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@article{faucris.229750441,
abstract = {Odor masking is a very prominent problem in our daily routines, mainly concerning unpleasant sweat or toilet odors. In the current study we explored the effectiveness of odor masking both on a behavioral and neuronal level. By definition, participants cannot differentiate a fully masked unpleasant odor from the pleasant pure odor used as a masking agent on a behavioral level. We hypothesized, however, that one can still discriminate between a fully masked odor mixture and the pure masking odor on a neuronal level and that, using a reinforcing feedback paradigm, participants could be trained to perceive this difference. A pleasant, lemon-like odor (citral) and a mixture of citral and minor amounts of an unpleasant, goat-like odor (caproic acid) were presented to participants repeatedly using a computer-controlled olfactometer and participants had to decide whether two presented stimuli were the same or different. Accuracy of this task was incentivized with a possible monetary reward. Functional imaging was used throughout the task to investigate central processing of the two stimuli. The participants rated both stimuli as isopleasant and isointense, indicating that the unpleasant odor was fully masked by the pleasant odor. The isolated caproic acid component of the mixture was rated less pleasant than the pleasant odor in a prior experimental session. Although the masked and pure stimuli were not discriminated in the forced-choice task, quality ratings on a dimensional scale differed. Further, we observed an increased activation of the insula and ventral striatum/putamen for the pure in contrast to the fully masked odor, hence revealing a difference in neuronal processing. Our hypothesis that perceptual discrimination and neuronal processing can be enhanced using a reinforcing feedback paradigm is not supported by our data.},
author = {Rodriguez-Raecke, Rea and Loos, Helene and Sijben, Rik and Singer, Marco and Beauchamp, Jonathan and Büttner, Andrea and Freiherr, Jessica},
doi = {10.3389/fnins.2019.01219},
faupublication = {yes},
journal = {Frontiers in Neuroscience},
keywords = {FMRI; Odor masking; Odor mixture; Piriform cortex; Ventral striatum},
note = {CRIS-Team Scopus Importer:2019-11-26},
peerreviewed = {Yes},
title = {{A} masked aversive odor cannot be discriminated from the masking odor but can be identified through odor quality ratings and neural activation patterns},
volume = {13},
year = {2019}
}
@incollection{faucris.285404116,
abstract = {Analytical technologies represent the core of volatile biomarker detection in human health applications. A wide range of techniques exist, each exhibiting a varying degree of complexity, from comprehensive laboratory-based instrumentation to portable handheld sensor systems. Each tool has unique features that make it suitable for its specified application in the detection of volatile organic compounds (VOCs) as biomarkers in human health. This chapter reviews the most common and applicable analytical approaches for VOC detection in diverse bodily fluids, primarily in exhaled breath, as well as in urine, sweat and feces. Technologies covered in this chapter include gas chromatography–mass spectrometry (GC–MS), including multidimensional GC–MS (GC × GC–MS and GC–GC–MS), real-time mass spectrometry, including proton transfer reaction-mass spectrometry (PTR-MS), selected ion flow tube-mass spectrometry (SIFT-MS) and secondary electrospray ionization-mass spectrometry (SESI-MS), as well as ion mobility spectrometry (IMS) and optical spectroscopy. The chapter covers the basic operating principles of these key techniques in the analysis and detection of VOCs and offers an overview of representative studies that demonstrate their strengths and suitability relating to volatile biomarker detection in human health applications.
},
author = {Pham, Y Lan and Beauchamp, Jonathan},
booktitle = {Volatile Biomarkers for Human Health: From Nature to Artificial Senses},
editor = {Hossam Haick},
faupublication = {yes},
isbn = {9781839164309},
note = {CRIS-Team Scopus Importer:2022-11-18},
peerreviewed = {unknown},
publisher = {Royal Society of Chemistry},
title = {{Analytical} approaches for disease detection},
year = {2022}
}
@article{faucris.262411927,
abstract = {This study aimed to fabricate cinnamon essential oil (CO)-laden 45S5 bioactive glass (BG)/soy protein (SP) scaffolds exhibiting antioxidant and antibacterial activity. In this regard, 45S5 BG-based scaffolds were produced by the foam replica method, and subsequently the scaffolds were coated with various concentrations of CO (2.5, 5 and 7 (v/v) %) incorporated SP solution. Scanning electron microscopy images revealed that the CO-laden SP effectively attached to the 45S5 BG scaffold struts. The presence of 45S5 BG, SP and CO was confirmed using Fourier transform infrared spectroscopy. Compressive strength results indicated that SP based coatings improved the scaffolds' mechanical properties compared to uncoated BG scaffolds. The loading efficiency and releasing behaviour of the different CO concentrations were tested by gas chromatography-mass spectroscopy and UV–Vis spectroscopy. The results showed that CO incorporated scaffolds have controlled releasing behaviour over seven days. Furthermore, the coating on the scaffold surfaces slightly retarded, but it did not inhibit, the in vitro bioactivity of the scaffolds. Moreover, the antioxidant and antibacterial activity of CO was studied. The free radical scavenging activity measured by DPPH was 5 ± 1, 41 ± 3, 44 ± 1 and 43 ± 1 % for BGSP, CO2.5, CO5 and CO7, respectively. The antioxidant activity was thus enhanced by incorporating CO. Agar diffusion and colony counting results indicated that the incorporation of CO increased the antibacterial activity of scaffolds against S. aureus and E. coli. In addition, cytotoxicity of the scaffolds was investigated using MG-63 osteoblast-like cells. The results showed that the BG-SP scaffold was non-toxic under the investigated conditions, whereas dose-dependent toxicity was observed in CO-laden scaffolds. Considered together, the developed phytotherapeutic agent laden 45S5 BG-based scaffolds are promising for bone tissue engineering exhibiting capability to combat bone infections and to protect against oxidative stress damage.},
author = {Ünalan, Irem and Fuggerer, Tim and Slavik, Benedikt and Büttner, Andrea and Boccaccini, Aldo R.},
doi = {10.1016/j.msec.2021.112320},
faupublication = {yes},
journal = {Materials Science and Engineering C},
keywords = {45S5 bioactive glass; And bone infection; Antibacterial activity; Antioxidant activity; Cinnamon essential oil},
note = {CRIS-Team Scopus Importer:2021-08-06},
peerreviewed = {Yes},
title = {{Antibacterial} and antioxidant activity of cinnamon essential oil-laden {45S5} bioactive glass/soy protein composite scaffolds for the treatment of bone infections and oxidative stress},
volume = {128},
year = {2021}
}
@article{faucris.257187559,
author = {Denzer, Melanie and Kirsch, Fabian and Büttner, Andrea},
doi = {10.1021/jf504073d},
faupublication = {yes},
journal = {Journal of Agricultural and Food Chemistry},
peerreviewed = {Yes},
title = {{Are} odorant constituents of herbal tea transferred into human milk?},
year = {2015}
}
@article{faucris.261540259,
abstract = {Wet coffee processing generates a large amount of coffee pulp waste that is mostly dis-posed of in the processing units. To reduce this waste and the associated environmental burden, an alternative strategy would be to exploit the coffee pulp to produce a durable and stable consumable product. Accordingly, a puree produced from Robusta coffee pulp was investigated in relation to its physicochemical and sensory properties. After thermal and chemical stabilization, the obtained puree (pH 3.6) was found to exhibit a multimodal particle size distribution, shear-thinning behavior, and lower discoloration, as well as an antioxidant capacity of 87.9 µmolTE/gDM. The flavor of the puree was examined by sensory evaluation and the corresponding analyses of aroma-active volatile compounds, as determined using aroma extract dilution analyses (AEDA) and gas chromatography-mass spectrometry/olfactometry (GC-MS/O). The puree was characterized by dominant fruity (4.4), floral (3.4), citrusy (3.3) and hay-like (3.3) odor impressions. The aroma-active compounds were pre-dominantly aldehydes, acids, and lactones, whereby (E)-β-damascenone, geraniol, 4-methylphenol, 3-hydroxy-4,5-dimethylfuran-2(5H)-one, and 4-hydroxy-3-methoxybenzaldehyde exhibited the high-est flavor dilution (FD) factor (1024), thereby indicating their high impact on the overall aroma of the puree. This study demonstrates an approach to stabilize coffee pulp to produce a sweet, fruity puree with comparable physical properties to other fruit purees and that can be used as a new and versatile flavoring ingredient for various food applications.},
author = {Buck, Nina and Wohlt, Daria and Winter, Anne Ruth and Ortner, Eva},
doi = {10.3390/molecules26133925},
faupublication = {yes},
journal = {Molecules},
keywords = {Aroma extract dilution analysis; By-product; Coffea canephora; Coffee cherry; Gas chromatography-olfactometry; Residue; Sustainability},
note = {CRIS-Team Scopus Importer:2021-07-16},
peerreviewed = {Yes},
title = {{Aroma}-active compounds in robusta coffee pulp puree—evaluation of physicochemical and sensory properties},
volume = {26},
year = {2021}
}
@article{faucris.284487817,
abstract = {Chocolate conching is a highly complex, thermomechanical process that transforms the aroma and flow properties of a dry starting material. Different conched plastic masses of dark chocolate were characterized. Rheological characterization of plastic masses was performed for the first time using a closed cavity rheometer (CCR). In free cocoa butter derived from the plastic masses, acetic acid, benzaldehyde, (R,S)-(±)-linalool, 2,3,5,6-tetramethylpyrazine, and 2-phenylethanol were quantified by stable isotope dilution analysis (SIDA) and gas chromatography-mass spectrometry. During the conching process, the amount of free cocoa butter increased possibly due to de-agglomeration. The complex viscosity of the plastic mass decreased as a function of conching time. Regarding aroma refinement, the concentrations of all five aroma-active volatiles decreased with increasing conching duration, albeit to varying degrees. The level of acetic acid showed the most pronounced decrease of about 60%, whereas linalool exhibited the lowest decrease in concentration, up to 26%. Overall, a lower polarity or boiling point of the aroma-active volatiles was linked to a stronger decrease in concentration during conching. These data illustrate the influence of conching on texture and the respective aroma changes, which deepens understanding of the conching effect on the sensory quality of dark chocolate.},
author = {Guckenbiehl, Yvonne and Martin, Anna and Ortner, Eva and Rothkopf, Isabell and Schweiggert-Weisz, Ute and Büttner, Andrea and Naumann-Gola, Susanne},
doi = {10.1016/j.foodres.2022.112063},
faupublication = {yes},
journal = {Food Research International},
keywords = {Aroma concentration; Chocolate flavor; Chocolate texture; Closed cavity rheometer; Free cocoa butter; Plastic conching},
note = {CRIS-Team Scopus Importer:2022-11-04},
peerreviewed = {Yes},
title = {{Aroma}-active volatiles and rheological characteristics of the plastic mass during conching of dark chocolate},
volume = {162},
year = {2022}
}
@article{faucris.257959045,
abstract = {A few odor-active epoxyaldehydes, formed during lipid peroxidation, have recently been reported as intense aroma compounds in foods. However, very little is known about their flavor properties in general. Syntheses of homologous trans-2,3-epoxyalkanals (C(6)-C(12)) and trans-4,5-epoxy-(E)-2-alkenals (C(7)-C(12)) followed by structural characterization using mass spectrometry (MS/EI; MS/CI) and (1)H NMR measurements were performed. An evaluation of their odor qualities and odor thresholds by gas chromatography-olfactometry revealed the following: within the trans-2,3-epoxyalkanals, the odor quality changed from grassy for the compounds with six and seven carbon atoms to citrus-like or soapy for aldehydes with eight and more carbon atoms. The odor thresholds lay in the range of 3-15 ng/L (in air) and were nearly identical within the series; however, a slight minimum was measured for trans-2,3-epoxyoctanal to trans-2,3-epoxydecanal. In the series of the trans-4,5-epoxyalk-(E)-2-enals the C(10) compound was characterized by the lowest odor threshold of 0.6-2.5 pg/L of air. However, all trans-4,5-epoxy-alk-(E)-2-enals smelled intensely metallic.
(Cuon alpinus), African wild dogs (Lycaon pictus), South American bush dogs (Speothos venaticus), and Siberian tigers (Panthera tigris altaica) when presented with wooden logs that were impregnated either with mammalian blood or with the blood odor component trans-4,5-epoxy-(E)-2-decenal, and compared it to their behavior towards a fruity odor (iso-pentyl acetate) and a near-odorless solvent (diethyl phthalate) as control. We found that all four species displayed significantly more interactions with the odorized wooden logs such as sniffing, licking, biting, pawing, and toying, when they were impregnated with the two prey-associated odors compared to the two non-prey-associated odors. Most importantly, no significant differences were found in the number of interactions with the wooden logs impregnated with mammalian blood and the blood odor component in any of the four species. Only one of the four species, the South American bush dogs, displayed a significant decrease in the number of interactions with the odorized logs across the five sessions performed per odor stimulus. Taken together, the results demonstrate that a single blood odor component can be as efficient in eliciting behavioral responses in large carnivores as the odor of real blood, suggesting that trans-4,5-epoxy-(E)-2-decenal may be perceived by predators as a “character impact compound” of mammalian blood odor. Further, the results suggest that odorized wooden logs are a suitable manner of environmental enrichment for captive carnivores.
E,Z,Z)-2,4,7-tridecatrienal, (E)-4,5-epoxy-(E)-2-decenal, 4-ethyloctanoic acid, 3-methylindole (skatole), d-limonene, and indole. The analytical findings were further compared to sensory evaluation of the samples, and previously obtained data on the respective aquacultural wate},
author = {Mahmoud, Mohamed and Büttner, Andrea},
doi = {10.1016/j.foodchem.2016.09.172},
faupublication = {yes},
journal = {Food Chemistry},
keywords = {Aroma extract dilution analysis; Solvent assisted flavour evaporation; Gas chromatography-olfactometry; Odour-active compounds; Skatole; 4-Ethyloctanoic acid},
pages = {841-849},
peerreviewed = {Yes},
title = {{Characterisation} of aroma-active and off-odour compounds in {German} rainbow trout ({Oncorhynchus} mykiss). {Part} {II}: {Case} of fish meat and skin from earthen-ponds farming},
volume = {232},
year = {2017}
}
@article{faucris.257935464,
abstract = {Sterilisation of plastic packaging materials for food, pharmaceutical or cosmetic products with 60Co γ-irradiation in the presence of oxygen can result in the formation of volatile substances. These may subsequently induce off-odours in these materials that might be regarded as negative by the consumers. Trace volatiles and odorous substances of polypropylene, irradiated with 60Co γ rays at 10 and 20 kGy, respectively, were collected and analysed by gas chromatography–olfactometry (GC–O), GC–MS and GC–GC–MS. The methodology was successfully applied for identification of 29 characteristic odorants in a non-irradiated control sample and 38 odorants in γ-irradiated polypropylene samples. Selected odour-active compounds were quantified using GC–GC–MS in combination with stable isotope dilution assays. The quantitative data mirrors the compositional changes in volatile odorous substances from polypropylene during treatment with ionising γ rays in a 60Co-irradiation plant.
(Z)-hex-3-en-1-ol (cis-3-hexenol), benzaldehyde, ethyl butanoate and 2-methylpropyl 3-methylbutanoate (isobutyl isovalerate) was determined using proton-transfer-reaction mass spectrometry (PTR-MS).
In-vitro studies showed that the replacement of sucrose with erythritol did not influence flavour release, whereas the release tended to be higher and faster for erythritol- or erythritol/sucralose-containing gels during in-vivo measurements. Additionally, different flavour release patterns were obtained between harder and softer pectin gels during in-vivo measurements, while only release of isobutyl isovalerate was significantly different during in-vitro analysis. The sensory analysis exhibited significant differences between the flavoured pectin gels with similar textures, confirming the results of PTR-MS measurements. Generally, flavour perception was reduced with increased gel hardness independently of the nose-space concentrations, reflecting perceptual interactions between texture and flavou},
author = {Tyapkova, Oxana and Bader-Mittermaier, Stephanie and Schweiggert-Weisz, Ute and Wurzinger, Sandrina and Beauchamp, Jonathan and Büttner, Andrea},
doi = {10.1016/j.foodres.2013.10.048},
faupublication = {yes},
journal = {Food Research International},
pages = {336-346},
peerreviewed = {Yes},
title = {{Characterisation} of flavour-texture interactions in sugar-free and sugar-containing pectin gels.},
year = {2014}
}
@article{faucris.257932643,
abstract = {
BACKGROUND: Lupin ingredients are promising alternatives to soybean products owing to their similarly high protein content. Lupin flour exhibits a green and bean‐like off‐flavour in higher amounts. The aim of this study was to characterise and identify the main odour‐active compounds in lupin flour.
RESULTS: The orthonasal aroma of lupin flour was evaluated by means of aroma profile analysis and was found to be characterised by grassy‐green, metallic, fatty, fruity, hay‐like, cheese‐like, and meat‐like odour qualities. Volatile compounds of lupin flour of Lupinus angustifolius cv. Boregine were extracted with dichloromethane and isolated by solvent‐assisted flavour evaporation. Aroma extract dilution analysis (AEDA) was carried out with the obtained extract. In total, 50 odorants were detected by high‐resolution gas chromatography–olfactometry. AEDA revealed 26 odour‐active compounds with flavour dilution factors higher or equal to 32. The substances were unequivocally identified by their odour characteristics, their retention indices and their mass spectra using one‐dimensional or two‐dimensional gas chromatography–mass spectrometry, respectively.
CONCLUSION: A series of unsaturated and saturated aldehydes, ketones, carboxylic acids, alkyl‐methoxypyrazines and terpenes were identified for the first time as odour‐active contributors to the aroma of lupin flour. Copyright © 2009 Society of Chemical Indust},
author = {Bader-Mittermaier, Stephanie and Czerny, Michael and Eisner, Peter and Büttner, Andrea},
doi = {10.1002/jsfa.3739},
faupublication = {yes},
journal = {Journal of the Science of Food and Agriculture},
peerreviewed = {Yes},
title = {{Characterisation} of odour-active compounds in lupin flour.},
year = {2009}
}
@article{faucris.257449477,
abstract = {1,8-Cineole is a widely distributed odorant that also shows physiological effects, but whose human metabolism has hitherto not been extensively investigated. The aim of the present study was, thus, to characterise the metabolites of 1,8-cineole, identified previously in human milk, after the oral intake of 100 mg of this substance. Special emphasis was placed on the enantiomeric composition of the metabolites since these data may provide important insights into potential biotransformation pathways, as well as potential biological activities of these substances, for example on the breastfed child. The volatile fraction of the human milk samples was therefore isolated via Solvent Assisted Flavour Evaporation (SAFE) and subjected to gas chromatography-mass spectrometry (GC-MS). The absolute concentrations of each metabolite were determined by matrix calibration with an internal standard, and the ratios of enantiomers were analysed on chiral capillaries. The concentrations varied over a broad range, from traces in the upper ng/kg region up to 40 µg/kg milk, with the exception of the main metabolite α2-hydroxy-1,8-cineole that showed concentrations of 100-250 µg/kg. Also, large inter- and intra-individual variations were recorded for the enantiomers, with nearly enantiomerically pure α2-hydroxy- and 3-oxo-1,8-cineole, while all other metabolites showed ratios of ~30:70 to 80:20.
ppb-level in its early stages. Thereby, it was possible to screen oxidative variances on the basis of such volatile markers already within eight weeks after production of the products, which is an earlier indication of oxidative deterioration than achievable via conventional methods. In detail, oxidative variances between the formulations revealed that lipid oxidation was low when copper was administered in an encapsulated form and when antioxidants (vitamin E, ascorbyl palmitate) were present.
2). Of these, only AMS had a garlic-like odor whereas the other two metabolites were odorless. This demonstrates that the odor change in human milk is not related to a direct transfer of garlic odorants, as is currently believed, but rather derives from a single metabolite. The formation of these metabolites is not fully understood, but AMSO and AMSO2 are most likely formed by the oxidation of AMS in the human body. The excretion rates of these metabolites into breast milk were strongly time-dependent with large inter-individual difference},
author = {Scheffler, Laura and Sauermann, Yvonne and Zeh, Gina and Hauf, Katharina and Heinlein, Anja and Sharapa, Constanze and Büttner, Andrea},
doi = {10.3390/metabo6020018},
faupublication = {yes},
journal = {Metabolites},
keywords = {garlic; human milk; gas-chromatography mass-spectrometry; allyl methyl ulfide; allyl methyl sulfoxide; allyl methyl sulfone},
peerreviewed = {unknown},
title = {{Detection} of volatile metabolites of garlic in human breast milk},
volume = {6},
year = {2016}
}
@article{faucris.123585704,
abstract = {Olfactory tests are an important tool in human nutritional research for studying food preferences, yet comprehensive tests dedicated solely to food odors are currently lacking. Therefore, within this study, an innovative food-associated olfactory test (FAOT) system was developed. The FAOT comprises 16 odorant pens that contain representative food odors relating to different macronutrient classes. The test underwent a sensory validation based on identification rate, intensity, hedonic value, and food association scores. The accuracy of the test was further compared to the accuracy of the established Sniffin’ Sticks identification test. The identification rates and intensities of this new FAOT were found to be comparable to the Sniffin’ Sticks olfactory identification test. The odorant pens were also assessed chemo-analytically and were found to be chemically stable for at least 24 weeks. Overall, this new identification test for use in assessing olfaction in a food-associated context is valid both in terms of its use in sensory perception studies and its chemical stability. The FOAT is particularly suited to examinations of the sense of smell regarding food odor},
author = {Denzer-Lippmann, Melanie and Beauchamp, Jonathan and Freiherr, Jessica and Thürauf, Norbert and Kornhuber, Johannes and Büttner, Andrea},
doi = {10.1093/chemse/bjw099},
faupublication = {yes},
journal = {Chemical Senses},
keywords = {food odorants; identification test; olfactory test; olfaction; PT-MS; smell},
note = {EVALuna2:33556},
pages = {47-57},
peerreviewed = {Yes},
title = {{Development} and validation of a food-associated olfactory test ({FAOT})},
volume = {42},
year = {2017}
}
@article{faucris.257513356,
abstract = {A method was developed for the quantification of 5-α-androst-16-en-3-one in human breast milk based on application of a stable isotope dilution assay using 5α-androst-16-en-3-one-6, 6-d(2). The procedure includes extraction of the human milk by hexane with subsequent clean-up of the obtained extract by gel permeation and silica gel column chromatography. The extracted samples were analyzed by gas chromatography-mass spectrometry. Using this method 5-α-androst-16-en-3-one could be identified and for the first time quantified in a concentration range of 26-155 ng/kg in human milk.
Botrytis cinerea and Erysiphe necator are among the most relevant fungi in viticulture. In order to deepen our knowledge about their potential impact on wine quality, their effects on the aroma character of the initial stage of wine production, i.e. the must were studied. The main aroma compounds were determined by gas chromatography–olfactometry (GC-O) and ranked according to their relative intensities by means of aroma extract dilution analysis (AEDA). Clear differences between healthy and infected samples were observed. Botrytis cinerea had a positive impact on fruity and floral notes while several earthy smelling compounds were developed as result of the infection. Unlike in previous studies, however, we did not observe any clear differences in the quantities of earthy-mushroom-like smelling substances as result of the infection process with Erysiphe necatord3,2 < 0.4 μm, and maintained stability over 50 d. The relatively lower stability of lupin emulsions was significantly correlated with the low protein surface hydrophobicity and IT of the emulsion. After heating the proteins, the droplet size of pea and lupin emulsions decreased. The VOC release profile was similar between the protein‐stabilized emulsions, and greater retention was observed for Tween 20‐stabilized emulsions. This study demonstrates the potential application of legume proteins as alternative emulsifiers to milk proteins in emulsion products.
In an extract of the peel from clementines, prepared by solvent extraction, 42 odour-active compounds were detected by application of an aroma extract dilution analysis and subsequently identified by using the respective reference odorants. Among them, by far the highest flavour dilution factors were determined for the flowery smelling linalool, the fatty smelling (E,E)-deca-2,4-dienal and the winelactone eliciting a sweet odour quality. These were followed by α-pinene, myrcene and octanal with pinetree-like, geranium leaf-like and citrus-like aromas. Among the 30 odour-active compounds identified, 11 aroma compounds are reported here for the first time as important contributors to clementine peel aroma, e.g. winelactone, (E,E)-nona-2,4-dienal, carvone, (Z)-hex-3-enal or tr–4,5-epoxy-(E)-dec-2-enal.
},
author = {Büttner, Andrea and Mestres, Montse and Fischer, Anja and Guasch, Josep and Schieberle, Peter},
doi = {10.1007/s00217-002-0586-y},
faupublication = {yes},
journal = {European Food Research and Technology},
peerreviewed = {Yes},
title = {{Evaluation} of the most odour-active compounds in the peel oil of clementines ({Citrus} reticulata blanco cv. clementine).},
volume = {216},
year = {2004}
}
@article{faucris.206334073,
author = {Zareian, Mohsen and Böhner, Nadine and Loos, Helene and Silcock, Patrick and Bremer, Phil and Beauchamp, Jonathan},
doi = {10.1016/j.fpsl.2018.08.001},
faupublication = {yes},
journal = {Food Packaging and Shelf Life},
keywords = {Food spoilage; Sensory analysis; Volatile organic compounds; Microbial metabolomics; Proton transfer reaction mass spectrometry},
pages = {51-61},
peerreviewed = {Yes},
title = {{Evaluation} of volatile organic compound release in modified atmosphere-packaged minced raw pork in relation to shelf-life},
volume = {18},
year = {2018}
}
@article{faucris.299124921,
abstract = {Since its emergence from the communication engineering community around one and a half decades ago, the field of Synthetic Molecular Communication (SMC) has experienced continued growth, both in the number of technical contributions from a vibrant community and in terms of research funding. Throughout this process, the vision of SMC as a novel, revolutionary communication paradigm has constantly evolved, driven by feedback from theoretical and experimental studies, respectively. It is believed that especially the latter ones will be crucial for the transition of SMC towards a higher technology readiness level in the near future. In this spirit, we present here a comprehensive survey of experimental research in SMC. In particular, this survey focuses on highlighting the major drivers behind different lines of experimental research in terms of the respective envisioned applications. This approach allows us to categorize existing works and identify current research gaps that still hinder the development of practical SMC-based applications. Our survey consists of two parts: this paper and a companion paper. While the companion paper focuses on SMC with relatively long communication ranges, this paper covers SMC over short distances of typically not more than a few millimeters.
in vitro and in vivo release of four flavor compounds, namely (Z)-hex-3-en-1-ol, benzaldehyde, ethyl butanoate, and 2-methylpropyl 3-methylbutanoate was investigated using proton-transfer-reaction mass spectrometry (PTR-MS). Foam density was highest for the sugar-free reference (294.5 g L−1) and lowest for the sugar-containing protein foam (193.2 g L−1), whereas egg albumen foams with combinations of polyols and bulking agents revealed medium foam densities (212.2 g L−1 and 217.9 g L−1). Flavor release was affected by foam density to a significantly higher extent than by foam firmness, whereby decreased in vitro and increased in vivo flavor release with increased foam density was observed for all compounds. The flavor release data were also in good agreement with the perceived aroma intensities, supporting the role of texture-flavor interactions in perception. This study highlights the impact that complex interactions of physical and chemical properties have on flavor release, with the egg albumen foams representing complex aerated food matrices commonly used for confectionery product},
author = {Tyapkova, Oxana and Siefarth, Caroline and Schweiggert-Weisz, Ute and Beauchamp, Jonathan and Büttner, Andrea and Bader-Mittermaier, Stephanie},
doi = {10.1016/j.lwt.2016.01.075},
faupublication = {yes},
journal = {Lwt-Food Science and Technology},
keywords = {Erythritol; Maltitol; Rheology; Density; Flavor release},
pages = {538-545},
peerreviewed = {Yes},
title = {{Flavor} release from sugar-containing and sugar-free confectionary egg albumen foams},
volume = {69},
year = {2016}
}
@article{faucris.273210878,
abstract = {Volatile organic compounds of the vehicle interior are well investigated, but only limited information is available on the odorants of the passenger cabin. To close this gap, we aimed at specifically elucidating the odor, as a general proof of principle, of two new cars with different seat upholstery in a controlled environment using a targeted odorant analysis. In a first step, odor profiles were evaluated by a descriptive sensory analysis. Then, potent odorants of the passenger cabins were characterized by gas chromatography-olfactometry and ranked according to their odor potency via odor extract dilution analysis. Using this approach, 41 potent odorants were detected, and 39 odorants were successfully identified by two-dimensional gas chromatography-mass spectrometry/olfactometry. In a third step, important odorants of the vehicle interior were quantified by means of internal standard addition. The most dominant odorants could be assigned to several specific substance classes comprising esters, saturated and unsaturated aldehydes, unsaturated ketones, rose ketones, phenolic and benzene derivatives, and pyrazines, occurring in a concentration range between 0.05 and 219 ng/L in air. Of these potent odorants, the aldehydes 2-butylhept-2-enal, 2-propyloct-2-enal, and (Z)-2-butyloct-2-enal are reported here for the first time as odorants in the environment of a passenger cabin.},
author = {Buchecker, Florian and Baum, Adina and Loos, Helene and Büttner, Andrea},
doi = {10.1111/ina.13014},
faupublication = {yes},
journal = {Indoor Air},
keywords = {automotive leather; descriptive sensory analysis; gas chromatography-mass spectrometry/olfactometry; leatherette; odor; vehicle interior},
note = {CRIS-Team Scopus Importer:2022-04-15},
peerreviewed = {Yes},
title = {{Follow} your nose - {Traveling} the world of odorants in new cars},
volume = {32},
year = {2022}
}
@article{faucris.123871924,
abstract = {In a previous study, two highly potent yet unidentified odorants were detected that were present at trace levels in the volatile fraction of Boswellia sacra gum resin. These two compounds were isolated semipreparatively from the volatile oil by a sensory-guided fractionation process involving microscale bulb-to-bulb distillation, countercurrent chromatography, and preparative gas chromatography. In this manner, the two oxygenated sesquiterpenes could be identified as rotundone (1) and mustakone (2). Compound 2 is described for the first time as a potent odorant with a very low odor threshol},
author = {Niebler, Johannes and Zhuravlova, Katharina and Minceva, Mirjana and Büttner, Andrea},
doi = {10.1021/acs.jnatprod.5b00836},
faupublication = {yes},
journal = {Journal of Natural Products},
pages = {1160-1164},
peerreviewed = {Yes},
title = {{Fragrant} {Sesquiterpene} {Ketones} as {Trace} {Constituents} in {Frankincense} {Volatile} {Oil} of {Boswellia} sacra},
volume = {79},
year = {2016}
}
@article{faucris.122212024,
abstract = {The genus Boswellia comprises a number of species which are famous for their production of frankincense, a fragrant gum resin. In the published literature, manifold studies on the volatiles and semivolatiles in individual samples of these gum resins exist, yet very few studies have investigated multiple samples. Contradictory results with regard to the volatile composition exist in literature. In this first part of the study, a large sample set (n=46) of mostly commercially obtained gum resins and essential oils was investigated by solid phase micro-extraction gas chromatography-mass spectrometry (SPME-GC-MS) or GC-MS. In the four commercially relevant species, namely B. sacra, B. serrata, B. papyrifera and B. frereana, 216 compounds were identified or tentatively identified, and the statistical evaluation of the resulting chemical profiles allowed a clear distinction between the species by their volatile profile. With only few exceptions, the designated species was found to be in accordance with the composition reported in reliable literature sources and detected in botanically identified samples. Chemotaxonomic marker substances were suggested to facilitate the differentiation of commercial gum resins or essential oils based on their volatile profil},
author = {Niebler, Johannes and Büttner, Andrea},
doi = {10.1002/cbdv.201500329},
faupublication = {yes},
journal = {Chemistry & Biodiversity},
keywords = {Boswellia ;Burseraceae;Frankincense;Olibanum;SPME-GC-MS;Essential oil},
pages = {613-629},
peerreviewed = {Yes},
title = {{Frankincense} {Revisited}, {Part} {I}: {Comparative} {Analysis} of {Volatiles} in {Commercially} {Relevant} {Boswellia} {Species}},
volume = {13},
year = {2016}
}
@article{faucris.122129964,
abstract = {In this second part of the investigation of volatiles and semivolatiles in Boswellia gum resins, an additional five less common species were analyzed by (SPME-)GC-MS, namely B. ameero, B. elongata, B. neglecta, B. popoviana and B. rivae. Moreover, the results of hybridization experiments are reported in combination with the volatile composition of their gum resins. Our study shows that B. sacra benefits from an intra-specific cross-pollination, as the resulting hybrid B. sacra var. supersacra has a far higher seed germination rate and viabilit},
author = {Niebler, Johannes and Eslamieh, Jason and Büttner, Andrea},
doi = {10.1002/cbdv.201500339},
faupublication = {yes},
journal = {Chemistry & Biodiversity},
keywords = {Boswellia ;Burseraceae;Hybrid;Frankincense;Olibanum;SPME-GC-MS},
pages = {630-643},
peerreviewed = {Yes},
title = {{Frankincense} {Revisited}, {Part} {II}: {Volatiles} in {Rare} {Boswellia} {Species} and {Hybrids}},
volume = {13},
year = {2016}
}
@article{faucris.257427976,
abstract = {Scope
GABAA receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible for GABAA receptor modulation.
Methods and results
Single volatile substances identified by GC have been tested in two expression systems, Xenopus oocytes and human embryonic kidney cells. Some of these substances, especially carvacrol, were highly potent on GABAA receptors composed of α1β2 and α1β2γ2 subunits. All effects measured were independent from the presence of the γ2 subunit. As Sideritis extracts contain a high amount of terpenes, 13 terpenes with similar structure elements were tested in the same way. Following a prescreening on α1β2 GABAA receptors, a high-throughput method was used for identification of the most effective terpenoid substances on GABA-affinity of α1β2γ2 receptors expressed in transfected cell lines. Isopulegol, pinocarveol, verbenol, and myrtenol were the most potent modifiers of GABAA receptor function.
Conclusion
Comparing the chemical structures, the action of terpenes on GABAA receptors is most probably due to the presence of hydroxyl groups and a bicyclic character of the substances tested. We propose an allosteric modulation independent from the γ2 subunit and similar to the action of alcohols and anesthetics.
},
author = {Kessler, Artur and Sahin-Nadeem, Hilal and Lummis, Sarah C. R. and Weigel, Ingrid and Pischetsrieder, Monika and Büttner, Andrea and Villmann, Carmen},
doi = {10.1002/mnfr.201300420},
faupublication = {yes},
journal = {Molecular Nutrition & Food Research},
pages = {851–862},
peerreviewed = {Yes},
title = {{GABAA} receptor modulation by terpenoids from {Sideritis} extracts.},
year = {2014}
}
@article{faucris.257899167,
abstract = {Sideritis spp. is a member of the Labiateae family, used in traditional folk medicine and as a calming tea preparation. Dichloromethane extracts of the aerial parts of four Sideritis species were prepared, and the volatile fractions were separated via solvent‐assisted flavour evaporation distillation. In vitro electrophysiological techniques were used to investigate the physiological effects of these aroma extracts on ionotropic γ‐aminobutyric acid receptors (GABAA) in comparison to extracts of Lavandula spp. (lavender) obtained by the same approach. The plant extracts of Sideritis spp. and Lavandula spp. increased the maximal current responses gated by the agonist GABA, both in whole cell patch clamp recordings as well as in two electrode voltage clamp assays. Thereby, the volatile fractions caused a dose‐dependent enhancement of GABAergic currents. Differences in activity between the various species were probably due to variations in odorant composition, either on a qualitative or quantitative basis. Thus, the plant material contains volatile organic compounds, which are able to modulate a GABA‐mediated response and thereby possibly contribute to a sedative effect in vivo. Copyright © 2012 John Wiley & Sons, Ltd.
N-α-conjugates of the fatty acids (E)/(Z)-3-methylhex-2-enoic acid and (R)/(S)-3-hydroxy-3-methylhexanoic acid as well as cysteinylglycine-S-conjugates of (R)/(S)-3-methyl-3-sulphanylhexan-1-ol and (R)/(S)-3-sulphanylhexan-1-ol as constituents of human milk and colostrum. The glutamine-N-α-conjugates were detected also in human amniotic fluids. The mean values of glutamine-N-α-conjugate of (R)/(S)-3-hydroxy-3-methylhexanoic acid were highest in colostrums with a range of <0.1–382 μg/kg, followed by the mature human milk with values from <0.1 to 39.6 μg/kg for defatted milk, and 0.8–7.0 μg/kg in amniotic fluids. The cysteinylglycine-S-conjugate of (R)/(S)-3-methyl-3-sulphanylhexan-1-ol were detected in the range of 2–24 ng/kg in human milk, and 7–101 ng/kg in colostrums. Our data demonstrate that concentrations in human milk vary between individuals, and with lactation period as the mean concentrations of the glutamine conjugates in colostrums were elevated in comparison to mature milk and the concentrations of acid precursors were close to 10 times higher. Further, these precursors were not detected in cow milk.
longissimus muscle and the fatty acid composition in phospholipids and triacylglycerols were investigated. Significant influences of feeding were shown in most fatty acids measured in both lipid classes. In concentrate-fed bulls a higher content of linoleic acid (C18:2n-6) was detected, corresponding to the large amount of linoleic acid found in concentrate used as feed. In contrast, bulls fed grass proved to have a higher linolenic acid (C18:3n-3) content, also correlating well with the larger amount of linolenic acid found in grass. Pressure-cooking of the beef followed by an analysis of eight important meat odorants revealed that, in line with the higher concentrations of the precursor fatty acids C18:3n-3 and C18:1 in muscle of group 2, (E,Z)-2,6-nonadienal (from C18:3n-3) as well as nonanal and octanal (from C18:1) were much higher in the processed meat of animals fed grass. On the other hand, the much higher amounts of C18:2n-6 in bulls fed concentrate were well-reflected by higher concentrations of five aroma compounds known to be formed by a thermal degradation of this acid, e.g. (E,E)-2,4-decadienal.
cis-3-hexen-1-ol, benzaldehyde, ethyl butanoate and butyl isovalerate) from pure water and various low-viscosity aqueous solutions (sucrose, maltitol, erythritol, polydextrose and oligofructose, each at 20% (w/w)) was investigated. Dynamic headspace concentrations of the flavour compounds at thermodynamic equilibrium were monitored by proton-transfer-reaction mass spectrometry (PTR-MS). The rheological properties of the solutions were characterised by their viscosity. Flavour release from pure water increased with increasing hydrophobicity and volatility of the flavour compounds. The highly volatile compounds were retained more extensively in the presence of sucrose, polyols and bulking agents, compared to in pure water, whereas an increase in the release of the less volatile cis-3-hexen-1-ol was observed. All aqueous solutions had similar viscosities, although bulking agent solutions tended to have higher viscosities than polyol solutions of the same concentration. A correlation between viscosity and flavour release in the low-viscosity solutions was not evident.
in vivo sampling conditions, together with analysis via high resolution gas chromatography–olfactometry (HRGC–O). The obtained analytical data were related to timeresolved retronasal aroma evaluation. This allowed the characterization of prolongued aroma perception elicited after oral aroma application in relation to aroma concentration changes in vivo. For validation of the system, model assays were performed on important aroma compounds in aqueous solutions to ensure sufficient sensitivity of the applied SBSE system under the given extraction conditions. Copyright © 2004 John Wiley & Sons, Ltd.
−1 creatinine into urine is observed for linalool, 1,8-cineole, and eugenol. Maximum concentrations are reached 1.5 h after the intervention for 1,8-cineole and eugenol as well as 2.5 h after the intervention for linalool. Comparison with previous results reveals that the excretion pattern of odorants into urine is divergent from the one into milk. In a second intervention study (n = 6), excretion of phase II metabolites into urine is studied using β-glucuronidase treatment. Linalool and eugenol concentrations are 23 and 77 times higher after treatment than before treatment with β-glucuronidase, respectively. Conclusion: The study demonstrates transition of linalool, 1,8-cineole, and eugenol from the diet into urine and excretion of glucuronides in the case of linalool, eugenol, and vanillin.},
author = {Debong, Marcel and N'Diaye, Katharina and Schöberl, Daniela and Yin, Yue and Lang, Roman and Büttner, Andrea and Hofmann, Thomas and Loos, Helene},
doi = {10.1002/mnfr.202300396},
faupublication = {yes},
journal = {Molecular Nutrition & Food Research},
keywords = {aroma transition; gas chromatography-mass spectrometry/olfactometry; maternal diet; milk; phase II-metabolism},
note = {CRIS-Team Scopus Importer:2023-12-08},
peerreviewed = {Yes},
title = {{Linalool}, 1,8-{Cineole}, and {Eugenol} {Transfer} from a {Curry} {Dish} into {Human} {Urine}},
year = {2023}
}
@article{faucris.285667264,
abstract = {Magnetic fields are very attractive for non-invasive neuromodulation because they easily penetrate trough the skull and tissue. Cell specific neuromodulation requires the magnetic field energy to be converted by an actuator to a biologically relevant signal. Miniaturized actuators available today range from small, isotropic magnetic nanoparticles to larger, submicron anisotropic magnetic nanomaterials. Depending on the parameters of external magnetic fields and the properties of the nanoactuators, they create either a thermal or a mechanical stimulus. Ferromagnetic nanomaterials generate heat in response to high frequency alternating magnetic fields associated with dissipative losses. Anisotropic nanomaterials with large magnetic moments are capable of exerting forces at stationary or slowly varying magnetic fields. These tools allow exploiting thermosensitive or mechanosensitive neurons in circuit or cell specific tetherless neuromodulation schemes. This review will address assortment of available magnetic nanomaterial-based neuromodulation techniques that rely on application of external magnetic fields.},
author = {Signorelli, Lorenzo and Hescham, Sarah Anna and Pralle, Arnd and Gregurec, Danijela},
doi = {10.1016/j.isci.2022.105401},
faupublication = {yes},
journal = {iScience},
keywords = {Applied sciences; Nanomaterials; Neuroscience},
note = {CRIS-Team Scopus Importer:2022-11-25},
peerreviewed = {Yes},
title = {{Magnetic} nanomaterials for wireless thermal and mechanical neuromodulation},
volume = {25},
year = {2022}
}
@article{faucris.248078336,
abstract = {Earthy and musty off-flavors are routinely observed in farmed trout worldwide. The microbial association to the production of those off-flavors was previously reported. The current manuscript aimed to catalog the microbial enrichment (eukaryotes and prokaryotes) in semi-intensive aquaculture freshwater sources that might influence the trout aquaculture quality production. The 16S rRNA and ITS metabarcoding analyses were applied on the inflow- and pond-water samples from trout farms previously recorded a malodor fish products and located alongside Moosach and Sempt Rivers in Bavaria province, Germany. The results showed that more than 99% of the detected prokaryotic OTUs (Operational Taxonomic Unit identification) were bacteria as of ~ 75.57% were Proteobacteria, and ~ 14.4% were Bacteroidetes. Meanwhile, 118 out of 233 of the eukaryotic OTUs were known species. Of these, ~ 45% were plant pathogens, and ~ 28% were mushroom/yeasts. Based on the comparative analysis between inflow- and pond-water samples, several pro- and eukaryotic microorganisms that affect the trout aquaculture water quality and industry have been detected, including the malodor-producing microorganisms, e.g., Cyanobacteria and Actinobacteria, along with fish infectious microorganisms, e.g., Chilodonella cyprinid, Metschnikowia bicuspidate. Additionally, the effect of the human- and industrial-related activities around the sampling area on the microbiota of the investigated farms were highlighted.},
author = {Mahmoud, Mohamed and Magdy, Mahmoud},
doi = {10.1038/s41598-020-80236-x},
faupublication = {yes},
journal = {Scientific Reports},
note = {CRIS-Team Scopus Importer:2021-01-22},
peerreviewed = {Yes},
title = {{Metabarcoding} profiling of microbial diversity associated with trout fish farming},
volume = {11},
year = {2021}
}
@article{faucris.203435606,
abstract = {Terpenoids are major subcomponents in aroma substances which harbor sedative physiological potential. We have demonstrated that various monoterpenoids such as the acyclic linalool enhance GABAergic currents in an allosteric manner in vitro upon overexpression of inhibitory alpha 1 beta 2 GABA(A) receptors in various expression systems. However, in plants or humans, i.e., following intake via inhalation or ingestion, linalool undergoes metabolic modifications including oxygenation and acetylation, which may affect the modulatory efficacy of the generated linalool derivatives. Here, we analyzed the modulatory potential of linalool derivatives at alpha 1 beta 2 gamma 2 GABA(A) receptors upon transient overexpression. Following receptor expression control, electrophysiological recordings in a whole cell configuration were used to determine the chloride influx upon co-application of GABA EC10-30 together with the modulatory substance. Our results show that only oxygenated linaloolmetabolites at carbon 8 positively affect GABAergic currents whereas derivatives hydroxylated or carboxylated at carbon 8 were rather ineffective. Acetylated linalool derivatives resulted in non-significant changes of GABAergic currents. We can conclude that metabolism of linalool reduces its positive allosteric potential at GABA(A) receptors compared to the significant potentiation effects of the parent molecule linalool itself.},
author = {Milanos, Sinem and Elsharif, Shaimaa and Janzen, Dieter and Büttner, Andrea and Villmann, Carmen},
doi = {10.3389/fchem.2017.00046},
faupublication = {yes},
journal = {Frontiers in Chemistry},
keywords = {Cys-loop receptor;GABA(A) receptor;linalool;linalyl acetate;oxygenation;patch-clamp},
peerreviewed = {Yes},
title = {{Metabolic} {Products} of {Linalool} and {Modulation} of {GABA}({A}) {Receptors}},
volume = {5},
year = {2017}
}
@article{faucris.257446175,
abstract = {A metal free synthesis of S-alkyl thioesters, which does not involve alkylthiol or thiocarboxylic acid as sulfur source is disclosed. The process involves first an acylation at the nitrogen of the readily available N-(2-aminophenyl)-4-methyl-thiazolin-2-thione, second an alkylation at sulfur of the resulting amides and finally a base catalyzed metathetic reaction, which provides under very mild conditions and in high isolated yields the S-alkyl thioesters. An ion-pair intermediate (9-acyl-3-methyl[1,3]thiazolo[3,2-a][3,1]benzimidazol-9-ium alkylthiolate) accounts for the formation of mixed thioesters during cross-coupling experiments.
S-Alkyl diversity is provided by the alkylating agent and the acyl diversity comes from the acylating agent, while the sulfur atom is provided by the heterocycl},
author = {Mehdid, Mohammed Amine and Djafri, Ayada and Andreoli, Federico and Vanthuyne, Nicolas and Farran, Daniel and Niebler, Johannes and Büttner, Andrea and Giorgi, Michel and Roussel, Christian},
doi = {10.1016/j.tet.2013.04.013},
faupublication = {yes},
journal = {Tetrahedron},
peerreviewed = {unknown},
title = {{Metathetic} {Sulfur} {Transfer} mediated by {N}-(2-aminophenyl)-4-methyl-thiazolin-2-thione derivatives: {Part} {III}: a new {Route} to {Diversely} {Substituted} {S}-alkyl thioesters.},
year = {2013}
}
@article{faucris.257900869,
abstract = {Flavor release from mixtures of maltitol, erythritol, polydextrose and oligofructose dissolved in water at concentrations of 43% (w/w) was investigated to analyze possible interactions between the viscous matrix and the volatiles using an experimental mixture design in combination with data analysis and response modeling tools. The dynamic release of four flavor compounds (cis-3-hexenol, benzaldehyde, ethyl butanoate and butyl isovalerate) from the matrices at 37 °C was determined by headspace analyses using proton-transfer-reaction mass spectrometry (PTR-MS). The aim of the present study was to understand the complex release mechanisms from high-viscosity polyol and bulking agent solutions for the intention of conducting further studies on flavor release from sugar-free confectionary products. Each of the non-volatiles had a significant effect (p < 0.05) on flavor release with regression coefficients (R²) between 0.72 and 0.93 for the release parameters Imax, t½, and Δc/Δt, and 0.99 for viscosity. However, the magnitude of influence varied between the bulking agents and polyols due to their different molecular weights. A clear correlation between viscosity of the solutions and flavor release was found, revealing complex matrix-volatile interactions in the high-viscosity solutions. The release of all investigated flavor compounds decreased when the viscosity of the solutions increased. Therefore, it is assumed that the flavor release is significantly influenced by the non-volatiles when a critical concentration (c*) is exceeded. Interactions between the sugar substitutes were found to affect the viscosity of the matrices, whereas flavor release was not affected by interactions between the polyols and bulking agents investigated.
der Spur.
Background & aims: The effect of human milk storage in the refrigerator has been investigated with regard to sensory changes and modifications to the molecular composition of the milk odour-active volatiles.
Methods: In the present study, characteristic odorants from fat oxidation, known from previous studies, as well as free fatty acids were quantified as representative marker substances by means of stable isotope dilution assays of fresh milk samples and milk samples stored at +4 °C for one and three days, respectively.
Results: Sensory evaluation showed that rancid and sweaty odour attributes were generated during storage, resulting in an unpleasant aroma profile for adults; however, odour changes were not as pronounced as those observed in our previous study for freeze storage. Fatty and buttery odour notes and a cooked milk-like smell were also generated. In total eight odorants from fat oxidation were determined and some potent odorants showed slight concentration increases. Moreover, five free fatty acids were determined and these all showed drastic concentration increases, even after storage for just one day.
Conclusions: These investigations support our previous findings that storage recommendations for breast milk might need to be slightly reconsidered in view of potential sensory changes; on the other hand, no negative physiological effects are to be expected from these changes.
Keywords: Fatty acid oxidation; Human milk; Polyunsaturated fatty acid (PUFA); Quantification; Stable isotope dilution assays (SIDA); Storage at +4 °C.
},
author = {Spitzer, Johanna and Klos, Katharina and Büttner, Andrea},
doi = {10.1016/j.clnu.2013.01.015},
faupublication = {yes},
journal = {Clinical Nutrition},
pages = {1036-1042},
peerreviewed = {Yes},
title = {{Monitoring} aroma changes during human milk storage at +4°{C} by sensory and quantification experiments.},
year = {2013}
}
@article{faucris.257898111,
author = {Heinlein, Anja and Büttner, Andrea},
doi = {10.1039/C2FO30061C},
faupublication = {yes},
journal = {Food and Function},
pages = {1059-1067},
peerreviewed = {unknown},
title = {{Monitoring} of biotransformation of hop aroma compounds in an in vitro digestion model.},
year = {2012}
}
@article{faucris.234387234,
abstract = {The significance of wood odors beyond flavoring effects for barbecues and wine aged in barrels has recently been under discussion. Wood has an immense influence on our physical and mental condition through our palate, such as positive health and mood-stimulating effects. As a result of increased public interest, the key odorants from various natural wood species were recently decoded. To gain profound insights into the contribution of single odorants to the overall scent of distinct wood types, this study compares several softwood species (Scots pine, incense cedar, European larch, Norway spruce, and white fir) by odor profile analysis. Nine odor-active constituents, which were previously detected in those woods, were quantified using stable isotope dilution analysis (SIDA). Odor activity values (OAVs) calculated on the basis of odor thresholds (OTs) determined in cellulose revealed hexanal, octanal, (E)-non-2-enal, p-cresol, vanillin, and thymoquinone as dominant odorants for wood odor. Recombination experiments by mixing the odorants in their naturally occurring concentrations in a cellulose matrix confirmed the successful characterization of the key odorants for Scots pine and incense cedar wood.},
author = {Schreiner, Linda and Ortner, Eva and Büttner, Andrea},
doi = {10.1007/s00216-019-02339-3},
faupublication = {yes},
journal = {Analytical and Bioanalytical Chemistry},
keywords = {Odor activity values; Odor recombination; Thymoquinone; Wood; α-Pinene},
note = {CRIS-Team Scopus Importer:2020-02-18},
pages = {1137-1149},
peerreviewed = {Yes},
title = {{Nosy} confirmation: reconstitution of the characteristic odor of softwood via quantitative analysis and human sensory evaluation},
volume = {412},
year = {2020}
}
@article{faucris.257958718,
abstract = {The process of eating and drinking was observed in vivo by application of videofluoroscopy, a dynamic X-ray technique, as well as real-time magnetic resonance imaging. The study was aimed at elucidating the timing and performance of the physiological organs involved in mastication and swallowing, mainly the tongue, the pharynx and the soft palate (velum palatinum). It was shown for the first time that effective physiological barriers do exist during food consumption that are capable of retaining volatiles such as helium within the oral cavity. These barriers allow the access of odorants to the nasal cavity only at certain times during the eating process. Their effectiveness is related to the texture of the food as well as the amount of food material present in the oral cavity and, thereby, directly influences retronasal aroma perception.
E)-non-2-enal, (R/S)-γ-nonalactone, 2-methoxyphenol, (R/S)-δ-decalactone, p-anisaldehyde, 3-propylphenol, and a woody-smelling unknown compound. Most of the identified compounds were described as odor-active cardboard constituents for the first time. Sensory experiments demonstrated that extensive release of odor-active compounds occurred upon moistening of the cardboard. Accordingly, data indicated that the odorants are present in cardboard in relatively high amounts. In a further sensory study, a transfer of the released odor to food was demonstrated in a model experiment showing that cardboards with high odor potential can cause unwanted flavor changes in foods.
R different types of receptors in order to detect the emitted molecule mixtures. The design of an MC system based on orthogonal molecule-receptor pairs implies that the hardware complexity of the receiver linearly scales with the number of signaling molecule types Q (i.e., R = Q). Natural olfaction systems avoid such high complexity by employing arrays of cross-reactive receptors, where each type of molecule activates multiple types of receptors and each type of receptor is predominantly activated by multiple types of molecules albeit with different activation strengths. For instance, the human olfactory system is believed to discriminate several thousands of chemicals using only a few hundred receptor types, i.e., Q ≫ R. Motivated by this observation, we first develop an end-to-end MC channel model that accounts for the key properties of olfaction. Subsequently, we present the proposed transmitter and receiver designs. In particular, given a set of signaling molecules, we develop algorithms that allocate molecules to different transmitters and optimize the mixture alphabet for communication. Moreover, we formulate the molecule mixture recovery as a convex compressive sensing problem which can be efficiently solved via available numerical solvers. Finally, we present a comprehensive set of simulation results to evaluate the performance of the proposed MC designs revealing interesting insights regarding the design parameters. For instance, we show that mixtures comprising few types of molecules are best suited for communication since they can be more reliably detected by the cross-reactive array than one type of molecule or mixtures of many molecule types.},
author = {Jamali, Vahid and Loos, Helene and Büttner, Andrea and Schober, Robert and Vincent Poor, H.},
doi = {10.1109/TCOMM.2023.3242379},
faupublication = {yes},
journal = {IEEE Transactions on Communications},
keywords = {compressive sensing; Engineered molecular communication; generalist receptors; molecule mixture modulation; odor; pheromone; transmitter and receiver design},
note = {CRIS-Team Scopus Importer:2023-03-03},
pages = {1-1},
peerreviewed = {Yes},
title = {{Olfaction}-inspired {MCs}: {Molecule} {Mixture} {Shift} {Keying} and {Cross}-{Reactive} {Receptor} {Arrays}},
year = {2023}
}
@article{faucris.238262856,
abstract = {The impact of the olfactory sense is regularly apparent across development. The fetus is bathed in amniotic fluid (AF) that conveys the mother's chemical ecology. Transnatal olfactory continuity between the odours of AF and milk assists in the transition to nursing. At the same time, odours emanating from the mammary areas provoke appetitive responses in newborns. Odours experienced from the mother's diet during breastfeeding, and from practices such as pre-mastication, may assist in the dietary transition at weaning. In parallel, infants are attracted to and recognize their mother's odours; later, children are able to recognize other kin and peers based on their odours. Familiar odours, such as those of the mother, regulate the child's emotions, and scaffold perception and learning through non-olfactory senses. During juvenility and adolescence, individuals become more sensitive to some bodily odours, while the timing of adolescence itself has been speculated to draw from the chemical ecology of the family unit. Odours learnt early in life and within the family niche continue to influence preferences as mate choice becomes relevant. Olfaction thus appears significant in turning on, sustaining and, in cases when mother odour is altered, disturbing adaptive reciprocity between offspring and carer during the multiple transitions of development between birth and adolescence. This article is part of the Theo Murphy meeting issue 'Olfactory communication in humans'.},
author = {Schaal, Benoist and Saxton, Tamsin K. and Loos, Helene and Soussignan, Robert and Durand, Karine},
doi = {10.1098/rstb.2019.0261},
faupublication = {yes},
journal = {Philosophical Transactions of the Royal Society B-Biological Sciences},
note = {CRIS-Team WoS Importer:2020-05-12},
peerreviewed = {Yes},
title = {{Olfaction} scaffolds the developing human from neonate to adolescent and beyond},
volume = {375},
year = {2020}
}
@article{faucris.286946205,
abstract = {Indoor air is a complex and dynamic mixture comprising manifold volatile organic compounds (VOCs) that may cause physiological and/or psychological discomfort, depending on the nature of exposure. This technical note presents a novel approach to analyze VOC emissions by coupling a microchamber/thermal extractor (μ-CTE) system to a proton transfer reaction-mass spectrometer (PTR-MS). This configuration provides an alternative to conventional emissions testing of small objects. The dynamic emission profiles of VOCs from a representative 3D-printed model are presented as a proof-of-concept analysis. Emission profiles are related to the target compound volatility, whereby 2-propanol and acetaldehyde exhibited the highest emissions and most rapid changes compared to the less volatile vinyl crotonate, 2-hydroxymethyl methacrylate, and mesitaldehyde, which were present at lower concentrations and showed different dynamics. Comparative measurements of the emission profiles of these compounds either with or without prior static equilibration yielded stark differences in their dynamics, albeit converging to similar values after 15 min of sampling time. Further, the utility of this system to determine the time required to capture a specific proportion of volatile emissions over the sampling period was demonstrated, with a mean duration of 8.4 ± 0.3 min to sample 50% of emissions across all compounds. This novel configuration provides a means to characterize the dynamic nature of VOC emissions from small objects and is especially suited to measuring highly volatile compounds, which can present a challenge for conventional sampling and analysis approaches. Further, it represents an opportunity for rapid, targeted emissions analyses of products to screen for potentially harmful volatiles.},
author = {Pham, Y Lan and Wojnowski, Wojciech and Beauchamp, Jonathan},
doi = {10.1021/acs.analchem.2c03454},
faupublication = {yes},
journal = {Analytical Chemistry},
note = {CRIS-Team Scopus Importer:2022-12-23},
peerreviewed = {Yes},
title = {{Online} {Volatile} {Compound} {Emissions} {Analysis} {Using} a {Microchamber}/{Thermal} {Extractor} {Coupled} to {Proton} {Transfer} {Reaction}-{Mass} {Spectrometry}},
year = {2022}
}
@article{faucris.242409468,
abstract = {Wood has been an important raw material for centuries, and humans encounter it in the form of furniture and building materials or in products of daily use. The odors emanating from such wood-based materials can add another facet to their functionality by influencing human well-being and mood. Moreover, wood odors can be used in odor-enhanced environments to foster relaxation and stress recovery. The current study was conducted to assess the subjective evaluation of, and physiological responses to, wood odors and individual wood odor constituents. The subjects smelled the odors of pine needles oil, cedar wood oil, α-pinene, and thymoquinone and evaluated the odor percept and their subjective feelings. Heart rate, finger temperature, and skin conductance were monitored throughout the experiment. The results showed that wood odors were distinct regarding their pleasantness, familiarity, and intensity. All odors enhanced the subjective feelings of happiness and content. Though no odor-specific physiological effects became evident, certain physiological measures correlated with self-reports of happy and relaxed feelings and the intensity ratings of the odors. The present study provides a basis for further studies on the use of wood odors as ambient scents and helps understanding the influence of natural odors on humans.},
author = {Schreiner, Linda and Karacan, Brid and Blankenagel, Sonja and Packhaeuser, Kai and Freiherr, Jessica and Loos, Helene},
doi = {10.1007/s00226-020-01216-y},
faupublication = {yes},
journal = {Wood Science and Technology},
note = {CRIS-Team Scopus Importer:2020-09-11},
peerreviewed = {Yes},
title = {{Out} of the woods: psychophysiological investigations on wood odors to estimate their suitability as ambient scents},
year = {2020}
}
@article{faucris.257425869,
abstract = {Characterisation of food-flavour release using quadrupole-based on-line mass spectrometers such as proton-transfer-reaction mass spectrometry (PTR-MS, or PTR-QMS) can be complicated when nominally isobaric aroma compounds are present in complex food matrices. The recent combination of PTR-MS with time-of-flight mass spectrometry (PTR-TOF-MS) offers an analytical tool potentially capable of overcoming this problem because of its enhanced mass resolution. In this context, four pairs of isobaric compounds (cis-3-hexenol and 2,3-pentanedione, benzaldehyde and m-xylene, ethyl butanoate and 2-methylbutanol, and isobutyl isopentanoate and 1-hexanol) were investigated by PTR-TOF-MS to assess its mass-resolving power for food-flavour applications. Headspace analyses of aqueous solutions containing nominally isobaric aroma compounds that are unresolvable by PTR-QMS demonstrated that the PTR-TOF-MS mass-resolving power, which is m/z-dependent, enabled discrimination between isobaric peaks at a centre of mass separation down to at least 0.030 Da. Visual discrimination between these isobaric compound peaks in the headspace of aqueous solutions down to a concentration range of a few tens of ng mL−1 was also possible, enabling an empirical method for determining the limit of quantitation in solution for single compounds. PTR-TOF-MS offers distinct advantages over conventional PTR-MS for certain flavour release applications.
n-butanol was chosen for evaluation. The gas-phase concentration of n-butanol at the tip of each pen was measured directly in a new set of pens via proton-transfer-reaction mass spectrometry (PTR-MS). Measurements were additionally made on the same pens after 6 months and two older pen sets, namely a 3-year-old (used) and 4-year-old (new) set. Furthermore, application-related tests were made to determine the performance of the pens during routine use and under stress. These data demonstrate that the gas-phase n-butanol concentrations of the threshold pens are linear over the entire set, both for brand-new pens and 6 months later; this reflects the expected performance that was previously only assumed. Furthermore, the application–simulation tests demonstrated a good performance of the pens when used according to their intended protocol. Measurements of the older pen sets suggest that storage conditions are more critical than usage for pen stability. The present findings confirm that the n-butanol odorant pens are an appropriate tool for threshold testing, provided they are stored and handled correctly.
Eucalyptol (1,8-cineole) is a common active agent in non-prescription pharmaceutical products that is employed to clear the airways during mucus blockages. Following ingestion of a eucalyptol-containing capsule, the capsule dissolves in the gut and transfers eucalyptol into the blood, which is subsequently expelled via the lungs, thus exposing this decongesting and inflammation-abating compound to the airways. The breath gas concentrations of eucalyptol in 11 healthy adult volunteers were monitored at regular intervals after capsule ingestion using on-line proton-transfer-reaction mass spectrometry (PTR-MS). Eucalyptol appeared in exhaled breath gas at varying times following ingestion, with its onset ranging from 1 h and 6 min to 4 h and 48 min (mean ± SD: 2.1 ± 0.5 h). Maximum concentrations also varied greatly, with peak eucalyptol levels between 106 and 1589 ppb(v) (mean ± SD: 489 ± 319 ppb(v)). These variations were not only inter-subject, but also intra-subject, i.e. repeated tests with the same participant yielded different onset times and a broad range of concentration maxima. A considerable contribution to these variations from infrequent sampling and analysis is discussed. This study characterized the temporal transfer of eucalyptol via the blood into the airways by examining exhaled breath and thereby demonstrated the suitability of on-line breath gas analyses, particularly PTR-MS, for certain pharmacokinetic investigations.
},
author = {Beauchamp, Jonathan and Kirsch, Frauke and Büttner, Andrea},
doi = {10.1088/1752-7155/4/2/026006},
faupublication = {yes},
journal = {Journal of Breath Research},
peerreviewed = {Yes},
title = {{Real}-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules.},
year = {2010}
}
@article{faucris.293802630,
abstract = {Background: Body odor is an important aspect in interpersonal communication. For psychological and chemical research on body odors, suitable procedures for sampling and application, and analysis of body odors are essential. In this study, different textile fabrics (polyester, cotton, and Gazin gauze) were comparatively evaluated in view of their potential suitability for body odor sampling by determining recovery rates of selected body odor substances. In addition, the impact of sample preparation and storage conditions on the recovery rates was determined. Results: The recovery rates of dimethyl disulfide, (E)-non-2-enal, 5α-androst-16-en-3-one, 6-methylhept-5-en-2-one, heptanal and 3-sulfanylhexan-1-ol were determined under different conditions of storage (storage for 30 min at room temperature or storage for 30 min at room temperature followed by freezing at – 80 °C for 4 weeks) and sample work-up (solvent extraction with and without solvent-assisted flavour evaporation, in the following: SAFE). SAFE led to overall lower recovery rates with a significant effect for (E)-non-2-enal and 5α-androst-16-en-3-one. Nevertheless, the results showed that SAFE can be an essential step when working with a complex matrix. When comparing the different fabrics, except for (E)-non-2-enal no difference between the recovery rates obtained for cotton and polyester became evident. Gazin gauze showed lower recovery rates for all compounds. Finally, our results showed that the here investigated target compounds are stable during storage for four weeks at – 80 °C. Significance and Novelty: The results show on the one hand that the here investigated compounds were stable during storage and that the fiber type had limited influence on overall recovery rates. On the other hand, they highlight the limitations of using textile materials for sampling of volatile substances, especially with regard to low recovery rates for certain substances and the necessity of material pre-treatment or distillation steps for enabling GC-MS analysis after solvent extraction.},
author = {Alves Soares, Tatjana and Owsienko, Diana and Härtl, Tobias and Loos, Helene},
doi = {10.1016/j.aca.2023.341067},
faupublication = {no},
journal = {Analytica Chimica Acta},
keywords = {Adsorption; Cotton; Gazin gauze; Polyester; Release; Storage stability},
note = {CRIS-Team Scopus Importer:2023-03-24},
peerreviewed = {Yes},
title = {{Recovery} rates of selected body odor substances in different textiles applying various work-up and storage conditions measured by gas chromatography-mass spectrometry},
volume = {1252},
year = {2023}
}
@article{faucris.257943552,
author = {Mestres, Montse and Kieffer, Rolf and Büttner, Andrea},
doi = {10.1021/jf0517501},
faupublication = {yes},
journal = {Journal of Agricultural and Food Chemistry},
peerreviewed = {Yes},
title = {{Release} and perception of {Ethyl} butanoate during and after consumption of flavored whey protein gels – relation between textural and physiological parameters.},
year = {2006}
}
@article{faucris.256961856,
author = {Denk, Philipp and Velasco-Schön, Cristina and Büttner, Andrea},
doi = {10.1007/s00216-017-0469-5},
faupublication = {yes},
journal = {Analytical and Bioanalytical Chemistry},
pages = {5249-5258},
peerreviewed = {Yes},
title = {{Resolving} the chemical structures of off-odorants and potentially harmful substances in toys – example of children’s swords.},
year = {2017}
}
@article{faucris.203876523,
abstract = {Being one of the most common trees in forests, Pinus sylvestris L. is a frequently used raw material for wood products. Its specific odour is, however, mostly unresolved to date. Accordingly, we investigated Scots pine wood samples grown in Germany for their main odorant composition. We employed dedicated odorant analysis techniques such as gas chromatography-olfactometry (GC-O) and aroma extract dilution analysis (AEDA) and successfully detected 44 odour-active compounds; of these, 39 substances were successfully identified by gas chromatography-mass spectrometry/olfactometry (GC-MS/O) and two-dimensional gas chromatography-mass spectrometry/olfactometry (2D-GC-MS/O). Among the main odorants found were (E, E)-nona-2,4-dienal, vanillin, phenylacetic acid, 3-phenylpropanoic acid, d-octalactone and a-pinene, all of them having been detected with high flavour dilution factors during GC-O analyses. The majority of the identified odorants were fatty acid degradation products, plus some terpenoic substances and odorous substances resulting from the degradation of lignin. Although some of the detected substances have previously been reported as constituents of wood, 11 substances are reported here for the first time as odour-active compounds in wood, amongst them heptanoic acid,gamma-octalactone, delta-nonalactone and (E, Z, Z)-trideca-2,4,7-trienal.},
author = {Schreiner, Linda and Bauer, Patrick and Büttner, Andrea},
doi = {10.1038/s41598-018-26626-8},
faupublication = {yes},
journal = {Scientific Reports},
peerreviewed = {Yes},
title = {{Resolving} the smell of wood - identification of odour-active compounds in {Scots} pine ({Pinus} sylvestris {L}.)},
volume = {8},
year = {2018}
}
@article{faucris.257180036,
author = {Loos, Helene and Doucet, Sèbastien and Vedrines, Fanny and Sharapa, Constanze and Soussignan, Robert and Durand, Karine and Sagot, Paul and Büttner, Andrea and Schaal, Benoist},
doi = {10.1007/s10886-016-0804-x},
faupublication = {yes},
journal = {Journal of Chemical Ecology},
pages = {106 - 177},
peerreviewed = {Yes},
title = {{Responses} of human neonates to highly diluted odorants from sweat.},
year = {2017}
}
@article{faucris.257267783,
abstract = {The odorous steroid 5α-androst-16-en-3-one (AND) occurs in numerous biological fluids in mammals, including man, where it is believed to play a chemocommunicative role. As AND was recently detected in milk and amniotic fluid, sensitivity and hedonic responses to this substance were assessed in human neonates. To this aim, respiration and facial expressions were recorded in 3-day-old newborns in response to aqueous solutions of AND, ranging from 500ng/mL to 0.5 fg/mL. Although analyses of respiratory rate did not lead to clear-cut results, the newborns changed their facial expressions at concentrations not detected by adults in a triangle test. Newborns displayed negative facial actions of longer duration to AND relative to an odorless control. Thus, AND may be considered to be offensive to newborns, which is a counterintuitive outcome as they are exposed to this compound in the womb (and it should therefore be familiar), in milk, and on the mother's skin surface (and it should therefore be conditioned as positive). Multiple reasons for this perceptual-behavioral paradox are discussed.
that form pentameric arrangements of various subunits.
Positive allosteric modulators of GABAA receptors
have been reported as being isolated either from plants
or synthesized analogs of known GABAA receptor targeting
drugs. Recently, we identified monoterpenes, e.g.
myrtenol as a positive allosteric modulator at α1β2 GABAA
receptors. Here, along with pharmacophore-based virtual
screening studies, we demonstrate that scaffold modifications
of myrtenol resulted in the loss of modulatory activity.
Two independent approaches, fluorescence-based
compound analysis and electrophysiological recordings
in whole-cell configurations were used for analysis
of transfected cells. C-atoms 1 and 2 of the myrtenol
backbone were identified as crucial to preserve positive
allosteric potential. A modification at C-atom 2 and lack
of the hydroxyl group at C-atom 1 exhibited significantly
reduced GABAergic currents at α1β2, α1β2γ, α2β3, α2β3γ
and α4β3δ receptors. This effect was independent of
the γ2 subunit. A sub-screen with side chain length and
volume differences at the C-atom 1 identified two compounds
that inhibited GABAergic responses but without
receptor subtype specificity. Our combined approach of
pharmacophore-based virtual screening and functional
readouts reveals that side chain modifications of the
bridged six-membered ring structure of myrtenol are
crucial for its modulatory potential at GABAA receptor},
author = {Milanos, Sinem and Künzel, Katharina and Gilbert, Daniel and Janzen, Dieter and Sasi, Manju and Büttner, Andrea and Frimurer, Thomas M. and Villmann, Carmen},
doi = {10.1515/hsz-2017-0262},
faupublication = {yes},
journal = {Biological Chemistry},
keywords = {allosteric modulation; GABAA receptor; myrtenol; patch clamp recording; virtual screening; YFPI152L},
peerreviewed = {Yes},
title = {{Structural} changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory {GABAA} receptor modulation.},
year = {2018}
}
@article{faucris.236674897,
abstract = {Thymoquinone was recently reported as having a unique pencil-like odor and being the impact compound for the cedar-like and cedar wood-based product smell such as pencils. The compounds thymol and carvacrol are structurally related odorants commonly found in plants and foods such as thyme and oregano, also having a significant contribution to their overall aroma. However, a systematic elucidation of the sensory properties in this class of oxygenated, aromatic monoterpenoids has not been carried out. To close this gap and gain new insights into structure-odor relationships leading to pencil-like and woody odors, 19 structurally related derivatives of p-cymene starting from thymol and carvacrol were synthesized and characterized. The compounds had odor thresholds ranging from 2.0 ng/L air to 388.8 ng/L air, being lowest for thymol and carvacrol and highest for thymohydroquinone. The compounds smelled mostly thyme-like, oregano-like, and pencil-like with phenolic, earthy, and medicinal variations in their odor character, which could be successfully linked to structural motifs.},
author = {Schreiner, Linda and Bauer, Johannes and Ortner, Eva and Büttner, Andrea},
doi = {10.1021/acs.jnatprod.9b00339},
faupublication = {yes},
journal = {Journal of Natural Products},
note = {CRIS-Team Scopus Importer:2020-03-31},
peerreviewed = {Yes},
title = {{Structure}-{Odor} {Activity} {Studies} on {Derivatives} of {Aromatic} and {Oxygenated} {Monoterpenoids} {Synthesized} by {Modifying} p-{Cymene}},
year = {2020}
}
@article{faucris.121204204,
abstract = {Linalool 1 is an odorant that is commonly perceived as having a pleasant odor, but is also known to elicit physiological effects such as inducing calmness and enhancing sleep. However, no comprehensive studies are at hand to show which structural features are responsible for these prominent effects. Therefore, a total of six oxygenated derivatives were synthesized from both 1 and linalyl acetate 2, and were tested for their odor qualities and relative odor thresholds (OTs) in air. Linalool was found to be the most potent odorant among the investigated compounds, with an average OT of 3.2 ng/L, while the 8-hydroxylinalool derivative was the least odorous compound with an OT of 160 ng/L; 8-carboxylinalool was found to be odorless. The odorant 8-oxolinalyl acetate, which has very similar odor properties to linalool, was the most potent odorant besides linalool, exhibiting an OT of 5.9 ng/L. By comparison, 8-carboxylinalyl acetate had a similar OT (6.1 ng/L) as its corresponding 8-oxo derivative but exhibited divergent odor properties (fatty, greasy, musty). Overall, oxygenation on carbon 8 had a substantial effect on the aroma profiles of structural derivatives of linalool and linalyl acetat},
author = {Elsharif, Shaimaa and Banerjee, Ashutosh and Büttner, Andrea},
doi = {10.3389/fchem.2015.00057},
faupublication = {yes},
journal = {Frontiers in Chemistry},
keywords = {Linalool, linalyl acetate; gas chromatography-olfactometry; odor threshold in air; 8-oxolinalyl acetate; 8-carboxylinalyl acetate; odor qualities; retention index},
peerreviewed = {Yes},
title = {{Structure}-odor relationships of linalool, linalyl acetate and their corresponding oxygenated derivatives},
url = {http://journal.frontiersin.org/article/10.3389/fchem.2015.00057/full},
volume = {3},
year = {2015}
}
@article{faucris.203877452,
author = {Lorber, Katja and Zeh, Gina and Regler, Johanna and Büttner, Andrea},
doi = {10.1021/acs.jafc.6b04780},
faupublication = {yes},
journal = {Journal of Agricultural and Food Chemistry},
keywords = {odor activity; odor intensity; chemo-communicative; gas chromatography-olfactometry; retention index; odor threshold in air; odorant},
pages = {2334-2343},
peerreviewed = {Yes},
title = {{Structure}-{Odor} {Relationships} of ({Z})-3-{Alken}-1-ols, ({Z})-3-{Alkenals}, and ({Z})-3-{Alkenoic} {Acids}},
volume = {66},
year = {2018}
}
@article{faucris.256830475,
author = {Elsharif, Shaimaa and Büttner, Andrea},
doi = {10.1021/acs.jafc.6b04534},
faupublication = {yes},
journal = {Journal of Agricultural and Food Chemistry},
peerreviewed = {Yes},
title = {{Structure}-{Odor} {Relationship} {Study} on {Geraniol}, {Nerol} and their synthesized {Oxygenated} {Derivatives}.},
year = {2018}
}
@article{faucris.257513833,
abstract = {The chiral metabolites in human urine were investigated after ingestion of a 1,8‐cineole (eucalyptol)‐containing entero‐coated capsule (Soledum). For identification of the various enantiomers the enantiomerically pure (−/+)‐α2‐hydroxy‐1,8‐cineole, (−/+)‐β2‐hydroxy‐1,8‐cineole, (−/+)‐9‐hydroxy‐1,8‐cineole, and (−/+)‐2‐oxo‐1,8‐cineole were prepared. To achieve this aim, after acetylation of the synthesized racemic 2‐ and 9‐hydroxy‐1,8‐cineoles, pig liver esterase‐ or yeast‐mediated hydrolysis provided the (−)‐alcohols with their antipodal (+)‐acetates with enantiomeric excess of 33–100 %. Dess–Martin periodinane oxidation of the alcohol (+)‐α2‐hydroxy‐1,8‐cineole, obtained by hydrolysis of the resolved acetate, provided the corresponding (+)‐2‐oxo‐1,8‐cineole, meanwhile the oxidation of (−)‐α2‐hydroxy‐1,8‐cineole gave (−)‐2‐oxo‐1,8‐cineole. Using these standards seven metabolites (+/−)‐α2‐hydroxy‐1,8‐cineole, (+/−)‐β2‐hydroxy‐1,8‐cineole, (+/−)‐α3‐hydroxycineole, (+/−)‐3‐oxo‐1,8‐cineole, 4‐hydroxy‐1,8‐cineole, 7‐hydroxy‐1,8‐cineole, and (+/−)‐9‐hydroxy‐1,8‐cineole, all liberated from their glucuronides, were identified in urine by GC‐MS on a chiral stationary phase after consumption of 100 mg of 1,8‐cineole. Metabolite screening using 2H3‐1,8‐cineol as the internal standard revealed (+/−)‐α2‐hydroxy‐1,8‐cineole as the predominant metabolite followed by (+/−)‐9‐hydroxy‐1,8‐cineole. Furthermore, the results showed that one enantiomer is always formed preferentially.
fat > carbohydrate. Our study reveals that the type of nutrient exerts a significant influence on metabolic parameters, hunger and food craving.},
author = {Bachlechner, Stephan and Denzer-Lippmann, Melanie Y. and Wielopolski, Jan and Fischer, Marie and Büttner, Andrea and Dörfler, Arnd and Schöfl, Christof and Muench, Gerald and Kornhuber, Johannes and Thürauf, Norbert},
doi = {10.3389/fpsyg.2017.01988},
faupublication = {yes},
journal = {Frontiers in Psychology},
keywords = {food ingestion;food intake;oral intake;olfaction;psychophysical function},
peerreviewed = {Yes},
title = {{The} {Effects} of {Different} {Isocaloric} {Oral} {Nutrient} {Solutions} on {Psychophysical}, {Metabolic}, {Cognitive}, and {Olfactory} {Function} in {Young} {Male} {Subjects}},
volume = {8},
year = {2017}
}
@article{faucris.257956171,
abstract = {The influence of human whole saliva on odor-active esters and thiols was investigated. Special emphasis was placed on food-relevant concentrations of the odorants. It was found that the amounts of the esters were reduced during incubation with saliva to different extents according to their chemical structures. Considerable degradations were also observed for 2-furfurylthiol, 2-phenylethanethiol, and 3-mercapto-3-methyl-1-butanol, being reduced from approximately 70 to 20% of their initial concentrations within a period of 10 min. Decrease of the odorants did not occur after thermal treatment of the saliva. Generally, the enzymic processes were found to be dependent on the salivary activity of each individual panelist as well as on the odorant's concentrations applied. These investigations were aimed at finding an explanation for the persistence of aftertaste in humans, as it is induced by some odor-active compounds after the consumption of food materials.
Boswellia varieties. Altogether, more than 300 volatiles in frankincense have been reported in the literature. In particular, a broad diversity has been found in the qualitative and quantitative composition of the volatiles with respect to different varieties of Boswellia. A detailed discussion of the various analytical approaches applied to isolating and analysing the volatile fractions of frankincense is also presented. Copyright © 2009 John Wiley & Sons, Ltd.
Background & aims: This study investigates time-dependent aroma changes in human milk after intake of an odorant-containing pharmaceutical preparation by correlating sensory evaluation with quantitative results.Methods: Human milk donors ingested 100 mg of encapsulated 1,8-cineole. 21 milk samples from 12 participants underwent sensory analysis, of which 14 samples were quantified by stable isotope dilution assay (SIDA) analysis. Furthermore, several consecutive breast milk and exhaled breath gas samples from one volunteer after intake of 1,8-cineole were analysed by proton-transfer-reaction mass spectrometry (PTR-MS) and sensory evaluation on three separate days.
Results: The emergence of the characteristic eucalyptus-like odour of 1,8-cineole in exhaled breath after capsule ingestion coincided with its transfer into milk; its presence in breath was therefore used to indicate the time at which milk should be expressed for gathering samples. Odorant transfer could not be confirmed by sensory analysis in 7 of the 21 milk samples, most likely due to disadvantageous timing of milk expression. The other 14 samples exhibited a distinct eucalyptus-like odour. Quantitative results matched these observations with <20 μg/kg 1,8-cineole in the odourless samples and 70 to an estimated 2090 μg/kg 1,8-cineole in the other samples.
Conclusions: Transfer of 1,8-cineole into human milk after oral intake is time dependent and exhibits large inter and intra-individual difference},
author = {Kirsch, Frauke and Beauchamp, Jonathan and Büttner, Andrea},
doi = {10.1016/j.clnu.2012.02.002},
faupublication = {yes},
journal = {The Journal of clinical nutrition},
peerreviewed = {unknown},
title = {{Time}-dependent aroma changes in breastmilk after oral intake of a pharmacological preparation containing 1,8-cineole.},
year = {2012}
}
@article{faucris.257517398,
abstract = {The release of volatile organic compounds (VOCs) into the mouth cavity is an integral part of the way flavor is perceived. An in vitro model mouth with an artificial tongue was developed to measure the dynamic release of VOCs from liquid model systems [e.g., aqueous solution, oil, and oil-in-water (O/W) emulsions] under oral conditions. The release of seven selected VOCs was affected by the different polarity and vapor pressure of the compounds and their affinity to the liquid system media. Different tongue pressure patterns were applied to the liquid systems, and the release of VOCs was monitored in real time using proton transfer reaction-mass spectrometry. The release was significantly more intense for longer tongue pressure duration and was influenced by the tongue altering the sample surface area and the distribution of the VOCs. The role of saliva (artificial versus human) and the sample temperature had a significant effect on VOC release. Saliva containing mucin and a higher sample temperature enhanced the release.
The transfer of certain substances from the maternal diet or medication into breast milk has been known for many years. There is currently also an increasing interest in odorants in human milk and their potential influence on the breastfed child. Nevertheless, metabolic products originating from bioconversion of odorants within the maternal organism have hitherto not been considered. Breastfed children may take in xenobiotic compounds that are transferred unmodified into human milk, but also their metabolic derivatives. Metabolic activation is a crucial point for evaluation of both positive and negative biological effects, thus it is important to understand the basic principles of metabolism in human milk. The present study investigated metabolite profiles of the odorant 1,8-cineole (eucalyptol) in human milk after lactating mothers ingested a non-prescription pharmaceutical (Soledum®) containing this substance. Ten different metabolites were identified, five of which have been previously described in humans and other mammals (α2-hydroxy-1,8-cineole, β2-hydroxy-1,8-cineole, α3-hydroxy-1,8-cineole, 7-hydroxy-1,8-cineole, 9-hydroxy-1,8-cineole). Three of the metabolites have hitherto only been found in microorganisms and insects (2-oxo-1,8-cineole, 3-oxo-1,8-cineole, 2,3-dehydro-1,8-cineole) and the derivatives α2,3-epoxy-1,8-cineole and 4-hydroxy-1,8-cineole have never before been identified as metabolites of 1,8-cineole. Metabolism profiles showed large inter- and intra-individual differences and were strongly related to sampling time. Identification and relative quantification of the metabolites were accomplished by gas chromatography–mass spectrometry (GC–MS) after preparation of the human milk extracts by solvent assisted flavour evaporation (SAFE). Synthesised reference substances were used to confirm the chemical identity of the detected substances.