or delayed analyses for research purposes and in pharmacokinetic studies, such as in forensic medicine.}, author = {Wehrfritz, Andreas and Schmidt, Stefanie and Ihmsen, Harald and Schüttler, Jürgen and Jeleazcov, Christian}, doi = {10.1155/2022/3645048}, faupublication = {yes}, journal = {International Journal of Analytical Chemistry}, note = {CRIS-Team WoS Importer:2022-07-29}, peerreviewed = {Yes}, title = {{Long}-{Term} {Stability} of {Hydromorphone} in {Human} {Plasma} {Frozen} at-20 degrees {C} for {Three} {Years} {Quantified} by {LC}-{MS}/{MS}}, volume = {2022}, year = {2022} } @inproceedings{faucris.266781330, address = {BETHESDA}, author = {Tausche, Patrick and Trufa, Denis and Geppert, Carol-Immanuel and Rieker, Ralf and Sirbu, Horia and Neurath-Finotto, Susetta}, booktitle = {JOURNAL OF IMMUNOLOGY}, doi = {10.4049/jimmunol.206.supp.56.07}, faupublication = {yes}, note = {CRIS-Team WoS Importer:2021-12-03}, peerreviewed = {unknown}, publisher = {AMER ASSOC IMMUNOLOGISTS}, title = {{Lung} tumor immune evasion mechanism in {Non}-small cell lung cancer ({NSCLC}) targets {pSTAT5} in {CD4}+{CD25}+{FoxP3}-{T} effector cells}, year = {2021} } @article{faucris.110583484, abstract = {Stroke-associated immunosuppression is an increasingly recognized factor triggering infections and thus potentially influencing outcome after stroke. Specifically, lymphocytopenia after intracerebral hemorrhage (ICH) has only been addressed in small-sized retrospective studies of mixed intracranial bleedings. This cohort study investigated the natural course of lymphocytopenia, parameters associated with lymphocytopenia on admission (LOA) and during stay, and evaluated the clinical impact of lymphocytopenia in solely ICH patients.This observational study included 855 consecutive patients with ICH. Patient demographics, clinical and neuroradiological data as well as laboratory and in-hospital measures were retrieved from institutional prospective databases. Functional 3-month outcome was assessed by mailed questionnaires. Lymphocytopenia was defined as <1.0 (10(9)/L) and was correlated with patient's characteristics and outcome.Prevalence of LOA was 27.3%. Patients with LOA showed significant associations with poorer neurological status (18 [10-32] versus 13 [5-24]; P<0.001), larger hematoma volume (18.5 [6.2-46.2] versus 12.8 [4.4-37.8]; P=0.006), and unfavorable outcome (74.7% versus 63.3%; P=0.0018). Natural course of lymphocyte count during hospital stay revealed a lymphocyte nadir of 1.1 (0.80-1.53 [10(9)/L]) at day 5. Focusing on patients with day-5-lymphocytopenia, compared with patients with LOA, revealed increased rates of infections (63 [71.6] versus 113 [48.5]; P<0.001) and poorer functional outcome at 3 months (76 [86.4] versus 175 [75.1); P=0.029). Adjusting for baseline confounders, multivariable logistic and receiver operating characteristics analyses documented independent associations of day-5-lymphocytopenia with unfavorable outcome (day-5-lymphocytopenia: odds ratio, 2.017 [95% confidence interval, 1.029-3.955], P=0.041; LOA: odds ratio, 1.391 [0.795-2.432], P=0.248; receiver operating characteristics: day-5-lymphocytopenia: area under the curve=0.673, P<0.0001, Youden's index=0.290; LOA: area under the curve=0.513, P=0.676, Youden's index=0.084), whereas receiver operating characteristics analyses revealed no association of age or hematoma volume with day-5-lymphocytopenia (age: area under the curve=0.540, P=0.198, Youden's index=0.106; volume: area under the curve=0.550, P=0.0898, Youden's index=0.1224).Lymphocytopenia is frequently present in patients with ICH and may represent an independent parameter associated with unfavorable functional outcome. Developing lymphocytopenia affected outcome even stronger than LOA, a finding that may open up new therapeutic avenues in specific subsets of patients with ICH.}, author = {Giede-Jeppe, Antje and Bobinger, Tobias and Gerner, Stefan and Madzar, Dominik and Sembill, Jochen and Lücking, Hannes and Kloska, Stephan and Keil, Toni and Kuramatsu, Joji and Huttner, Hagen}, doi = {10.1161/STROKEAHA.116.013003}, faupublication = {yes}, journal = {Stroke}, note = {EVALuna2:22442}, pages = {1239-46}, peerreviewed = {unknown}, title = {{Lymphocytopenia} {Is} an {Independent} {Predictor} of {Unfavorable} {Functional} {Outcome} in {Spontaneous} {Intracerebral} {Hemorrhage}}, volume = {47}, year = {2016} } @article{faucris.106314604, abstract = {Fine-meshed perioperative measurements are offering enormous potential for automatically investigating clinical complications during general anesthesia. In this study, we employed multiple machine learning methods to model perioperative hypoxia and compare their respective capabilities. After exporting and visualizing 620 series of perioperative vital signs, we had ten anesthesiologists annotate the subjective presence and severity of temporary post-intubation oxygen desaturation. We then applied specific clustering and prediction methods on the acquired annotations, and evaluated their performance in comparison to the inter-rater agreement between experts. When reproducing the expert annotations, the sensitivity and specificity of multi-layer neural networks substantially outperformed clustering and simpler threshold-based methods. The achieved performance of our best automated hypoxia models thereby approximately equaled the observed agreement between different medical experts. Furthermore, we deployed our classification methods for processing unlabeled inputs to estimate the incidence of hypoxic episodes in another sizeable patient cohort, which attests to the feasibility of using the approach on a larger scale. We interpret that our machine learning models could be instrumental for computerized observational studies of the clinical determinants of post-intubation oxygen deficiency. Future research might also investigate potential benefits of more advanced preprocessing approaches such as automated feature learning.}, author = {Sippl, Philipp and Ganslandt, Thomas and Prokosch, Hans-Ulrich and Münster, Tino and Toddenroth, Dennis}, faupublication = {yes}, journal = {Studies in health technology and informatics}, note = {EVALuna2:179}, pages = {212-216}, peerreviewed = {Yes}, title = {{Machine} {Learning} {Models} of {Post}-{Intubation} {Hypoxia} {During} {General} {Anesthesia}}, volume = {243}, year = {2017} } @article{faucris.229748718, abstract = {Objectives: This prospective, comparative, clinical study analyzed the postoperative bleeding risk of patients on anticoagulation therapy (AT) who were undergoing tooth extractions and osteotomies. Materials and methods: Patients with the following ATs were included (test groups): (1.) platelet aggregation inhibitors (PAIs), (2.) vitamin K inhibitors, (3.) low molecular weight heparin (LMWH), and (4.) direct oral anticoagulants (DOACs). Patients in the control group were not on any AT (non-AT group). Patients were subdivided into the following treatment groups: (1.) single tooth extraction, (2.) serial extraction (≥ 2 adjacent teeth), and (3.) tooth osteotomy. Pre-, intra-, and postoperative data concerning the treatment, extent of the surgery, and bleeding were recorded and statistically evaluated. Results: There were 15 postoperative bleeding events in 838 patients (1.7%): four (0.7%) in the non-AT group (n = 603 patients) and 11 (4.7%) in the AT group (n = 235 patients). The surgical procedure had no statistically significant effect on postoperative bleeding frequencies. Patients taking vitamin K inhibitors had a significantly higher risk of postoperative bleeding compared with patients without AT (p < 0.00001). Four patients were hospitalized due to the severity of the bleeding (vitamin K inhibitor group). Postoperative bleeding events were all controlled with local hemostatic measures. Conclusions: The postoperative bleeding risk after tooth extractions and osteotomies in patients continuing AT is low, and bleeding can be controlled with local hemostatic measures. Clinical relevance: AT should be continued in patients undergoing tooth removal procedures under the provision that local hemostatic measures are applied.}, author = {Schmitt, Christopher and Rusche, Birgit and Clemm, Raphael and Neukam, Friedrich Wilhelm and Buchbender, Mayte}, doi = {10.1007/s00784-019-03124-3}, faupublication = {yes}, journal = {Clinical Oral Investigations}, keywords = {Anticoagulation therapy; Oral surgery; Osteotomy; Tooth extraction}, note = {CRIS-Team Scopus Importer:2019-11-26}, peerreviewed = {Yes}, title = {{Management} of anticoagulated patients in dentoalveolar surgery: a clinical comparative study}, year = {2019} } @article{faucris.124145384, abstract = {This prospective clinical comparative study aimed to analyze the postoperative bleeding risk of patients continuing their anticoagulation therapy (AT) and undergoing implant surgery and bone grafting procedures.The treatments ranged from the insertion of single or multiple dental implants over implant exposures to sinus floor augmentation and vertical and/or lateral bone grafting with autologous bone grafts. The patients of the test groups (AT groups) were treated with platelet aggregation inhibitors (PAIs), Vitamin-K inhibitors, Vitamin-K inhibitor withdrawal bridged with heparin (LMWH), or new/direct oral anticoagulants (NOACs/DOACs). Patients of the control group were non-anticoagulated (non-AT group). Surgical procedures were performed in the same manner in all groups. Pre, intra, and postoperative data concerning the treatment, extent of the surgery and bleedings was recorded and statistically evaluated.There were seven postoperative bleedings in 564 patients (1.2%), four in the AT groups (3.4%), and three in the non-AT group (0.6%). No thromboembolic complication occurred in the whole observation period. The invasiveness of the surgical procedure had no statistically significant effect on bleeding frequencies. Patients taking Vitamin-K inhibitors had a significantly higher risk of a postoperative bleeding compared to patients without any AT (P = 0.038). Two patients were hospitalized due to the severity of the bleeding as a precautionary measure (one in the non-AT and one in the PAI group). All bleedings were easily controllable with local hemostatic measures. There was no postoperative bleeding recorded for patients taking DOACs.Anticoagulation therapy should be continued in patients undergoing implant surgery and bone grafting procedures avoiding thromboembolic complications. Surgeons should always apply the most minimally invasive approach to reduce postoperative risks and be able to apply local hemostatic measures in terms of a bleeding complication.}, author = {Clemm, Raphael and Neukam, Friedrich Wilhelm and Rusche, Birgit and Bauersachs, A. and Musazada, S. and Schmitt, Christopher}, doi = {10.1111/clr.12732}, faupublication = {yes}, journal = {Clinical Oral Implants Research}, note = {EVALuna2:24426}, pages = {1274-1282}, peerreviewed = {Yes}, title = {{Management} of anticoagulated patients in implant therapy: a clinical comparative study}, volume = {27}, year = {2016} } @article{faucris.265504370, abstract = {The majority of asthma exacerbations in children are caused by Rhinovirus (RV), a positive sense single stranded RNA virus of the Picornavirus family. The host has developed virus defense mechanisms that are mediated by the upregulation of interferon-activated signaling. However, the virus evades the immune system by inducing immunosuppressive cytokines and surface molecules like programmed cell death protein 1 (PD-1) and its ligand (PD-L1) on immunocompetent cells. Initially, RV infects epithelial cells, which constitute a physiologic mucosal barrier. Upon virus entrance, the host cell immediately recognizes viral components like dsRNA, ssRNA, viral glycoproteins or CpG-DNA by host pattern recognition receptors (PRRs). Activation of toll like receptors (TLR) 3, 7 and 8 within the endosome and through MDA-5 and RIG-I in the cytosol leads to the production of interferon (IFN) type I and other antiviral agents. Every cell type expresses IFNAR1/IFNAR2 receptors thus allowing a generalized antiviral activity of IFN type I resulting in the inhibition of viral replication in infected cells and preventing viral spread to non-infected cells. Among immune evasion mechanisms of the virus, there is downregulation of IFN type I and its receptor as well as induction of the immunosuppressive cytokine TGF-β. TGF-β promotes viral replication and is associated with induction of the immunosuppression signature markers LAP3, IDO and PD-L1. This article reviews the recent advances on the regulation of interferon type I expression in association with RV infection in asthmatics and the immunosuppression induced by the virus.}, author = {Yang, Zuqin and Mitländer, Hannah and Vuorinen, Tytti and Finotto, Susetta}, doi = {10.3389/fimmu.2021.731846}, faupublication = {yes}, journal = {Frontiers in Immunology}, keywords = {asthma; host defense; immune evasion; interferon type I; rhinovirus}, note = {CRIS-Team Scopus Importer:2021-10-29}, peerreviewed = {Yes}, title = {{Mechanism} of {Rhinovirus} {Immunity} and {Asthma}}, volume = {12}, year = {2021} } @article{faucris.108042484, abstract = {The heart as a contractile hollow organ finely tunes mechanical parameters such as stroke volume, stroke pressure and cardiac output according to filling volumes, filling pressures via intrinsic and neuronal routes. At the cellular level, cardiomyocytes in beating hearts are exposed to large mechanical stress during successive heart beats. Although the mechanisms of excitation-contraction coupling are well established in mammalian heart cells, the putative contribution of mechanosensitive channels to Ca homeostasis, Ca signaling and force generation has been primarily investigated in relation to heart disease states. For instance, transient receptor potential channels (TRPs) are up-regulated in animal models of congestive heart failure or hypertension models and seem to play a vital role in pathological Ca overload to cardiomyocytes, thus aggravating the pathology of disease at the cellular level. Apart from that, the contribution of mechanosensitive channels (MsC) in the normal beating heart to the downstream force activation cascade has not been addressed. We present an overview of the current literature and concepts of mechanosensitive channel involvement in failing hearts and cardiomyopathies and novel data showing a likely contribution of Ca influx via mechanosensitive channels in beating normal cardiomyocytes during systolic shortening. © 2012 Elsevier Ltd.}, author = {Friedrich, Oliver and Wagner, Sören and Battle, Andrew and Schürmann, Sebastian and Martinac, Boris}, doi = {10.1016/j.pbiomolbio.2012.08.009}, faupublication = {yes}, journal = {Progress in Biophysics & Molecular Biology}, keywords = {Calcium homeostasis; Cardiomyocytes; Heartbeat; Mechanosensitive channel; Transient receptor potential channel}, pages = {226-238}, peerreviewed = {Yes}, title = {{Mechano}-regulation of the beating heart at the cellular level - {Mechanosensitive} channels in normal and diseased heart}, volume = {110}, year = {2012} } @article{faucris.211349304, author = {Ostgathe, Christoph and Lang, Frieder and Bogdan, Christian and Sieber, Cornel and Schöffski, Oliver and Stiel, Stephanie and Heckel, Maria and Tiedtke, Johanna and Sturm, Alexander and Adelhardt, Thomas}, doi = {10.1055/s-0034-1374204}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, peerreviewed = {No}, title = {{M}-{EndoL}: {MRSA} in der {Versorgung} am {Lebensende} - {Untersuchung} der {Auswirkungen} von {MRSA}- (oder andere multiresistente {Keim}-) {Kolonisation} oder {Infektion} auf {Patienten} am {Lebensende}, deren {Angehörige}, {Teammitglieder} und {Einrichtungen}}, volume = {15}, year = {2014} } @article{faucris.211351214, author = {Peters, Joachim and Dykes, Nathan and Habermann, Mechthild and Ostgathe, Christoph and Heckel, Maria}, faupublication = {yes}, journal = {Metaphor and the Social World}, pages = {221-241}, peerreviewed = {Yes}, title = {{Metaphors} for multidrug-resistant bacteria in {German} newspaper articles, 1995-2015. {A} computer-assisted qualitative study.}, volume = {9}, year = {2019} } @article{faucris.248703463, abstract = {Long-lived antibody-secreting plasma cells are essential to establish humoral memory against pathogens. While a regulatory transcription factor network has been established in plasma cell differentiation, the regulatory role of miRNAs remains enigmatic. We have recently identified miR-148a as the most abundant miRNA in primary mouse and human plasma cells. To determine whether this plasma cell signature miRNA controls the in vivo development of B cells into long-lived plasma cells, we established mice with genomic, conditional, and inducible deletions of miR-148a. The analysis of miR-148a-deficient mice revealed reduced serum Ig, decreased numbers of newly formed plasmablasts and reduced CD19-negative, CD93-positive long-lived plasma cells. Transcriptome and metabolic analysis revealed an impaired glucose uptake, a reduced oxidative phosphorylation-based energy metabolism, and an altered abundance of homing receptors CXCR3 (increase) and CXCR4 (reduction) in miR-148a-deficient plasma cells. These findings support the role of miR-148a as a positive regulator of the maintenance of long-lived plasma cells.}, author = {Pracht, Katharina and Meinzinger, Julia and Schulz, Sebastian and Daum, Patrick and Corte-Real, Joana and Hauke, Manuela and Roth, Eduard and Kindermann, Dorothea and Mielenz, Dirk and Schuh, Wolfgang and Wittmann, Jürgen and Jäck, Hans-Martin}, doi = {10.1002/eji.202048993}, faupublication = {yes}, journal = {European Journal of Immunology}, keywords = {CXC receptors; Glut-1; miR-148a; Oxidative phosphorylation; Plasma cells}, note = {CRIS-Team Scopus Importer:2021-02-05}, peerreviewed = {Yes}, title = {{miR}-148a controls metabolic programming and survival of mature {CD19}-negative plasma cells in mice}, year = {2021} } @article{faucris.123429944, abstract = {B cells undergo affinity maturation and class switch recombination of their immunoglobulin receptors during a germinal center (GC) reaction, before they differentiate into long-lived antibody-secreting plasma cells (PCs). Transcription factors such as Bach2 and Mitf are essential during this process, as they delay premature differentiation of GC B cells by repressing Blimp-1 and IRF4, two transcription factors required for terminal PC differentiation. Therefore, Bach2 and Mitf expression must be attenuated in activated B cells to allow terminal PC differentiation, but the precise mechanism remains enigmatic. Here, we provide evidence that miR-148a, a small noncoding microRNA, fosters PC differentiation and survival. Next-generation sequencing revealed that miR-148a is the most abundant microRNA in primary human and murine PCs, and its expression is upregulated in activated murine B cells and coincides with Blimp-1 synthesis. miR-148a targets Bach2, Mitf and proapoptotic factors such as PTEN and Bim. When prematurely expressed, miR-148a promotes the differentiation and survival of plasmablasts and reduces frequencies of IgG1(+) cells in primary B-cell cultures. In summary, we propose that miR-148a is a new player in the regulatory network controlling terminal PC differentiation and could, therefore, be a therapeutic target for interfering with PC differentiation and survival.}, author = {Porstner, Martina and Winkelmann, Rebecca and Daum, Patrick and Schmid, Julia and Pracht, Katharina and Corte-Real, Joana and Schreiber, Sandra and Haftmann, Claudia and Brandl, Andreas and Mashreghi, Mir-Farzin and Gelse, Kolja and Hauke, Manuela and Wirries, Ina and Zwick, Markus and Roth, Edith and Radbruch, Andreas and Wittmann, Jürgen and Jäck, Hans-Martin}, doi = {10.1002/eji.201444637}, faupublication = {yes}, journal = {European Journal of Immunology}, note = {EVALuna2:13632}, pages = {1206-15}, peerreviewed = {Yes}, title = {{miR}-148a promotes plasma cell differentiation and targets the germinal center transcription factors {Mitf} and {Bach2}}, volume = {45}, year = {2015} } @article{faucris.207825193, abstract = {INTRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. Similar to other large international data sharing networks (e.g. OHDSI, PCORnet, eMerge, RD-Connect) MIRACUM is a consortium of academic and hospital partners as well as one industrial partner in eight German cities which have joined forces to create interoperable data integration centres (DIC) and make data within those DIC available for innovative new IT solutions in patient care and medical research. OBJECTIVES: Sharing data shall be supported by common interoperable tools and services, in order to leverage the power of such data for biomedical discovery and moving towards a learning health system. This paper aims at illustrating the major building blocks and concepts which MIRACUM will apply to achieve this goal. GOVERNANCE AND POLICIES: Besides establishing an efficient governance structure within the MIRACUM consortium (based on the steering board, a central administrative office, the general MIRACUM assembly, six working groups and the international scientific advisory board), defining DIC governance rules and data sharing policies, as well as establishing (at each MIRACUM DIC site, but also for MIRACUM in total) use and access committees are major building blocks for the success of such an endeavor. ARCHITECTURAL FRAMEWORK AND METHODOLOGY: The MIRACUM DIC architecture builds on a comprehensive ecosystem of reusable open source tools (MIRACOLIX), which are linkable and interoperable amongst each other, but also with the existing software environment of the MIRACUM hospitals. Efficient data protection measures, considering patient consent, data harmonization and a MIRACUM metadata repository as well as a common data model are major pillars of this framework. The methodological approach for shared data usage relies on a federated querying and analysis concept. USE CASES: MIRACUM aims at proving the value of their DIC with three use cases: IT support for patient recruitment into clinical trials, the development and routine care implementation of a clinico-molecular predictive knowledge tool, and molecular-guided therapy recommendations in molecular tumor boards. RESULTS: Based on the MIRACUM DIC release in the nine months conceptual phase first large scale analysis for stroke and colorectal cancer cohorts have been pursued. DISCUSSION: Beyond all technological challenges successfully applying the MIRACUM tools for the enrichment of our knowledge about diagnostic and therapeutic concepts, thus supporting the concept of a Learning Health System will be crucial for the acceptance and sustainability in the medical community and the MIRACUM university hospitals. }, author = {Prokosch, Hans-Ulrich and Acker, Till and Bernarding, Johannes and Binder, Harald and Boeker, Martin and Boerries, Melanie and Daumke, Philipp and Ganslandt, Thomas and Hesser, Juergen and Hoening, Gunther and Neumaier, Michael and Marquardt, Kurt and Renz, Harald and Rothkoetter, Hermann-Josef and Schade-Brittinger, Carmen and Schmuecker, Paul and Schüttler, Jürgen and Sedlmayr, Martin and Serve, Hubert and Sohrabi, Keywan and Storf, Holger}, doi = {10.3414/ME17-02-0025}, faupublication = {yes}, journal = {Methods of Information in Medicine}, note = {EVALuna2:34832}, pages = {e82-e91}, peerreviewed = {Yes}, title = {{MIRACUM}: {Medical} {Informatics} in {Research} and {Care} in {University} {Medicine}}, volume = {57}, year = {2018} } @article{faucris.240545582, abstract = {Entscheidend fur die Methodenwahl ist die Passung zur Forschungsfrage. Gemischt-methodische Ansatze sind als drittes Forschungsparadigma neben qualitativen und quantitativen Herangehensweisen einzuordnen. Sie haben zum Ziel, ein inhaltlich breites und tiefes Verstandnis uber den Forschungsgegenstand zu gewinnen und durch die Kombination der Starken gleichzeitig die Schwachen der Methoden auszugleichen.}, author = {Heckel, Maria and Kremeike, Kerstin and Stiel, Stephanie and Herbst, Franziska A.}, doi = {10.1055/a-1174-8056}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, note = {CRIS-Team WoS Importer:2020-07-17}, pages = {169-172}, peerreviewed = {No}, title = {{Mixed}-methodical {Study} {Designs} in {Palliative} {Research}}, volume = {21}, year = {2020} } @article{faucris.271018501, author = {Kurkowski, Sandra and Ziegler, Kerstin and Jäger, Christian and Torres Cavazos, Jorge and Heckel, Maria and Klein, Carsten and Ostgathe, Christoph}, doi = {10.1055/a-1744-5270}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, note = {CRIS-Team WoS Importer:2022-03-18}, pages = {86-89}, peerreviewed = {No}, title = {{More} {Barriers} than {Bridges} - {Research} in {Times} of the {GDPR}}, volume = {23}, year = {2022} } @article{faucris.116045864, abstract = {Hintergrund: Die Auswirkungen von Kolonisation oder Infektion mit multiresistenten Erregern (MRE) und der Isolationsmaßnahmen auf Patienten am Lebensende, deren Angehörige sowie andere Beteiligte innerhalb des Gesundheitswesens sind unbekannt.
Ziel der Studie: Die vorliegende Studie beschäftigt sich mit der Frage, inwieweit die speziellen Anforderungen von Patienten am Ende des Lebens in den aktuellen Leitlinien der beteiligten Krankenhäuser Berücksichtigung finden. Langfristig sollen dabei gewonnene Erkenntnisse über Struktur und Aufbau der analysierten Dokumente dazu beitragen, innerhalb des Gesamtprojekts allgemeingültige Verfahrensanweisungen für die oben angeführte Problematik zu definieren und zu etablieren.
Methodik: Eine Dokumentenanalyse der Leitfäden und Informationsunterlagen von 2 deutschen Krankenhäusern zum Umgang mit MRE-positiven Patienten wurde durchgeführt. Nach Zuordnung zu Dokumentensets erfolgte eine Analyse mittels inhaltsanalytischem Vorgehen. Die daraus entstandene Codestruktur wurde deskriptiv und inhaltlich bezüglich der Zielgruppen der Dokumente analysiert.
Ergebnisse: Insgesamt wurden 23 interne Dokumente analysiert. Am häufigsten fanden sich Textstellen zuSchutzmaßnahmen, Material sowie Screening. Das Thema MRE bei Patienten am Lebensende fand kaum Erwähnung.
Schlussfolgerungen: In Dokumenten zur Versorgung von MRE-positiven Patienten liegt der Fokus auf allgemeingültigen Verfahrensanweisungen mit vorrangig praktischen Themen wie zur Pflege benötigtes Material bzw. Schutzmaßnahmen gegen MRE. Die Versorgung von Patienten am Lebensende spielt eine untergeordnete Rolle, weshalb dieses Thema zukünftig in Verfahrensanweisungen stärker fokussiert werden sollt}, author = {Adelhardt, Thomas and Heckel, Maria and Stiel, Stephanie and Ostgathe, Christoph and Schöffski, Oliver}, doi = {10.1055/s-0041-110168}, faupublication = {yes}, journal = {Zeitschrift für Palliativmedizin}, keywords = {Palliativversorgung; multiresistente Erreger; MRSA; klinische Guidelines; Dokumentenanalyse}, pages = {30-37}, peerreviewed = {No}, title = {{MRE}-{Kolonisation} oder -{Infektion} in der {Versorgung} von {Menschen} am {Lebensende} ({End}-of-{Life} {Care}): {Handlungsanweisungen} und {Informationsmaterialien} in zwei deutschen {Krankenhäusern} - {Eine} {Dokumentenanalyse}}, url = {https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0041-110168}, volume = {17}, year = {2016} } @article{faucris.204324924, abstract = {Purpose Palliative care professionals are frequently confronted with patients colonized or infected with MDRO. One major challenge is how to balance necessary isolation measures and social inclusion as one of the main principles of palliative and end-of-life care. To date, MDRO-specific policies and protocols vary widely between institutions. Aim: provide empirical recommendations on how to deal with hospitalized MDRO patients in end-of-life care.Methods Recommendations were developed based on (i) initial results of face-to-face interviews and focus groups, (ii) impartial experts' comments and consensus on the draft via online survey and (iii) a face-to-face meeting with consortium members to finalize recommendations. Findings of 158 interviews and six focus groups (39 participants) with patients, family caregivers, staff members and institutional stakeholders contributed to the recommendations. The assessments of 17 experts were considered.Results In total, 21 recommendations were approved. The recommended strategy in dealing with MDRO at the end of life allows case-based application of protection and isolation measures. MDRO diagnostics and therapy involve screening at admission. The recommendations suggest consideration of required accommodation facilities, provided material as well as staff and time resources. The recommendations further highlight the importance of providing for strategies enabling the patient's social inclusion and provision of verbal and written information about MDRO for patients and family caregivers, transparent medical documentation, and staff member training.Conclusion The recommendations summarize the perspectives of individuals and groups affected by MDRO at the end of life and provide practical guidance for clinical routine. Further dissemination and implementation requirements are discussed and should contain the evaluation of the knowledge, views, worries, and anxieties of the target groups.}, author = {Heckel, Maria and Stiel, Stephanie and Herbst, Franziska A. and Tiedtke, Johanna and Sturm, Alexander and Adelhardt, Thomas and Bogdan, Christian and Sieber, Cornel and Schöffski, Oliver and Lang, Frieder and Ostgathe, Christoph}, doi = {10.1007/s00520-018-4149-6}, faupublication = {yes}, journal = {Supportive Care in Cancer}, keywords = {Palliative care;Terminal care;Drug resistance;Multiple;Practice guideline;Methicillin-resistant Staphylococcus aureus;Empirical research}, pages = {3021-3027}, peerreviewed = {Yes}, title = {{Multidrug}-resistant bacterial microorganisms ({MDRO}) in end-of-life care: development of recommendations for hospitalized patients using a mixed-methods approach}, volume = {26}, year = {2018} } @article{faucris.265763133, abstract = {Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.}, author = {Le, Trang T. and Gutierrez-Sacristan, Alba and Son, Jiyeon and Hong, Chuan and South, Andrew M. and Beaulieu-Jones, Brett K. and Loh, Ne Hooi Will and Luo, Yuan and Morris, Michele and Ngiam, Kee Yuan and Patel, Lav P. and Samayamuthu, Malarkodi J. and Schriver, Emily and Tan, Amelia Lm and Moore, Jason and Cai, Tianxi and Omenn, Gilbert S. and Avillach, Paul and Kohane, Isaac S. and Schüttler, Jürgen and Prokosch, Hans-Ulrich and Ganslandt, Thomas and Visweswaran, Shyam and Mowery, Danielle L. and Xia, Zongqi}, doi = {10.1038/s41598-021-99481-9}, faupublication = {yes}, journal = {Scientific Reports}, note = {CRIS-Team Scopus Importer:2021-11-05}, peerreviewed = {Yes}, title = {{Multinational} characterization of neurological phenotypes in patients hospitalized with {COVID}-19}, volume = {11}, year = {2021} } @article{faucris.204796001, abstract = {BACKGROUND: The emergence of multidrug-resistant bacterial microorganisms is a particular challenge for the health care systems. Little is known about the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Gram-negative bacteria (MDRGNB) in patients of palliative care units (PCU). AIM: The primary aim of this study was to determine the carriage of MRSA among patients of a PCU at a German University Hospital and to assess whether the positive cases would have been detected by a risk-factor-based screening-approach. DESIGN: Between February 2014 and January 2015 patients from our PCU were tested for MRSA carriage within 48 hours following admission irrespective of pre-existing risk factors. In addition, risk factors for MRSA colonization were assessed. Samples from the nostrils and, if applicable, from pre-existing wounds were analysed by standardized culture-based laboratory techniques for the presence of MRSA and of other bacteria and fungi. Results from swabs taken prior to admission were also recorded if available. RESULTS: 297 out of 317 patients (93.7%) fulfilled one or more MRSA screening criteria. Swabs from 299 patients were tested. The detection rate was 2.1% for MRSA. All MRSA cases would have been detected by a risk-factor-based screening-approach. Considering the detected cases and the results from swabs taken prior to admission, 4.1% of the patients (n = 13) were diagnosed with MRSA and 4.1% with MDRGNB (n = 13), including two patients with MRSA and MDRGNB (0.6%). The rate of MRSA carriage in PCU patients (4.1%) was elevated compared to the rate seen in the general cohort of patients admitted to our University Hospital (2.7%). CONCLUSIONS: PCU patients have an increased risk to carry MRSA compared to other hospitalized patients. Although a risk factor-based screening is likely to detect all MRSA carriers amongst PCU patients, we rather recommend a universal screening to avoid the extra effort to identify the few risk factor-negative patients (<7%). As we did not perform a systematic MDRGNB screening, further studies are needed to determine the true prevalence of MDRGNB amongst PCU patients.}, author = {Heckel, Maria and Geißdörfer, Walter and Herbst, Franziska A. and Stiel, Stephanie and Ostgathe, Christoph and Bogdan, Christian}, doi = {10.1371/journal.pone.0188940}, faupublication = {yes}, journal = {PLoS ONE}, note = {EVALuna2:33307}, peerreviewed = {Yes}, title = {{Nasal} carriage of methicillin-resistant {Staphylococcus} aureus ({MRSA}) at a palliative care unit: {A} prospective single service analysis}, volume = {12}, year = {2017} } @article{faucris.212471742, abstract = {Lysophosphatidic acid (LPA) is a bioactive lipid that impacts neurological outcomes after neurotrauma by inhibiting neuroregeneration, promoting inflammation, and contributing to behavioral deficits. Blocking LPA signaling with a novel anti-LPA monoclonal antibody (mAb) is neuroprotective after traumatic brain injury (TBI) if given to injured animals whose blood-brain barrier (BBB) has been compromised. It is hypothesized that the anti-LPA mAb could improve chronic pain initiated by TBI. However, poor brain penetration after systemic application of the antibody makes access to the central nervous system (CNS) problematic in situations where the BBB is intact. Our experiments investigated whether intranasal delivery of the anti-LPA mAb could bypass the BBB, allowing for direct entry of the antibody to certain areas of the CNS. When the humanized anti-LPA mAb, LT3114, was intranasally applied to injured rats within 30 minutes after mild TBI using the central lateral percussion model, enzyme-linked immunospecific assay and immunohistochemistry demonstrated antibody uptake to several areas in the CNS, including the area of cortical injury, the corpus callosum, cerebellum, and the subventricular region. Compared with control rats that received LT3114 but no TBI, TBI rats demonstrated significantly higher concentrations of intranasally administered LT3114 antibody in some tissues. In behavioral studies, a significant attenuation of mechanical allodynia after TBI was observed in the anti-LPA treatment group (P = 0.0079), when compared with vehicle controls within 14 days after TBI. These results suggest that intranasal application of the anti-LPA antibody directly accesses CNS sites involved in TBI-related pain and that this access attenuates pain sequelae to the neurotrauma.}, author = {Eisenried, Andreas and Meidahl, Anders C. N. and Klukinov, Michael and Tzabazis, Alexander Z. and Sabbadini, Roger A. and Clark, J. David and Yeomans, David C.}, doi = {10.1097/j.pain.0000000000001019}, faupublication = {yes}, journal = {Pain}, note = {EVALuna2:36285}, pages = {2181-2188}, peerreviewed = {Yes}, title = {{Nervous} system delivery of antilysophosphatidic acid antibody by nasal application attenuates mechanical allodynia after traumatic brain injury in rats}, volume = {158}, year = {2017} } @inproceedings{faucris.107042364, author = {Malessa, Anke and Steigleder, Tobias and Shi, Kilin and Will, Christoph and Michler, Fabian and Kölpin, Alexander and Ostgathe, Christoph}, booktitle = {Wissenschaftliche Arbeitstage der DGP}, date = {2018-03-09/2018-03-10}, faupublication = {yes}, peerreviewed = {Yes}, title = {{Neue} {Wege} in der {Palliativmedizin} – {Herausforderungen} bei der {Entwicklung} einer berührungslosen, nicht-belastenden {Messung} von {Vitalparametern}}, venue = {Göttingen}, year = {2018} } @article{faucris.279672740, abstract = {Background: Neuroendocrine changes have been reported after ischemic stroke, subarachnoid hemorrhage, and brain trauma. As there are no corresponding data in patients with intracerebral hemorrhage (ICH) we analyzed various neuroendocrine parameters to investigate possible alterations in hormone profiles of patients with ICH. Methods: Twenty patients with ICH were prospectively enrolled in the study. Patients were a priori parted into two groups: Ten non-ventilated patients treated on the stroke-unit (hemorrhage volumes <20 ml, "small ICH"), and 10 ventilated patients treated on the neurocritical care unit (hematoma volumes >20 ml with possible additional ventricular involvement ("large ICH"). Neuroendocrine parameters were compared between both groups referring to reference values. The following parameters were obtained over a period of 9 days in 20 patients with spontaneous supratentorial ICH: thyrotropin, free thiiodothyronine and thyroxine, human growth hormone, insulin-like growth factor 1, luteinizing hormone, follicle-stimulating hormone, testosterone, prolactin, adrenocorticotropic hormone, and cortisol. Results: Small ICH patients were in a median 71 (54-88) years old and had a mean ICH volume of 9.5 ± 6.5 ml, whereas large ICH patients were 65 (47-80) years old and showed a mean volume of 56 ± 30.2 ml. None of the patients revealed pathological alterations for thyrotropin, free thiiodothyronine, thyroxine, human growth hormone, insulin-like growth factor 1, and testosterone. There was only a mild decrease of adrenocorticotropic hormone and cortisol on day 3 in large ICH patients. Small ICH patients showed pathologically elevated levels of luteinizing and follicle-stimulating hormone throughout the observation period. Large ICH patients showed a marked increase of prolactin that developed during the course. Conclusions: Overall, neuroendocrine changes in ICH patients are not as profound as reported for ischemic stroke or subarachnoid hemorrhage. The clinical significance of increased LH and FSH levels in small ICH is unclear, whereas elevation of prolactin in large ICH was anticipated. Future randomized controlled trials should also focus on neuroendocrine parameters to clarify the impact of possible hormonal alterations on functional outcome. © 2011 Springer Science+Business Media, LLC.}, author = {Huttner, Hagen and Kiphuth, Ines-Christine and Teuber, Linda and Lücking, Hannes and Kloska, Stephan and Staykov, Dimitre and Kuramatsu, Joji and Mauer, Christoph and Breuer, Lorenz and Dörfler, Arnd and Köhrmann, Martin}, doi = {10.1007/s12028-011-9622-8}, faupublication = {yes}, journal = {Neurocritical Care}, keywords = {Hormone profile; Intracerebral hemorrhage; Neuroendocrine}, note = {CRIS-Team Scopus Importer:2022-08-05}, pages = {39-44}, peerreviewed = {Yes}, title = {{Neuroendocrine} changes in patients with spontaneous supratentorial intracerebral hemorrhage}, volume = {18}, year = {2013} } @article{faucris.122556324, abstract = {Out of the anesthetist's perspective, some uncertainties remain with the perioperative management of the so-called NOACs. This review emphasizes on the question of bleeding and thromboembolic risk as well as the management of bleedings and the discontinuing intervals in the context of regional anesthesia.Managing patients with NOAC therapy, an interdisciplinary approach and consent with surgeons and specialist in hemostaseology has to be found. For severe and lifethreatening bleeding there are specific antidotes in development; however, until clinical provement is not yet finished the application of four-factor prothrombin complex concentrate may be the most promising approach.NOACs like dabigatran etexilate, rivaroxaban, apixaban and edoxaban are effective alternatives to warfarin in primary and secondary prophylaxis of thromboembolic conditions. In the perioperative setting, some uncertainties and evidence gaps remain in estimating the bleeding risks associated with surgical procedures, emergency trauma and neuroaxial anesthesia. A discontinuation of NOACs should be at least 1 day before elective operation. Renal and liver impairment, older age, or co-medications could afford longer intervals. As no specific reversal agents are yet available for life-threatening bleeding or emergency surgery; nonspecific prohemostatic therapies are mainly recommended. Oral charcoal, application of tranexamic acid or hemodialysis could bring additional benefit depending on the individual NOAC. Practitioners need to be aware that NOACs can interfere in different pathways with the measurement of common hemostasis parameters. Estimating the bleeding risks and reversal strategies requires careful evaluation also in the light of a potential risk of thromboembolic complications. In difference to warfarin, 'bridging' concepts are not generally recommended for NOACs.}, author = {Breuer, Georg and Weiss, Dominik R. and Ringwald, Jürgen}, doi = {10.1097/ACO.0000000000000100}, faupublication = {yes}, journal = {Current Opinion in Anaesthesiology}, note = {EVALuna2:15984}, pages = {409-19}, peerreviewed = {Yes}, title = {'{New}' direct oral anticoagulants in the perioperative setting}, volume = {27}, year = {2014} } @article{faucris.312691132, abstract = {Purpose: To study the tissue architecture, isthmus (connection between two lobes) of the lacrimal gland using preclinical 7T MRI in combination with histology and electron microscopy. Methods: Ten lacrimal glands from Caucasian body donors (mean age 78.7 years) were studied using 7T-MRI (N = 5; scanned at 75-μm intervals), histology, and electron microscopy (N = 5) and 3D cinematic rendering (CR) techniques. Results: 3D CR images showed uniform-sized lobules (widest lobule diameter, 1.68 ± 0.19 mm in orbital lobe, 1.68 ± 0.17 mm in palpebral lobe) in both lobes, separated by septae (size, 0.29 ± 0.09 mm). The internal framework of the gland resembled a honeycoomb pattern. In CR and histology, the isthmus contained glandular acini, large blood vessels, nerves, and no more than two ducts having a tortuous course towards the conjunctival surface. On assigning a color display to the rendered lacrimal gland, all glands showed a blood vessel originating from the main lacrimal artery just 5 mm beyond the hilum and making it course to the palpebral lobe via isthmus. The distance between the conjunctiva and the central substance of the orbital and palpebral lobe was 9.4 ± 0.2 mm and 2.8 ± 0.7 mm, respectively. Electron microscopy of the palpebral lobe revealed compact subepithelial layer in the overlying conjunctiva, followed by loosely scattered collagen bundles that contained the gland lobules. Conclusion: 3D-CR can be used to study the lacrimal gland microstructure, help fabricate a 3D scaffold for lacrimal gland bioprinting, and serve as guide for transconjunctival lacrimal gland targeted therapies i.e., 2.9 & 9 mm long needle to reach the orbital and palpebral lobe center, respectively in normal-size glands.}, author = {Singh, Swati and Winter, Zoltan and Necker, Fabian and Bäuerle, Tobias and Scholz, Michael and Bräuer, Lars and Paulsen, Friedrich}, doi = {10.1016/j.jtos.2023.09.010}, faupublication = {yes}, journal = {Ocular Surface}, keywords = {3D printing; 7T MRI; Cinematic rendering; Dry eye disease; Lacrimal gland; Palpebral lobe}, note = {CRIS-Team Scopus Importer:2023-10-13}, pages = {204-212}, peerreviewed = {Yes}, title = {{New} insights into lacrimal gland anatomy using {7T} {MRI} and electron microscopy: {Relevance} for lacrimal gland targeted therapies and bioengineering}, volume = {30}, year = {2023} } @article{faucris.116736884, abstract = {NFATc1 is a member of the nuclear factor of activated T cells (NFAT) family of transcription factors. NFAT is activated upon T-cell receptor activation followed by intracytoplasmatic calcium influx where calmodulin, a calcium sensor protein, activates the phosphatase calcineurin that dephosphorylates NFAT proteins and results in NFAT nuclear import. Here, we show the analysis of conditional NFATc1-deficient mice bearing a deletion of NFATc1 in CD4(+) and CD8(+) T cells. NFATc1-deficient CD4(+) T cells polarized under Th17 conditions express reduced levels of the Th17-associated transcription factor ROR?T (where ROR is RAR-related orphan receptor) as well as the Th17-associated cytokines IL-17A, IL-17F, IL-21, and IL-10. In the murine model of experimental EAE, we found a strong reduction of the disease outcome in conditional NFATc1-deficient mice, as compared with control littermates. This was accompanied by a diminished inflammation in the brain and spinal cord and reduced IL-17A and IFN-? expression by antigen-specific spleen, spinal cord, and brain cells. Altogether, these results reveal an important role of NFATc1 in inducing Th17-cell responses and IFN-?, both being relevant for the EAE development.}, author = {Reppert, Sarah and Zinser, Elisabeth and Holzinger, Corinna and Sandrock, Lena and Koch, Sonja and Finotto, Susetta}, doi = {10.1002/eji.201445150}, faupublication = {yes}, journal = {European Journal of Immunology}, note = {EVALuna2:25967}, pages = {1426-40}, peerreviewed = {Yes}, title = {{NFATc1} deficiency in {T} cells protects mice from experimental autoimmune encephalomyelitis}, volume = {45}, year = {2015} } @article{faucris.121480964, abstract = {NFATc1 isoforms are highly regulated in peripheral T cells where they contribute to the effector function and cell homeostasis.Here, we investigated the role of NFATc1 in asthma and in T cells.In a murine model of allergic asthma, we analysed differences in T-cell development in this allergic disease model, between wild-type and NFATc1 conditional knockout mice. Thus, we performed quantitative real-time PCR to investigate the mRNA expression of Th2-associated genes as well as genes that are involved in IgE immunoglobulin class-switch. Additionally, we used ELISA, Western blot and flow cytometry (FACS) to analyse protein concentrations of Th1-, Th2- and Th17-specific transcription factors and cytokines and the Th2 chemokine, thymus and activation-regulated chemokine/chemokine ligand 17 (TARC/CCL17) by ELISA.Mice lacking NFATc1 in CD4(+) T cells display a significant reduction in lung Th2 and Th17 as well as an increase of Th1 cells in an experimental asthma model. Additionally, Batf gene, a recently described transcription factor of the Th2 and Th17 cell differentiation as well as a key T and B transcription factor involved in the IgE immunoglobulin class-switch, was found decreased in the lungs of these mice. As a consequence, serum OVA-specific IgE and IgG1 levels were found significantly decreased after allergen exposure and in the absence of NFATc1 in T cells in experimental allergic asthma.Targeting NFATc1 in T lymphocytes ameliorated the allergic trait in the airways of NFATc1(fl/fl) xCD4Cre mice. NFATc1 emerges as a novel target for anti-allergy intervention.}, author = {Koch, S. and Reppert, S. and Finotto, Susetta}, doi = {10.1111/cea.12493}, faupublication = {yes}, journal = {Clinical and Experimental Allergy}, note = {EVALuna2:25971}, pages = {1356-66}, peerreviewed = {Yes}, title = {{NFATc1} deletion in {T} lymphocytes inhibits the allergic trait in a murine model of asthma}, volume = {45}, year = {2015} } @article{faucris.208701303, abstract = {Nuclear factor of activated T cells 1 (NFATc1) is a transcription factor activated by T-cell receptor (TCR) and Ca2+ signaling that affects T-cell activation and effector function. Upon tumor antigen challenge, TCR and calcium-release-activated channels are induced, promoting NFAT dephosphorylation and translocation into the nucleus. In this study, we report a progressive decrease of NFATc1 in lung tumor tissue and in tumor-infiltrating lymphocytes (TIL) of patients suffering from advanced-stage non-small cell lung cancer (NSCLC). Mice harboring conditionally inactivated NFATc1 in T cells (NFATc1ΔCD4) showed increased lung tumor growth associated with impaired T-cell activation and function. Furthermore, in the absence of NFATc1, reduced IL2 influenced the development of memory CD8+ T cells. We found a reduction of effector memory and CD103+ tissue-resident memory (TRM) T cells in the lung of tumor-bearing NFATc1ΔCD4 mice, underlining an impaired cytotoxic T-cell response and a reduced TRM tissue-homing capacity. In CD4+ICOS+ T cells, programmed cell death 1 (PD-1) was induced in the draining lymph nodes of these mice and associated with lung tumor cell growth. Targeting PD-1 resulted in NFATc1 induction in CD4+ and CD8+ T cells in tumor-bearing mice and was associated with increased antitumor cytotoxic functions. This study reveals a role of NFATc1 in the activation and cytotoxic functions of T cells, in the development of memory CD8+ T-cell subsets, and in the regulation of T-cell exhaustion. These data underline the indispensability of NFATc1 for successful antitumor immune responses in patients with NSCLC.Significance: The multifaceted role of NFATc1 in the activation and function of T cells during lung cancer development makes it a critical participant in antitumor immune responses in patients with NSCLC. Cancer Res; 78(13); 3619-33. ©2018 AACR.}, author = {Heim, Lisanne and Friedrich, Juliane and Engelhardt, Marina and Trufa, Denis and Geppert, Carol-Immanuel and Rieker, Ralf and Sirbu, Horia and Finotto, Susetta}, doi = {10.1158/0008-5472.CAN-17-3297}, faupublication = {yes}, journal = {Cancer Research}, note = {EVALuna2:34901}, pages = {3619-3633}, peerreviewed = {Yes}, title = {{NFATc1} {Promotes} {Antitumoral} {Effector} {Functions} and {Memory} {CD8}+ {T}-cell {Differentiation} during {Non}-{Small} {Cell} {Lung} {Cancer} {Development}}, volume = {78}, year = {2018} } @article{faucris.235415574, abstract = {Background: The effects of environmental changes on the somato-sensory system during long-distance air ambulance flights need to be further investigated. Changes in nociceptive capacity are conceivable in light of previous studies performed under related environmental settings. We used standardized somato-sensory testing to investigate nociception in healthy volunteers during air-ambulance flights. Methods: Twenty-five healthy individuals were submitted to a test compilation analogous to the quantitative sensory testing battery-performed during actual air-ambulance flights. Measurements were paired around the major changes of external factors during take-off/climb and descent/ landing. Bland-Altman-Plots were calculated to identify possible systemic effects. Results: Bland-Altman-analyses suggest that the thresholds of stimulus detection and pain as well as above-threshold pain along critical waypoints of travel are not subject to systemic effects but instead demonstrate random variations. Conclusions: We provide a novel description of a real-life experimental setup and demonstrate the general feasibility of performing somato-sensory testing during ambulance flights. No systematic effects on the nociception of healthy individuals were apparent from our data. Our findings open up the possibility of future investigations into potential effects of ambulance flights on patients suffering acute or chronic pain.}, author = {Prottengeier, Johannes and Elsner, Stefan and Wehrfritz, Andreas and Moritz, Andreas and Schmidt, Joachim and Meyer, Michael}, doi = {10.1371/journal.pone.0217530}, faupublication = {yes}, journal = {PLoS ONE}, note = {CRIS-Team Scopus Importer:2020-03-06}, peerreviewed = {Yes}, title = {{Nociception} testing during fixed-wing ambulance flights. {An} interventional pilot study on the effects of flight-related environmental changes on the nociception of healthy volunteers}, volume = {15}, year = {2020} } @inproceedings{faucris.212473272, author = {Eisenried, Andreas and Akhbardeh, A. and Yeomans, D. C. and Tzabazis, A. Z.}, faupublication = {yes}, note = {EVALuna2:36288}, peerreviewed = {Yes}, title = {{OBJECTIVE} {MEASUREMENT} {OF} {PAIN} {PERCEPTION} {IN} {VOLUNTEERS} {AND} {ANESTHETIZED} {PATIENTS}}, volume = {122}, year = {2016} } @article{faucris.262675411, author = {Sotelo-Hitschfeld, Pamela and Bernal, Laura and Zimmermann, Katharina}, doi = {10.1080/23328940.2021.1933365}, faupublication = {yes}, journal = {Temperature}, note = {CRIS-Team Scopus Importer:2021-08-13}, peerreviewed = {Yes}, title = {{Odontoblasts} are cold sensory cells in teeth: {Comment} on: {L}. {Bernal}, {P}. {Sotelo}-{Hitschfeld}, {C}. {König}, {V}. {Sinica}, {A}. {Wyatt}, {Z}. {Winter}, {A}. {Hein}, {F}. {Touska}, {S}. {Reinhardt}, {A}. {Tragl}, {R}. {Kusuda}, {P}. {Wartenberg}, {A}. {Sclaroff}, {J}. {D}. {Pfeifer}, {F}. {Ectors}, {A}. {Dahl}, {M}. {Freichel}, {V}. {Vlachova}, {S}. {Brauchi}, {C}. {Roza}, {U}. {Boehm}, {D}. {E}. {Clapham}, {J}. {K}. {Lennerz}, {K}. {Zimmermann}, {Odontoblast} {TRPC5} channels signal cold pain in teeth. {Sci}. {Adv}. 7, eabf5567 (2021).}, year = {2021} } @article{faucris.254751623, abstract = {Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5's relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.}, author = {Bernal, Laura and Sotelo-Hitschfeld, Pamela and König, Christine and Sinica, Viktor and Wyatt, Amanda and Winter, Zoltan and Hein, Alexander and Touska, Filip and Reinhardt, Susanne and Tragl, Aaron and Kusuda, Ricardo and Wartenberg, Philipp and Sclaroff, Allen and Pfeifer, John D. and Ectors, Fabien and Dahl, Andreas and Freichel, Marc and Vlachova, Viktorie and Brauchi, Sebastian and Roza, Carolina and Boehm, Ulrich and Clapham, David E. and Lennerz, Jochen K. and Zimmermann, Katharina}, doi = {10.1126/sciadv.abf5567}, faupublication = {yes}, journal = {Science Advances}, note = {CRIS-Team WoS Importer:2021-04-09}, peerreviewed = {Yes}, title = {{Odontoblast} {TRPC5} channels signal cold pain in teeth}, volume = {7}, year = {2021} } @article{faucris.121327624, author = {Moritz, Andreas and Schreiner, Waldemar and Schmidt, Joachim}, doi = {10.1016/j.jclinane.2015.10.013}, faupublication = {yes}, journal = {Journal of Clinical Anesthesia}, note = {EVALuna2:16729}, pages = {48-9}, peerreviewed = {Yes}, title = {{One}-lung ventilation after rapid-sequence intubation: a novel approach using an {ETView} tracheoscopic ventilation tube for placement of an {EZ}-{Blocker} without bronchoscopy}, volume = {29}, year = {2016} } @article{faucris.211539503, abstract = {Thoracic trauma can be a life-threatening condition due to the involvement of vital organs, such as the heart, lungs, tracheobronchial tree and the great vessels. A coordinated interdisciplinary management is vital for the survival of the injured person. Modern diagnostic procedures provide an essential basis for the surgical treatment of patients. Surgical treatment principles include insertion of chest drainage, emergency thoracotomy, complex bronchoplastic and vascular reconstructive techniques and cardiac surgical maneuvers. For this reason highly complex surgical procedures are available, which can be effectively and specifically integrated into an interdisciplinary concept. In this review, the most frequent and prognostically relevant conditions, the indicated diagnostics and their significance as well as the surgical treatment principles, are comprehensively presented under consideration of the clinical situation.}, author = {Schreiner, Waldemar and Castellanos, I. and Dudek, Wojciech and Sirbu, Horia}, doi = {10.1007/s00113-018-0525-4}, faupublication = {yes}, journal = {Unfallchirurg}, note = {EVALuna2:35730}, pages = {596-604}, peerreviewed = {Yes}, title = {{Organ} injuries due to thoracic trauma : {Diagnostics}, clinical importance and treatment principles}, volume = {121}, year = {2018} } @article{faucris.212488854, abstract = {The target of OrphanAnesthesia is the publication of anaesthesia recommendations for patients suffering from rare diseases in order to improve patients' safety. When it comes to the management of patients with rare diseases, there are only sparse evidence-based facts and even far less knowledge in the anaesthetic outcome. OrphanAnesthesia would like to merge this knowledge based on scientific publications and proven experience of specialists making it available for physicians worldwide free of charge. All OrphanAnesthesia recommendations are standardized and need to pass a peer review process. They are being reviewed by at least one anaesthesiologist and another disease expert (e.g. paediatrician or neurologist) involved in the treatment of this group of patients. The project OrphanAnesthesia is internationally oriented. Thus all recommendations will be published in English. Starting with issue 5/2014, we'll publish the OrphanAnesthesia recommenations as a monthly supplement of A&I (Anasthesiologie & Intensivmedizin). Thus they can be accessed and downloaded via www.ai-online.info. As being part of the journal, the recommendations will be quotable. Reprints can be ordered for payment.}, author = {Münster, Tino}, faupublication = {yes}, journal = {Anästhesiologie & Intensivmedizin}, note = {EVALuna2:36113}, pages = {S622-S671}, peerreviewed = {Yes}, title = {{OrphanAnesthesia} - a common project of the {Scientific} {Working} {Group} of {Paediatric} {Anaesthesia} of the {German} {Society} of {Anaesthesiology} and {Intensive} {Care} {Medicine}}, volume = {59}, year = {2018} } @article{faucris.123830124, abstract = {Orphan diseases certainly have a challenging impact on anesthesia practice. Low prevalence by definition leads to a profound lack of evidence-based medical knowledge, and anesthetists usually cannot rely on personal experience for handling this unique group of patients. Then again, more than 7000 known orphan diseases are estimated to affect 5% of the general population in total. Therefore, it is imperative to have a universally valid approach to anesthesia for orphan diseases.Patients suffering from orphan diseases will be in need of anesthesia for disease-related diagnostic and therapeutic procedures as well as unrelated elective and emergency surgery and may present themselves on all levels of medical care. Instead of itemizing specifics for each disorder and procedure, we rather present a structured - checklist-like - approach to individually prepare for anesthesia and will highlight the most relevant anesthesiological problems and possible countermeasures. We will discuss a variety of sources of information to gain specific disease knowledge and procedural advice and will close this review by discussing the limitations of anesthesia for orphan diseases.Thanks to fast growing resources of knowledge, well tolerated and patient-oriented anesthesia is possible in spite of the inherent challenges of orphan diseases. We invite anesthetists to adapt, modify and improve our proposed structured approach to orphan anesthesia in the context of their daily practice.}, author = {Prottengeier, Johannes and Weith, Thomas and Münster, Tino}, doi = {10.1097/ACO.0000000000000248}, faupublication = {yes}, journal = {Current Opinion in Anaesthesiology}, note = {EVALuna2:16686}, pages = {691-6}, peerreviewed = {Yes}, title = {{Orphan} diseases: impact for anesthesia practice}, volume = {28}, year = {2015} } @article{faucris.207824500, abstract = {Pseudomonas aeruginosa produces increased levels of alginate in response to oxygen-deprived conditions. The regulatory pathway(s) that links oxygen limitation to increased synthesis of alginate has remained elusive. In the present study, using immunofluorescence microscopy, we show that anaerobiosis-induced alginate production by planktonic PAO1 requires the diguanylate cyclase (DGC) SadC, previously identified as a regulator of surface-associated lifestyles. Furthermore, we found that the gene products of PA4330 and PA4331, located in a predicted operon with sadC, have a major impact on alginate production: deletion of PA4330 (odaA, for oxygen-dependent alginate synthesis activator) caused an alginate production defect under anaerobic conditions, whereas a PA4331 (odaI, for oxygen-dependent alginate synthesis inhibitor) deletion mutant produced alginate also in the presence of oxygen, which would normally inhibit alginate synthesis. Based on their sequence, OdaA and OdaI have predicted hydratase and dioxygenase reductase activities, respectively. Enzymatic assays using purified protein showed that unlike OdaA, which did not significantly affect DGC activity of SadC, OdaI inhibited c-di-GMP production by SadC. Our data indicate that SadC, OdaA and OdaI are components of a novel response pathway of P. aeruginosa that regulates alginate synthesis in an oxygen-dependent manner.}, author = {Schmidt, Annika and Hammerbacher, Anna Silke and Bastian, Mike and Nieken, Karen Jule and Klockgether, Jens and Merighi, Massimo and Lapouge, Karine and Poschgan, Claudia and Kölle, Julia and Acharya, K. Ravi and Ulrich, Martina and Tuemmler, Burkhard and Unden, Gottfried and Kaever, Volkhard and Lory, Stephen and Haas, Dieter and Schwarz, Sandra and Doering, Gerd}, doi = {10.1111/1462-2920.13208}, faupublication = {yes}, journal = {ENVIRON MICROBIOL }, note = {EVALuna2:34822}, pages = {3390-3402}, peerreviewed = {Yes}, title = {{Oxygen}-dependent regulation of c-di-{GMP} synthesis by {SadC} controls alginate production in {Pseudomonas} aeruginosa}, volume = {18}, year = {2016} } @inproceedings{faucris.235693360, author = {Nersesyan, Yelena and Demirkhanyan, Lusine and Cabezas-Bratesco, Deny and Oakes, Victoria and Kusuda, Ricardo and Dawson, Tyler and Sun, Xiaohui and Cao, Chike and Cohen, Alejandro and Zimmermann, Katharina and Domene, Carmen and Brauchi, Sebastian and Zakharian, Eleonora}, doi = {10.1016/j.bpj.2017.11.2192}, faupublication = {yes}, note = {EVALuna2:213282}, pages = {396A-396A}, peerreviewed = {Yes}, title = {{Oxytocin} {Modulates} {Nociception} as a {Direct} {Agonist} of {Pain}-{Sensing} {TRPV1}}, volume = {114}, year = {2018} } @article{faucris.207824961, abstract = {Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is an ionotropic oxytocin receptor. Oxytocin elicits TRPV1 activity in native and heterologous expression systems, regardless of the presence of the classical oxytocin receptor. In TRPV1 knockout mice, DRG neurons exhibit reduced oxytocin sensitivity relative to controls, and oxytocin injections significantly attenuate capsaicin-induced nociception in in vivo experiments. Furthermore, oxytocin potentiates TRPV1 in planar lipid bilayers, supporting a direct agonistic action. Molecular modeling and simulation experiments provide insight into oxytocin-TRPV1 interactions, which resemble DkTx. Together, our findings suggest the existence of endogenous regulatory pathways that modulate nociception via direct action of oxytocin on TRPV1, implying its analgesic effect via channel desensitization.}, author = {Nersesyan, Yelena and Demirkhanyan, Lusine and Cabezas-Bratesco, Deny and Oakes, Victoria and Kusuda, Ricardo and Dawson, Tyler and Sun, Xiaohui and Cao, Chike and Cohen, Alejandro Martin and Chelluboina, Bharath and Veeravalli, Krishna Kumar and Zimmermann, Katharina and Domene, Carmen and Brauchi, Sebastian and Zakharian, Eleonora}, doi = {10.1016/j.celrep.2017.10.063}, faupublication = {yes}, journal = {Cell Reports}, note = {EVALuna2:34830}, pages = {1681-1691}, peerreviewed = {Yes}, title = {{Oxytocin} {Modulates} {Nociception} as an {Agonist} of {Pain}-{Sensing} {TRPV1}}, volume = {21}, year = {2017} } @article{faucris.123469104, abstract = {Neoplasms with a myopericytomatous pattern represent a morphological spectrum of lesions encompassing myopericytoma of the skin and soft tissue, angioleiomyoma, myofibromatosis/infantile haemangiopericytoma and putative neoplasms reported as malignant myopericytoma. Lack of reproducible phenotypic and genetic features of malignant myopericytic neoplasms have prevented the establishment of myopericytic sarcoma as an acceptable diagnostic category. Following detection of a LMNA-NTRK1 gene fusion in an index case of paediatric haemangiopericytoma-like sarcoma by combined whole-genome and RNA sequencing, we identified three additional sarcomas harbouring NTRK1 gene fusions, termed 'spindle cell sarcoma, NOS with myo/haemangiopericytic growth pattern'. The patients were two children aged 11 months and 2 years and two adults aged 51 and 80 years. While the tumours of the adults were strikingly myopericytoma-like, but with clear-cut atypical features, the paediatric cases were more akin to infantile myofibromatosis/haemangiopericytoma. All cases contained numerous thick-walled dysplastic-like vessels with segmental or diffuse nodular myxohyaline myo-intimal proliferations of smooth muscle actin-positive cells, occasionally associated with thrombosis. Immunohistochemistry showed variable expression of smooth muscle actin and CD34, but other mesenchymal markers, including STAT6, were negative. This study showed a novel variant of myo/haemangiopericytic sarcoma with recurrent NTRK1 gene fusions. Given the recent introduction of a novel therapeutic approach targeting NTRK fusion-positive neoplasms, recognition of this rare but likely under-reported sarcoma variant is strongly encouraged.}, author = {Haller, Florian and Knopf, Jasmin and Ackermann, Andreas and Bieg, Matthias and Kleinheinz, Kortine and Schlesner, Matthias and Moskalev, Evgeny and Will, Rainer and Satir, Ali Abdel and Abdelmagid, Ibtihalat E. and Giedl, Josef and Carbon, Roman and Rompel, Oliver and Hartmann, Arndt and Wiemann, Stefan and Metzler, Markus and Agaimy, Abbas}, doi = {10.1002/path.4701}, faupublication = {yes}, journal = {Journal of Pathology}, note = {EVALuna2:6792}, pages = {700-10}, peerreviewed = {Yes}, title = {{Paediatric} and adult soft tissue sarcomas with {NTRK1} gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern}, volume = {238}, year = {2016} } @article{faucris.209898369, abstract = {BACKGROUND: Small fiber neuropathy (SFN) is a severe and disabling chronic pain syndrome with no causal and limited symptomatic treatment options. Mechanistically based individual treatment is not available. We report an in-vitro predicted individualized treatment success in one therapy-refractory Caucasian patient suffering from SFN for over ten years. METHODS: Intrinsic excitability of human induced pluripotent stem cell (iPSC) derived nociceptors from this patient and respective controls were recorded on multi-electrode (MEA) arrays, in the presence and absence of lacosamide. The patient's pain ratings were assessed by a visual analogue scale (10: worst pain, 0: no pain) and treatment effect was objectified by microneurography recordings of the patient's single nerve C-fibers. FINDINGS: We identified patient-specific changes in iPSC-derived nociceptor excitability in MEA recordings, which were reverted by the FDA-approved compound lacosamide in vitro. Using this drug for individualized treatment of this patient, the patient's pain ratings decreased from 7.5 to 1.5. Consistent with the pain relief reported by the patient, microneurography recordings of the patient's single nerve fibers mirrored a reduced spontaneous nociceptor (C-fiber) activity in the patient during lacosamide treatment. Microneurography recordings yielded an objective measurement of altered peripheral nociceptor activity following treatment. INTERPRETATION: Thus, we are here presenting one example of successful patient specific precision medicine using iPSC technology and individualized therapeutic treatment based on patient-derived sensory neurons.}, author = {Namer, Barbara and Schmidt, Diana and Eberhardt, Esther and Maroni, Michele and Dorfmeister, Eva and Kleggetveit, Inge Petter and Kaluza, Luisa and Meents, Jannis and Gerlach, Aaron and Lin, Zhixin and Winterpacht, Andreas and Dragicevic, Elena and Kohl, Zacharias and Schüttler, Jürgen and Kurth, Ingo and Warncke, Torhild and Jorum, Ellen and Winner, Beate and Lampert, Angelika}, doi = {10.1016/j.ebiom.2018.11.042}, faupublication = {yes}, journal = {EBioMedicine}, note = {EVALuna2:35119}, peerreviewed = {Yes}, title = {{Pain} relief in a neuropathy patient by lacosamide: {Proof} of principle of clinical translation from patient-specific {iPS} cell-derived nociceptors}, year = {2018} } @article{faucris.114556024, abstract = {Beyond doubt the provision of pain therapy for patients with acute and chronic pain in Germany has improved over the last 30 years. This positive development comprises i.e. the growing impact of acute pain services on the treatment of patients with postoperative pain and the implementation of new developments in research into the clinical setting of obstetric pain therapy. Nevertheless, the provision of pain therapy for patients with chronic pain syndromes, for children, and in the fields of cancer pain and palliative medicine is neither qualitatively nor quantitatively sufficient.}, author = {Ostgathe, Christoph and et al.}, author_hint = {Ostgathe C., Nauck F., Klaschik E.}, doi = {10.1055/s-2003-38216}, faupublication = {no}, journal = {AINS - Anästhesiologie. Intensivmedizin. Notfallmedizin. Schmerztherapie.}, keywords = {Education; Germany; Pain; Pain therapy; Research}, pages = {312-320}, peerreviewed = {Yes}, support_note = {Author relations incomplete. You may find additional data in field 'author{\_}hint'}, title = {{Pain} treatment today - {Current} standing of pain treatment in {Germany}}, volume = {38}, year = {2003} } @article{faucris.296075046, abstract = {Background Palliative care is an integral part of health care, which in term has become increasingly technologized in recent decades. Lately, innovative smart sensors combined with artificial intelligence promise better diagnosis and treatment. But to date, it is unclear: how are palliative care concepts and their underlying assumptions about humans challenged by smart sensor technologies (SST) and how can care benefit from SST?
Aims The paper aims to identify changes and challenges in palliative care due to the use of SST. In addition, normative guiding criteria for the use of SST are developed.
Methods The principle of Total Care used by the European Association for Palliative Care (EAPC) forms the basis for the ethical analysis. Drawing on this, its underlying conceptions of the human and its socio-ethical aspects are examined with a phenomenological focus. In the second step, the advantages, limitations, and socio-ethical challenges of using SST with respect to the Total Care principle are explored. Finally, ethical-normative requirements for the application of SST are derived.
Results and Conclusion First, SST are limited in their measurement capabilities. Second, SST have an impact on human agency and autonomy. This concerns both the patient and the caregiver. Third, some aspects of the Total Care principle are likely to be marginalized due to the use of SST. The paper formulates normative requirements for using SST to serve human flourishing. It unfolds three criteria according to which SST must be aligned: (1) evidence and purposefulness, (2) autonomy, and (3) Total Care.
Chronic illnesses and multi-morbidity can threaten competence and independence, particularly in old age. Autonomy becomes increasingly important in the context of sedation, as in this case medication leads to (further) changes of consciousness. The study aimed to identify possible age-related differences in the perspectives of healthcare professionals on patients’ autonomy, in the context of sedation in specialised palliative care.
Method
Secondary analysis of interviews with healthcare professionals, analysed by qualitative content and linguistic conversation analysis. The interviews analysed span 51 healthcare professionals in specialised palliative care across 17 centres (adult inpatient and specialist palliative home care services) in Germany.
Results
The study shows that the perspectives of healthcare professionals on patients’ autonomy differs according to the age of the patient in the context of sedation in specialised palliative care. The different perspectives may lead to different ways of treating the patients, for example a greater space of autonomy and decision-making for younger patients.
Conclusion
In particular, measures that may restrict consciousness (e.g. sedation) and thus influence patients’ ability to fully exercise their autonomy and fully participate in decision-making require special attention by healthcare professionals with respect to possible influences on treatment, such as different perceptions by healthcare professionals based on the patient’s age or age-related stereotype},
author = {Kurkowski, Sandra and Heckel, Maria and Pfaller, Larissa and Peters, Joachim and Jeremias, Bazata and Eva, Schildmann and Ostgathe, Christoph},
doi = {10.1186/s12904-022-00963-y},
faupublication = {yes},
journal = {BMC Palliative Care},
keywords = {End of life care; Palliative care; Age; Ageing; Autonomy; Qualitative content analysis; Linguistic conversation analysis},
peerreviewed = {Yes},
title = {{Possible} age-related differences in healthcare professionals’ perspectives on younger and older patients’ autonomy and decision-making in the context of sedation in specialised palliative care: exploratory secondary qualitative content and linguistic conversation analysis of interviews with healthcare professionals},
url = {https://bmcpalliatcare.biomedcentral.com/articles/10.1186/s12904-022-00963-y},
volume = {21},
year = {2022}
}
@article{faucris.121397364,
author = {Tzabazis, Alexander Z. and Schmitt, Heike and Münster, Tino},
doi = {10.1097/YCT.0000000000000103},
faupublication = {yes},
journal = {Journal of Ect},
note = {EVALuna2:16664},
pages = {e27-8},
peerreviewed = {Yes},
title = {{Postictal} agitation after electroconvulsive therapy},
volume = {30},
year = {2014}
}
@article{faucris.222395060,
abstract = {Background: Small-for-gestational-age (SGA) birth bears an enhanced risk of developing hypertension, obesity, insulin resistance and mental health disorders in later life as a consequence of adaptive processes in utero. Only a small number of studies on pain perception in SGA infants exist. These are indicative of a blunted stress response to pain in SGA newborns. Aim: We initiated a pilot study investigating differences in postoperative pain perception between SGA and appropriate-for-gestational-age (AGA) infants. Methods: Pain and alertness levels of 10 formerly SGA and 14 AGA infants at the age 0.5–2 years were evaluated by the FLACC scale, Steward and Aldrete Scores following hernia repair, reconstructive surgery of hypospadia and orchidopexy. In addition, the postoperative consumption of non-steroidal anti-inflammatory drugs was compared between SGA and AGA. Results: Postoperative pain and alertness levels were not significantly different in SGA and AGA children. We did not observe significant group differences regarding the consumption of non-steroidal anti-inflammatory drugs. Conclusion: While previous studies were suggestive of a suppressed stress response to pain in SGA newborns, these findings did not fully translate into an altered response to pain beyond the newborn age. Further studies in a larger cohort seem necessary to verify this finding.},
author = {Schüssler, Stephanie C. and Kußmann, Franziska and Fahlbusch, Fabian B. and Münster, Tino and Hirsch, Karin and Carbon, Roman and Albrecht, Sven and Dötsch, Jörg and Rascher, Wolfgang},
doi = {10.1016/j.earlhumdev.2019.07.003},
faupublication = {yes},
journal = {Early Human Development},
note = {CRIS-Team Scopus Importer:2019-07-16},
pages = {39-44},
peerreviewed = {Yes},
title = {{Postoperative} pain in small-for-gestational age infants after hernia repair, orchidopexy and urethral reconstruction surgery: {A} pilot study},
volume = {136},
year = {2019}
}
@article{faucris.245898883,
abstract = {BACKGROUND The challenge of managing acute postoperative pain is the well tolerated and effective administration of analgesics with a minimum of side effects. The standard therapeutic approach is patient-controlled analgesia (PCA) with systemic opioids. To overcome problems of oscillating opioid concentrations, we studied patient-controlled analgesia by target-controlled infusion (TCI-PCA) as an alternative. OBJECTIVE To compare efficacy, safety and side effects of standard PCA with TCI-PCA for postoperative pain therapy with hydromorphone. DESIGN Single-blinded, randomised trial. SETTING University Hospital, Germany from December 2013 to April 2015. PARTICIPANTS Fifty adults undergoing cardiac surgery. INTERVENTIONS Postoperative pain therapy on the ICU was managed with intravenous (i.v.) hydromorphone and patients randomised to TCI-PCA with target plasma concentrations between 0.8 and 10 ng ml(-1), or PCA with bolus doses of 0.2 mg. Pain was regularly assessed using the 11-point numerical rating scale (NRS). Blood pressure, heart rate, oxygen saturation and cardiac output were continuously monitored, and adverse events were registered throughout the study. MAIN OUTCOME MEASURES NRS pain ratings, hydromorphone doses, haemodynamic effects and side effects. RESULTS NRS pain ratings, total doses of hydromorphone and haemodynamic data did not differ significantly between TCI-PCA and PCA. The number of bolus doses during PCA was significantly higher than the number of target increases during TCI-PCA (P = 0.006). The number of negative requests was also significantly higher during PCA than during TCI-PCA (P = 0.02). The respiratory rate on the first postoperative morning was 25 +/- 6 min(-1) during TCI-PCA, compared with 19 +/- 4 min(-1) during PCA (P = 0.022). Nausea occurred in 30% after TCI-PCA and 24% after PCA (P = 0.46). CONCLUSION TCI-PCA was effective and well tolerated in acute postoperative pain management after cardiac surgery. Further studies are needed to evaluate this approach in clinical practice.},
author = {Wehrfritz, Andreas and Ihmsen, Harald and Fuchte, Tobias and Kim, Michael and Kremer, Sven and Weiss, Alexander and Schüttler, Jürgen and Jeleazcov, Christian},
doi = {10.1097/EJA.0000000000001360},
faupublication = {yes},
journal = {European Journal of Anaesthesiology},
note = {CRIS-Team WoS Importer:2020-11-27},
pages = {1168-1175},
peerreviewed = {Yes},
title = {{Postoperative} pain therapy with hydromorphone; comparison of patient-controlled analgesia with target-controlled infusion and standard patient-controlled analgesia {A} randomised controlled trial},
volume = {37},
year = {2020}
}
@article{faucris.116514244,
abstract = {Introduction: An algorithm to convert from any other opioid to oral levo-methadone was developed in Germany, the German model of levo-methadone conversion (GMLC). According to this GMLC, the pre-existing opioid is stopped, then titration of oral levo-methadone is initiated with a starting dose of 5 mg orally q 4 h (plus prn q 1 h). If necessary, levomethadone dose is increased (pain) or decreased (side effects) by 30% q 4 h (plus prn q 1 h). After 72 h, the achieved single dose is maintained, but the dosing interval increases twofold to q 8 h (plus prn q 3 h). The aim of this study was to obtain information about the practicability, safety, and efficacy of the GMLC in clinical routine. Methods: A retrospective, systematic chart review of levomethadone conversions for the treatment of pain in inpatient palliative care was performed. Results: Fifty-two patients were analyzed. The dosing interval was increased correctly after 72 h as demanded by the GMLC in 60% of patients. In 85% of the patients, opioid medication with levo-methadone could be maintained until the end of the inpatient stay. In three patients (6%), levo-methadone administration had to be stopped due to side effects. No serious adverse events could be detected during opioid rotation. Pain intensity was reduced significantly (p<0.001) after conversion concerning mean (NRS 0.9; range 0-4) and maximum pain over the day (NRS 3.9; range 0-10). Conclusion: The presented study indicates that the GMLC provides a practical and reasonably safe approach to perform opioid rotation to levo-methadone in a palliative care setting. © Springer-Verlag 2011.},
author = {Ostgathe, Christoph and Voltz, Raymond and Van Aaaken, Annika and Klein, Carsten and Sabatowski, Rainer and Nauck, Friedemann and Gaertner, Jan},
doi = {10.1007/s00520-011-1320-8},
faupublication = {yes},
journal = {Supportive Care in Cancer},
keywords = {Conversion; Levo-methadone; Opioid; Opioid rotation; Pain; Palliative care},
pages = {2105-2110},
peerreviewed = {Yes},
title = {{Practicability}, safety, and efficacy of a "{German} model" for opioid conversion to oral levo-methadone},
volume = {20},
year = {2012}
}
@article{faucris.245003934,
author = {Peters, Joachim and Dykes, Nathan and Heckel, Maria and Ostgathe, Christoph and Habermann, Mechthild},
doi = {10.1055/a-1689-7524},
faupublication = {yes},
journal = {Zeitschrift für Palliativmedizin},
pages = {46-53},
peerreviewed = {Yes},
title = {{Präsentation} von {Palliativstationen} und {SAPV}-{Teams} im {Internet} - eine korpusbasierte {Metaanalyse} von {Webseiten}},
volume = {23},
year = {2022}
}
@inproceedings{faucris.261563539,
address = {AMSTERDAM},
author = {Allner, Moritz and Gostian, M. and Balk, Matthias and Rupp, Robin and Hecht, Markus and Ostgathe, Christoph and Mueller, Sarina K. and Iro, Heinrich and Gostian, Antoniu-Oreste},
booktitle = {ORAL ONCOLOGY},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2021-07-16},
peerreviewed = {unknown},
publisher = {ELSEVIER},
title = {{Precautionary} documents in patients with head and neck cancer - status quo and factors influencing their creation},
year = {2021}
}
@article{faucris.263666730,
abstract = {We propose a novel knowledge extraction method based on Bayesian-inspired association rule mining to classify anxiety in heterogeneous, routinely collected data from 9,924 palliative patients. The method extracts association rules mined using lift and local support as selection criteria. The extracted rules are used to assess the maximum evidence supporting and rejecting anxiety for each patient in the test set. We evaluated the predictive accuracy by calculating the area under the receiver operating characteristic curve (AUC). The evaluation produced an AUC of 0.89 and a set of 55 atomic rules with one item in the premise and the conclusion, respectively. The selected rules include variables like pain, nausea, and various medications. Our method outperforms the previous state of the art (AUC = 0.72). We analyzed the relevance and novelty of the mined rules. Palliative experts were asked about the correlation between variables in the data set and anxiety. By comparing expert answers with the retrieved rules, we grouped rules into expected and unexpected ones and found several rules for which experts' opinions and the data-backed rules differ, most notably with the patients' sex. The proposed method offers a novel way to predict anxiety in palliative settings using routinely collected data with an explainable and effective model based on Bayesian-inspired association rule mining. The extracted rules give further insight into potential knowledge gaps in the palliative care field.},
author = {Haas, Oliver and Lopera Gonzalez, Luis Ignacio and Hofmann, Sonja and Ostgathe, Christoph and Maier, Andreas and Rothgang, Eva and Amft, Oliver and Steigleder, Tobias},
doi = {10.3389/fdgth.2021.724049},
faupublication = {yes},
journal = {Frontiers in Digital Health},
keywords = {anxiety; machine learning; association rule mining; palliative care; routine data; questionnaire},
peerreviewed = {Yes},
title = {{Predicting} {Anxiety} in {Routine} {Palliative} {Care} {Using} {Bayesian}-{Inspired} {Association} {Rule} {Mining}},
volume = {3},
year = {2021}
}
@article{faucris.212527599,
abstract = {BACKGROUND: Psychological variables and acute post-operative pain are of proven relevance for the prediction of persistent post-operative pain. We aimed at investigating whether pain-specific psychological variables like pain catastrophizing add to the predictive power of acute pain and more general psychological variables like depression.
METHODS: In all, 104 young male patients undergoing thoracic surgery for pectus excavatum correction were studied on the pre-operative day (T0) and 1 week (T1) and 3 months (T2) after surgery. They provided self-report ratings (pain-related: Pain Catastrophizing Scale, Pain Anxiety Symptoms Scale = PASS, Pain Vigilance and Awareness Questionnaire = PVAQ; general psychological: Screening for Somatoform Symptoms, State-Anxiety Inventory-X1, Center for Epidemiologic Studies Depression Scale = CES-D). Additional predictors (T1) as well as criterion variables (T2) were pain intensity (Numerical Rating Scale) and pain disability (Pain Disability Index).
RESULTS: Three months after surgery, 25% of the patients still reported clinically relevant pain (pain intensity ≥3) and over 50% still reported pain-related disability. Acute post-operative pain as well as general psychological variables did not allow for a significant prediction of persistent post-operative pain; in contrast, pain-related psychological variables did. The best single predictors were PASS for pain intensity and PVAQ for pain disability.
CONCLUSIONS: Pain-related psychological variables derived from the fear-avoidance model contributed significantly to the prediction of persistent post-operative pain. The best possible compilation of these measures requires further research. More general psychological variables may become relevant predictors later in the medical history.
SIGNIFICANCE: Our results suggest that pain-specific psychological variables such as pain anxiety and pain hypervigilance add significantly to the prediction of persistent post-operative pain and might even outperform established predictors such as acute pain and general psychological variables. Clinicians might benefit from the development of time-economic screening tools based on these variables.},
author = {Horn-Hofmann, C. and Scheel, J. and Dimova, V. and Parthum, A. and Carbon, R. and Grießinger, Norbert and Sittl, R. and Lautenbacher, S.},
doi = {10.1002/ejp.1115},
faupublication = {yes},
journal = {European Journal of Pain},
note = {EVALuna2:36086},
pages = {191-202},
peerreviewed = {Yes},
title = {{Prediction} of persistent post-operative pain: {Pain}-specific psychological variables compared with acute post-operative pain and general psychological variables},
volume = {22},
year = {2018}
}
@article{faucris.244618491,
author = {Josse, Florent and Stohr, Andreas and Lechner, Raimund and Helm, Matthias and Hossfeld, Bjorn},
doi = {10.1055/a-0967-1586},
faupublication = {yes},
journal = {AINS - Anästhesiologie. Intensivmedizin. Notfallmedizin. Schmerztherapie.},
note = {CRIS-Team WoS Importer:2020-10-30},
pages = {603-617},
peerreviewed = {unknown},
title = {{Prehospital} {Strategies} to {Stop} the {Bleeding}},
volume = {55},
year = {2020}
}
@article{faucris.235697567,
abstract = {Triage is a mainstay of early mass casualty incident (MCI) management. Standardized triage protocols aim at providing valid and reproducible results and, thus, improve triage quality. To date, there is little data supporting the extent and content of training and re-training on using such triage protocols within the Emergency Medical Services (EMS). The study objective was to assess the decline in triage skills indicating a minimum time interval for re-training. In addition, the effect of a one-hour repeating lesson on triage quality was analyzed.A dummy based trial on primary MCI triage with yearly follow-up after initial training using the ASAV algorithm (Amberg-Schwandorf Algorithm for Primary Triage) was undertaken. Triage was assessed concerning accuracy, sensitivity, specificity, over-triage, under-triage, time requirement, and a comprehensive performance measure. A subgroup analysis of professional paramedics was made.Nine hundred ninety triage procedures performed by 51 providers were analyzed. At 1 year after initial training, triage accuracy and overall performance dropped significantly. Professional paramedic's rate of correctly assigned triage categories deteriorated from 84 to 71%, and the overall performance score decreased from 95 to 90 points (maximum = 100). The observed decline in triage performance at 1 year after education made it necessary to conduct re-training. A brief didactic lecture of 45 min duration increased accuracy to 88% and the overall performance measure to 97.To improve disaster preparedness, triage skills should be refreshed yearly by a brief re-education of all EMS providers.},
author = {Dittmar, Michael S. and Wolf, Philipp and Bigalke, Marc and Graf, Bernhard M. and Birkholz, Torsten},
doi = {10.1186/s13049-018-0501-6},
faupublication = {yes},
journal = {Scandinavian Journal of Trauma Resuscitation & Emergency Medicine},
note = {EVALuna2:103523},
pages = {35},
peerreviewed = {Yes},
title = {{Primary} mass casualty incident triage: evidence for the benefit of yearly brief re-training from a simulation study},
volume = {26},
year = {2018}
}
@article{faucris.109008504,
abstract = {Psychological parameters have been shown to contribute significantly to the development of acute postoperative pain (APOP). For the prediction of APOP in chest malformation patients and cancer patients, we found pain-specific psychological predictors to be of higher relevance than general psychological predictors. The current study aims to further substantiate these findings.In a sample of 73 middle-aged hysterectomy patients, three predictor sets were assessed 1 day before surgery: attentional biases (towards pain-related, social threat, and positive words in a dot-probe task), pain-related emotions and cognitions (pain anxiety, pain catastrophizing, and pain hypervigilance), and affective state variables (depression and somatization). APOP intensity rated 2-3 days after surgery and analgesic consumption during the first 48 postoperative hours were used as outcome measures.APOP intensity ratings were significantly explained by their best single predictors in a multiple regression analysis: social threat words of the dot-probe task, pain anxiety, and somatization (14.7% of explained variance). When comparing standardized beta coefficients, pain-specific psychological predictors appeared to be of higher explanatory relevance than general psychological predictors. In contrast, analgesic consumption could not be significantly predicted by the psychological variables.Hysterectomy patients at risk for high APOP intensity could be characterized by the psychological variables used, whereas their predictive value for analgesic consumption was limited. The high predictive potency of pain-specific psychological variables should be considered for further improvement of pain management and prevention, because pain-specific variables like pain anxiety can be the target of focal psychological interventions when preparing for surgery.},
author = {Scheel, Jennifer and Sittl, Reinhard and Grießinger, Norbert and Strupf, Marion and Parthum, Andreas and Dimova, Violeta and Horn-Hofmann, Claudia and Thiel, Falk and Beckmann, Matthias and Lautenbacher, Stefan},
doi = {10.1097/AJP.0000000000000442},
faupublication = {yes},
journal = {Clinical Journal of Pain},
note = {EVALuna2:16734},
peerreviewed = {Yes},
title = {{Psychological} {Predictors} of {Acute} {Postoperative} {Pain} after {Hysterectomy} for {Benign} {Causes}},
year = {2016}
}
@article{faucris.117838204,
abstract = {The present study was performed to investigate the effect of multidimensional psychological prophylaxis training focusing on coping with cognitive-emotional pain on recovery within the first 12 months after surgery. The training included the following three components: (1) education about pain, analgesia and psychological aspects of coping with pain, (2) training for coping with pain and (3) body-centered relaxation.In the study 48 young male patients (surgical correction of a chest malformation) were assessed 1 day before surgery, at discharge and 3, 6 and 12 months postoperatively concerning postoperative pain intensity and pain disability as well as pain anxiety, pain catastrophizing and pain hypervigilance. Additionally, 24 of these patients received training on cognitive-emotional coping with pain 1 day before surgery and 1-3 days after surgery (each session 1 h).The proportion of patients with clinically relevant improvement was significantly higher in the training group compared to the control group. This was the case for acute pain intensity (approximately 1 week after surgery), pain disability 3 months later and pain anxiety 12 months after surgery.The resurgence of pain anxiety after 12 months could only be found in the control group and could be due to the upcoming surgical removal of the transsternal metal implant. The prophylaxis training can therefore be seen as a protective factor for long-term management of surgery-related consequences and future pain experiences.},
author = {Scheel, J. and Parthum, A. and Dimova, V. and Horn-Hoffmann, C. and Meinfelder, F. and Carbon, R. and Grießinger, Norbert and Sittl, R. and Lautenbacher, S.},
doi = {10.1007/s00482-014-1476-5},
faupublication = {yes},
journal = {Schmerz},
note = {EVALuna2:15688},
pages = {513-9},
peerreviewed = {Yes},
title = {{Psychological} prophylaxis training for coping with postoperative pain. {Long}-term effects},
volume = {28},
year = {2014}
}
@article{faucris.211856200,
abstract = {Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure. By contrast, a hallmark feature of fibroblasts in arthritis is degradation of the extracellular matrix because of the release of metalloproteinases and degrading enzymes, and subsequent tissue destruction. The mechanisms that drive these functionally opposing pro-fibrotic and pro-inflammatory phenotypes of fibroblasts remain unknown. Here we identify the transcription factor PU.1 as an essential regulator of the pro-fibrotic gene expression program. The interplay between transcriptional and post-transcriptional mechanisms that normally control the expression of PU.1 expression is perturbed in various fibrotic diseases, resulting in the upregulation of PU.1, induction of fibrosis-associated gene sets and a phenotypic switch in extracellular matrix-producing pro-fibrotic fibroblasts. By contrast, pharmacological and genetic inactivation of PU.1 disrupts the fibrotic network and enables reprogramming of fibrotic fibroblasts into resting fibroblasts, leading to regression of fibrosis in several organs.},
author = {Wohlfahrt, Thomas and Rauber, Simon and Uebe, Steffen and Luber, Markus and Soare, Alina and Ekici, Arif Bülent and Weber, Stefanie and Matei, Alexandru-Emil and Chen, Chih Wei and Maier, Christiane and Karouzakis, Emmanuel and Kiener, Hans P. and Pachera, Elena and Dees, Clara and Beyer, Christian and Daniel, Christoph and Gelse, Kolja and Kremer, Andreas and Naschberger, Elisabeth and Stürzl, Michael and Butter, Falk and Sticherling, Michael and Finotto, Susetta and Kreuter, Alexander and Kaplan, Mark H. and Jüngel, Astrid and Gay, Steffen and Nutt, Stephen L. and Boykin, David W. and Poon, Gregory M.K. and Distler, Oliver and Schett, Georg and Distler, Jörg and Ramming, Andreas},
doi = {10.1038/s41586-019-0896-x},
faupublication = {yes},
journal = {Nature},
note = {EVALuna2:35476},
peerreviewed = {Yes},
title = {{PU}.1 controls fibroblast polarization and tissue fibrosis},
year = {2019}
}
@article{faucris.107805764,
abstract = {The most effective action for primary prevention of chronic obstructive lung disease is smoking cessation early enough. In secondary prevention, smokers with airway obstruction were more likely to quit smoking. The aim of this study was to evaluate the impact of a public spirometry on smoking habits in terms of primary prevention.Spirometry with its medical analysis was offered to visitors of a local public event called 'Lange Nacht der Wissenschaften' ('Long night of sciences'). The impact of results on smoking habits was evaluated in all smokers with an anonymized questionnaire afterwards.Two hundred fifty-seven people with the median age of 30 years (interquartile range 22-46) were examined. Out of 44 current smokers (17.1%), only two individuals showed a prebronchodilator FEV1/forced vital capacity-value <0.7. Fourteen smokers stated to have an increased motivation to quit smoking whereas 28 smokers declared that their motivation to quit smoking was independent of spirometry result. These smokers were significantly younger (median age 28 vs. 40 years, P = 0.025) without differences in spirometry results or smoking habits.In an unselected population with a high amount of younger adults, normal spirometry did not show a short-term benefit for primary prevention of chronic obstructive lung disease in terms of increasing motivation to quit smoking.},
author = {Zirlik, Sabine and Wich, Christina and Frieser, Markus and Hildner, Kai and Kleye, Christin and Neurath, Markus and Fuchs, Florian S.},
doi = {10.1111/jep.12077},
faupublication = {yes},
journal = {Journal of Evaluation in Clinical Practice},
note = {EVALuna2:1869},
pages = {43-7},
peerreviewed = {Yes},
title = {{Public} spirometry for primary prevention of {COPD}},
volume = {20},
year = {2014}
}
@article{faucris.286950418,
abstract = {A new assay was developed to measure the concentration of remimazolam besylate (CNS7056B) and its major carboxylic acid metabolite (CNS7054X) in human plasma. For this new assay method, midazolam-d4 maleate was used as an internal standard. After setting up a previously described assay method, using CNS7056-d4 and CNS7054-d4 as internal standards, analytical results of both methods were compared. For the new analytical method, ultra-high-performance liquid chromatography (UHPLC) with tandem mass spectrometry was applied. A purification method, using solid phase extraction, was developed and validated. The chromatographic separation of the analytes was achieved with a mobile phase gradient using a Water Acquity (TM) UHPLC-System. The Kinetex (TM) biphenyl 50 x 2.1 mm UHPLC column was used with a particle diameter of 1.7 mu m (Phenomenex, Germany). A measuring range of 0.6-2,000 ng/mL for CNS7056B and of 6-20,000 ng/mL for CNS7054X could be achieved with this new assay. The lower limit of quantification was 0.6 ng/mL for CNS7056B and 6 ng/mL for CNS7054X. The assay was validated according to US Food and Drug Administration guidelines. The new method showed an accuracy of 96.9-110.4% and a precision of 2.1-6.7% for both analytes.},
author = {Schmidt, Stefanie and Krajinovic, Ljubica and Mertens, Christian and Schramm, Lisa and Schüttler, Jürgen and Fechner, Jörg},
doi = {10.1093/chromsci/bmac097},
faupublication = {yes},
journal = {Journal of Chromatographic Science},
note = {CRIS-Team WoS Importer:2022-12-23},
peerreviewed = {Yes},
title = {{Quantification} of {Remimazolam} {Besylate} ({CNS7056B}) and {Its} {Metabolite} ({CNS7054X}) by {LC}-{MS}/{MS} in {Human} {Plasma} {Using} {Midazolam}-d4 {Maleate} as {Internal} {Standard}},
year = {2022}
}
@inproceedings{faucris.263893629,
abstract = {The phase relationship between respiration and cardio- vascular system is investigated under the influence of paced respiration with respiratory rates from 4 to 25 breaths per minute. Particularly, the phase shift dependency on breathing rate as well as the correlation between respiratory sinus arrhythmia (RSA) and breathing frequency is examined. It can be shown that there is an increasing phase relationship between RSA and breathing frequency and that RSA diminishes with rising breathing frequenc},
author = {Leutheuser, Heike and Schaffer, Thorsten and Hensel, Bernhard and Weigand, Christian and Schüttler, Jürgen and Jeleazcov, Christian},
booktitle = {7th Russian-Bavarian Conference on Biomedical Engineering (RBC)},
faupublication = {yes},
keywords = {respiratory sinus arrhythmia; paced respiration; cardiorespiratory system},
pages = {9-10},
peerreviewed = {unknown},
title = {{Quantitative} analysis of the cardiorespiratory system during paced respiration},
year = {2011}
}
@article{faucris.202373734,
abstract = {This paper introduces heart sound detection by radar systems, which enables touch-free and continuous monitoring of heart sounds. The proposed measurement principle entails two enhancements in modern vital sign monitoring. First, common touch-based auscultation with a phonocardiograph can be simplified by using biomedical radar systems. Second, detecting heart sounds offers a further feasibility in radar-based heartbeat monitoring. To analyse the performance of the proposed measurement principle, 9930 seconds of eleven persons-under-tests' vital signs were acquired and stored in a database using multiple, synchronised sensors: a continuous wave radar system, a phonocardiograph (PCG), an electrocardiograph (ECG), and a temperature-based respiration sensor. A hidden semi-Markov model is utilised to detect the heart sounds in the phonocardiograph and radar data and additionally, an advanced template matching (ATM) algorithm is used for state-of-the-art radar-based heartbeat detection. The feasibility of the proposed measurement principle is shown by a morphology analysis between the data acquired by radar and PCG for the dominant heart sounds S1 and S2: The correlation is 82.97 ± 11.15% for 5274 used occurrences of S1 and 80.72 ± 12.16% for 5277 used occurrences of S2. The performance of the proposed detection method is evaluated by comparing the F-scores for radar and PCG-based heart sound detection with ECG as reference: Achieving an F1 value of 92.22 ± 2.07%, the radar system approximates the score of 94.15 ± 1.61% for the PCG. The accuracy regarding the detection timing of heartbeat occurrences is analysed by means of the root-mean-square error: In comparison to the ATM algorithm (144.9 ms) and the PCG-based variant (59.4 ms), the proposed method has the lowest error value (44.2 ms). Based on these results, utilising the detected heart sounds considerably improves radar-based heartbeat monitoring, while the achieved performance is also competitive to phonocardiography.
},
author = {Will, Christoph and Shi, Kilin and Schellenberger, Sven and Steigleder, Tobias and Michler, Fabian and Fuchs, Jonas and Weigel, Robert and Ostgathe, Christoph and Kölpin, Alexander},
doi = {10.1038/s41598-018-29984-5},
faupublication = {yes},
journal = {Scientific Reports},
peerreviewed = {Yes},
title = {{Radar}-{Based} {Heart} {Sound} {Detection}},
year = {2018}
}
@inproceedings{faucris.314919511,
abstract = {The accurate detection and quantification of activities of daily life (ADL) are crucial for assessing the health status of palliative patients to allow an optimized treatment in the last phase of life. Current evaluation methods heavily rely on subjective self-reports or external observations by clinical staff, lacking objectivity. To address this limitation, we propose a radar-based approach for recognizing ADLs in a palliative care context. In our proof of concept study, we recorded five different ADLs relevant to palliative care, all occurring within a hospital bed, from N=14 healthy participants (57% women, aged 28.6 ± 5.3years). All movements were recorded using two frequency-modulated continuous wave radar systems measuring velocity, range, and angle. A convolutional neural network combined with long short-term memory achieved a classification accuracy of 99.8 ± 0.4% across five cross-validation folds. Furthermore, we compare our initial approach, which takes into account all dimensions of the available radar data, to a simplified version, where only velocity information over time is fed into the network. While these results demonstrate the high potential of radar-based sensing to automatically detect and quantify activities in a palliative care context, future work is still necessary to assess the applicability to real-world hospital scenarios.
75% agreement), (122) were original EAPC recommendations with 13 new recommendations included emerging specialisms: neonatal, geriatric and dementia care, and better care practices. Seven statements failed to reach consensus and four were removed as irrelevant or repetition. Conclusions: Most recommendations on standards and norms for palliative care in Europe remain unchanged since 2009. Evolving concepts in palliative care can be used to support advocacy.},
author = {Payne, Sheila and Harding, Andrew and Williams, Tom and Ling, Julie and Ostgathe, Christoph},
doi = {10.1177/02692163221074547},
faupublication = {yes},
journal = {Palliative Medicine},
note = {CRIS-Team WoS Importer:2022-02-25},
peerreviewed = {Yes},
title = {{Revised} recommendations on standards and norms for palliative care in {Europe} from the {European} {Association} for {Palliative} {Care} ({EAPC}): {A} {Delphi} study},
year = {2022}
}
@article{faucris.111198164,
abstract = {The proinflammatory cytokine interleukin-17A (IL-17A) is known to mediate antimicrobial activity, but its role during rhinovirus (RV) infections and in asthma needs further investigation. Therefore, we addressed the role of IL-17A during allergic asthma and antiviral immune response in human and murine immunocompetent cells. In this study we found that asthmatic children with a RV infection in their upper airways have upregulated mRNA levels of the antiviral cytokine interferon type I (IFN)-? and the transcription factor T-box 21 (TBX21) and reduced levels of IL-17A protein in their peripheral blood mononuclear cells (PBMCs). We also found that IL-17A inhibited RV1b replication in infected human lung epithelial cells A549. Furthermore, by using gene array analysis we discovered that targeted deletion of Il17a in murine lung CD4(+) T cells impaired Oas1g mRNA downstream of Ifn?, independently from RV infection. Additionally, in PBMCs of children with a RV infection in their nasalpharyngeal fluid OAS1 gene expression was found downregulated. Finally RV1b inhibited IL-17A production in lung CD4(+) T cells in a setting of experimental asthma. These results indicate that the RV1b inhibits IL-17A in T helper type 17 cells and IL-17A clears RV1b infection in epithelial cells. In both cases IL-17A contributes to fend off RV1b infection by inducing genes downstream of interferon type I pathway.},
author = {Graser, Anna and Ekici, Arif Bülent and Sopel, Nina and Melichar, V. O. and Zimmermann, Theodor and Papadopoulos, N. G. and Taka, S. and Ferrazzi, Fulvia and Vuorinen, T. and Finotto, Susetta},
doi = {10.1038/mi.2015.130},
faupublication = {yes},
journal = {Mucosal Immunology},
note = {EVALuna2:9312},
pages = {1183-92},
peerreviewed = {Yes},
title = {{Rhinovirus} inhibits {IL}-{17A} and the downstream immune responses in allergic asthma},
volume = {9},
year = {2016}
}
@article{faucris.122328844,
author = {Bergauer, Annika and Sopel, Nina and Kro, Bettina and Vuorinen, Tytti and Xepapadaki, Paraskevi and Weiss, Scott T. and Blau, Ashley and Sharma, Himanshu and Kraus, Cornelia and Springel, Rebekka and Rauh, Manfred and Mittler, Susanne and Graser, Anna and Zimmermann, Theodor and Melichar, Volker O. and Kiefer, Alexander and Kowalski, Marek L. and Sobanska, Anna and Jartti, Tuomas and Lukkarinen, Heikki and Papadopoulos, Nikolaos G. and Finotto, Susetta},
doi = {10.1183/13993003.00265-2017},
faupublication = {yes},
journal = {European Respiratory Journal},
note = {EVALuna2:25986},
peerreviewed = {Yes},
title = {{Rhinovirus} species/genotypes and interferon-λ: subtypes, receptor and polymorphisms - missing pieces of the puzzle of childhood asthma?},
volume = {49},
year = {2017}
}
@article{faucris.215289504,
abstract = {RATIONALE: Rhinoviruses are major triggers of common cold and acute asthma exacerbations; Rhinovirus species A, B and C may have distinct clinical impact; however, little is known regarding RV species-specific antibody responses in health and asthma.
OBJECTIVES: To describe and compare total and rhinovirus species-specific antibody levels in healthy and asthmatic children, away from an acute event.
METHODS: Serum samples from 163 preschool children with mild to moderate asthma and 72 healthy controls from the multinational Predicta cohort were analysed using the recently developed PreDicta rhinovirus antibody chip.
MAIN RESULTS: Rhinovirus antibody levels varied, with rhinovirus C and rhinovirus A being higher than rhinovirus B in both groups. Compared to controls, asthma was characterised by significantly higher levels of antibodies to rhinovirus A and rhinovirus C, but not rhinovirus B. Rhinovirus antibody levels positively correlated with the number of common colds over the previous year in healthy children, and wheeze episodes in asthmatics. Antibody levels also positively correlated with asthma severity but not with current asthma control.
CONCLUSIONS: The variable humoral response to rhinovirus species in both groups, suggests a differential infectivity pattern between rhinovirus species. In healthy pre-schoolers, rhinovirus antibodies accumulate with colds. In asthma, rhinovirus A and rhinovirus C antibodies are much higher and further increase with disease severity and wheeze episodes. Higher antibody levels in asthma may be due to a compromised innate immune response, leading to increased exposure of the adaptive immunity to the virus. Importantly, there is no apparent protection with increasing levels of antibodies.},
author = {Megremis, Spyridon and Niespodziana, Katarzyna and Cabauatan, Clarissa and Xepapadaki, Paraskevi and Kowalski, Marek L. and Jartti, Tuomas and Bachert, Claus and Finotto, Susetta and West, Peter and Stamataki, Sofia and Lewandowska-Polak, Anna and Lukkarinen, Heikki and Zhang, Nan and Zimmermann, Theodor and Stolz, Frank and Neubauer, Angela and Akdis, Mubeccel and Andreakos, Evangelos and Valenta, Rudolf and Papadopoulos, Nikolaos G.},
doi = {10.1164/rccm.201803-0575OC},
faupublication = {yes},
journal = {American Journal of Respiratory and Critical Care Medicine},
note = {EVALuna2:52974},
pages = {1490-1499},
peerreviewed = {Yes},
title = {{Rhinovirus} {Species}-{Specific} {Antibodies} {Differentially} {Reflect} {Clinical} {Outcomes} in {Health} and {Asthma}},
volume = {198},
year = {2018}
}
@article{faucris.287846647,
abstract = {Asthma is a chronic airway disease whose exacerbations are often triggered by rhinovirus infection. TGF-β1 induces rhinovirus replication in infected cells. Moreover, TGF-β1 is a pleiotropic mediator that is produced by many immune cells in the latent, inactive form bound to the latency-associated peptide (LAP) and to the transmembrane protein glycoprotein A repetitions predominant (GARP). In this study we wanted to investigate the effect of rhinovirus infection on the TGF-β secretion and the downstream signaling via TGF-βRI/RII in peripheral blood mononuclear cells from control and asthmatic patients after rhinovirus infection ex vivo. Here, we found a significant upregulation of TGF-βRII in untouched PBMCs of asthmatics as well as a suppression of TGF-β release in the rhinovirus-infected PBMC condition. Moreover, consistent with an effect of TGF-β on Tregs, PBMCs infected with RV induced Tregs, and TGF-βRII directly correlated with RV1b mRNA. Finally, we found via flow cytometry that NK cells expressed less GARP surface-bound TGF-β, while cytokine-producing NKbright cells were induced. In summary, we show that rhinovirus infection inhibits TGF-β release in PBMCs, which results in the activation of both Treg and NK cells.},
author = {Krammer, Susanne and Yang, Zuqin and Mitländer, Hannah and Grund, Janina and Trump, Sonja and Mittler, Susanne and Zirlik, Sabine and Neurath-Finotto, Susetta},
doi = {10.3390/cells12010129},
faupublication = {yes},
journal = {Cells},
keywords = {asthma; NK cells; rhinovirus; TGF-β; TGF-β RI; TGF-β RII},
month = {Jan},
note = {CRIS-Team Scopus Importer:2023-01-20},
peerreviewed = {Yes},
title = {{Rhinovirus} {Suppresses} {TGF}-β-{GARP} {Presentation} by {Peripheral} {NK} {Cells}},
volume = {12},
year = {2023}
}
@article{faucris.116750744,
abstract = {Type III interferons (IFNs), or IFN-?, are known to have potent antiviral and antiproliferative activities. It inhibits viral replication and upregulates cytotoxic responses to virally infected cells. Besides these characteristics, IFN-? also has additional activities in the immune system. In fact, it induces the proliferation of Foxp3-expressing regulatory T cells mediated in part by dendritic cells and inhibit the production of IL-5 and IL-13 in vitro. Regulatory T cells and the Th2 cytokines like IL-5 and IL-13 play important roles in the pathogenesis of allergic asthma. In humans, there seems to be an inverse link between IFN-? and the severity of allergic asthma and allergic asthma exacerbations. Asthmatic patients, without a detectable viral infection show an inverse correlation between IL-28 and IL-29 mRNA levels and severity of allergic responses in the airways. These additional features of IFN-? that affect the adaptive immune system make it a potential immunotherapeutic agent for the treatment of allergic asthma.},
author = {Koch, Sonja and Finotto, Susetta},
doi = {10.1159/000369459},
faupublication = {yes},
journal = {Journal of Innate Immunity},
note = {EVALuna2:25969},
pages = {224-30},
peerreviewed = {Yes},
title = {{Role} of {Interferon}-? in {Allergic} {Asthma}},
volume = {7},
year = {2015}
}
@article{faucris.244609496,
abstract = {Background: We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies. Objective: NFATc2 has been described to associate with IRF4 to induce interleukin-4, and to be inhibited by T-bet. Here, we analyzed the role of NFATc2 in asthmatic children and adults. Methods: PBMCs were isolated from the blood of control of asthmatics subjects. Some PBMCs were analyzed untreated and some cultured with and without phytohemagglutinin. Then, RNA was extracted from the cells and cytokines were measured in the supernatants via enzyme-linked immunosorbent assay or multiplex analysis. RNA was then reverse-transcribed and NFATc1, NFATC2, IRF4, and T-bet mRNA were analyzed by real-time polymerase chain reaction. In addition, in peripheral blood cells, NFATc2 expression was analyzed, in a population of asthmatic children and adults from the Asthma BRIDGE study. Results: In addition to NFATc1 and NIP45, also NFATc2 was found upregulated in PBMCs and peripheral blood cells from asthmatic children and adults with allergic asthma. Moreover, NFATc1 directly correlated with lymphocytes number whereas NFATc2 correlated with peripheral eosinophilia in asthma. Conclusions: In addition to NFATc1 and NIP45, NFATc2 was found upregulated in asthma. Moreover, NFATc1 mRNA correlated with lymphocytes both in control and asthma, and NFATC1 and NFATc2 mRNA showed a direct correlation with eosinophils in controls but not in asthma, indicating that NFATc1 is associated with lymphocytes and not eosinophils in asthma. Clinical Significance: Targeting NFATc2 in T lymphocytes might ameliorate the allergic phenotype in asthmatic subjects.},
author = {Jakobi, Marielena and Kiefer, Alexander and Mirzakhani, Hooman and Rauh, Manfred and Zimmermann, Theodor and Xepapadaki, Paraskevi and Stanic, Barbara and Akdis, Mubeccel and Papadopoulos, Nikolaos G. and Raby, Benjamin A. and Weiss, Scott T. and Neurath-Finotto, Susetta},
doi = {10.1002/iid3.360},
faupublication = {yes},
journal = {Immunity, Inflammation and Disease},
keywords = {allergy processes; animals; eosinophils cells; human; T cells},
note = {CRIS-Team Scopus Importer:2020-10-30},
peerreviewed = {Yes},
title = {{Role} of nuclear factor of activated {T} cells 2 ({NFATc2}) in allergic asthma},
year = {2020}
}
@inproceedings{faucris.243345327,
address = {HOBOKEN},
author = {Jakobi, M. and Mirzakahni, H. and Kiefer, Alexander and Rauh, Manfred and Zimmermann, Theodor and Papadopoulos, N. G. and Raby, B. A. and Weiss, S. T. and Finotto, Susetta},
booktitle = {ALLERGY},
doi = {10.1002/iid3.360},
faupublication = {yes},
note = {CRIS-Team WoS Importer:2020-10-02},
pages = {181-182},
peerreviewed = {unknown},
publisher = {WILEY},
title = {{Role} of nuclear factor of activated {T} cells 2 ({NFATc2}) in allergic asthma},
venue = {London},
year = {2020}
}
@article{faucris.206924227,
author = {Bielor, Carina and Sopel, Nina and Maier, Anja and Blau, Ashley and Sharma, Himanshu and Vuorinen, Tytti and Kross, Bettina and Mittler, Susanne and Graser, Anna and Mousset, Stephanie and Melichar, Volker O. and Kiefer, Alexander and Zimmermann, Theodor and Springel, Rebekka and Holzinger, Corinna and Trump, Sonja and Taka, Stella and Papadopoulos, Nikolaos G. and Weiss, Scott T. and Finotto, Susetta},
doi = {10.1016/j.jaci.2016.10.049},
faupublication = {yes},
journal = {Journal of Allergy and Clinical Immunology},
note = {EVALuna2:32796},
pages = {283-286.e10},
peerreviewed = {Yes},
title = {{Role} of {TGF}-β in anti-rhinovirus immune responses in asthmatic patients},
volume = {140},
year = {2017}
}
@article{faucris.107631964,
abstract = {In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. We also observed increased Th9 cells expressing IL-9 and IL-10 as well as T helper cells expressing IL-6, IL-10 and IL-21 with a defect in IL-17A and IL-17F production. This T helper phenotype was accompanied by increased SOCS3 in the lung of Tyk-2 deficient asthmatic mice. Finally, in vivo treatment with rIL-17A inhibited local CD4(+)CD25(+)Foxp3(+) T regulatory cells as well as Th2 cytokines without affecting IL-9 in the lung. These results suggest a role of Tyk-2 in different subsets of T helper cells mediated by SOCS3 regulation that is relevant for the treatment of asthma, cancer and autoimmune diseases.},
author = {Ubel, Caroline and Graser, Anna and Koch, Sonja and Rieker, Ralf J. and Lehr, Hans A. and Mueller, Mathias and Finotto, Susetta},
doi = {10.1038/srep05865},
faupublication = {yes},
journal = {Scientific Reports},
note = {EVALuna2:6656},
pages = {5865},
peerreviewed = {Yes},
title = {{Role} of {Tyk}-2 in {Th9} and {Th17} cells in allergic asthma},
volume = {4},
year = {2014}
}
@article{faucris.286634058,
author = {Heckel, Maria and Berendt, Julia and Gahr, Susanne and Kauzner, Saskia and Schleef, Tanja and Herbst, Franziska A.},
doi = {10.1055/a-1933-4555},
faupublication = {yes},
journal = {Zeitschrift für Palliativmedizin},
note = {CRIS-Team WoS Importer:2022-12-16},
pages = {309-313},
peerreviewed = {unknown},
title = {{Scoping} {Reviews} in {Palliative} {Research}},
volume = {23},
year = {2022}
}
@article{faucris.265788594,
abstract = {PURPOSE: Guidelines recommend several screening tools to identify patients with complex palliative needs. This diversity and lack of structural recommendations offer a wide scope for implementing screening. Against this background, the current status of implementation at German Comprehensive Cancer Centers (CCCs) funded by the German Cancer Aid has not yet been investigated. METHODS: e-mail survey of the 17 hospital sites of the 13 CCCs. The questionnaire asked for structural characteristics of the centers as well as preconditions of the screening process. Structurally established screening procedures (one item) and standardized workflows, modes of performance, screening tools (four items), modes of training how to screen, and responsibilities (two items) were assessed. RESULTS: In a 2-month period, 15 hospital sites responded; seven hospital sites conducted a palliative care needs (PCN) screening. Only one hospital site carried out PCN screening in almost all oncology departments, but only with the distress thermometer. Other hospital sites determined palliative needs by assessing physical symptoms using the Integrated Palliative Care Outcome Scale or the Minimal Documentation System, and two hospital sites combined tools to determine both physical and psychological stress. The type of screening varied from paper-pencil-based to tablet computer-based documentation. The main barriers to implementation were identified as a lack of human resources and a lack of structural conditions. CONCLUSION: There is a lack of consensus among palliative care specialists and oncologists in the CCCs supported by the German Cancer Aid in PCN screening as well as of structured guidelines and the professional association. Structural requirements should be adapted to these needs, which include both technical and human resources. A combined psycho-oncologic and palliative care screening might help to formulate best practice recommendations.},
author = {Roch, Carmen and Heckel, Maria and Van Oorschot, Birgitt and Alt-Epping, Bernd and Tewes, Mitra},
doi = {10.1200/OP.20.00698},
faupublication = {yes},
journal = {JCO Oncology Practice},
note = {CRIS-Team WoS Importer:2021-11-05},
pages = {639-+},
peerreviewed = {Yes},
title = {{Screening} for {Palliative} {Care} {Needs}: {Pilot} {Data} {From} {German} {Comprehensive} {Cancer} {Centers}},
volume = {17},
year = {2021}
}
@article{faucris.109272284,
abstract = {There is a need for a way to measure success in multi-modal pain therapy that researchers and clinicians can agree upon. According to developments in health services research, operationalizing success should take patient-reported outcomes into account. We will present a success criterion for pain therapy that combines different patient-reported variables and includes validity measures. The usable criterion should be part of a statistically significant and satisfactory model identifying predictors of successful pain therapy.Routine data from 375 patients treated with multi-modal pain therapy from 2008 to 2013 were used. The change scores of five constructs were used for the combined success criterion: pain severity, disability due to pain, depressiveness, and physical- and mental-health-related quality of life. According to the literature, an improvement of at least ½ standard deviation was required on at least four of the five constructs to count as successful. A three-step analytical approach including multiple binary logistic regression analysis was chosen to identify the predictors of therapy success with the success criterion as the dependent variable.A total of 58.1% of the patients were classified as successful. Convergent and predictive validity data show significant correlations between the criterion and established instruments, while discriminative validity could also be shown. A multiple binary logistic regression analysis confirmed the feasibility; a significant model (Chi(2) (8) = 52.585; p < .001) that explained 17.6% of the variance identified the following predictors of therapy success: highest pain severity in the last 4 weeks, disability due to pain, and number of physician visits in the last 6 months.It is possible to develop a feasible success criterion that combines several variables and includes patient-reported outcomes ("PROs") with routine data that can be used in a predictor analysis in multi-modal pain therapy. The criterion was based on basic constructs used in pain therapy and used widespread validated self-rating instruments. Thus, it should be easy to transfer this criterion to other institutions.},
author = {Donath, Carolin and Dorscht, Lisa and Grässel, Elmar and Sittl, Reinhard and Schoen, Christoph},
doi = {10.1186/s12913-015-0939-4},
faupublication = {yes},
journal = {BMC Health Services Research},
note = {EVALuna2:16678},
pages = {272},
peerreviewed = {Yes},
title = {{Searching} for success: {Development} of a combined patient-reported-outcome ("{PRO}") criterion for operationalizing success in multi-modal pain therapy},
volume = {15},
year = {2015}
}
@article{faucris.106735464,
abstract = {The critically-ill undergoing inter-hospital transfers commonly receive sedatives in continuation of their therapeutic regime or to facilitate a safe transfer shielded from external stressors. While sedation assessment is well established in critical care in general, there is only little data available relating to the special conditions during patient transport and their effect on patient sedation levels. The aim of this prospective study was to investigate the feasibility and relationship of clinical sedation assessment (Richmond Agitation-Sedation Scale (RASS)) and objective physiological monitoring (bispectral index (BIS)) during patient transfers in our Mobile-ICU.The levels of sedation of 30 pharmacologically sedated patients were evaluated at 12 to 17 distinct measurement points spread strategically over the course of a transfer by use of the RASS and BIS. To investigate the relation between the RASS and the BIS, Spearman's squared rank correlation coefficient (?(2)) and the Kendall's rank correlation coefficient (?) were calculated. The diagnostic value of the BIS with respect to the RASS was investigated by its sensitivity and positive predictive value for possible patient awakening. Therefore, measurements were dichotomized considering a clinically sensible threshold of 80 for BIS-values and classifying RASS values being nonnegative.Spearman's rank correlation resulted to ?(2) = 0.431 (confidence interval (CI) = 0.341 to 0.513). The Kendall's correlation coefficient was calculated as ? = 0.522 (CI = 0.459 to 0.576). Awakening of patients (RASS >= 0) was detected by a BIS value of 80 and above with a sensitivity of 0.97 (CI = 0.89 to 1.00) and a positive predictive value of 0.59 (CI = 0.45 to 0.71).Our study demonstrates that the BIS-Monitor can be used for the assessment of sedation levels in the intricate environment of a Mobile-ICU, especially when well-established clinical scores as the RASS are impracticable. The use of BIS is highly sensitive in the detection of unwanted awakening of patients during transfers.},
author = {Prottengeier, Johannes and Moritz, Andreas and Heinrich, Stefan and Gall, Christine and Schmidt, Joachim},
doi = {10.1186/s13054-014-0615-9},
faupublication = {yes},
journal = {Critical Care},
note = {EVALuna2:5483},
pages = {615},
peerreviewed = {Yes},
title = {{Sedation} assessment in a mobile intensive care unit: a prospective pilot-study on the relation of clinical sedation scales and the bispectral index},
volume = {18},
year = {2014}
}
@article{faucris.307308586,
abstract = {BACKGROUND: The appropriate provision of sedation as a last resort for the relief of suffering in palliative care is dealt with variably in actual practice. This article is intended as an overview of practically relevant information found in treatment recommendations and guidelines.
METHODS: A systematic literature search was conducted in the PubMed, Scopus, and Google Scholar databases, and a manual search was carried out online. Recommendations that were not available in either German or English, or that were specific to pediatric practice, were excluded. Publication quality was assessed with the AGREE II instrument (Appraisal of Guidelines for Research & Evaluation II). The recommendations in the documents were qualitatively evaluated.
RESULTS: 29 publications (11 journal articles, 18 other) of varying quality according to AGREE II were included. All recommendations and guidelines were essentially based on expert consensus. The common indications for sedation are otherwise intractable delirium, dyspnea, and pain, in patients with a life expectancy of no more than two weeks. Existential distress is a controversial indication. The drug of first choice is midazolam. As the sedating effect of opioids is hard to predict, they should not be used as sedatives. The risks of sedation include respiratory and circulatory depression, as well as the loss of communicative ability, control, and autonomy. It is generally recommended that the patient's symptom burden and depth of sedation should be monitored; clinical and technically supported monitoring are recommended in some publications as well, depending on the situation.
CONCLUSION: There is a broad consensus in favor of sedation to relieve suffering in the last days and hours of life. Recommendations vary for patients with a longer life expectancy and for those with existential distress, and with respect to monitoring.},
author = {Klein, Carsten and Voss, Rafaela and Ostgathe, Christoph and Schildmann, Jan Ansgar},
doi = {10.3238/arztebl.m2023.0034},
faupublication = {yes},
journal = {Deutsches Ärzteblatt international},
note = {EVALuna2:537178},
pages = {235-242},
peerreviewed = {Yes},
title = {{Sedation} in {Palliative} {Care}.},
volume = {120},
year = {2023}
}
@inproceedings{faucris.215822199,
abstract = {Sounds caused by the action of the heart reflect both its health as well as deficiencies and are examined by physicians since antiquity. Pathologies of the valves, e.g. insufficiencies and stenosis, cardiac effusion, arrhythmia, inflammation of the surrounding tissue and other diagnosis can be reached by experienced physicians. However, practice is needed to assess the findings correctly. Furthermore, stethoscopes do not allow for long-term monitoring of a patient. Recently, radar technology has shown the ability to perform continuous touchless and thereby burden-free heart sound measurements. In order to perform automated classification of the signals, the first and most important step is to segment the heart sounds into their physiological phases. This paper examines the use of different Long Short-Term Memory (LSTM) architectures for this purpose based on a large dataset of radar-recorded heart sounds gathered from 30 different test persons in a clinical study. The best-performing network, a bidirectional LSTM, achieves a sample-wise accuracy of 93.4% and a F1 score for the first heart sound of 95.8%.
80/100) levels of workload. Severity of distress as indicated by the NACA score (delta TLX 2.71 per 1 NACA point), execution of invasive procedures (e.g. delta TLX 8.20 for intravenous access), obese patients (delta TLX 0.05 per 1 kg of weight) and aggression incidences (e.g. delta TLX 10.54 for physical aggression), amongst others, resulted in significant increases in workload. Good teamwork decreased workload by 2.18 points per 1 point on the Weller-Teamwork Measurement Tool. Conclusion: Distinct factors result in significant increases in workload for EMS paramedics. Improvements in training for certain medical scenarios, strategies against aggression events and enhancements in EMS logistics - especially for the transfer of obese patients - should be implemented and tested for their presumably positive effect on workload, EMS performance and paramedics' well-being.},
author = {Prottengeier, Johannes and Keunecke, Johann Georg and Gall, Christine and Eiche, Christian and Moritz, Andreas and Birkholz, Torsten},
doi = {10.1186/s13049-019-0650-2},
faupublication = {yes},
journal = {Scandinavian Journal of Trauma Resuscitation & Emergency Medicine},
keywords = {Emergency medical service; Ergonomics; Human factors; NASA task-load-index; Paramedic; Teamwork; Workload},
note = {CRIS-Team Scopus Importer:2019-08-30},
peerreviewed = {Yes},
title = {{Single} mission workload and influencing factors in {German} prehospital emergency medicine - {A} nationwide prospective survey of 1361emergency missions},
volume = {27},
year = {2019}
}
@article{faucris.211489558,
abstract = {Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH)-VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2, was found up-regulated in the blood cells of asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of RV in their airways. Furthermore, in blood cells from control and asthmatic children with RV in their airways, soluble (s) ST2 (sST2) protein was found reduced. Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their airways at the time of the analysis had the lowest sST2 protein levels in the peripheral blood compared to control children without RV and high levels of 25(OH)-VitD3. Amphiregulin (AREG), another ILC2-associated marker, was found induced in the control children with RV in their airways and low serum levels of 25(OH)-VitD3. In conclusion, the anti-inflammatory soluble form of ST2, also known as sST2, in serum correlated directly with interleukin (IL)-33 in the airways of asthmatic children. Furthermore, RV colonization in the airways and low serum levels of 25(OH)-VitD3 were found to be associated with down-regulation of sST2 in serum in paediatric asthma. These data indicate a counter-regulatory role of 25(OH)-VitD3 on RV-induced down-regulation of serum sST2 in paediatric asthma, which is relevant for the therapy of this disease.
},
author = {Haag, Patricia and Sharma, H. and Rauh, Manfred and Zimmermann, Theodor and Vuorinen, T. and Papadopoulos, N. G. and Weiss, S. T. and Finotto, Susetta},
doi = {10.1111/cei.13135},
faupublication = {yes},
journal = {Clinical and Experimental Immunology},
note = {EVALuna2:35820},
pages = {207-220},
peerreviewed = {Yes},
title = {{Soluble} {ST2} regulation by rhinovirus and 25({OH})-vitamin {D3} in the blood of asthmatic children},
volume = {193},
year = {2018}
}
@article{faucris.207423337,
author = {Ostgathe, Christoph and Stachura, Peter and Hofmann, Sonja and Van Oorschot, Birgitt and Oechsle, Karin and Bogdan, Christian and Kunz, Hans Bernd and Foertsch, Baerbel and Klein, Carsten},
faupublication = {yes},
journal = {Onkologe},
note = {EVALuna2:33311},
pages = {303-310},
peerreviewed = {No},
title = {{SOP} - {Dealing} with multidrug-resistant pathogens on the palliative care unit},
volume = {23},
year = {2017}
}
@article{faucris.212602156,
author = {Ostgathe, Christoph and Stachura, Peter and Hofmann, Sonja and Van Oorschot, Birgitt and Oechsle, Karin and Bogdan, Christian and Kunz, Hans Bernd and Foertsch, Baerbel and Klein, Carsten},
faupublication = {yes},
journal = {Onkologe},
note = {EVALuna2:36423},
pages = {75-81},
peerreviewed = {Yes},
title = {{SOP} - {Handling} of multidrug-resistant {Pathogens} in the {Palliative} {Care} {Unit}},
volume = {24},
year = {2018}
}
@article{faucris.282852114,
abstract = {Infobox 1 SOP aus der Reihe
„SOPs zur palliativen Versorgung von Patienten im Netzwerk der deutschen Comprehensive Cancer Center“, erstellt von der AG Palliativmedizin der von der Deutschen Krebshilfe geförderten Comprehensive Cancer Center (CCC},
author = {Ostgathe, Christoph and Stachura, Peter and Heckel, Maria and Brunner, Sarah and Gahr, Susanne and Hofmann, Sonja and Van Oorschot, Birgitt and Oechsle, Karin and Bogdan, Christian and Kunz, Bernd and Foertsch, Baerbel and Klein, Carsten},
doi = {10.1007/s00761-022-01201-z},
faupublication = {yes},
journal = {Die Onkologie},
note = {CRIS-Team WoS Importer:2022-10-07},
peerreviewed = {unknown},
title = {{SOP} - {Management} of multiresistent {Pathogens} in the {Palliative} {Care} {Unit}},
year = {2022}
}
@article{faucris.207424668,
author = {Oechsle, Karin and Radbruch, Lukas and Wolf, Carolin and Ostgathe, Christoph},
faupublication = {yes},
journal = {Onkologe},
note = {EVALuna2:33294},
pages = {469-475},
peerreviewed = {No},
title = {{SOP}-palliative sedation},
volume = {23},
year = {2017}
}
@article{faucris.318016424,
author = {Rosenbruch, Johannes and Eschbach, Corinna and Viehrig, Marén and Ostgathe, Christoph and Bausewein, Claudia},
doi = {10.1007/s00761-024-01475-5},
faupublication = {yes},
journal = {Die Onkologie},
note = {CRIS-Team Scopus Importer:2024-02-09},
peerreviewed = {Yes},
title = {{SOP} – {Respiratory} distress in adult palliative care patients {SOP} – {Atemnot} bei erwachsenen {Palliativpatienten}},
year = {2024}
}
@article{faucris.311090985,
author = {Hense, J. and Przyborek, M. and Rosenbruch, J. and Ostgathe, Christoph and Wolf, C.},
doi = {10.1007/s00761-023-01409-7},
faupublication = {yes},
journal = {Die Onkologie},
note = {CRIS-Team Scopus Importer:2023-09-29},
peerreviewed = {Yes},
title = {{SOP} – {Subkutane} {Medikamentengabe} und {Infusionen} in der erwachsenen {Palliativmedizin} {Version} {II}},
year = {2023}
}
@inproceedings{faucris.114327004,
author = {Wagner, Sören and Chan, Stephen and Murphy, Robyn and Houweling, Peter and Quinlan, Kate and North, Kathryn and Head, Stewart and Friedrich, Oliver},
faupublication = {yes},
pages = {66-66},
peerreviewed = {Yes},
publisher = {Wiley-Blackwell},
title = {{Speed} of shortening is not altered in the alpha-actinin-3 ({ACTN3}) 'gene of speed' knock-out mutation in fast-twitch skeletal muscle},
volume = {213},
year = {2015}
}
@article{faucris.213515481,
author = {Peters, Joachim and Heckel, Maria and Ostgathe, Christoph and Habermann, Mechthild},
doi = {10.1055/a-0873-4234},
faupublication = {yes},
journal = {Zeitschrift für Palliativmedizin},
pages = {125-131},
peerreviewed = {Yes},
title = {{Sprache} in {Bewegung} – {Schlüsselbegriffe} der {Palliativmedizin} im {Wandel} der {Zeit}},
volume = {20},
year = {2019}
}
@article{faucris.113526204,
author = {Breuer, Georg and Schweizer, Karin and Schüttler, Jürgen and Weiß, Marina and Vladut, Anamaria},
faupublication = {yes},
journal = {Anaesthesist},
pages = {16-22},
peerreviewed = {Yes},
title = {„{Sprung} ins kalte {Wasser}“. {Simulatorbasiertes} {Lernen} in akutmedizinischen {Bereichen}},
volume = {63},
year = {2014}
}
@article{faucris.204325982,
abstract = {Aims and objectivesTo explore healthcare professionals' personal experiences, feelings and attitudes about caring for hospitalised patients with multidrug-resistant bacteria in palliative and geriatric care.BackgroundWorking in end-of-life care involves at times burdening demands that affect not only healthcare professionals personally but also their actions. It is suggested that multidrug-resistant bacteria and their consequences for colonised or infected patients in hospitals are among the challenges for all professionals in end-of-life care. Little is known about the feelings and experiences of staff members during healthcare activities with regard to these bacteria.DesignA qualitative interview study in two German hospitals.MethodsWe interviewed 35 staff members from a German palliative care unit and a geriatric unit about their experiences with multidrug-resistant bacteria in end-of-life care and the management of colonised or infected patients. Semistructured interviews were transcribed verbatim and analysed using grounded theory.ResultsInterviewees represented two interdisciplinary teams with 40% nurses, 26% physicians and 34% other professionals. Salient themes that were identified included impact of multidrug-resistant bacteria on staff members' personal actions, feelings and attitudes towards the bacteria and the required isolation measures. Besides higher workload and consequences for working routines, the patients' palliative care needs were recognised, as well as the necessary protection measures to avoid contaminations in hospital. Healthcare professionals reported a dilemma that they experienced when facing these diverse demands.ConclusionsFindings point to emotional and behavioural ambivalence in end-of-life care among staff members because necessary isolation measures and particular situation in end-of-life care create unsolvable conflicts for healthcare professionals. Possible strategies to cope with ambivalence are discussed.Relevance to clinical practiceHealthcare professionals in palliative and geriatric care have to deal with multidrug-resistant bacteria and have to face contradictory feelings while trying to fulfil patients' needs as well as isolation requirements.},
author = {Tiedtke, Johanna and Stiel, Stephanie and Heckel, Maria and Herbst, Franziska A. and Sturm, Alexander and Sieber, Cornel and Ostgathe, Christoph and Lang, Frieder},
doi = {10.1111/jocn.14503},
faupublication = {yes},
journal = {Journal of Clinical Nursing},
keywords = {dual-process model;end-of-life care;geriatric care;interdisciplinary teams;multidrug-resistant bacteria;palliative care;protective measures;qualitative research},
pages = {3115-3122},
peerreviewed = {Yes},
title = {{Staff} members' ambivalence on caring for patients with multidrug-resistant bacteria at their end of life: {A} qualitative study},
volume = {27},
year = {2018}
}
@article{faucris.286181748,
abstract = {Due to the global COVID-19 pandemic, a concomitant increase in awareness for end-of-life decisions (EOLDs) and advance care planning has been noted. Whether the dynamic pandemic situation impacted EOLD-processes on the intensive care unit (ICU) and patient-sided advance care planning in Germany is unknown. This is a retrospective analysis of all deceased patients of surgical ICUs of a university medical center from March 2020 to July 2021. All included ICUs had established standardized protocols and documentation for EOLD-related aspects of ICU therapy. The frequency of EOLDs and advance directives and the process of EOLDs were analyzed (No. of ethical approval EA2/308/20). A total number of 319 (85.5%) of all deceased patients received an EOLD. Advance directives were possessed by 83 (22.3%) of the patients and a precautionary power of attorney by 92 (24.7%) of the patients. There was no difference in the frequency of EOLDs and patient-sided advance care planning between patients with COVID-19 and non-COVID-19 patients. In addition, no differences in frequencies of do-not-resuscitate orders, withholding or withdrawing of intensive care medicine therapeutic approaches, timing of EOLDs, and participation of senior ICU attendings in EOLDs were noted between patients with COVID-19 and non-COVID-19 patients. Documentation of family conferences occurred more often in deceased patients with COVID-19 compared to non-COVID-19 patients (COVID-19: 80.0% vs. non-COVID-19: 56.8, p = 0.001). Frequency of EOLDs and completion rates of advance directives remained unchanged during the pandemic compared to pre-pandemic years. The EOLD process did not differ between patients with COVID-19 and non-COVID-19 patients. Institutional standard procedures might contribute to support the robustness of EOLD-making processes during unprecedented medical emergencies, such as new pandemic diseases.},
author = {Marsch, Fanny and Spies, Claudia D. and Francis, Roland and Graw, Jan A.},
doi = {10.3390/ijerph192215015},
faupublication = {yes},
journal = {International Journal of Environmental Research and Public Health},
keywords = {advance directive; COVID-19; end-of-life decision; intensive care unit; shared decision making},
note = {CRIS-Team Scopus Importer:2022-12-02},
peerreviewed = {Yes},
title = {{Standardized} {High}-{Quality} {Processes} for {End}-of-{Life}-{Decision} {Making} in the {Intensive} {Care} {Unit} {Remain} {Robust} during an {Unprecedented} {New} {Pandemic}—{A} {Single}-{Center} {Experience}},
volume = {19},
year = {2022}
}
@article{faucris.238354776,
abstract = {Background: The working group for palliative medicine within the Comprehensive Cancer Center (CCC) network funded by the German Cancer Aid in Germany has developed and published 14 Standard Operating Procedures (SOPs) for palliative care in CCCs. This study analyzed to what extent these SOPs have been implemented in the clinical routine in the CCC network one year after their publication. Methods: An online-based survey on the implementation status, limitations in daily practice and further themes was conducted between April and July 2018. In total, 125 health professionals in specialized palliative care from all 16 CCC locations were invited to participate. The data were analyzed descriptively using SPSS. Results: The response rate was 52.8%. More than half of the respondents (57.6%) knew about the free availability of SOPs on the CCC network website. The extent to which each SOP was being used actively in practice by the survey respondents ranged from a low of 22.7% (for the "Fatigue" SOP) to a highest of 48.5% (for the "Palliative Sedation" and "Respiratory Distress" SOPs). The respondents became aware of the SOP through recommendations from colleagues, team meetings or from the head of the department. The SOPs "Respiratory distress of an adult palliative patient" and "Palliative sedation" were perceived as the most practically oriented and understandable. Barriers to use SOPs were mainly limited time resources and lack of knowledge of existence and availability. Conclusions: In practice, better knowledge about the SOPs and at the same time increased use can be achieved through systematic training or discussion of SOPs in regular team meetings. There is a need to take measures to optimize the implementation in clinical practice.},
author = {Lödel, Sarah and Ostgathe, Christoph and Heckel, Maria and Oechsle, Karin and Gahr, Susanne},
doi = {10.1186/s12904-020-00565-6},
faupublication = {yes},
journal = {BMC Palliative Care},
keywords = {Comprehensive Cancer Center (CCC); Implementation status; Palliative Care; Standard Operating Procedure (SOP); Survey; Symptoms},
note = {CRIS-Team Scopus Importer:2020-05-15},
peerreviewed = {Yes},
title = {{Standard} {Operating} {Procedures} ({SOPs}) for {Palliative} {Care} in {German} {Comprehensive} {Cancer} {Centers} - {An} evaluation of the implementation status},
volume = {19},
year = {2020}
}
@article{faucris.119219364,
abstract = {Standard operating procedures (SOPs) can contribute to the improvement of patient care.Survey the presence and relevance of SOPs for palliative care (PC) within the network of German Comprehensive Cancer Centers (CCCs) funded by the German Cancer Aid.In a descriptive survey, palliative care services within 15 CCCs funded by the German Cancer Aid were asked to rate availability and thematic relevance of (1) symptom-related, (2) clinical pathways and (3) measures- and processes-oriented SOPs using a structured questionnaire.Pain management SOPs were the most common (n =11; 73 %). The most thematic relevance showed SOPs dedicated to pain management, care in the last days of life and delirium and other neuro-psychiatric diseases (each n =13; 87 %), followed by bowel obstruction, dyspnoea, nausea and palliative sedation (each n =12; 80 %).There is a wide gap between availability and perceived relevance of palliative care SOPs within the network of German CCCs funded by the German Cancer Aid. It is obvious that there is a need for further development of relevant SOPs in palliative care.},
author = {Stachura, P. and Berendt, Julia and Stiel, Stephanie and Schuler, U. S. and Ostgathe, Christoph},
doi = {10.1007/s00482-016-0132-7},
faupublication = {yes},
journal = {Schmerz},
note = {EVALuna2:26210},
pages = {47-53},
peerreviewed = {No},
title = {{Standard} operating procedures ({SOPs}) for palliative care : {Presence} and relevance of palliative {SOPs} within the network of {German} {Comprehensive} {Cancer} {Centers} ({CCCs}) funded by the {German} {Cancer} {Aid}},
volume = {31},
year = {2017}
}
@article{faucris.118677504,
abstract = {Phenotyping, or the identification of patient cohorts, is a recurring challenge in medical informatics. While there are open source tools such as i2b2 that address this problem by providing user-friendly querying interfaces, these platforms lack semantic expressiveness to model complex phenotyping algorithms. The Arden Syntax provides procedural programming language construct, designed specifically for medical decision support and knowledge transfer. In this work, we investigate how language constructs of the Arden Syntax can be used for generic phenotyping. We implemented a prototypical tool to integrate i2b2 with an open source Arden execution environment. To demonstrate the applicability of our approach, we used the tool together with an Arden-based phenotyping algorithm to derive statistics about ICU-acquired hypernatremia. Finally, we discuss how the combination of i2b2's user-friendly cohort pre-selection and Arden's procedural expressiveness could benefit phenotyping.},
author = {Mate, Sebastian and Castellanos, Ixchel and Ganslandt, Thomas and Prokosch, Hans-Ulrich and Kraus, Stefan},
faupublication = {yes},
journal = {Studies in health technology and informatics},
note = {EVALuna2:177},
pages = {37-41},
peerreviewed = {Yes},
title = {{Standards}-{Based} {Procedural} {Phenotyping}: {The} {Arden} {Syntax} on i2b2},
volume = {243},
year = {2017}
}
@article{faucris.208948203,
author = {Ostgathe, Christoph and Thomas, Michael},
faupublication = {yes},
journal = {Onkologe},
note = {EVALuna2:34944},
pages = {2-3},
peerreviewed = {No},
title = {{Standards} for {Palliative} {Medicine}},
volume = {24},
year = {2018}
}
@article{faucris.230858071,
abstract = {In this study we described that Signal Transducer and Activator of Transcription 1 (STAT1) is a key point regulator of PD-1 in tumour infiltrating lymphocytes and PD-L1 in Tumour associated macrophages (TAM) in NSCLC. In our murine model of adenocarcinoma targeted deletion of Stat1 was found associated with enhanced tumour growth, impaired differentiation into M1-like macrophages from the bone marrow, the accumulation of tumor associated macrophages overexpressing PD-L1 and impaired T cell responses in the tumor microenvironment by affecting TNFα responses. In our human NSCLC patient cohort we found that loss of isoforms STAT1 α and STAT1β mRNA in the tumoural region of the lung correlates with increased tumor size in NSCLC patients. Therefore, STAT1 isoform regulation could be considered for future therapeutical strategies associated to current immune-checkpoint blockade therapy in NSCLC.},
author = {Friedrich, Juliane and Heim, Lisanne and Trufa, Denis and Sirbu, Horia and Rieker, Ralf and Neurath-Finotto, Susetta and Chiriac, Mircea-Teodor},
doi = {10.18632/oncotarget.26441},
faupublication = {yes},
journal = {Oncotarget},
note = {EVALuna2:207415},
pages = {37157-37172},
peerreviewed = {Yes},
title = {{STAT1} deficiency supports {PD}-1/{PD}-{L1} signaling resulting in dysfunctional {TNFα} mediated immune responses in a model of {NSCLC}},
volume = {9},
year = {2018}
}
@article{faucris.122772804,
abstract = {Similarities and differences of integration of palliative care in clinical care, research and education structures at German Comprehensive Cancer Centers (CCC) are not known in detail.Provide an overview of availability and the way of integration of specialized palliative care at CCCs funded by the German Cancer Aid (Deutsche Krebshilfe, DKH).We conducted structured interviews from May to August 2014 with heads of palliative care departments (personally or by telephone). The interviews included a quantitative and a qualitative part. Other stakeholders of CCCs were asked the questions of the qualitative part. We evaluated the qualitative data using the content analysis by Mayring and MAXQDA 11.0. SPSS 21.0 was used for quantitative analysis.26 interviews were realized in 13 CCCs with 14 sites, which received funding, by DKH till August 2014 (one CCC had two university hospitals). Of these, 12 sites had a palliative care unit (86 %), 11 sites had palliative care consulting services available (79 %). Participation of palliative care specialists in tumor boards is not provided in 3 institutions (21 %) and is often not feasible on regular basis in the other institutions, due to staffing shortage. In 7 sites (50 %) defined criteria to integrate palliative care into CCCs were available. In the last 5 years specialized palliative care of 4 sites received an invitation for a research project by another department within the CCC (29 %). 10 sites (71 %) had started own palliative care research projects. Chairs in palliative care were available in 4 CCCs (29 %).The extent and depth of palliative care integration in the 14 CCC sites is heterogeneous.},
author = {Berendt, Julia and Oechsle, K. and Thomas, M. and Van Oorschot, B. and Schmitz, A. and Radbruch, L. and Simon, S. T. and Gaertner, J. and Thuss-Patience, P. and Schuler, U. S. and Hense, J. and Gog, C. and Viehrig, M. and Mayer-Steinacker, R. and Stachura, Peter and Stiel, Stephanie and Ostgathe, Christoph},
doi = {10.1055/s-0041-106089},
faupublication = {yes},
journal = {Deutsche Medizinische Wochenschrift},
note = {EVALuna2:26189},
pages = {e16-23},
peerreviewed = {Yes},
title = {{State} of integration of palliative care at {Comprehensive} {Cancer} {Centers} funded by {German} {Cancer} {Aid}},
volume = {141},
year = {2016}
}
@misc{faucris.280026133,
abstract = {Pathogenic variants in SPAST, the gene coding for spastin, are the single most common cause of hereditary spastic paraplegia, a progressive motor neuron disease. Spastin regulates key cellular functions, including microtubule-severing and endoplasmic reticulum-morphogenesis. However, it remains unclear how alterations in these cellular functions due to SPAST pathogenic variants result in motor neuron dysfunction. Since spastin influences both microtubule network and endoplasmic reticulum structure, we hypothesized that spastin is necessary for the regulation of Ca2+ homeostasis via store-operated calcium entry. Here, we show that the lack of spastin enlarges the endoplasmic reticulum and reduces store-operated calcium entry. In addition, elevated levels of different spastin variants induced clustering of STIM1 within the endoplasmic reticulum, altered the transport of STIM1 to the plasma membrane and reduced store-operated calcium entry, which could be rescued by exogenous expression of STIM1. Importantly, store-operated calcium entry was strongly reduced in induced pluripotent stem cell-derived neurons from hereditary spastic paraplegia patients with pathogenic variants in SPAST resulting in spastin haploinsufficiency. These neurons developed axonal swellings in response to lack of spastin. We were able to rescue both store-operated calcium entry and axonal swellings in SPAST patient neurons by restoring spastin levels, using CRISPR/Cas9 to correct the pathogenic variants in SPAST. These findings demonstrate that proper amounts of spastin are a key regulatory component for store-operated calcium entry mediated Ca2+ homeostasis and suggest store-operated calcium entry as a disease relevant mechanism of spastin-linked motor neuron disease.Rizo et al. use iPSC-derived neurons from patients to investigate how pathogenic variants in SPAST give rise to hereditary spastic paraplegia. They show that dysregulation of spastin, a microtubule- and ER-remodelling protein encoded by SPAST, alters the dynamics of the ER, resulting in aberrant Ca2+ regulation.},
author = {Winner, Beate and Rizo Garza, Tania and Gebhardt, Lisa and Riedlberger, Julia and Eberhardt, Esther and Fester, Lars and Alansary, Dalia and Winkler, Jürgen and Turan, Sören and Arnold, Philipp and Niemeyer, Barbara and Fischer, Michael},
doi = {10.1093/brain/awac122},
faupublication = {yes},
keywords = {spastin;STIM1;microtubules;endoplasmic reticulum;store-operated calcium entry},
peerreviewed = {automatic},
title = {{Store}-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia},
url = {https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac122/6651093},
year = {2022}
}
@article{faucris.313211091,
abstract = {Streptococcal toxic shock syndrome is a severe, invasive and life-threatening infection associated with a high risk of rapid multiorgan failure. It is associated with high morbidity and mortality. Streptococcal toxic shock syndrome is very commonly caused by group A-Streptococcus pyogenes, ß-haemolytic streptococcus, a typical human-specific gram-positive bacterial pathogen. We present here the case report of a 54-year-old man with a rapidly progressive streptococcal toxic shock syndrome due to necrotising fasciitis of the left lower limb and describe the successful treatment through close interdisciplinary care.},
author = {Strecker, Thomas and Treutlein, Christoph and Agaimy, Abbas and Wehrfritz, Andreas},
doi = {10.1177/2050313X231207202},
faupublication = {yes},
journal = {SAGE Open Medical Case Reports},
keywords = {amputation; computer tomography; group A-Streptococcus pyogenes; necrotising fasciitis; Streptococcal toxic shock syndrome; β-haemolytic streptococcus},
month = {Jan},
note = {CRIS-Team Scopus Importer:2023-10-27},
peerreviewed = {Yes},
title = {{Streptococcal} toxic shock syndrome with associated necrotising fasciitis necessitating amputation of the lower extremity – {A} case report},
volume = {11},
year = {2023}
}
@article{faucris.260652822,
abstract = {Background: In the initial phase of the COVID-19 pandemic, a lower incidence and death rate was observed in Germany compared to its neighbouring countries, but some studies showed comparatively high death rates in ventilated COVID-19 patients. Methods: In this retrospective analysis, hospital stays of COVID-19 patients at 14 German university hospitals were analysed. For this purpose, local data integration centres of the German Medical Informatics Initiative (MII) combined their data to present death rates in different subgroups depending on gender, age, length of stay in the intensive care unit, ventilation and in combination with different comorbidities. Results: The total lethality rate in 1,318 COVID-19 patients was 18.8 %. In ventilated cases, the lethality rate was 38.8%. Common comorbidities were renal insufficiency (35.2 %), aplastic and other anaemia (26.0 %) diabetes mellitus (21.1 %). The average length of stay was 18 days, or 28 days in case of ventilated patients. Lethality decreased from 20.7 % to 12.7 % over the observation period. Conclusion: The observed decline in lethality rates may be explained with the continuous optimisation of COVID-19 treatment, increasing experience and improved therapy recommendations. The progress made so far by the MII allows cross-consortium analyses to be carried out just in time to better address the challenges of the COVID-19 pandemic.},
author = {Schüttler, Jürgen and Mang, Jonathan M. and Kapsner, Lorenz and Seuchter, Susanne A. and Binder, Harald and Zöller, Daniela and Kohlbacher, Oliver and Boeker, Martin and Zacharowski, Kai and Rohde, Gernot and Balig, Julien and Kampf, Marvin O. and Röhrig, Rainer and Prokosch, Hans-Ulrich},
doi = {10.19224/ai2021.244},
faupublication = {yes},
journal = {Anästhesiologie & Intensivmedizin},
keywords = {COVID-19; Lethality; Medical Informatics Initiative; SARS-CoV-2},
note = {CRIS-Team Scopus Importer:2021-06-25},
pages = {244-257},
peerreviewed = {Yes},
title = {{Studies} on {COVID}-19 lethality: {Causes} and dynamics at {German} {University} {Hospitals} {Letalität} von {Patienten} mit {COVID}-19: {Untersuchungen} zu {Ursachen} und {Dynamik} an deutschen {Universitätsklinika}},
volume = {62},
year = {2021}
}
@article{faucris.263545648,
abstract = {Zusammenfassung},
author = {Oechsle, Karin and Theissen, Tabea and Heckel, Maria and Schwenzitzki, Lisa and Ullrich, Anneke and Ostgathe, Christoph},
doi = {10.1055/a-1543-2511},
faupublication = {yes},
journal = {Deutsche Medizinische Wochenschrift},
note = {CRIS-Team WoS Importer:2021-09-03},
peerreviewed = {Yes},
title = {{Support} for and involvement of family caregivers in {Comprehensive} {Cancer} {Center} - an {Assessment} of the {Palliative} {Care} {Working} {Group} within the network of {Comprehensive} {Cancer} {Center} funded by the {German} {Cancer} {Aid}},
year = {2021}
}
@inproceedings{faucris.203101192,
abstract = {Instantaneous detection of missing vital signs at inpatient beds enables fast intervention for cardiac arrests.
Using a 24 GHz bistatic radar, a fast presence detection based on a support vector machine (SVM) classifer is realized. Large body motions or even small distance deviations, such as movement of the chest induced by heartbeat or breathing, are distinguishable from the measured noise of an unoccupied bed. For classifcation two features are calculated based on windowed I and Q data. Performance is evaluated by varying window sizes from 0.2 ... 1.5 s for feature calculation and training of the SVM classifer. In the resting scenario an accuracy of 99.2% and F1-score of 99.1% with windows of 0.2 s is achieved.
reg cells secrete IL-3 and repress inflammatory cells except for basophils. The present study aims to elucidate the contribution of IL-3 in the development and the course of allergic asthma. We therefore analyzed the secretion of IL-3 in PBMCs and total blood cells in two cohorts of pre-school children with and without asthma. In a murine model of allergic asthma, we analyzed the phenotype of IL-3−/− mice compared to wild-type mice. PBMCs from asthmatic children showed increased IL-3 secretion, which directly correlated with improved lung function. IL-3−/− asthmatic mice showed increased asthmatic traits. Moreover, IL-3-deficient mice had a defect in T regulatory cells in the lung. In conclusion, IL-3 downregulation was found associated with more severe allergic asthma in pre-school children. Consistently, targeting IL-3 resulted in an induced pathophysiological response in a murine model of allergic asthma.},
author = {Kölle, Julia and Zimmermann, Theodor and Kiefer, Alexander and Rieker, Ralf and Xepapadaki, Paraskevi and Zundler, Sebastian and Papadopoulos, Nikolaos G. and Finotto, Susetta},
doi = {10.1016/j.isci.2022.104440},
faupublication = {yes},
journal = {iScience},
keywords = {Biological sciences; immune response; Immunology},
note = {CRIS-Team Scopus Importer:2022-07-15},
peerreviewed = {Yes},
title = {{Targeted} deletion of {Interleukin}-3 results in asthma exacerbations},
volume = {25},
year = {2022}
}
@article{faucris.228832954,
abstract = {Here we investigated the role of NFAT-interacting protein (NIP)-45, an Interleukin (IL)-4 inducing Transcription Factor, and its impact on the differentiation of Group 2 Innate -Lymphoid -Cells (ILC2s) in the pathogenesis of asthma. NIP45, a transcription factor regulating NFATc1 activity, mRNA was found to be induced in the Peripheral Blood mononuclear cells (PMBCs) of asthmatic pre-school children with allergies and in the peripheral blood CD4+ T cells from adult asthmatic patients. In PBMCs of asthmatic and control children, NIP45 mRNA directly correlated with NFATc1 but not with T-bet. Targeted deletion of NIP45 in mice resulted in a protective phenotype in experimental asthma with reduced airway mucus production, airway hyperresponsiveness and eosinophils. This phenotype was reversed by intranasal delivery of recombinant r-IL-33. Consistently, ILC2s and not GATA3+ CD4+ T-cells were decreased in the lungs of asthmatic NIP45−/− mice. Reduced cell number spleen ILC2s could be differentiated from NIP45−/− as compared to wild-type mice after in vivo injection of a microcircle-DNA vector expressing IL-25 and decreased cytokines and ILC2 markers in ILC2 differentiated from the bone marrow of NIP45−/− mice. NIP45 thus emerges as a new therapeutic target for the resolution of the airway pathology, down-regulation of ILC2s and mucus production in asthma.},
author = {Koch, Sonja and Knipfer, Lisa and Kölle, Julia and Mirzakhani, Hooman and Graser, Anna and Zimmermann, Theodor and Kiefer, Alexander and Melichar, Volker O. and Rascher, Wolfgang and Papadopoulos, Nikolaos G. and Rieker, Ralf and Raby, Benjamin A. and Weiss, Scott T. and Wirtz, Stefan and Finotto, Susetta},
doi = {10.1038/s41598-019-51690-z},
faupublication = {yes},
journal = {Scientific Reports},
note = {CRIS-Team Scopus Importer:2019-11-08},
peerreviewed = {Yes},
title = {{Targeted} deletion of {NFAT}-{Interacting}-{Protein}-({NIP}) 45 resolves experimental asthma by inhibiting {Innate} {Lymphoid} {Cells} group 2 ({ILC2})},
volume = {9},
year = {2019}
}
@article{faucris.108545624,
abstract = {Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associated with increased RV-induced asthma exacerbation severity. We examined the contribution of T helper 1 cells to RV-induced airways inflammation using mice deficient in the transcription factor T-Box Expressed In T Cells (Tbet), a critical controller of T helper 1 cell differentiation. Using flow cytometry we showed that Tbet deficient mice lacked the T helper 1 response of wild type mice and instead developed mixed T helper 2/T helper 17 responses to RV infection, evidenced by increased numbers of GATA binding protein 3 (GATA-3) and RAR-related orphan receptor gamma t (ROR?t), and interleukin-13 and interleukin-17A expressing CD4+ T cells in the lung. Forkhead box P3 (FOXP3) and interleukin-10 expressing T cell numbers were unaffected. Tbet deficient mice also displayed deficiencies in lung Natural Killer, Natural Killer T cell and ??T cell responses, and serum neutralising antibody responses. Tbet deficient mice exhibited pronounced airways eosinophilia and mucus production in response to RV infection that, by utilising a CD4+ cell depleting antibody, were found to be T helper cell dependent. RV induction of T helper 2 and T helper 17 responses may therefore have an important role in directly driving features of allergic airways disease such as eosinophilia and mucus hypersecretion during asthma exacerbations.},
author = {Glanville, Nicholas and Peel, Tamlyn J. and Schroeder, Armin and Aniscenko, Julia and Walton, Ross P. and Finotto, Susetta and Johnston, Sebastian L.},
doi = {10.1371/journal.ppat.1005913},
faupublication = {yes},
journal = {PLoS Pathogens},
note = {EVALuna2:25985},
pages = {e1005913},
peerreviewed = {Yes},
title = {{Tbet} {Deficiency} {Causes} {T} {Helper} {Cell} {Dependent} {Airways} {Eosinophilia} and {Mucus} {Hypersecretion} in {Response} to {Rhinovirus} {Infection}},
volume = {12},
year = {2016}
}
@article{faucris.114839604,
abstract = {"Prospective Health Technology Assessment" (ProHTA) aims to develop a platform targeting health care manufacturers and decision makers that facilitates the assessment of innovative health technologies prior to their launch. The simulation has been run for the first case study of Mobile Stroke Units (MSUs). In the highly time sensitive setting of acute stroke, MSUs are an innovative approach as they aim to reduce 'time-to-thrombolysis'. The ProHTA approach focuses on interdisciplinary work related to forecasting with hybrid simulation consisting of system dynamics models for macro-simulation and agent-based models for micro-simulation. Results of the simulation show that MSUs save up to 49 min of time between ambulance call and therapy decision. Whereas without MSUs, only 0.2% of patients fall in the group with the most favourable time interval between 0 and 90 min, up to 16.6% of patients treated in MSUs fall into this group of early onset times to thrombolysis. As a flexible and primarily quantitative decision-making tool for foresight, ProHTA adds value to existing methodologies for pre-assessing health technology at a very early stage of technology research and development. With its emphasis on strategic planning, ProHTA helps to improve the efficiency of health care delivery in different settings using hybrid simulation techniques. © 2013 Elsevier Inc. All rights reserved.},
author = {Kolominsky-Rabas, Peter and Djanatliev, Anatoli and Wahlster, Philip and Gantner-Bär, Marion and Hofmann, Bernd and German, Reinhard and Sedlmayr, Martin and Reinhardt, Erich and Schüttler, Jürgen and Kriza, Christine},
doi = {10.1016/j.techfore.2013.12.005},
faupublication = {yes},
journal = {Technological Forecasting and Social Change},
keywords = {Early technology assessment; Foresight; Health care; Medical device; Simulation; Stroke},
note = {UnivIS-Import:2015-03-09:Pub.2014.tech.IMMD.IMMD7.techno},
pages = {105-114},
peerreviewed = {Yes},
title = {{Technology} foresight for medical device development through hybrid simulation: {The} {ProHTA} {Project}},
url = {http://www.sciencedirect.com/science/article/pii/S0040162513003119},
volume = {97},
year = {2015}
}
@article{faucris.250580202,
abstract = {Background Mechanical chest compression (mCPR) offers advantages during transport under cardiopulmonary resuscitation. Little is known how devices of different design perform en-route. Aim of the study was to measure performance of mCPR devices of different construction-design during ground-based pre-hospital transport. Methods We tested animax mono (AM), autopulse (AP), corpuls cpr (CC) and LUCAS2 (L2). The route had 6 stages (transport on soft stretcher or gurney involving a stairwell, trips with turntable ladder, rescue basket and ambulance including loading/unloading). Stationary mCPR with the respective device served as control. A four-person team carried an intubated and bag-ventilated mannequin under mCPR to assess device-stability (displacement, pressure point correctness), compliance with 2015 ERC guideline criteria for high-quality chest compressions (frequency, proportion of recommended pressure depth and compression-ventilation ratio) and user satisfaction (by standardized questionnaire). Results All devices performed comparable to stationary use. Displacement rates ranged from 83% (AM) to 11% (L2). Two incorrect pressure points occurred over 15,962 compressions (0.013%). Guideline-compliant pressure depth was > 90% in all devices. Electrically powered devices showed constant frequencies while muscle-powered AM showed more variability (median 100/min, interquartile range 9). Although physical effort of AM use was comparable (median 4.0 vs. 4.5 on visual scale up to 10), participants preferred electrical devices. Conclusion All devices showed good to very good performance although device-stability, guideline compliance and user satisfaction varied by design. Our results underline the importance to check stability and connection to patient under transport.},
author = {Joergens, Maximilian and Koeniger, Jurgen and Kanz, Karl-Georg and Birkholz, Torsten and Huebner, Heiko and Prueckner, Stephan and Zwissler, Bernhard and Trentzsch, Heiko},
doi = {10.1186/s12873-021-00409-3},
faupublication = {yes},
journal = {BMC Emergency Medicine},
note = {CRIS-Team WoS Importer:2021-02-26},
peerreviewed = {Yes},
title = {{Testing} mechanical chest compression devices of different design for their suitability for prehospital patient transport-a simulator-based study},
volume = {21},
year = {2021}
}
@inproceedings{faucris.207450994,
author = {Finotto, Susetta and Bielor, Carina and Sopel, Nina and Vuorinen, T. and Melichar, V. O. and Kiefer, Alexander and Zimmermann, Theodor and Papadopoulos, N. G. and Weiss, S. T.},
faupublication = {yes},
note = {EVALuna2:33023},
pages = {107-107},
peerreviewed = {Yes},
title = {{Tgf}-beta regulation and regulated anti-rhinovirus ({RV}) immune responses in asthma},
volume = {72},
year = {2017}
}
@article{faucris.211478893,
abstract = {Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the adaptive immune system in PD. Here, we show a role for human T lymphocytes as cell death inducers of induced pluripotent stem cell (iPSC)-derived MBNs in sporadic PD. Higher Th17 frequencies were found in the blood of PD patients and increased numbers of T lymphocytes were detected in postmortem PD brain tissues. We modeled this finding using autologous co-cultures of activated T lymphocytes and iPSC-derived MBNs of sporadic PD patients and controls. After co-culture with T lymphocytes or the addition of IL-17, PD iPSC-derived MBNs underwent increased neuronal death driven by upregulation of IL-17 receptor (IL-17R) and NF kappa B activation. Blockage of IL-17 or IL-17R, or the addition of the FDA-approved anti-IL-17 antibody, secukinumab, rescued the neuronal death. Our findings indicate a critical role for IL-17-producing T lymphocytes in sporadic PD.},
author = {Sommer, Annika and Maxreiter, Franz and Krach, Florian and Fadler, Tanja and Grosch, Janina and Maroni, Michele and Graef, Daniela and Eberhardt, Esther and Riemenschneider, Markus J. and Yeo, Gene W. and Kohl, Zacharias and Xiang, Wei and Gage, Fred H. and Winkler, Jürgen and Prots, Iryna and Winner, Beate},
doi = {10.1016/j.stem.2018.06.015},
faupublication = {yes},
journal = {Cell Stem Cell},
note = {EVALuna2:35782},
pages = {123-+},
peerreviewed = {Yes},
title = {{Th17} {Lymphocytes} {Induce} {Neuronal} {Cell} {Death} in a {Human} {iPSC}-{Based} {Model} of {Parkinson}'s {Disease}},
volume = {23},
year = {2018}
}
@article{faucris.106373784,
abstract = {Allergic asthma is a worldwide increasing chronic disease of the airways which affects more than 300 million people. It is associated with increased IgE, mast cell activation, airway hyperresponsiveness (AHR), mucus overproduction and remodeling of the airways. Previously, this pathological trait has been associated with T helper type 2 (Th2) cells. Recently, different CD4(+) T cell subsets (Th17, Th9) as well as cells of innate immunity, like mast cells and innate lymphoid cells type 2 (ILC2s), which are all capable of producing the rediscovered cytokine IL-9, are known to contribute to this disease. Regarding Th9 cells, it is known that naïve T cells develop into IL-9-producing cells in the presence of interleukin-4 (IL-4) and transforming growth factor beta (TGF?). Downstream of IL-4, several transcription factors like signal transducer and activator of transcription 6 (STAT6), interferon regulatory factor 4 (IRF4), GATA binding protein 3 (GATA3), basic leucine zipper transcription factor, ATF-like (BATF) and nuclear factor of activated T cells (NFAT) are activated. Additionally, the transcription factor PU.1, which is downstream of TGF? signaling, also seems to be crucial in the development of Th9 cells. IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma.},
author = {Koch, Sonja and Sopel, Nina and Finotto, Susetta},
doi = {10.1007/s00281-016-0601-1},
faupublication = {yes},
journal = {Seminars in Immunopathology},
note = {EVALuna2:25987},
pages = {55-68},
peerreviewed = {Yes},
title = {{Th9} and other {IL}-9-producing cells in allergic asthma},
volume = {39},
year = {2017}
}
@article{faucris.106691244,
abstract = {Mice without the basic leucine zipper transcription factor, ATF-like (BATF) gene (Batf(-/-)) lack TH17 and follicular helper T cells, which demonstrates that Batf is a transcription factor important for T- and B-cell differentiation.In this study we examined whether BATF expression would influence allergic asthma.In a cohort of preschool control children and children with asthma, we analyzed BATF mRNA expression using real-time PCR in PBMCs. In a murine model of allergic asthma, we analyzed differences in this allergic disease between wild-type, Batf transgenic, and Batf(-/-) mice.In the absence of corticosteroid treatment, children with recurrent asthma have a significant increase in BATF mRNA expression in their PBMCs. Batf(-/-) mice display a significant reduction in the pathophysiologic responses seen in asthmatic wild-type littermates. Moreover, we discovered a decrease in IL-3 production and IL-3-dependent mast cell development in Batf(-/-) mice. By contrast, IFN-? was induced in lung CD4(+) and CD8(+) T cells. Intranasal delivery of anti-IFN-? antibodies induced airway hyperresponsiveness and inflammation in wild-type but not in Batf(-/-) mice. Transgenic overexpression of Batf under the control of the CD2 promoter/enhancer augmented lung inflammation and IgE levels in the setting of experimental asthma.BATF is increased in non-steroid-treated asthmatic children. Targeting BATF expression resulted in amelioration of the pathophysiologic responses seen in children with allergic asthma, and BATF has emerged as a novel target for antiasthma interventions.},
author = {Ubel, Caroline and Sopel, Nina and Graser, Anna and Hildner, Kai and Reinhardt, Cornelia and Zimmermann, Theodor and Rieker, Ralf Joachim and Maier, Anja and Neurath, Markus and Murphy, Kenneth M. and Finotto, Susetta},
doi = {10.1016/j.jaci.2013.09.049},
faupublication = {yes},
journal = {Journal of Allergy and Clinical Immunology},
note = {EVALuna2:1742},
pages = {198-206.e9},
peerreviewed = {Yes},
title = {{The} activating protein 1 transcription factor basic leucine zipper transcription factor, {ATF}-like ({BATF}), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma},
volume = {133},
year = {2014}
}
@inproceedings{faucris.207446549,
author = {Graser, Anna and Ekici, Arif Bülent and Melichar, Volker O. and Zimmermann, Theodor and Papadopoulos, Nikolaos G. and Taka, Stella and Ferrazzi, Fulvia and Vuorinen, Tytti and Finotto, Susetta},
faupublication = {yes},
note = {EVALuna2:25975},
pages = {96-96},
peerreviewed = {Yes},
title = {{The} anti-viral properties of {IL}-{17A} in allergic asthma},
volume = {76},
year = {2015}
}
@article{faucris.123568764,
abstract = {Some patients with advanced and progressive diseases express a desire to hasten death.This study evaluated the motivations of patients expressing such a desire in a country with prohibitive legislation on euthanasia and physician-assisted suicide.A modified form of Grounded Theory was used.Patients from the departments of palliative medicine in three hospitals in Germany were recruited when they had made a statement or request to hasten death. Participants were interviewed face to face. Recruitment was stopped with 12 participants because of data saturation.Thematic analysis revealed three main motivational themes: self-determination, agony, and time. Expectations toward health professionals, attitudes toward death, and secureness related to the end of life were additional main themes emerging from the analysis.The desire to hasten death may be used as an extreme coping strategy to maintain control against anticipated agony. Patients expected health professionals to listen to and respect their experiences. Emerging hypotheses included the following: (a) patients try to balance life time and anticipated agony, and the perception of time is distressing in this balancing act; (b) anticipated images of agony and suffering in the dying process occur frequently and are experienced by patients as intrusive; (c) patients expressing a desire to hasten death are in need of more information about the dying process; and (d) patients wanted their caregivers to listen to and respect their wish to hasten death, and they did not expect the caregivers to understand this as an order to actually hasten their death.},
author = {Pestinger, Martina and Stiel, Stephanie and Elsner, Frank and Widdershoven, Guy and Voltz, Raymond and Nauck, Friedemann and Radbruch, Lukas},
doi = {10.1177/0269216315577748},
faupublication = {yes},
journal = {Palliative Medicine},
note = {EVALuna2:26200},
pages = {711-9},
peerreviewed = {Yes},
title = {{The} desire to hasten death: {Using} {Grounded} {Theory} for a better understanding "{When} perception of time tends to be a slippery slope"},
volume = {29},
year = {2015}
}
@article{faucris.110847484,
abstract = {Classical tumor therapy consists of surgery, radio(RT)- and/or chemotherapy. Additive immunotherapy has gained in impact and antitumor in situ immunization strategies are promising to strengthen innate and adaptive immune responses. Immunological effects of RT and especially in combination with immune stimulation are mostly described for melanoma. Since hyperthermia (HT) in multimodal settings is capable of rendering tumor cells immunogenic, we analyzed the in vivo immunogenic potential of RT plus HT-treated B16 melanoma cells with an immunization and therapeutic assay. We focused on the role of natural killer (NK) cells in the triggered antitumor reactions. In vitro experiments showed that RT plus HT-treated B16 melanoma cells died via apoptosis and necrosis and released especially the danger signal HMGB1. The in vivo analyses revealed that melanoma cells are rendered immunogenic by RT plus HT. Especially, the repetitive immunization with treated melanoma cells led to an increase in NK cell number in draining lymph nodes, particularly of the immune regulatory CD27(+)CD11b(-) NK cell subpopulation. While permanent NK cell depletion after immunization led to a significant acceleration of tumor outgrowth, a single NK cell depletion two days before immunization resulted in significant tumor growth retardation. The therapeutic model, a local in situ immunization closely resembling the clinical situation when solid tumors are exposed locally to RT plus HT, confirmed these effects. We conclude that a dual and time-dependent impact of NK cells on the efficacy of antitumor immune reactions induced by immunogenic tumor cells generated with RT plus HT exists.},
author = {Finkel, Patrick and Frey, Benjamin and Mayer, Friederike and Bösl, Karina and Werthmöller, Nina and Mackensen, Andreas and Gaipl, Udo and Ullrich, Evelyn},
doi = {10.1080/2162402X.2015.1101206},
faupublication = {yes},
journal = {OncoImmunology},
note = {EVALuna2:18356},
pages = {e1101206},
peerreviewed = {Yes},
title = {{The} dual role of {NK} cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia},
volume = {5},
year = {2016}
}
@article{faucris.283844841,
abstract = {Background:
Patients’ knowledge was found to be a key contributor to the success of therapy. Many efforts have been made to educate patients in their disease. However, research found that many patients still lack knowledge regarding their disease. Integrating patient education into social media platforms can bring materials closer to recipients.
Objective:
The aim of this study is to test the effectiveness of patient education via Instagram.
Methods:
A randomized controlled trial was conducted to test the effectiveness of patient education via Instagram among patients with inflammatory bowel disease. Participants were recruited online from the open Instagram page of a patient organization. The intervention group was educated via Instagram for 5 weeks by the research team; the control group did not receive any educational intervention. The knowledge about their disease was measured pre- and postintervention using the Inflammatory Bowel Disease Knowledge questionnaire. Data were analyzed by comparing mean knowledge scores and by regression analysis. The trial was purely web based.
Results:
In total, 49 participants filled out both questionnaires. The intervention group included 25 participants, and the control group included 24 participants. The preintervention knowledge level of the intervention group was reflected as a score of 18.67 out of 24 points; this improved by 3 points to 21.67 postintervention. The postintervention difference between the control and intervention groups was 3.59 points and was statistically significant (t32.88=–4.56, 95% CI 1.98-5.19; P<.001). Results of the regression analysis, accounting for preintervention knowledge and group heterogeneity, indicated an increase of 3.33 points that was explained by the intervention (P<.001).
Conclusions:
Patient education via Instagram is an effective way to increase disease-related knowledge. Future studies are needed to assess the effects in other conditions and to compare different means of patient educatio}, author = {Blunck, Dominik and Kastner, Lena and Nissen, Michael and Winkler, Jacqueline}, doi = {10.2196/36767}, faupublication = {yes}, journal = {Journal of Medical Internet Research}, keywords = {social media; Instagram; patient training; patient education; disease-related knowledge; RCT; randomized controlled trial; Germany; inflammatory bowel disease; IBD-KNOW}, pages = {e36767}, peerreviewed = {Yes}, title = {{The} {Effectiveness} of {Patient} {Training} in {Inflammatory} {Bowel} {Disease} {Knowledge} via {Instagram}: {Randomized} {Controlled} {Trial}}, url = {https://jmir.org/2022/10/e36767}, volume = {24}, year = {2022} } @article{faucris.209552631, abstract = {BACKGROUND: Cognitive aids have come to be viewed as promising tools in the management of perioperative critical events. The majority of published simulation studies have focussed on perioperative crises that are characterised by time pressure, rare occurrence, or complex management steps (e.g., cardiac arrest emergencies, management of the difficult airway). At present, there is limited information on the usefulness of cognitive aids in critical situations with moderate time pressure and complexity. Intraoperative myocardial infarction may be an emergency to which these limitations apply. METHODS: Anaesthetic teams were allocated to control (no cognitive aid; n = 10) or intervention (cognitive aid provided; n = 10) groups. The primary aim of this study was to compare cognitive aid versus memory for intraoperative ST-elevation myocardial infarction (STEMI) management in a simulation of caesarean delivery under spinal anaesthesia. We identified nine evidence-based metrics of essential care from current guidelines and subdivided them into mandatory (high level of evidence; no interference with surgery) and optional (lower class of recommendation; possible impact on surgery) tasks. Six clinically relevant tasks were added by consensus. Implementation of these steps was measured by scoring task items in a binary fashion (yes/no). The interval between the diagnosis of STEMI and the first contact with the cardiac catheterisation lab was measured. To determine whether or not the cognitive aid had prompted an action, participants from the cognitive aid group were interviewed during debriefing on every single treatment step. At the end of the simulation, session participants were asked to complete a survey. RESULTS: The presence of the cognitive aid did not shorten the time interval until the cardiac catheterisation lab was contacted. The availability of the cognitive aid improved task performance in the tasks identified from the guidelines (93% vs. 69%; p < 0.001) as well as overall task performance (87.5% vs. 59%; p < 0.001). The observed difference in performance can be attributed to the use of the cognitive aid, as performance from memory alone would have been comparable across both groups. Trainees appeared to derive greater benefit from the cognitive aid than did consultants and nurses. CONCLUSIONS: The management of intraoperative ST-elevation myocardial infarction can be improved if teams use a cognitive aid. Trainees appeared to derive greater benefit from the cognitive aid than did consultants and nurses.}, author = {St. Pierre, Michael and Lütcke, Björn and Strembski, Dieter and Schmitt, Christopher and Breuer, Georg}, doi = {10.1186/s12871-017-0340-4}, faupublication = {yes}, journal = {BMC Anesthesiology}, note = {EVALuna2:35111}, peerreviewed = {Yes}, title = {{The} effect of an electronic cognitive aid on the management of {ST}-elevation myocardial infarction during caesarean section: a prospective randomised simulation study}, volume = {17}, year = {2017} } @article{faucris.108936564, abstract = {Dual-tasking, the need to divide attention between concurrent tasks, causes a severe increase in workload in emergency situations and yet there is no standardised training simulation scenario for this key difficulty.We introduced and validated a quantifiable source of divided attention and investigated its effects on performance and workload in airway management.A randomised, crossover, interventional simulation study.Center for Training and Simulation, Department of Anaesthesiology, Erlangen University Hospital, Germany.One hundred and fifty volunteer medical students, paramedics and anaesthesiologists of all levels of training.Participants secured the airway of a manikin using a supraglottic airway, conventional endotracheal intubation and video-assisted endotracheal intubation with and without the Paced Auditory Serial Addition Test (PASAT), which served as a quantifiable source of divided attention.Primary endpoint was the time for the completion of each airway task. Secondary endpoints were the number of procedural mistakes made and the perceived workload as measured by the National Aeronautics and Space Administration's task load index (NASA-TLX). This is a six-dimensional questionnaire, which assesses the perception of demands, performance and frustration with respect to a task on a scale of 0 to 100.All 150 participants completed the tests. Volunteers perceived our test to be challenging (99%) and the experience of stress and distraction true to an emergency situation (80%), but still fair (98%) and entertaining (95%). The negative effects of divided attention were reproducible in participants of all levels of expertise. Time consumption and perceived workload increased and almost half the participants make procedural mistakes under divided attention. The supraglottic airway technique was least affected by divided attention.The scenario was effective for simulation training involving divided attention in acute care medicine. The significant effects on performance and perceived workload demonstrate the validity of the model, which was also characterised by high acceptability, technical simplicity and a novel degree of standardisation.}, author = {Prottengeier, Johannes and Petzoldt, Marlen and Jess, Nikola and Moritz, Andreas and Gall, Christine and Schmidt, Joachim and Breuer, Georg}, doi = {10.1097/EJA.0000000000000315}, faupublication = {yes}, journal = {European Journal of Anaesthesiology}, note = {EVALuna2:5546}, pages = {195-203}, peerreviewed = {Yes}, title = {{The} effect of a standardised source of divided attention in airway management: {A} randomised, crossover, interventional manikin study}, volume = {33}, year = {2016} } @article{faucris.121816904, abstract = {Opioids may have effects on susceptibility to HIV-infection, viral replication and disease progression. Injecting drug users (IDU), as well as anyone receiving opioids for anesthesia and analgesia may suffer the clinical consequences of such interactions. There is conflicting data between in vitro experiments showing an enhancing effect of opioids on HIV replication and clinical data, mostly showing no such effect. For clarification we studied the effects of the opioids heroin and morphine on HIV replication in cultured CD4-positive T cells at several concentrations and we related the observed effects with the relevant reached plasma concentrations found in IDUs.Latently-infected ACH-2 T lymphoblasts were incubated with different concentrations of morphine and heroine. Reactivation of HIV was assessed by intracellular staining of viral Gag p24 protein and subsequent flow cytometric quantification of p24-positive cells. The influence of the opioid antagonist naloxone and the antioxidants N-acetyl-cysteine (NAC) and glutathione (GSH) on HIV reactivation was determined. Cell viability was investigated by 7-AAD staining and flow cytometric quantification.Morphine and heroine triggered reactivation of HIV replication in ACH-2 cells in a dose-dependent manner at concentrations above 1 mM (EC50 morphine 2.82 mM; EC50 morphine 1.96 mM). Naloxone did not interfere with heroine-mediated HIV reactivation, even at high concentrations (1 mM). Opioids also triggered necrotic cell death at similar concentrations at which HIV reactivation was observed. Both opioid-mediated reactivation of HIV and opioid-triggered cell death could be inhibited by the antioxidants GSH and NAC.Opioids reactivate HIV in vitro but at concentrations that are far above the plasma levels of analgesic regimes or drug concentrations found in IDUs. HIV reactivation was mediated by effects unrelated to opioid-receptor activation and was tightly linked to the cytotoxic activity of the substances at millimolar concentrations, suggesting that opioid-mediated reactivation of HIV was due to accompanying effects of cellular necrosis such as activation of reactive oxygen species and NF-?B.}, author = {Prottengeier, Johannes and Koutsilieri, Eleni and Scheller, Carsten}, doi = {10.1186/1742-6405-11-17}, faupublication = {yes}, journal = {AIDS Research and Therapy}, note = {EVALuna2:16669}, pages = {17}, peerreviewed = {Yes}, title = {{The} effects of opioids on {HIV} reactivation in latently-infected {T}-lymphoblasts}, volume = {11}, year = {2014} } @article{faucris.273949615, abstract = {